Proteins conferred by the virulence-specifying plasmid of Agrobacterium tumefaciens C-58.

abstract：:We have shown that the silk fibroin gene from Bombyx mori is faithfully transcribed in an in vitro transcription system of the HeLa cell extract prepared by the method of Manley et al. [Manley, J. L., Fire, A., Cano, A., Sharp, P. A. & Gefter, M. L. (1980) Proc. Natl. Acad. Sci. USA 77, 3855-3859]. Using this system a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsujimoto Y,Hirose S,Tsuda M,Suzuki Y

更新日期：1981-08-01 00:00:00

abstract：:Therapeutic cancer vaccines can be effective for treating patients, but clinical responses vary considerably from patient to patient. Early indicators of a favorable response are crucial for making individualized treatment decisions and advancing vaccine design, but no validated biomarkers are currently available. In ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campbell CT,Gulley JL,Oyelaran O,Hodge JW,Schlom J,Gildersleeve JC

更新日期：2014-04-29 00:00:00

abstract：:Self-assembling dendrimers have facilitated the discovery of periodic and quasiperiodic arrays of supramolecular architectures and the diverse functions derived from them. Examples are liquid quasicrystals and their approximants plus helical columns and spheres, including some that disregard chirality. The same period...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rodriguez-Emmenegger C,Xiao Q,Kostina NY,Sherman SE,Rahimi K,Partridge BE,Li S,Sahoo D,Reveron Perez AM,Buzzacchera I,Han H,Kerzner M,Malhotra I,Möller M,Wilson CJ,Good MC,Goulian M,Baumgart T,Klein ML,Percec V

更新日期：2019-03-19 00:00:00

abstract：:We have previously reported the cloning, sequencing, and partial characterization of Kid-1, a zinc finger-encoding cDNA from the rat kidney. The Kid-1 protein and approximately one-third of all other zinc finger proteins contain a highly conserved region of approximately 75 amino acids at their NH2 terminus named Krüp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Witzgall R,O'Leary E,Leaf A,Onaldi D,Bonventre JV

更新日期：1994-05-10 00:00:00

abstract：:The feasibility of long-term information storage by brain type II Ca2+/calmodulin-dependent protein kinase molecules is explored. Recent evidence indicates that this protein has switch-like properties. Equations are derived showing that a single kinase holoenzyme could form a bistable switch having the stability neces...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lisman JE,Goldring MA

更新日期：1988-07-01 00:00:00

abstract：:Many discoveries in cell biology rely on making specific proteins visible within their native cellular environment. There are various genetically encoded tags, such as fluorescent proteins, developed for fluorescence microscopy (FM). However, there are almost no genetically encoded tags that enable cellular proteins t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doh JK,White JD,Zane HK,Chang YH,López CS,Enns CA,Beatty KE

更新日期：2018-12-18 00:00:00

abstract：:The Get3 ATPase directs the delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER). TA-proteins are characterized by having a single transmembrane helix (TM) at their extreme C terminus and include many essential proteins, such as SNAREs, apoptosis factors, and protein translocation components. Thes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suloway CJ,Chartron JW,Zaslaver M,Clemons WM Jr

更新日期：2009-09-01 00:00:00

abstract：:Fibrinogen binding to receptors on stimulated platelets is a prerequisite for platelet aggregation. To gain further insight into the role of fibrinogen in platelet aggregation and to identify the platelet fibrinogen receptor, we developed a monoclonal anti-platelet antibody that inhibited platelet aggregation. The pur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett JS,Hoxie JA,Leitman SF,Vilaire G,Cines DB

更新日期：1983-05-01 00:00:00

abstract：:In monocots, many genes demonstrate a significant negative GC gradient, meaning that the GC content declines along the orientation of transcription. Such a gradient is not observed in the genes of the dicot plant Arabidopsis. In addition, a lack of homology is often observed when comparing the 5' end of the coding reg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jiang N,Ferguson AA,Slotkin RK,Lisch D

更新日期：2011-01-25 00:00:00

abstract：:Conventional wisdom regarding mechanisms of bacterial pathogenesis holds that pathogens arise by external acquisition of distinct virulence factors, whereas determinants shared by pathogens and commensals are considered to be functionally equivalent and have been ignored as genes that could become adapted specifically...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sokurenko EV,Chesnokova V,Dykhuizen DE,Ofek I,Wu XR,Krogfelt KA,Struve C,Schembri MA,Hasty DL

