Abstract:
:Interleukin (IL)-2 is a type I four-alpha-helical bundle cytokine that plays vital roles in antigen-mediated proliferation of peripheral blood T cells and also is critical for activation-induced cell death. We now demonstrate that IL-2 potently decreases expression of IL-7 receptor alpha chain (IL-7Ralpha) mRNA and protein. The fact that IL-7Ralpha is a component of the receptors for both IL-7 and thymic stromal lymphopoietin (TSLP) suggests that IL-2 can negatively regulate signals by each of these cytokines. Previously it was known that the IL-2 and IL-7 receptors shared the common cytokine receptor gamma chain, gamma(c), which suggested a possible competition between these cytokines for a receptor component. Our findings now suggest a previously unknown type of cross-talk between IL-2 and IL-7 signaling by showing that IL-2 signaling can diminish IL-7Ralpha expression via a phosphatidylinositol 3-kinase/Akt-dependent mechanism.
journal_name
Proc Natl Acad Sci U S Aauthors
Xue HH,Kovanen PE,Pise-Masison CA,Berg M,Radovich MF,Brady JN,Leonard WJdoi
10.1073/pnas.212214999keywords:
subject
Has Abstractpub_date
2002-10-15 00:00:00pages
13759-64issue
21eissn
0027-8424issn
1091-6490pii
212214999journal_volume
99pub_type
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