Lymphospecific toxicity in adenosine deaminase deficiency and purine nucleoside phosphorylase deficiency: possible role of nucleoside kinase(s).

abstract：:In regulating gene expression in mammalian tissues, steroid hormones bind to cytoplasmic receptors and the resulting complex associates with the nucleus. In an attempt to study this nuclear association under more precisely controlled conditions, we examined the binding of receptor-[(3)H]steroid complexes to isolated n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Higgins SJ,Rousseau GG,Baxter JD,Tomkins GM

更新日期：1973-12-01 00:00:00

abstract：:Natural environments are filled with multiple, often competing, signals. In contrast, biological systems are often studied in "well-controlled" environments where only a single input is varied, potentially missing important interactions between signals. Catabolite repression of galactose by glucose is one of the best-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Escalante-Chong R,Savir Y,Carroll SM,Ingraham JB,Wang J,Marx CJ,Springer M

更新日期：2015-02-03 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) cells (PCC) have an exceptional propensity to metastasize early into intratumoral, chemokine-secreting nerves. However, we hypothesized the opposite process, that precancerous pancreatic cells secrete chemokines that chemoattract Schwann cells (SC) of nerves and thus induce read...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Demir IE,Kujundzic K,Pfitzinger PL,Saricaoglu ÖC,Teller S,Kehl T,Reyes CM,Ertl LS,Miao Z,Schall TJ,Tieftrunk E,Haller B,Diakopoulos KN,Kurkowski MU,Lesina M,Krüger A,Algül H,Friess H,Ceyhan GO

更新日期：2017-01-03 00:00:00

abstract：:Dictyostelium actin was shown to become phosphorylated on Tyr-53 late in the developmental cycle and when cells in the amoeboid stage are subjected to stress but the phosphorylated actin had not been purified and characterized. We have separated phosphorylated and unphosphorylated actin and shown that Tyr-53 phosphory...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu X,Shu S,Hong MS,Levine RL,Korn ED

更新日期：2006-09-12 00:00:00

abstract：:Whereas the neurodegeneration associated with various polyglutamine (polyQ) diseases has prompted extensive studies of polyQ-induced cell death, the neuronal loss that typically appears during late stages of the diseases may not account for the preceding movement and mental disorders. The cellular basis for polyQ-indu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee SB,Bagley JA,Lee HY,Jan LY,Jan YN

更新日期：2011-10-04 00:00:00

abstract：:NFATc (a member of the family of nuclear factors of activated T cells) is a transcriptional factor responsible for the Ca(2+)-inducible activation of cytokine genes during the immune response. In resting T cells, NFATc is retained in the cytoplasm by a mechanism that depends on multiple phosphorylations in an N-termin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park S,Uesugi M,Verdine GL

更新日期：2000-06-20 00:00:00

abstract：:The POT1-TPP1 heterodimer, the major telomere-specific single-stranded DNA-binding protein in mammalian cells, protects chromosome ends and contributes to the regulation of telomerase. The recent discovery of telomeric RNA raises the question of how POT1 faithfully binds telomeric ssDNA and avoids illicit RNA binding ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nandakumar J,Podell ER,Cech TR

更新日期：2010-01-12 00:00:00

abstract：:Dopamine (DA) promotes wakefulness, and DA transporter inhibitors such as dextroamphetamine and methylphenidate are effective for increasing arousal and inducing reanimation, or active emergence from general anesthesia. DA neurons in the ventral tegmental area (VTA) are involved in reward processing, motivation, emoti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Taylor NE,Van Dort CJ,Kenny JD,Pei J,Guidera JA,Vlasov KY,Lee JT,Boyden ES,Brown EN,Solt K

更新日期：2016-11-08 00:00:00

abstract：:For a series of different proteins, including a structural protein, enzyme, inhibitor, protein marker, and a charge-transfer system, we have quantified the higher affinity of Na+ over K+ to the protein surface by means of molecular dynamics simulations and conductivity measurements. Both approaches show that sodium bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vrbka L,Vondrásek J,Jagoda-Cwiklik B,Vácha R,Jungwirth P

更新日期：2006-10-17 00:00:00

abstract：:The gluconate (gnt) operon of Bacillus subtilis consists of four gnt genes; the second and third genes code for gluconate kinase (gluconokinase, EC 2.7.1.12) and gluconate permease, respectively. A fragment carrying the promoter of this operon (gnt promoter) and the first gene (gntR) was subcloned into a promoter prob...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fujita Y,Fujita T

