Increased substance P responses in dorsal root ganglia and intestinal macrophages during Clostridium difficile toxin A enteritis in rats.

abstract：:Tregs are essential for maintaining peripheral tolerance, and thus targeting these cells may aid in the treatment of autoimmunity and cancer by enhancing or reducing suppressive functions, respectively. Before these cells can be harnessed for therapeutic purposes, it is necessary to understand how they maintain tolera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pabbisetty SK,Rabacal W,Volanakis EJ,Parekh VV,Olivares-Villagómez D,Cendron D,Boyd KL,Van Kaer L,Sebzda E

更新日期：2016-08-09 00:00:00

abstract：:Serotonin (5-HT) binding sites from bovine and rat cerebral cortex membranes share pharmacological properties that allow both to be subclassified by the same criteria. We show here that [3H]5-HT binding sites from human cortex also possess pharmacological properties that follow the same subclassification scheme as for...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Todd RD,Ciaranello RD

更新日期：1985-01-01 00:00:00

abstract：:A power-law distribution of the length of perfectly conserved sequence from mouse/human whole-genome intersection and alignment is exhibited. Spatial correlations of these elements within the mouse genome are studied. It is argued that these power-law distributions and correlations are comprised in part by functional ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salerno W,Havlak P,Miller J

更新日期：2006-08-29 00:00:00

abstract：:Plasmids have been constructed to generate substrates for the study of proteinases 2A and 3C of poliovirus. They contain the P1 (capsomer precursor) region of the poliovirus genome or P1 and part of P2 (a nonstructural precursor), which can be transcribed and translated in vitro. A transcript containing the entire 5' ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nicklin MJ,Kräusslich HG,Toyoda H,Dunn JJ,Wimmer E

更新日期：1987-06-01 00:00:00

abstract：:Long noncoding RNAs (lncRNAs) have been implicated in a variety of physiological and pathological processes, including cancer. In prostate cancer, prostate cancer gene expression marker 1 (PCGEM1) is an androgen-induced prostate-specific lncRNA whose overexpression is highly associated with prostate tumors. PCGEM1's t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hung CL,Wang LY,Yu YL,Chen HW,Srivastava S,Petrovics G,Kung HJ

更新日期：2014-12-30 00:00:00

abstract：:Dust grains of organic matter were the main reservoir of C and N in the forming Solar System and are thus considered to be an essential ingredient for the emergence of life. However, the physical environment and the chemical mechanisms at the origin of these organic grains are still highly debated. In this study, we r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tartèse R,Chaussidon M,Gurenko A,Delarue F,Robert F

更新日期：2018-08-21 00:00:00

abstract：:Protein interactions with the collagen triple helix play a critical role in collagen fibril formation, cell adhesion, and signaling. However, structural insight into sequence-specific collagen recognition is limited to an integrin-peptide complex. A GVMGFO motif in fibrillar collagens (O denotes 4-hydroxyproline) bind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hohenester E,Sasaki T,Giudici C,Farndale RW,Bächinger HP

更新日期：2008-11-25 00:00:00

abstract：:Mutations in WNK1 and WNK4 lead to familial hyperkalemic hypertension (FHHt). Because FHHt associates net positive Na(+) balance together with K(+) and H(+) renal retention, the identification of WNK1 and WNK4 led to a new paradigm to explain how aldosterone can promote either Na(+) reabsorption or K(+) secretion in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hadchouel J,Soukaseum C,Büsst C,Zhou XO,Baudrie V,Zürrer T,Cambillau M,Elghozi JL,Lifton RP,Loffing J,Jeunemaitre X

更新日期：2010-10-19 00:00:00

abstract：:The opportunistic pathogen Candida albicans can undergo phenotypic switching between a benign, unicellular phenotype and an invasive, multicellular form that causes candidiasis. Increasingly, strains of Candida are becoming resistant to antifungal drugs, making the treatment of candidiasis difficult, especially in imm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Uchida M,McDermott G,Wetzler M,Le Gros MA,Myllys M,Knoechel C,Barron AE,Larabell CA

更新日期：2009-11-17 00:00:00

abstract：:MCF10A mammary epithelial cells form growth-arrested structures when cultured in three-dimensional basement membrane gels. Activation of the receptor tyrosine kinase ErbB2 induces formation of proliferative structures that share properties with noninvasive early stage lesions. We conducted a genetic screen to identify...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seton-Rogers SE,Lu Y,Hines LM,Koundinya M,LaBaer J,Muthuswamy SK,Brugge JS

