Piezo2 channel regulates RhoA and actin cytoskeleton to promote cell mechanobiological responses.

abstract：:We have produced a soluble form of a mouse alpha beta T-cell antigen receptor (TCR) by shuffling its variable (V) and constant (C) domains to the C region of an immunoglobulin kappa light chain. These chimeric molecules composed of V alpha C alpha C kappa and V beta C beta C kappa chains were efficiently secreted (up ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grégoire C,Rebaï N,Schweisguth F,Necker A,Mazza G,Auphan N,Millward A,Schmitt-Verhulst AM,Malissen B

更新日期：1991-09-15 00:00:00

abstract：:We previously demonstrated that the B chain of platelet-derived growth factor (PDGF-B) is transcribed in human atherosclerotic plaques, indicating that production of growth factors within plaques could occur during atherogenesis. However, since atherosclerotic plaques are composed of several cell types and three of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barrett TB,Benditt EP

更新日期：1988-04-01 00:00:00

abstract：:Somatic fungal hyphae are generally assumed to elongate at steady linear rates when grown under constant environmental conditions with ample nutrients. However, patterns of pulsed hyphal elongation were detected during apparent steady growth of hyphal tips in fungi from several major taxonomic groups (Oomycetes, Pythi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： López-Franco R,Bartnicki-Garcia S,Bracker CE

更新日期：1994-12-06 00:00:00

abstract：:During mitosis, the mammalian Golgi vesiculates and, upon partitioning, reassembles in each daughter cell; however, it is not clear whether the disassembly process per se is important for partitioning or is merely an outcome of mitotic entry. Here, we show that Golgi vesiculation is required for progression to metapha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guizzunti G,Seemann J

更新日期：2016-10-25 00:00:00

abstract：:In recent years, considerable progress has been made in understanding the molecular mechanisms underlying olfaction in insects. Because of the diverse nature of the gene families involved, this process has largely relied on genomic data. As a consequence, studies have focused on a small subset of species with extensiv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grosse-Wilde E,Kuebler LS,Bucks S,Vogel H,Wicher D,Hansson BS

更新日期：2011-05-03 00:00:00

abstract：:Recent demonstrations of correlated low-frequency MRI signal variations between subregions of the spinal cord at rest in humans, similar to those found in the brain, suggest that such resting-state functional connectivity constitutes a common feature of the intrinsic organization of the entire central nervous system. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen LM,Mishra A,Yang PF,Wang F,Gore JC

更新日期：2015-05-12 00:00:00

abstract：:Coherent oscillations in the theta-to-gamma frequency range have been proposed as a mechanism that coordinates neural activity in large-scale cortical networks in sensory, motor, and cognitive tasks. Whether this mechanism also involves coherent oscillations at delta frequencies (1-4 Hz) is not known. Rather, delta os...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nácher V,Ledberg A,Deco G,Romo R

更新日期：2013-09-10 00:00:00

abstract：:Chromosome 14 was transferred into tumorigenic nasopharyngeal carcinoma and esophageal carcinoma cell lines by a microcell-mediated chromosome transfer approach. Functional complementation of defects present in the cancer cells suppressed tumor formation. A candidate tumor-suppressor gene, cysteine-rich intestinal pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung AK,Ko JM,Lung HL,Chan KW,Stanbridge EJ,Zabarovsky E,Tokino T,Kashima L,Suzuki T,Kwong DL,Chua D,Tsao SW,Lung ML

更新日期：2011-05-17 00:00:00

abstract：:The early detection of pathogens with epidemic potential is of major importance to public health. Most emerging infections result in dead-end "spillover" events in which a pathogen is transmitted from an animal reservoir to a human but is unable to achieve the sustained human-to-human transmission necessary for a full...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geoghegan JL,Senior AM,Di Giallonardo F,Holmes EC

更新日期：2016-04-12 00:00:00

abstract：:Thioredoxins are 12-kDa proteins functional in the regulation of cellular processes throughout the animal, plant, and microbial kingdoms. Growing evidence with seeds suggests that an h-type of thioredoxin, reduced by NADPH via NADP-thioredoxin reductase, reduces disulfide bonds of target proteins and thereby acts as a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yano H,Wong JH,Lee YM,Cho MJ,Buchanan BB

