Superconductivity in the PbO-type structure alpha-FeSe.

abstract：:Real-world studies show that the facial expressions produced during pain and orgasm-two different and intense affective experiences-are virtually indistinguishable. However, this finding is counterintuitive, because facial expressions are widely considered to be a powerful tool for social interaction. Consequently, de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen C,Crivelli C,Garrod OGB,Schyns PG,Fernández-Dols JM,Jack RE

更新日期：2018-10-23 00:00:00

abstract：:Arabinose-binding protein, maltose-binding protein, and lambda receptor are synthesized in vitro on membrane-bound polysomes from Escherichia coli. All three proteins are exported from the cytoplasm of E. coli and all three are made in vitro in a form a few thousand daltons larger than the authentic protein. The large...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Randall LL,Hardy SJ,Josefsson LG

更新日期：1978-03-01 00:00:00

abstract：:The RNA-directed DNA polymerase (deoxynucleosidetriphosphate:DNA deoxynucleotidyltransferase EC 2.7.7.7) of avian oncornavirus requires a tryptophan tRNA (tRNATrp) primer molecule located close to the 5' end of the viral RNA genome for the initiation of DNA synthesis in vitro. In this communication we demonstrate that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collett MS,Faras AJ

更新日期：1976-04-01 00:00:00

abstract：:Mechanisms of bacterial pathogenesis have become an increasingly important subject as pathogens have become increasingly resistant to current antibiotics. The adhesion of microorganisms to the surface of host tissue is often a first step in pathogenesis and is a plausible target for new antiinfective agents. Examinati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liang MN,Smith SP,Metallo SJ,Choi IS,Prentiss M,Whitesides GM

更新日期：2000-11-21 00:00:00

abstract：:One can imagine a variety of mechanisms that should result in self-perpetuating biological states. It is generally assumed that cytosine methylation is propagated in eukaryotes by enzymes that specifically methylate hemimethylated symmetrical sites (e.g., (5')CpGGpC(5') or (5')CpNpGGpNpC(5')). Although there is wide s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Selker EU,Freitag M,Kothe GO,Margolin BS,Rountree MR,Allis CD,Tamaru H

更新日期：2002-12-10 00:00:00

abstract：:Inosine monophosphate dehydrogenase (IMPDH) controls a key metabolic step in the regulation of cell growth and differentiation. This step is the NAD-dependent oxidation of inosine 5' monophosphate (IMP) to xanthosine 5' monophosphate, the rate-limiting step in the synthesis of the guanine nucleotides. Two isoforms of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colby TD,Vanderveen K,Strickler MD,Markham GD,Goldstein BM

更新日期：1999-03-30 00:00:00

abstract：:GTP-tubulin forms a cap on microtubule ends during aggregation. The bulk of the microtubule is GDP-tubulin. This complicates the usual simple kinetic theory of subunit exchange at microtubule ends to such an extent that Monte Carlo calculations are needed to handle the complications, except in special cases. The Monte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen Y,Hill TL

更新日期：1983-12-01 00:00:00

abstract：:Changes in the secondary structure of some dozen different proteins upon lyophilization of their aqueous solutions have been investigated by means of Fourier-transform infrared spectroscopy in the amide III band region. Dehydration markedly (but reversibly) alters the secondary structure of all the proteins studied, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griebenow K,Klibanov AM

更新日期：1995-11-21 00:00:00

abstract：:Bone morphogenetic protein 2 (BMP-2) is a potent inducer of differentiation of osteoblasts both in vivo and in vitro. We examined the action of BMP-2 on expression of a helix-loop-helix-type transcription factor, Id (inhibitor of differentiation), in osteoblast-like cells, as well as in osteoblast-enriched cells and p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogata T,Wozney JM,Benezra R,Noda M

更新日期：1993-10-01 00:00:00

abstract：:Worldwide dissemination of antibiotic resistance in bacteria is facilitated by plasmids that encode postsegregational killing (PSK) systems. These produce a stable toxin (T) and a labile antitoxin (A) conditioning cell survival to plasmid maintenance, because only this ensures neutralization of toxicity. Shortage of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pimentel B,Nair R,Bermejo-Rodríguez C,Preston MA,Agu CA,Wang X,Bernal JA,Sherratt DJ,de la Cueva-Méndez G