更新日期：2004-02-03 00:00:00

abstract：:The apparent failure of infants to understand "object permanence" by reaching for hidden objects is perhaps the most striking and debated phenomenon in cognitive development. Of particular interest is the extent to which infants perceive and remember objects in a similar way to that of adults. Here we report two findi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaufman J,Csibra G,Johnson MH

更新日期：2005-10-18 00:00:00

abstract：:A comprehensive nonredundant database of 475 cocrystallized protein-protein complexes was used to study low-resolution recognition, which was reported in earlier docking experiments with a small number of proteins. The docking program GRAMM was used to delete the atom-size structural details and systematically dock th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vakser IA,Matar OG,Lam CF

更新日期：1999-07-20 00:00:00

abstract：:All of the heme-degrading enzymes that have been characterized to date require molecular oxygen as a cosubstrate. Escherichia coli O157:H7 has been shown to express heme uptake and transport proteins, as well as use heme as an iron source. This enteric pathogen colonizes the anaerobic space of the lower intestine in m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： LaMattina JW,Nix DB,Lanzilotta WN

更新日期：2016-10-25 00:00:00

abstract：:RelB is an NF-κB family transcription factor activated in the noncanonical pathway downstream of NF-κB-inducing kinase (NIK) and TNF receptor family members including lymphotoxin-β receptor (LTβR) and CD40. Early analysis suggested that RelB is required for classical dendritic cell (cDC) development based on a severe ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briseño CG,Gargaro M,Durai V,Davidson JT,Theisen DJ,Anderson DA 3rd,Novack DV,Murphy TL,Murphy KM

更新日期：2017-04-11 00:00:00

abstract：:The chemokine receptor CCR5 is the major coreceptor for infection by macrophage-tropic R5 HIV-1. A 32-bp deletion in the gene coding for CCR5 (CCR5Delta32) occurs with a frequency of 10% in the Caucasian population and results in a receptor protein that is truncated and not expressed at the cell surface. CCR5Delta32 h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ditzel HJ,Rosenkilde MM,Garred P,Wang M,Koefoed K,Pedersen C,Burton DR,Schwartz TW

更新日期：1998-04-28 00:00:00

abstract：:The plant photoreceptor phytochrome plays an important role in the nucleus as a regulator of transcription. Numerous studies imply, however, that phytochromes in both higher and lower plants mediate physiological reactions within the cytoplasm. In particular, the tip cells of moss protonemal filaments use phytochrome ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mittmann F,Brücker G,Zeidler M,Repp A,Abts T,Hartmann E,Hughes J

更新日期：2004-09-21 00:00:00

abstract：:Chronic myeloid leukemia (CML) is associated with the Philadelphia chromosome, which arises by a reciprocal translocation between chromosomes 9 and 22 and harbors the BCR-ABL fusion oncogene. It is unknown whether any other mutations are needed for the chronic phase of the disease. The CML incidence increases as a fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Michor F,Iwasa Y,Nowak MA

更新日期：2006-10-03 00:00:00

abstract：:Although much of the brain's functional organization is genetically predetermined, it appears that some noninnate functions can come to depend on dedicated and segregated neural tissue. In this paper, we describe a series of experiments that have investigated the neural development and organization of one such noninna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Polk TA,Farah MJ

更新日期：1998-02-03 00:00:00

abstract：:Phosphocholine (PC) is an abundant primary form of organic phosphate that is transported in plant xylem sap. Addition of PC to the perfusate of compressed Pi-starved sycamore cells monitored by 31P NMR spectroscopy resulted in an accumulation of PC and all the other phosphate esters in the cytoplasmic compartment. Add...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gout E,Bligny R,Roby C,Douce R

更新日期：1990-06-01 00:00:00

abstract：:The structurally diverse peroxisome proliferators ciprofibrate, clofibrate, and bis(2-ethylhexyl) phthalate [(EtHx)2 greater than Pht] increase the activities of hepatic catalase and peroxisomal fatty acid beta-oxidation enzymes in conjunction with profound proliferation of peroxisomes in hepatocytes. In order to deli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reddy JK,Goel SK,Nemali MR,Carrino JJ,Laffler TG,Reddy MK,Sperbeck SJ,Osumi T,Hashimoto T,Lalwani ND

