Epstein-Barr virus co-opts TFIIH component XPB to specifically activate essential viral lytic promoters.

abstract：:The Arabidopsis thaliana SOS1 protein is a putative Na+/H+ antiporter that functions in Na+ extrusion and is essential for the NaCl tolerance of plants. sos1 mutant plants share phenotypic similarities with mutants lacking the protein kinase SOS2 and the Ca2+ sensor SOS3. To investigate whether the three SOS proteins ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quintero FJ,Ohta M,Shi H,Zhu JK,Pardo JM

更新日期：2002-06-25 00:00:00

abstract：:Studies in animals demonstrate a crucial role for the amygdala in emotional and social behavior, especially as related to fear and aggression. Whereas lesion and functional-imaging studies in humans indicate the amygdala's participation in assessing the significance of nonverbal as well as paralinguistic cues, direct ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Isenberg N,Silbersweig D,Engelien A,Emmerich S,Malavade K,Beattie B,Leon AC,Stern E

更新日期：1999-08-31 00:00:00

abstract：:Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per cell (aneuploidy) a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nowak MA,Komarova NL,Sengupta A,Jallepalli PV,Shih IeM,Vogelstein B,Lengauer C

更新日期：2002-12-10 00:00:00

abstract：:Limited trypsinization of the fatty acid synthetase multienzyme complex from rat mammary gland results in the release of a protein, molecular weight 32,000, with thioesterase activity. The other components of the multienzyme complex--the acyl carrier protein, acetyl and malonyl transferases, condensing enzyme, keto re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith S,Agradi E,Libertini L,Dileepan KN

更新日期：1976-04-01 00:00:00

abstract：:Mammalian nervous system function involves billions of neurons which are interconnected in a multitude of neural circuits. Here we describe a genetic approach to chart neural circuits. By using an olfactory-specific promoter, we selectively expressed barley lectin in sensory neurons in the olfactory epithelium and vom...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horowitz LF,Montmayeur JP,Echelard Y,Buck LB

更新日期：1999-03-16 00:00:00

abstract：:A segment of DNA containing cya, the gene for adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1], has been isolated from Salmonella typhimurium. The phage lambda gt4 was used as a cloning vector and adenylate cyclase-positive hybrid phages were isolated that complemented adenylate cyclase-negative bac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang JY,Clegg DO,Koshland DE Jr

更新日期：1981-08-01 00:00:00

abstract：:Electromyographic recordings from individual identified ankle muscles of the 7-day chick embryo (stage 31) were used to determine the organization of motor output at a developmental stage shortly after the onset of spontaneous motility in the leg. During spontaneous motility of the embryo, the electromyographic record...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bekoff A,Stein PS,Hamburger V

更新日期：1975-04-01 00:00:00

abstract：:It has been shown that the pituitary contains a cytotropic factor (CTF) that stimulates the secretion of catecholamines by dopaminergic neurons of the hypothalamus. In the present study, CTF was purified from rat pituitaries and found by means of mass spectrometric analysis to be adenosine. This finding was corroborat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Porter JC,Ijames CF,Wang TC,Markey SP

更新日期：1995-06-06 00:00:00

abstract：:It has long been recognized that a suite of proteins exists in coral skeletons that is critical for the oriented precipitation of calcium carbonate crystals, yet these proteins remain poorly characterized. Using liquid chromatography-tandem mass spectrometry analysis of proteins extracted from the cell-free skeleton o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Drake JL,Mass T,Haramaty L,Zelzion E,Bhattacharya D,Falkowski PG

更新日期：2013-03-05 00:00:00

abstract：:The matrix 2 (M2) protein from influenza A virus is a proton channel that uses His37 as a selectivity filter. Here we report high-resolution (1.10 Å) cryogenic crystallographic structures of the transmembrane domain of M2 at low and high pH. These structures reveal that waters within the pore form hydrogen-bonded netw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomaston JL,Alfonso-Prieto M,Woldeyes RA,Fraser JS,Klein ML,Fiorin G,DeGrado WF