更新日期：2001-04-10 00:00:00

abstract：:The emergence of the nematic electronic state that breaks rotational symmetry is one of the most fascinating properties of the iron-based superconductors, and has relevance to cuprates as well. FeSe has a unique ground state in which superconductivity coexists with a nematic order without long-range magnetic ordering,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sato Y,Kasahara S,Taniguchi T,Xing X,Kasahara Y,Tokiwa Y,Yamakawa Y,Kontani H,Shibauchi T,Matsuda Y

更新日期：2018-02-06 00:00:00

abstract：:To modify the lac permease of Escherichia coli for fluorescence spectroscopy, six tryptophan residues at positions 10, 33, 78, 151, 171, and 223 were first replaced individually with phenylalanine by using oligonucleotide-directed site-specific mutagenesis. None of the tryptophan residues is critical for activity, as ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Menezes ME,Roepe PD,Kaback HR

更新日期：1990-03-01 00:00:00

abstract：:Gecko and many insects have adopted nanoscale fibrillar structures on their feet as adhesion devices. Here, we consider adhesion between a single fiber and a substrate by van der Waals or electrostatic interactions. For a given contact area A, the theoretical pull-off force of the fiber is sigma(th)A where sigma(th) i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao H,Yao H

更新日期：2004-05-25 00:00:00

abstract：:Multiple sclerosis is a chronic disease of the central nervous system (CNS) characterized by inflammation, demyelination, and axonal loss. The immunopathogenesis of demyelination in multiple sclerosis involves an autoantibody response to myelin oligodendrocyte glycoprotein (MOG), a type I transmembrane protein located...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breithaupt C,Schubart A,Zander H,Skerra A,Huber R,Linington C,Jacob U

更新日期：2003-08-05 00:00:00

abstract：:Opportunistic infections are often polymicrobial. Two of the most important bacterial opportunistic pathogens of humans, Pseudomonas aeruginosa and Staphylococcus aureus, frequently are coisolated from infections of catheters, endotracheal tubes, skin, eyes, and the respiratory tract, including the airways of people w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoffman LR,Déziel E,D'Argenio DA,Lépine F,Emerson J,McNamara S,Gibson RL,Ramsey BW,Miller SI

更新日期：2006-12-26 00:00:00

abstract：:Underactivity of the glutamatergic system is an attractive model for the pathophysiology of several major mental illnesses. We previously described a chromosome abnormality disrupting the kainate class ionotropic glutamate receptor gene, GRIK4/KA1, in an individual with schizophrenia and learning disability (mental re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pickard BS,Knight HM,Hamilton RS,Soares DC,Walker R,Boyd JK,Machell J,Maclean A,McGhee KA,Condie A,Porteous DJ,St Clair D,Davis I,Blackwood DH,Muir WJ

更新日期：2008-09-30 00:00:00

abstract：:Site-specific heritable mutations in maize genes were engineered by introducing chimeric RNA/DNA oligonucleotides. Two independent targets within the endogenous maize acetohydroxyacid synthase gene sequence were modified in a site-specific fashion, thereby conferring resistance to either imidazolinone or sulfonylurea ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu T,Peterson DJ,Tagliani L,St Clair G,Baszczynski CL,Bowen B

更新日期：1999-07-20 00:00:00

abstract：:We have cloned and determined the entire nucleotide sequence of cDNAs corresponding to the putative alpha subunits of the human and rat mast cell high-affinity IgE receptors. Both human and rat cDNAs encode an NH2-terminal signal peptide, two immunoglobulin-like extracellular domains (encoded by discrete exons), a hyd...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimizu A,Tepler I,Benfey PN,Berenstein EH,Siraganian RP,Leder P

更新日期：1988-03-01 00:00:00

abstract：:Evolutionary processes leading to adaptive radiation regularly occur too fast to be accurately recorded in the fossil record but too slowly to be readily observed in living biota. The study of evolutionary radiations is thereby confronted with an epistemological gap between the timescales and approaches used by neonto...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Bocxlaer B,Hunt G

更新日期：2013-08-20 00:00:00

abstract：:Interphase chromosomes were isolated in good yield from four species of fungi. In no case does the chromatin contain histones such as are characteristic of the chromosomes of other eukaryotic organisms. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leighton TJ,Dill BC,Stock JJ,Phillips C

