The Na+/I symporter (NIS) mediates electroneutral active transport of the environmental pollutant perchlorate.

abstract：:The biosynthetic origin of the 10,000 molecular weight neurophysins, carriers of the peptide hormones oxytocin and vasopressin, has been studied by cell-free synthesis, Poly(A)-RNA was isolated from bovine hypothalamus and translated in a wheat germ system containing (35)S- or (3)H-labeled amino acids. A number of uni...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giudice LC,Chaiken IM

更新日期：1979-08-01 00:00:00

abstract：:Nonsense-mediated mRNA decay (NMD), which degrades transcripts harboring a premature termination codon (PTC), depends on the helicase up-frameshift 1 (UPF1). However, mRNAs that are not NMD targets also bind UPF1. What governs the timing, position, and function of UPF1 binding to mRNAs remains unclear. We provide evid...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurosaki T,Maquat LE

更新日期：2013-02-26 00:00:00

abstract：:The modern Old World Monkeys (Superfamily Cercopithecoidea, Family Cercopithecidae) can be traced back into the late Miocene, but their origin and subsequent diversification is obscured by the scarcity of terrestrial fossil sites in Africa between 15 and 6 Ma. Here, we document the presence of cercopithecids at 12.5 M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rossie JB,Gilbert CC,Hill A

更新日期：2013-04-09 00:00:00

abstract：:Swainsonine, an indolizidine alkaloid, inhibits the processing of asparagine-linked glycoproteins in both cell-free extracts and animal cells in culture. Thus, in a liver particulate enzyme preparation, swainsonine at 0.1-1.0 microM inhibited the mannosidase that releases [3H]mannose from a high mannose glycopeptide b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elbein AD,Solf R,Dorling PR,Vosbeck K

更新日期：1981-12-01 00:00:00

abstract：:Infant acute lymphoblastic leukemia (ALL) with MLL gene rearrangements is characterized by early pre-B phenotype (CD10(-)/CD19(+)) and poor treatment outcome. The t(4;11), creating MLL-AF4 chimeric transcripts, is the predominant 11q23 chromosome translocation in infant ALL and is associated with extremely poor progno...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taki T,Kano H,Taniwaki M,Sako M,Yanagisawa M,Hayashi Y

更新日期：1999-12-07 00:00:00

abstract：:Cerebellar granule cells grown in the presence of a serum complex differentiate but are resistant to the lethal action of excitatory amino acids. When these cells are grown also in the presence of insulin-like growth factor I (IGF-I) they become fully susceptible to the toxic, lethal action of glutamate. The glutamate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calissano P,Ciotti MT,Battistini L,Zona C,Angelini A,Merlo D,Mercanti D

更新日期：1993-09-15 00:00:00

abstract：:Antibodies from three different lines of monoclonal hybridomas crossreact with both the beta subunit of spectrin and the 90-kDa peptide present in highly purified preparations of the heme-controlled eIF-2 alpha (initiation factor 2 alpha-subunit) kinase from rabbit reticulocytes. Antibodies from two of the three lines...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kudlicki W,Fullilove S,Kramer G,Hardesty B

更新日期：1985-08-01 00:00:00

abstract：:The type specimen for Australopithecus africanus (Taung) includes a natural endocast that reproduces most of the external morphology of the right cerebral hemisphere and a fragment of fossilized face that articulates with the endocast. Despite the fact that Taung died between 3 and 4 y of age, the endocast reproduces ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Falk D,Zollikofer CP,Morimoto N,Ponce de León MS

更新日期：2012-05-29 00:00:00

abstract：:Within the Ig superfamily (IgSF), intercellular adhesion molecules (ICAMs) form a subfamily that binds the leukocyte integrin alphaLbeta2. We report a 1.65-A-resolution crystal structure of the ICAM-3 N-terminal domain (D1) in complex with the inserted domain, the ligand-binding domain of alphaLbeta2. This high-resolu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song G,Yang Y,Liu JH,Casasnovas JM,Shimaoka M,Springer TA,Wang JH

更新日期：2005-03-01 00:00:00

abstract：:Arsenic has played a key medicinal role against a variety of ailments for several millennia, but during the past century its prominence has been displaced by modern therapeutics. Recently, attention has been drawn to arsenic by its dramatic clinical efficacy against acute promyelocytic leukemia. Although toxic reactiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chou WC,Jie C,Kenedy AA,Jones RJ,Trush MA,Dang CV