更新日期：1987-07-01 00:00:00

abstract：:Actin polymerization and assembly into stress fibers (SFs) is central to many cellular processes. However, how SFs form in response to the mechanical interaction of cells with their environment is not fully understood. Here we have identified Piezo2 mechanosensitive cationic channel as a transducer of environmental ph...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pardo-Pastor C,Rubio-Moscardo F,Vogel-González M,Serra SA,Afthinos A,Mrkonjic S,Destaing O,Abenza JF,Fernández-Fernández JM,Trepat X,Albiges-Rizo C,Konstantopoulos K,Valverde MA

更新日期：2018-02-20 00:00:00

abstract：:Cholera vibrios produce a single polymeric protein that (i) causes hemagglutination; (ii) appears to participate in their attachment to gut epithelium; (iii) may mediate their detachment from gut epithelium; and (iv) is a protease that hydrolyzes fibronectin and mucin, cleaves lactoferrin, and nicks the A subunit of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Finkelstein RA,Boesman-Finkelstein M,Holt P

更新日期：1983-02-01 00:00:00

abstract：:Yeast fatty acid synthetase consists of two multifunctional proteins, alpha and beta, which are arranged in a complex of alpha(6)beta(6). Electron microscopic studies of this complex led to a model for the synthetase as an ovate structure consisting of an equatorial plate-like structure to which six arches are equally...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stoops JK,Wakil SJ

更新日期：1980-08-01 00:00:00

abstract：:Memory formation requires the placement of experienced events in the same order in which they appeared. A large body of evidence from human studies indicates that structures in the medial temporal lobe are critically involved in forming and maintaining such memories, and complementing evidence from lesion and electrop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paz R,Gelbard-Sagiv H,Mukamel R,Harel M,Malach R,Fried I

更新日期：2010-03-30 00:00:00

abstract：:The generation of toxic oligomers during the aggregation of the amyloid-β (Aβ) peptide Aβ42 into amyloid fibrils and plaques has emerged as a central feature of the onset and progression of Alzheimer's disease, but the molecular pathways that control pathological aggregation have proved challenging to identify. Here, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen SI,Linse S,Luheshi LM,Hellstrand E,White DA,Rajah L,Otzen DE,Vendruscolo M,Dobson CM,Knowles TP

更新日期：2013-06-11 00:00:00

abstract：:Cytosine methylation at CpG dinucleotides contributes to the epigenetic maintenance of gene silencing. Dynamic reprogramming of DNA methylation patterns is believed to play a key role during development and differentiation in vertebrates. The mechanisms of DNA demethylation remain unclear and controversial. Here, we p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kress C,Thomassin H,Grange T

更新日期：2006-07-25 00:00:00

abstract：:Regulation of ion balance in spermatozoa has been shown to be essential for sperm motility and fertility. Control of intracellular ion levels requires the function of distinct ion-transport mechanisms at the cell plasma membrane. Active Na(+) and K(+) exchange in sperm is under the control of the Na,K-ATPase. Two mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jimenez T,McDermott JP,Sánchez G,Blanco G

更新日期：2011-01-11 00:00:00

abstract：:Bones of the flightless sea duck (Chendytes lawi) from 14 archaeological sites along the California coast indicate that humans hunted the species for at least 8,000 years before it was driven to extinction. Direct (14)C dates on Chendytes bones show that the duck was exploited on the southern California islands as ear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones TL,Porcasi JF,Erlandson JM,Dallas H Jr,Wake TA,Schwaderer R

更新日期：2008-03-18 00:00:00

abstract：:A high-pressure investigation of the Xe*H(2)O chemical system was conducted by using diamond-anvil cell techniques combined with in situ Raman spectroscopy, synchrotron x-ray diffraction, and laser heating. Structure I xenon clathrate was observed to be stable up to 1.8 GPa, at which pressure it transforms to a new Xe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sanloup C,Mao Hk HK,Hemley RJ

更新日期：2002-01-08 00:00:00

abstract：:A critical step in neuronal development is the formation of axon/dendrite polarity, a process involving symmetry breaking in the newborn neuron. Local self-amplifying processes could enhance and stabilize the initial asymmetry in the distribution of axon/dendrite determinants, but the identity of these processes remai...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng PL,Song AH,Wong YH,Wang S,Zhang X,Poo MM