更新日期：2014-02-18 00:00:00

abstract：:Aspergillus fumigatus is commonly associated with allergic bronchopulmonary aspergillosis in patients with severe asthma in which chronic airway neutrophilia predicts a poor outcome. We were able to recapitulate fungus-induced neutrophilic airway inflammation in a mouse model in our efforts to understand the underlyin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fei M,Bhatia S,Oriss TB,Yarlagadda M,Khare A,Akira S,Saijo S,Iwakura Y,Fallert Junecko BA,Reinhart TA,Foreman O,Ray P,Kolls J,Ray A

更新日期：2011-03-29 00:00:00

abstract：:Epstein-Barr virus (EBV) is associated with epithelial and lymphoid malignancies, establishes latent infection in memory B cells, and intermittently produces infectious virions through lytic replication. Released virions play a key role in latent reservoir maintenance and transmission. Lytic EBV transcription differs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verma D,Church TM,Swaminathan S

更新日期：2020-06-09 00:00:00

abstract：:Serotonin (5-HT) binding sites from bovine and rat cerebral cortex membranes share pharmacological properties that allow both to be subclassified by the same criteria. We show here that [3H]5-HT binding sites from human cortex also possess pharmacological properties that follow the same subclassification scheme as for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Todd RD,Ciaranello RD

更新日期：1985-01-01 00:00:00

abstract：:The phosphoinositide 3-kinase (PI3K) pathway is central to the metabolic actions of insulin on liver. Here, we show that mice with a liver-specific deletion of the p85alpha regulatory subunit of PI3K (L-Pik3r1KO) exhibit a paradoxical improvement of hepatic and peripheral insulin sensitivity. Although PI3K enzymatic a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taniguchi CM,Tran TT,Kondo T,Luo J,Ueki K,Cantley LC,Kahn CR

更新日期：2006-08-08 00:00:00

abstract：:The temperature dependence of migration rate and of the thermotactic sensitivity of pseudoplasmodia of Dictyostelium discoideum has been measured. Migration rate increases with temperature to 20 degrees, is temperature insensitive from 20 degrees to 27.5 degrees, and decreases with temperature to 29 degrees, above whi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Poff KL,Skokut M

更新日期：1977-05-01 00:00:00

abstract：:Although the binding change mechanism of rotary catalysis by which F1-ATPase hydrolyzes ATP has been supported by equilibrium, kinetic, and structural observations, many questions concerning the function remain unanswered. Because of the importance of this enzyme, the search for a full understanding of its mechanism i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao YQ,Yang W,Marcus RA,Karplus M

更新日期：2003-09-30 00:00:00

abstract：:Minimally invasive detection of cell death could prove an invaluable resource in many physiologic and pathologic situations. Cell-free circulating DNA (cfDNA) released from dying cells is emerging as a diagnostic tool for monitoring cancer dynamics and graft failure. However, existing methods rely on differences in DN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehmann-Werman R,Neiman D,Zemmour H,Moss J,Magenheim J,Vaknin-Dembinsky A,Rubertsson S,Nellgård B,Blennow K,Zetterberg H,Spalding K,Haller MJ,Wasserfall CH,Schatz DA,Greenbaum CJ,Dorrell C,Grompe M,Zick A,Hubert A,M

更新日期：2016-03-29 00:00:00

abstract：:The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Webster GD,Sanderson MR,Skelly JV,Neidle S,Swann PF,Li BF,Tickle IJ

更新日期：1990-09-01 00:00:00

abstract：:Beta subunits of voltage-gated Ca2+ channels are encoded in four genes and display additional molecular diversity because of alternative splicing. At the functional level, all forms are very similar except for beta2a, which differs in that it does not support prepulse facilitation of alpha1C Ca2+ channels, inhibits vo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Qin N,Platano D,Olcese R,Costantin JL,Stefani E,Birnbaumer L

更新日期：1998-04-14 00:00:00

abstract：:Alzheimer's disease (AD) neuropathological hallmarks include senile plaques with aggregated amyloid beta as a major component, neurofibrillary tangles (NFT) containing truncated and hyperphosphorylated Tau, extensive neuronal loss, and chronic neuroinflammation. However, the key molecular mechanism that dominates the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang H,Liu X,Chen S,Ye K