更新日期：2004-03-30 00:00:00

abstract：:Prenatal stress exposure is associated with risk for psychiatric disorders later in life. This may be mediated in part via enhanced exposure to glucocorticoids (GCs), which are known to impact neurogenesis. We aimed to identify molecular mediators of these effects, focusing on long-lasting epigenetic changes. In a hum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Provençal N,Arloth J,Cattaneo A,Anacker C,Cattane N,Wiechmann T,Röh S,Ködel M,Klengel T,Czamara D,Müller NS,Lahti J,PREDO team.,Räikkönen K,Pariante CM,Binder EB

更新日期：2020-09-22 00:00:00

abstract：:Zea mays plasma membrane intrinsic proteins (ZmPIPs) fall into two groups, ZmPIP1s and ZmPIP2s, that exhibit different water channel activities when expressed in Xenopus oocytes. ZmPIP1s are inactive, whereas ZmPIP2s induce a marked increase in the membrane osmotic water permeability coefficient, P(f). We previously s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zelazny E,Borst JW,Muylaert M,Batoko H,Hemminga MA,Chaumont F

更新日期：2007-07-24 00:00:00

abstract：:Because of increased numbers of recorded pertussis cases in the United States, this study sought to understand the role of nonmedical vaccine exemptions and waning immunity may have had on the resurgence of pertussis in the United States at the community level. We used geospatial scan statistics, SaTScan, version 9.4,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aloe C,Kulldorff M,Bloom BR

更新日期：2017-07-03 00:00:00

abstract：:We have investigated the pharmacologic and neurotoxic properties of 2,4,5-trihydroxyphenylalanine [topa; the 6-hydroxylated derivative of 3,4-dihydroxyphenylalanine (dopa)] in central neurons. Application of solutions of topa to the chicken eyecup preparation results in glutamatergic responses mediated predominantly b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenberg PA,Loring R,Xie Y,Zaleskas V,Aizenman E

更新日期：1991-06-01 00:00:00

abstract：:Previous experiments have demonstrated that the human beta-globin gene is correctly regulated in transgenic mice. The beta-globin gene is not expressed in yolk sac-derived erythroid cells in early embryonic development but is expressed concomitantly with the adult mouse beta-globin genes in 14- to 16-day fetal liver a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Behringer RR,Hammer RE,Brinster RL,Palmiter RD,Townes TM

更新日期：1987-10-01 00:00:00

abstract：:Regulation of irreversible cell lineage commitment depends on a delicate balance between positive and negative regulators, which comprise a sophisticated network of transcription factors. Receptor activator of NF-kappaB ligand (RANKL) stimulates the differentiation of bone-resorbing osteoclasts through the induction o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishikawa K,Nakashima T,Hayashi M,Fukunaga T,Kato S,Kodama T,Takahashi S,Calame K,Takayanagi H

更新日期：2010-02-16 00:00:00

abstract：:The suppressor of Hairy-wing [su(Hw)] protein exerts a polar effect on gene expression by repressing the function of transcriptional enhancers located distally from the promoter with respect to the location of su(Hw) binding sequences. The directionality of this effect suggests that the su(Hw) protein specifically int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Georgiev PG,Corces VG

更新日期：1995-05-23 00:00:00

abstract：:Bacteriophage T3-induced RNA polymerase, upon copying its specific template, native T3 DNA, initiates RNA chains only with GTP. Denaturation of the DNA results in loss of template specificity for the polymerase. With denatured T3 DNA as template, T3 polymerase initiates RNA chains with both ATP and GTP, and the averag...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maitra U,Huang HH

更新日期：1972-01-01 00:00:00

abstract：:Epidermal growth factor (EGF) stimulates membrane protein phosphorylation in a human cell line, A-431. The known hepatic mitogenic action of EGF and the reduction in EGF receptor number that occurs during liver regeneration led us to study whether EGF-dependent protein kinase activity was present in rat liver and whet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rubin RA,O'Keefe EJ,Earp HS

更新日期：1982-02-01 00:00:00

abstract：:The nucleus accumbens is considered a critical target of the action of drugs of abuse. In this nucleus a "shell" and a "core" have been distinguished on the basis of anatomical and histochemical criteria. The present study investigated the effect in freely moving rats of intravenous cocaine, amphetamine, and morphine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pontieri FE,Tanda G,Di Chiara G