更新日期：2011-11-08 00:00:00

abstract：:We have previously shown that nuclear transcripts of the multifunctional enzyme, carbamoyl-phosphate synthetase, aspartate transcarbamylase, dihydroorotase RNA can be released from nuclei of Syrian hamster cells as compact ribonucleoprotein (RNP) particles that sediment at the 200S region in a sucrose gradient. The 20...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spann P,Feinerman M,Sperling J,Sperling R

更新日期：1989-01-01 00:00:00

abstract：:The nucleolinus is an RNA-rich compartment, closely apposed to or embedded within the nucleolus. Discovered over 150 y ago, fewer than two dozen articles have been published on the nucleolinus, probably because complex histochemical stains are required for its visualization in the great majority of cells. The nucleoli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alliegro MA,Henry JJ,Alliegro MC

更新日期：2010-08-03 00:00:00

abstract：:Previously we reported that pretreatment of rats with the substance P (SP) antagonist CP-96,345 inhibits the enterotoxic responses following administration of toxin A from Clostridium difficile into ileal loops, indicating that SP participates in the intestinal responses to this toxin. We now report that injection of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Castagliuolo I,Keates AC,Qiu B,Kelly CP,Nikulasson S,Leeman SE,Pothoulakis C

更新日期：1997-04-29 00:00:00

abstract：:The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA receptor subunit devel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Condie BG,Bain G,Gottlieb DI,Capecchi MR

更新日期：1997-10-14 00:00:00

abstract：:Soluble epoxide hydrolase (sEH) is an emerging therapeutic target in a number of diseases that have inflammation as a common underlying cause. sEH limits tissue levels of cytochrome P450 (CYP) epoxides derived from omega-6 and omega-3 polyunsaturated fatty acids (PUFA) by converting these antiinflammatory mediators in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： López-Vicario C,Alcaraz-Quiles J,García-Alonso V,Rius B,Hwang SH,Titos E,Lopategi A,Hammock BD,Arroyo V,Clària J

更新日期：2015-01-13 00:00:00

abstract：:Proceedings of the National Academy of Sciences Colloquium on the roles of homologous recombination in DNA replication are summarized. Current findings in experimental systems ranging from bacteriophages to mammalian cell lines substantiate the idea that homologous recombination is a system supporting DNA replication ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuzminov A

更新日期：2001-07-17 00:00:00

abstract：:An exact treatment of adsorption from a one-dimensional lattice gas is used to eliminate and correct a well-known inconsistency in the Brunauer-Emmett-Teller (B.E.T.) equation-namely, Gibbs excess adsorption is not taken into account and the Gibbs integral diverges at the transition point. However, neither model shoul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL

更新日期：1996-12-10 00:00:00

abstract：:Translocations involving c-myc and an Ig locus have been reported rarely in human multiple myeloma (MM). Using specific fluorescence in situ hybridization probes, we show complex karyotypic abnormalities of the c-myc or L-myc locus in 19 of 20 MM cell lines and approximately 50% of advanced primary MM tumors. These ab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shou Y,Martelli ML,Gabrea A,Qi Y,Brents LA,Roschke A,Dewald G,Kirsch IR,Bergsagel PL,Kuehl WM

更新日期：2000-01-04 00:00:00

abstract：:Mast cells and nerve growth factor (NGF) have both been reported to be involved in neuroimmune interactions and tissue inflammation. In many peripheral tissues, mast cells interact with the innervating fibers. Changes in the behaviors of both of these elements occur after tissue injury/inflammation. As such conditions...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leon A,Buriani A,Dal Toso R,Fabris M,Romanello S,Aloe L,Levi-Montalcini R

更新日期：1994-04-26 00:00:00

abstract：:Lung cancers caused by activating mutations in the epidermal growth factor receptor (EGFR) are initially responsive to small molecule tyrosine kinase inhibitors (TKIs), but the efficacy of these agents is often limited because of the emergence of drug resistance conferred by a second mutation, T790M. Threonine 790 is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yun CH,Mengwasser KE,Toms AV,Woo MS,Greulich H,Wong KK,Meyerson M,Eck MJ

更新日期：2008-02-12 00:00:00