更新日期：2018-12-26 00:00:00

abstract：:The Na(+)/I(-) symporter (NIS) is a key plasma membrane protein that mediates active I(-) uptake in the thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na(+) per I(-). In the thyroid, NIS-mediated I(-) uptake is the first step in the biosynthesis of the iodine-containing thyroid ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dohán O,Portulano C,Basquin C,Reyna-Neyra A,Amzel LM,Carrasco N

更新日期：2007-12-18 00:00:00

abstract：:Genomic analyses of patients with congenital heart disease (CHD) have identified significant contribution from mutations affecting cilia genes and chromatin remodeling genes; however, the mechanism(s) connecting chromatin remodeling to CHD is unknown. Histone H2B monoubiquitination (H2Bub1) is catalyzed by the RNF20 c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robson A,Makova SZ,Barish S,Zaidi S,Mehta S,Drozd J,Jin SC,Gelb BD,Seidman CE,Chung WK,Lifton RP,Khokha MK,Brueckner M

更新日期：2019-07-09 00:00:00

abstract：:In the plant Nicotiana plumbaginifolia, manganese superoxide dismutase (MnSOD) is synthesized in the cytoplasm as a preprotein and is subsequently translocated to the mitochondrial matrix with corresponding cleavage of an NH2-terminal leader sequence. To determine whether the plant enzyme could replace the endogenous ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowler C,Alliotte T,Van den Bulcke M,Bauw G,Vandekerckhove J,Van Montagu M,Inzé D

更新日期：1989-05-01 00:00:00

abstract：:A Mr 35,000 calmodulin-binding protein, which also possesses the ability to interact with a number of cytoskeletal elements, was purified from bovine synaptosomal membranes, using hydroxylapatite and phosphocellulose column chromatography. We call this protein "cytosynalin," which is derived from a combination of the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sobue K,Okabe T,Kadowaki K,Itoh K,Tanaka T,Fujio Y

更新日期：1987-04-01 00:00:00

abstract：:Interleukin (IL)-2 is a type I four-alpha-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. We now demonstrate that IL-2 potently decreases expression of IL-7 receptor alpha chain (IL-7Ralpha) mRNA and pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xue HH,Kovanen PE,Pise-Masison CA,Berg M,Radovich MF,Brady JN,Leonard WJ

更新日期：2002-10-15 00:00:00

abstract：:The circadian clock modulates expression of a large fraction of the Arabidopsis genome and affects many aspects of plant growth and development. We have discovered one way in which the circadian system regulates hormone signaling, identifying a node that links the clock and auxin networks. Auxin plays key roles in dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rawat R,Schwartz J,Jones MA,Sairanen I,Cheng Y,Andersson CR,Zhao Y,Ljung K,Harmer SL

更新日期：2009-09-29 00:00:00

abstract：:Therapy-related acute myeloid leukemias (t-AML) with translocations of the MLL gene are associated with the use of topoisomerase II inhibitors. We established the emergence of the malignant clone in a child who developed t-AML with a t(11;19) (q23;p13.3) during treatment for acute lymphoblastic leukemia (ALL). The MLL...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blanco JG,Dervieux T,Edick MJ,Mehta PK,Rubnitz JE,Shurtleff S,Raimondi SC,Behm FG,Pui CH,Relling MV

更新日期：2001-08-28 00:00:00

abstract：:Oligomerization plays a critical role in shaping the light-harvesting properties of many photosynthetic pigment-protein complexes, but a detailed understanding of this process at the level of individual pigments is still lacking. To study the effects of oligomerization, we designed a single-molecule approach to probe ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Q,Moerner WE

更新日期：2015-11-10 00:00:00

abstract：:Xenotropic and polytropic murine leukemia viruses (X-MLVs and P-MLVs) cross-interfere to various extents in non-mouse species and in wild Asian mice, suggesting that they might use a common receptor for infection. Consistent with this hypothesis, the susceptibility of some wild mice to X-MLVs has been mapped to the P-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tailor CS,Nouri A,Lee CG,Kozak C,Kabat D

更新日期：1999-02-02 00:00:00

abstract：:The mechanism of phospholipase C regulation by inhibitory receptors was analyzed both in intact and in permeabilized rat thyroid cells (FRTL5). In this system, the muscarinic agonist carbachol inhibited phospholipase C, as indicated by the decrease in the basal levels of inositol 1,4,5-trisphosphate as well as by the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bizzarri C,Di Girolamo M,D'Orazio MC,Corda D

更新日期：1990-06-01 00:00:00