更新日期：1995-12-19 00:00:00

abstract：:The cell surface proteome, the surfaceome, is the interface for engaging the extracellular space in normal and cancer cells. Here we apply quantitative proteomics of N-linked glycoproteins to reveal how a collection of some 700 surface proteins is dramatically remodeled in an isogenic breast epithelial cell line stabl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leung KK,Wilson GM,Kirkemo LL,Riley NM,Coon JJ,Wells JA

更新日期：2020-04-07 00:00:00

abstract：:We have found that in the gill- and siphon- withdrawal reflex of Aplysia, the memory for short-term sensitization grades smoothly into long-term memory with increased amounts of sensitization training. One cellular locus for the storage of the memory underlying short-term sensitization is the set of monosynaptic conne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frost WN,Castellucci VF,Hawkins RD,Kandel ER

更新日期：1985-12-01 00:00:00

abstract：:The copy number of plasmid ColE1 has been known to increase when the Hae II-C segment downstream from the replication origin is deleted. The presence of the 306-base-pair (bp) Hpa II region in the segment is sufficient for reduction of the copy number. Plasmids harboring the region express a trans-acting function that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Som T,Tomizawa J

更新日期：1983-06-01 00:00:00

abstract：:Radiation therapy is a widely used cancer treatment, but it causes side effects even when localized radiotherapy is used. Extensive apoptosis of microvascular endothelial cells of the lamina propria is the primary lesion initiating intestinal radiation damage after abdominal radiation therapy. Many in vitro studies su...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cho CH,Kammerer RA,Lee HJ,Yasunaga K,Kim KT,Choi HH,Kim W,Kim SH,Park SK,Lee GM,Koh GY

更新日期：2004-04-13 00:00:00

abstract：:A human beta-globin gene derived from an established human lymphoblast cell line was introduced into murine erythroleukemia (MEL) cells by cell fusion. The globin genes in MEL cells are inducible by dimethyl sulfoxide (Me2SO); induction leads to the accumulation of mouse globin mRNA and hemoglobin. Globin mRNA was not...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyati J,Kucherlapati RS,Skoultchi AI

更新日期：1980-06-01 00:00:00

abstract：:The past two decades have seen an enormous growth in the field of human brain mapping. Investigators have extensively exploited techniques such as positron emission tomography and MRI to map patterns of brain activity based on changes in cerebral hemodynamics. However, until recently, most studies have investigated eq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosen BR,Buckner RL,Dale AM

更新日期：1998-02-03 00:00:00

abstract：:Mice lacking the beta1-subunit (gene, Kcnmb1; protein, BK-beta1) of the large Ca-activated K channel (BK) are hypertensive. This phenotype is thought to result from diminished BK currents in vascular smooth muscle where BK-beta1 is an ancillary subunit. However, the beta1-subunit is also expressed in the renal connect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grimm PR,Irsik DL,Settles DC,Holtzclaw JD,Sansom SC

更新日期：2009-07-14 00:00:00

abstract：:That the yolk proteins (YPs), or vitellins, stored in the oocytes of insects are a nutritional store for subsequent embryogenesis has long been assumed. Exhaustive data base searching programs revealed highly significant sequence similarity between the three YPs of Drosophila melanogaster and part of the triacylglycer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bownes M,Shirras A,Blair M,Collins J,Coulson A

更新日期：1988-03-01 00:00:00

abstract：:Treatment of the third component of human complement (C3) with methylamine results in a loss of hemolytic function and the appearance of a thiol group. Studies with [14C]methylamine have indicatd a stoichiometric and covalent reaction with the native protein. Hydrazine-inactivated C3 and C3b prepared with bovine tryps...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tack BF,Harrison RA,Janatova J,Thomas ML,Prahl JW

更新日期：1980-10-01 00:00:00

abstract：:FUS3 is functionally redundant with KSS1, a homologous yeast protein kinase, for a step(s) in signal transduction between the beta subunit of the guanine nucleotide binding protein (G protein), STE4, and the mating type-specific transcriptional activator, STE12. Either FUS3 or KSS1 can execute this function; when neit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elion EA,Brill JA,Fink GR

更新日期：1991-11-01 00:00:00