更新日期：1971-03-01 00:00:00

abstract：:Hsubc9, a human gene encoding a ubiquitin-conjugating enzyme, has been cloned. The 18-kDa HsUbc9 protein is homologous to the ubiquitin-conjugating enzymes Hus5 of Schizosaccharomyces pombe and Ubc9 of Saccharomyces cerevisiae. The Hsubc9 gene complements a ubc9 mutation of S. cerevisiae. It has been mapped to chromos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovalenko OV,Plug AW,Haaf T,Gonda DK,Ashley T,Ward DC,Radding CM,Golub EI

更新日期：1996-04-02 00:00:00

abstract：:The nematode Caenorhabditis elegans exhibits behavioral responses to many volatile odorants. Chemotaxis toward one such odorant, diacetyl (butanedione), requires the function of a seven-transmembrane receptor protein encoded by the odr-10 gene. To determine directly whether ODR-10 protein is an odorant receptor, it is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Chou JH,Bradley J,Bargmann CI,Zinn K

更新日期：1997-10-28 00:00:00

abstract：:To facilitate genetic analysis of the human pathogenic parvovirus B19, we constructed a hybrid B19 viral genome in which the defective B19 inverted terminal repeats were replaced with the full-length inverted terminal repeats from a nonpathogenic human parvovirus, the adeno-associated virus 2 (AAV). The hybrid AAV-B19...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava CH,Samulski RJ,Lu L,Larsen SH,Srivastava A

更新日期：1989-10-01 00:00:00

abstract：:The heptadecapeptide orphanin FQ (OFQ) is a recently discovered neuropeptide that exhibits structural features reminiscent of the opioid peptides and that is an endogenous ligand to a G protein-coupled receptor sequentially related to the opioid receptors. We have cloned both the human and rat cDNAs encoding the OFQ p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nothacker HP,Reinscheid RK,Mansour A,Henningsen RA,Ardati A,Monsma FJ Jr,Watson SJ,Civelli O

更新日期：1996-08-06 00:00:00

abstract：:The autoimmune dermatologic disease pemphigus vulgaris (PV) is associated with the HLA serotypes DR4 and DRw6. Susceptibility to PV could be conferred either by sequences shared between the DR4 and DRw6 haplotypes or by different sequences in these haplotypes. We have examined the distribution of DR and DQ beta-chain ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scharf SJ,Friedmann A,Brautbar C,Szafer F,Steinman L,Horn G,Gyllensten U,Erlich HA

更新日期：1988-05-01 00:00:00

abstract：:The orphan nuclear receptor Nur77/N10 has recently been demonstrated to be involved in apoptosis of T cell hybridomas. We report here that chronic expression of Nur77/N10 in thymocytes of transgenic mice results in a dramatic reduction of CD4+CD8+ double-positive as well as CD4+CD8- and CD4-CD8+ single-positive cell p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weih F,Ryseck RP,Chen L,Bravo R

更新日期：1996-05-28 00:00:00

abstract：:In the nitrogen-fixing symbiosis between legume hosts and rhizobia, the bacteria are engulfed by a plant cell membrane to become intracellular organelles. In the model legume Medicago truncatula, internalization and differentiation of Sinorhizobium (also known as Ensifer) meliloti is a prerequisite for nitrogen fixati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim M,Chen Y,Xi J,Waters C,Chen R,Wang D

更新日期：2015-12-08 00:00:00

abstract：:Fatty liver disease (FLD) is a disorder in which accumulation of triglycerides (TGs) in the liver can lead to inflammation, fibrosis, and cirrhosis. Previously, we identified a variant (I148M) in patatin-like phospholipase domain-containing protein 3 (PNPLA3) that is strongly associated with FLD, but the mechanistic b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： BasuRay S,Wang Y,Smagris E,Cohen JC,Hobbs HH

更新日期：2019-05-07 00:00:00

abstract：:Collective intelligence refers to the ability of groups to outperform individual decision makers when solving complex cognitive problems. Despite its potential to revolutionize decision making in a wide range of domains, including medical, economic, and political decision making, at present, little is known about the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurvers RH,Herzog SM,Hertwig R,Krause J,Carney PA,Bogart A,Argenziano G,Zalaudek I,Wolf M

更新日期：2016-08-02 00:00:00

abstract：:Membrane-associated and periplasmic proteins of Agrobacterium tumefaciens C-58 were compared with those from avirulent (nontumrigenic) derivative strains by slab and two-dimensional gel electrophoresis. Two proteins (Per-I and Per-2), with a molecular weight of 37,500 and 37,300, respectively, were detected in the sup...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sonoki S,Kado CI

更新日期：1978-08-01 00:00:00