更新日期：1986-03-01 00:00:00

abstract：:The kinetic inhibition of the gelation of hemoglobin S is compared to the change in hemoglobin S soulbility, when the solubility is altered by carbon monoxide, pH, or urea. By means of a new technique, the delay time and the extent of gelation are measured on the same sample. They delay time, td, is found to be propor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hofrichter J,Ross PD,Eaton WA

更新日期：1976-09-01 00:00:00

abstract：:Plants produce a wide range of allelochemicals to defend against herbivore attack, and generalist herbivores have evolved mechanisms to avoid, sequester, or detoxify a broad spectrum of natural defense compounds. Successful arthropod pests have also developed resistance to diverse classes of pesticides and this adapta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dermauw W,Wybouw N,Rombauts S,Menten B,Vontas J,Grbic M,Clark RM,Feyereisen R,Van Leeuwen T

更新日期：2013-01-08 00:00:00

abstract：:A potential new approach for gene therapy against human immunodeficiency virus type 1 (HIV-1) infection is the design of a nonstructural gene-based virion-specific inhibitory molecule that is packaged with virus to destroy its infectivity. We tested this approach for HIV-1 by using Vpx, a virion-associated protein of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsuda Z,Yu X,Yu QC,Lee TH,Essex M

更新日期：1993-04-15 00:00:00

abstract：:Autism spectrum disorders (ASDs) comprise a highly heritable, multifarious group of neurodevelopmental disorders, which are characterized by repetitive behaviors and impairments in social interactions. Point mutations have been identified in X-linked Neuroligin (NLGN) 3 and 4X genes in patients with ASDs and all of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bemben MA,Nguyen QA,Wang T,Li Y,Nicoll RA,Roche KW

更新日期：2015-02-24 00:00:00

abstract：:Copper homeostasis is essential for bacterial pathogen fitness and infection, and has been the focus of a number of recent studies. In Salmonella, envelope protection against copper overload and macrophage survival depends on CueP, a major copper-binding protein in the periplasm. This protein is also required to deliv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pezza A,Pontel LB,López C,Soncini FC

更新日期：2016-10-11 00:00:00

abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common blood disorder, presenting multiple symptoms, including hemolytic anemia. It affects 400 million people worldwide, with more than 160 single mutations reported in G6PD. The most severe mutations (about 70) are classified as class I, leading to more...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horikoshi N,Hwang S,Gati C,Matsui T,Castillo-Orellana C,Raub AG,Garcia AA,Jabbarpour F,Batyuk A,Broweleit J,Xiang X,Chiang A,Broweleit R,Vöhringer-Martinez E,Mochly-Rosen D,Wakatsuki S

更新日期：2021-01-26 00:00:00

abstract：:Humans walk and run over a wide range of speeds with remarkable efficiency. For steady locomotion, moving at different speeds requires the muscle-tendon units of the leg to modulate the amount of mechanical power the limb absorbs and outputs in each step. How individual muscles adapt their behavior to modulate limb po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Farris DJ,Sawicki GS

更新日期：2012-01-17 00:00:00

abstract：:Somatic fungal hyphae are generally assumed to elongate at steady linear rates when grown under constant environmental conditions with ample nutrients. However, patterns of pulsed hyphal elongation were detected during apparent steady growth of hyphal tips in fungi from several major taxonomic groups (Oomycetes, Pythi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： López-Franco R,Bartnicki-Garcia S,Bracker CE

更新日期：1994-12-06 00:00:00

abstract：:We use alternating-laser excitation to achieve fluorescence-aided molecule sorting (FAMS) and enable simultaneous analysis of biomolecular structure and interactions at the level of single molecules. This was performed by labeling biomolecules with fluorophores that serve as donor-acceptor pairs for Förster resonance ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kapanidis AN,Lee NK,Laurence TA,Doose S,Margeat E,Weiss S

更新日期：2004-06-15 00:00:00

abstract：:Grounding autonomous behavior in the nervous system is a fundamental challenge for neuroscience. In particular, self-organized behavioral development provides more questions than answers. Are there special functional units for curiosity, motivation, and creativity? This paper argues that these features can be grounded...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Der R,Martius G

更新日期：2015-11-10 00:00:00