Abstract:
:In choanoflagellates, the closest living relatives of animals, multicellular rosette development is regulated by environmental bacteria. The simplicity of this evolutionarily relevant interaction provides an opportunity to identify the molecules and regulatory logic underpinning bacterial regulation of development. We find that the rosette-inducing bacterium Algoriphagus machipongonensis produces three structurally divergent classes of bioactive lipids that, together, activate, enhance, and inhibit rosette development in the choanoflagellate Salpingoeca rosetta. One class of molecules, the lysophosphatidylethanolamines (LPEs), elicits no response on its own but synergizes with activating sulfonolipid rosette-inducing factors (RIFs) to recapitulate the full bioactivity of live Algoriphagus. LPEs, although ubiquitous in bacteria and eukaryotes, have not previously been implicated in the regulation of a host-microbe interaction. This study reveals that multiple bacterially produced lipids converge to activate, enhance, and inhibit multicellular development in a choanoflagellate.
journal_name
Proc Natl Acad Sci U S Aauthors
Woznica A,Cantley AM,Beemelmanns C,Freinkman E,Clardy J,King Ndoi
10.1073/pnas.1605015113subject
Has Abstractpub_date
2016-07-12 00:00:00pages
7894-9issue
28eissn
0027-8424issn
1091-6490pii
1605015113journal_volume
113pub_type
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