更新日期：1998-07-21 00:00:00

abstract：:Since 1930, areas of state-managed forest in the central Himalayas of India have increasingly been devolved to management by local communities. This article studies the long-run effects of the devolution on the cost of forest management and on forest conservation. Village council-management costs an order of magnitude...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Somanathan E,Prabhakar R,Mehta BS

更新日期：2009-03-17 00:00:00

abstract：:Structure and function of p185neu receptor tyrosine kinase were found to be regulated in a cell cycle-dependent manner. In M phase, p185neu is hyperphosphorylated at serine and/or threonine residues. The phosphotyrosine [Tyr(P)] content of p185neu is at its highest level in G0/G1 phase, decreases through S and G2 phas...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiyokawa N,Yan DH,Brown ME,Hung MC

更新日期：1995-02-14 00:00:00

abstract：:An elegant expression is obtained for the product of the inverse Weierstrass-Laguerre transforms of two functions in terms of their convolution. It is also shown how the main result can be extended to hold for the product of the inverse Weierstrass-Laguerre transforms of several functions. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava HM

更新日期：1971-03-01 00:00:00

abstract：:The developmental loss of neurons in sympathetic, sensory, and some parasympathetic ganglia in familial dysautonomia suggests an inherited defect in the action of beta-nerve growth factor (beta-NGF). The role of this growth factor in dysautonomia has been difficult to resolve as there is no known source of authentic h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breakefield XO,Orloff G,Castiglione C,Coussens L,Axelrod FB,Ullrich A

更新日期：1984-07-01 00:00:00

abstract：:Human workers ensure the functioning of governments around the world. The efficacy of human workers, in turn, is linked to the climatic conditions they face. Here we show that the same weather that amplifies human health hazards also reduces street-level government workers' oversight of these hazards. To do so, we emp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Obradovich N,Tingley D,Rahwan I

更新日期：2018-08-28 00:00:00

abstract：:A transformation-defective mutant of Abelson murine leukemia virus (A-MuLV), called A-MuLV-P92td, has been isolated. The mutant encodes a serologically identifiable A-MuLV protein of molecular weight 92,000 (P92) but it lacks the ability to transform either fibroblasts or bone marrow lymphoid cells. In contrast to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Witte ON,Goff S,Rosenberg N,Baltimore D

更新日期：1980-08-01 00:00:00

abstract：:p38 mitogen-activated protein kinase (MAPK) regulates cytokines in arthritis and is, in turn, regulated by MAPK kinase (MKK) 3 and MKK6. To modulate p38 function but potentially minimize toxicity, we evaluated the utility of targeting MKK3 by using MKK3(-/-) mice. These studies showed that TNF-alpha increased phosphor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Inoue T,Boyle DL,Corr M,Hammaker D,Davis RJ,Flavell RA,Firestein GS

更新日期：2006-04-04 00:00:00

abstract：:In HL-60 cells, a human promyelocytic leukemia cell line, the human c-myc gene, designated MYC, is amplified about 16-fold. On differentiation of the HL-60 cells into granulocytes induced by several inhibitors of poly(ADP-ribose) polymerase [NAD+ poly(adenosine diphosphate D-ribose)ADP-D-ribosyltransferase, EC 2.4.2.3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shima H,Nakayasu M,Aonuma S,Sugimura T,Nagao M

更新日期：1989-10-01 00:00:00

abstract：:Many complex systems are organized in the form of a network embedded in space. Important examples include the physical Internet infrastructure, road networks, flight connections, brain functional networks, and social networks. The effect of space on network topology has recently come under the spotlight because of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Expert P,Evans TS,Blondel VD,Lambiotte R

更新日期：2011-05-10 00:00:00

abstract：:Heme is a common factor linking several metabolic perturbations in Alzheimer's disease (AD), including iron metabolism, mitochondrial complex IV, heme oxygenase, and bilirubin. Therefore, we determined whether heme metabolism was altered in temporal lobes obtained at autopsy from AD patients and age-matched nondemente...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Atamna H,Frey WH 2nd

更新日期：2004-07-27 00:00:00

abstract：:Using a high-resolution isoelectric focusing system, we have been able to separate the products of the individual "nonallelic+ mouse hemoglobin alpha-chain genes. The hemoglobins of mice of inbred strains that make two structurally different, but electrophoretically identical, alpha chains resolve into two bands on is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Whitney JB 3rd,Copland GT,Skow LC,Russell ES

