Hormone-regulatable neoplastic transformation induced by a Jun-estrogen receptor chimera.

Abstract:

:The v-jun oncogene encodes a nuclear DNA binding protein that functions as a transcription factor and is part of the activator protein 1 complex. Oncogenic transformation by v-jun is thought to be mediated by the aberrant expression of specific target genes. To identify such Jun-regulated genes and to explore the mechanisms by which Jun affects their expression, we have fused the full-length v-Jun and an amino-terminally truncated form of v-Jun to the hormone-binding domain of the human estrogen receptor. The two chimeric proteins function as ligand-inducible transactivators. Expression of the fusion proteins in chicken embryo fibroblasts causes estrogen-dependent transformation.

authors

Kruse U,Iacovoni JS,Goller ME,Vogt PK

doi

10.1073/pnas.94.23.12396

subject

Has Abstract

pub_date

1997-11-11 00:00:00

pages

12396-400

issue

23

eissn

0027-8424

issn

1091-6490

journal_volume

94

pub_type

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