更新日期：2015-11-17 00:00:00

abstract：:Using short-term cultures of hamster embryo cells, we have examined the effects of the free-radical scavenger superoxide dismutase (superoxide:superoxide oxidoreductase, EC 1.15.1.1) and the enzyme catalase (hydrogen-peroxide:hydrogenperoxide oxidoreductase, EC 1.11.1.6) on x-ray- and bleomycin-induced transformation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Borek C,Troll W

更新日期：1983-03-01 00:00:00

abstract：:Synapsin I is a neuron-specific phosphoprotein associated with the membranes of small synaptic vesicles. Its function is not entirely clear, but evidence points to a possible role in the regulation of neurotransmitter release. Its biosynthesis is under developmental control. Assignment of the human synapsin I gene to ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang-Feng TL,DeGennaro LJ,Francke U

更新日期：1986-11-01 00:00:00

abstract：:The detrimental effects of elevated intensities of mid-UV radiation (UVB), a result of stratospheric ozone depletion during the austral spring, on the primary producers of the Antarctic marine ecosystem have been well documented. Here we report that natural populations of Antarctic zooplankton also sustain significant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malloy KD,Holman MA,Mitchell D,Detrich HW 3rd

更新日期：1997-02-18 00:00:00

abstract：:Somatic crossing-over was used in heterozygous Drosophila melanogaster to effect clonal homozygosity for three mutants (h, Hw, ac). In these mutants, one type of process, chaetae, replaces another type, trichomes, in specific patterns on the adult fly. Heterozygous individuals were irradiated at different larval or pu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Garcia-Bellido A,Merriam JR

更新日期：1971-09-01 00:00:00

abstract：:The gal operon of Escherichia coli is negatively regulated by repressor binding to bipartite operators separated by 11 helical turns of DNA. Synergistic binding of repressor to separate sites on DNA results in looping, with the intervening DNA as a topologically closed domain containing the two promoters. A closed DNA...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Choy HE,Park SW,Parrack P,Adhya S

更新日期：1995-08-01 00:00:00

abstract：:The dynamics of excited-state double proton transfer of model DNA base pairs, 7-azaindole dimers, is reported using femtosecond fluorescence spectroscopy. To elucidate the nature of the transfer in the condensed phase, here we examine variation of solvent polarity and viscosity, solute concentration, and isotopic frac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kwon OH,Zewail AH

更新日期：2007-05-22 00:00:00

abstract：:An enconuclease activity that reacts with x-irradiated DNA is present in extracts of E. coli. By using centrifugal methods to monitor the conversion of the supercoiled, circular double-stranded DNA for phage phi-x-174 (replicative form) or PM2 to the relaxed circular form it was possible to quantitate the rate of radi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Strniste GF,Wallace SS

更新日期：1975-06-01 00:00:00

abstract：:Murine mucopolysaccharidosis type VII is a heritable disease caused by a spontaneous mutation, gus(mps), closely linked to the beta-glucuronidase structural gene on chromosome 5. Mice homozygous for the mutation have a > 200-fold decrease in beta-glucuronidase mRNA levels and virtually no enzyme activity detectable by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sands MS,Birkenmeier EH

更新日期：1993-07-15 00:00:00

abstract：:Previous reports have shown that γδ T cells are important for the elimination of malaria parasites in humans and mice. However, how γδ T cells are involved in protective immunity against blood-stage malaria remains unknown. We infected γδ T-cell-deficient (TCRδ-KO) mice and control wild-type mice with Plasmodium bergh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue S,Niikura M,Takeo S,Mineo S,Kawakami Y,Uchida A,Kamiya S,Kobayashi F

更新日期：2012-07-24 00:00:00

abstract：:Cellular regulation by certain growth factor receptors and protooncogene products involves tyrosine kinase activity with the resultant tyrosine phosphorylation of protein substrates. In the present report we describe the distribution of phosphotyrosine-containing material detected by immunocytochemistry (ICC) in the r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moss AM,Unger JW,Moxley RT,Livingston JN

更新日期：1990-06-01 00:00:00

abstract：:Bicistronic cassettes under control of a single promoter have recently been suggested as useful tools for coordinate expression of two different foreign proteins in mammalian cells. Using the long 5' untranslated region of encephalomyocarditis virus as translational enhancer of the second gene, a bicistronic unit comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Aran JM,Gottesman MM,Pastan I