更新日期：1979-02-01 00:00:00

abstract：:Rapid electrical conduction in the His-Purkinje system tightly controls spatiotemporal activation of the ventricles. Although recent work has shed much light on the regulation of early specification and morphogenesis of the His-Purkinje system, less is known about how transcriptional regulation establishes impulse con...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang SS,Kim KH,Rosen A,Smyth JW,Sakuma R,Delgado-Olguín P,Davis M,Chi NC,Puviindran V,Gaborit N,Sukonnik T,Wylie JN,Brand-Arzamendi K,Farman GP,Kim J,Rose RA,Marsden PA,Zhu Y,Zhou YQ,Miquerol L,Henkelman RM,Sta

更新日期：2011-08-16 00:00:00

abstract：:We previously identified rat8 in the pathway involved in epithelial cell differentiation that occurs in the rat mammary gland at pregnancy when tubules and alveoli are formed. rat8, which encodes an IFN-inducible membrane protein, is the rat homologue of the mouse gene fragilis. By differential detergent extraction an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zucchi I,Prinetti A,Scotti M,Valsecchi V,Valaperta R,Mento E,Reinbold R,Vezzoni P,Sonnino S,Albertini A,Dulbecco R

更新日期：2004-02-17 00:00:00

abstract：:Multifunctional nanoparticles for biomedical applications have shown extraordinary potential as contrast agents in various bioimaging modalities, near-IR photothermal therapy, and for light-triggered therapeutic release processes. Over the past several years, numerous studies have been performed to synthesize and enha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marangoni VS,Neumann O,Henderson L,Kaffes CC,Zhang H,Zhang R,Bishnoi S,Ayala-Orozco C,Zucolotto V,Bankson JA,Nordlander P,Halas NJ

更新日期：2017-07-03 00:00:00

abstract：:The cationic conductances of purified bovine retinal rod membranes were studied by incorporation of vesicles into planar lipid bilayers. When the membranes were stripped of all peripheral proteins [guanine nucleotide-binding protein (G protein) and cGMP phosphodiesterase (3',5'-cyclic-GMP 5'-nucleotidohydrolase), EC 3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett N,Ildefonse M,Crouzy S,Chapron Y,Clerc A

更新日期：1989-05-01 00:00:00

abstract：:The liver plays a key role in the regulation of circulating levels of low density lipoproteins (LDL) because it is both the site for the production of and the major organ for the degradation of this class of lipoproteins. In this study, the effects of feeding polyunsaturated or saturated triacylglycerols on receptor-d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spady DK,Dietschy JM

更新日期：1985-07-01 00:00:00

abstract：:Although prairie voles (Microtus ochrogaster) are socially monogamous, males vary in both sexual and spatial fidelity. Most males form pairbonds, cohabit with one female, and defend territories. Wandering males, in contrast, have expansive home ranges that overlap many males and females. In the laboratory, pairing is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ophir AG,Wolff JO,Phelps SM

更新日期：2008-01-29 00:00:00

abstract：:In choanoflagellates, the closest living relatives of animals, multicellular rosette development is regulated by environmental bacteria. The simplicity of this evolutionarily relevant interaction provides an opportunity to identify the molecules and regulatory logic underpinning bacterial regulation of development. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Woznica A,Cantley AM,Beemelmanns C,Freinkman E,Clardy J,King N

更新日期：2016-07-12 00:00:00

abstract：:Interdigital webbing has evolved repeatedly in tropical salamanders (bolitoglossines). This derived foot morphology is only one of many homoplastic traits in this diverse amphibian clade. Indeed, few if any morphological traits sort lineages within this clade. We investigate the processes underlying the homoplastic ev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaekel M,Wake DB

更新日期：2007-12-18 00:00:00

abstract：:Secretion of inflammatory mediators by rat mast cells (line RBL-2H3) was earlier shown to be inhibited upon clustering a membrane glycoprotein by monoclonal antibody G63. This glycoprotein, named mast cell function-associated antigen (MAFA), was also shown to interfere with the coupling cascade of the type 1 Fc epsilo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guthmann MD,Tal M,Pecht I

更新日期：1995-09-26 00:00:00