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Chemical and mechanical stimuli act on common signal transduction and cytoskeletal networks.

Abstract：

:Signal transduction pathways activated by chemoattractants have been extensively studied, but little is known about the events mediating responses to mechanical stimuli. We discovered that acute mechanical perturbation of cells triggered transient activation of all tested components of the chemotactic signal transduction network, as well as actin polymerization. Similarly to chemoattractants, the shear flow-induced signal transduction events displayed features of excitability, including the ability to mount a full response irrespective of the length of the stimulation and a refractory period that is shared with that generated by chemoattractants. Loss of G protein subunits, inhibition of multiple signal transduction events, or disruption of calcium signaling attenuated the response to acute mechanical stimulation. Unlike the response to chemoattractants, an intact actin cytoskeleton was essential for reacting to mechanical perturbation. These results taken together suggest that chemotactic and mechanical stimuli trigger activation of a common signal transduction network that integrates external cues to regulate cytoskeletal activity and drive cell migration.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Artemenko Y,Axiotakis L Jr,Borleis J,Iglesias PA,Devreotes PN

doi

10.1073/pnas.1608767113

subject

Has Abstract

pub_date

2016-11-22 00:00:00

pages

E7500-E7509

issue

47

eissn

0027-8424

issn

1091-6490

pii

1608767113

journal_volume

113

pub_type

杂志文章

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