更新日期：1994-04-12 00:00:00

abstract：:PAX5 is a well-known haploinsufficient tumor suppressor gene in human B-cell precursor acute lymphoblastic leukemia (B-ALL) and is involved in various chromosomal translocations that fuse a part of PAX5 with other partners. However, the role of PAX5 fusion proteins in B-ALL initiation and transformation is ill-known. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jamrog L,Chemin G,Fregona V,Coster L,Pasquet M,Oudinet C,Rouquié N,Prade N,Lagarde S,Cresson C,Hébrard S,Nguyen Huu NS,Bousquet M,Quelen C,Brousset P,Mancini SJC,Delabesse E,Khamlichi AA,Gerby B,Broccardo C

更新日期：2018-10-09 00:00:00

abstract：:A recombinant plasmid containing sequences complementary to human pro-alpha l(I) collagen mRNA was used for the chromosomal assignment of the pro-alpha l(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromoso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huerre C,Junien C,Weil D,Chu ML,Morabito M,Van Cong N,Myers JC,Foubert C,Gross MS,Prockop DJ,Boué A,Kaplan JC,de la Chapelle A,Ramirez F

更新日期：1982-11-01 00:00:00

abstract：:Heme oxygenase (HO) catalyzes the opening of the heme ring with the release of iron in both plants and animals. In cyanobacteria, red algae, and cryptophyceae, HO is a key enzyme in the synthesis of the chromophoric part of the photosynthetic antennae. In an attempt to study the regulation of this key metabolic step, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Richaud C,Zabulon G

更新日期：1997-10-14 00:00:00

abstract：:Inherited deficiencies of the enzymes adenosine deaminase (adenosine aminohydrolase; EC 3.5.4.4) and purine nucleoside phosphorylase (purine-nucleoside:orthophosphate ribosyltransferase; EC 2.4.2.1) preferentially interfere with lymphocyte development while sparing most other organ systems. Previous experiments have s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Carson DA,Kaye J,Seegmiller JE

更新日期：1977-12-01 00:00:00

abstract：:Intramembrane proteolysis is a new paradigm in biology that controls signaling events throughout evolution. Hydrolysis of peptide bonds is thought to occur within the normally hydrophobic membrane environment, but insights into this unusual activity have been lacking because of difficulty in recapitulating activity in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Urban S,Wolfe MS

更新日期：2005-02-08 00:00:00

abstract：:Human interleukin 12 and interleukin 23 (IL12/23) influence susceptibility or resistance to multiple diseases. However, the reasons underlying individual differences in IL12/23 sensitivity remain poorly understood. Here we report that in human peripheral blood mononuclear cells (PBMCs) and inflamed lungs, the majority...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turner AJ,Aggarwal P,Miller HE,Waukau J,Routes JM,Broeckel U,Robinson RT

更新日期：2015-12-15 00:00:00

abstract：:The diversity of the T cell receptor (TCR) repertoire is limited, because of the processes of positive and negative T cell selection. To obtain T cells with specificities beyond the immune system's capacity, we have developed a strategy for retroviral TCR display. In this approach, a library of T cell variants is gene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kessels HW,van Den Boom MD,Spits H,Hooijberg E,Schumacher TN

更新日期：2000-12-19 00:00:00

abstract：:Regional cerebral blood flow was measured with positron-emission tomography during two encoding and two retrieval tasks that were designed to compare memory for object features with memory for object locations. Bilateral increases in regional cerebral blood flow were observed in both anterior and posterior regions of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Owen AM,Milner B,Petrides M,Evans AC

更新日期：1996-08-20 00:00:00

abstract：:Phosphorylation of ADP to ATP was induced in nonrespiring submitochondrial particles (SMP) from rat liver by the application of electric pulses with field strengths of 10-35 kV/cm and a decay time of 60 mus. In all cases respiration was inhibited completely by using cyanide or rotenone. Newly formed ATP was measured b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teissie J,Knox BE,Tsong TY,Wehrle J

更新日期：1981-12-01 00:00:00