Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis.

abstract：:C-1027 is an enediyne antitumor antibiotic composed of four distinct moieties: an enediyne core, a deoxy aminosugar, a beta-amino acid, and a benzoxazolinate moiety. We now show that the benzoxazolinate moiety is derived from chorismate by the sequential action of two enzymes-SgcD, a 2-amino-2-deoxyisochorismate (ADIC...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Lanen SG,Lin S,Shen B

更新日期：2008-01-15 00:00:00

abstract：:Cell-based or pharmacological approaches for promoting tendon repair are currently not available because the molecular mechanisms of tendon development and healing are not well understood. Although analysis of knockout mice provides many critical insights, small animals such as mice have some limitations. In particula...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suzuki H,Ito Y,Shinohara M,Yamashita S,Ichinose S,Kishida A,Oyaizu T,Kayama T,Nakamichi R,Koda N,Yagishita K,Lotz MK,Okawa A,Asahara H

更新日期：2016-07-12 00:00:00

abstract：:Nanos (Nos) is an evolutionarily conserved protein essential for the survival of primordial germ cells. In Drosophila, maternal Nos partitions into pole cells and suppresses apoptosis to permit proper germ-line development. However, how this critical event is regulated by Nos has remained elusive. Here, we report that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sato K,Hayashi Y,Ninomiya Y,Shigenobu S,Arita K,Mukai M,Kobayashi S

更新日期：2007-05-01 00:00:00

abstract：:A translocation involving human chromosome 10, band q24, in a subset of T-cell acute leukemias disrupts a region surrounding the putative oncogene HOX11, which encodes a protein with a homeodomain. The HOX11 protein binds to a specific DNA sequence, it localizes to the cell nucleus, and it transactivates transcription...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dear TN,Sanchez-Garcia I,Rabbitts TH

更新日期：1993-05-15 00:00:00

abstract：:Occurrence of the transversion mutation A.T to C.G is specifically enhanced in Escherichia coli mutT mutants. With the aid of the cloned mutT gene, the MutT protein, which has a molecular mass of 15 kilodaltons, was overproduced and purified to near homogeneity. The protein catalyzes hydrolysis of dGTP to dGMP. dGDP a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Akiyama M,Maki H,Sekiguchi M,Horiuchi T

更新日期：1989-06-01 00:00:00

abstract：:Healthy ocean ecosystems are needed to sustain people and livelihoods and to achieve the United Nations Sustainable Development Goals. Using the ocean sustainably requires overcoming many formidable challenges: overfishing, climate change, ocean acidification, and pollution. Despite gloomy forecasts, there is reason f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lubchenco J,Cerny-Chipman EB,Reimer JN,Levin SA

更新日期：2016-12-20 00:00:00

abstract：:The stimulatory activity of peptides from the alpha 1 domain of the major histocompatibility complex (MHC) class I antigen on adipose cell glucose transport was previously shown to require a preformed, ordered conformation of the peptide. The two peptides studied previously were Dk-(61-85) (ERETQIAKGNEQSFRVDLRTLLRYY) ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stagsted J,Mapelli C,Meyers C,Matthews BW,Anfinsen CB,Goldstein A,Olsson L

更新日期：1993-08-15 00:00:00

abstract：:The solar system formed from interstellar dust and gas in a molecular cloud. Astronomical observations show that typical interstellar dust consists of amorphous (a-) silicate and organic carbon. Bona fide physical samples for laboratory studies would yield unprecedented insight about solar system formation, but they w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ishii HA,Bradley JP,Bechtel HA,Brownlee DE,Bustillo KC,Ciston J,Cuzzi JN,Floss C,Joswiak DJ

更新日期：2018-06-26 00:00:00

abstract：:Distinct subsets of thymic epithelial cells (TECs) support T-cell development and selection. Isolated TECs contain multicellular complexes that enclose many viable thymocytes. However, the functions of those TECs, termed thymic nurse cells (TNCs), are unclear and the idea that TNCs are present in vivo is questioned. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakagawa Y,Ohigashi I,Nitta T,Sakata M,Tanaka K,Murata S,Kanagawa O,Takahama Y

更新日期：2012-12-11 00:00:00

abstract：:Decision-making accuracy typically increases through collective integration of people's judgments into group decisions, a phenomenon known as the wisdom of crowds. For simple perceptual laboratory tasks, classic signal detection theory specifies the upper limit for collective integration benefits obtained by weighted ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Juni MZ,Eckstein MP

更新日期：2017-05-23 00:00:00

abstract：:We demonstrate ordered orientation of the hydration water at the surface of phospholipid bilayers by use of coherent anti-Stokes Raman scattering (CARS) microscopy, a highly sensitive vibrational imaging method recently developed. We investigated negatively charged POPS (1-palmitoyl-2-oleoyl-sn-glycero-3-phospho-l-ser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng JX,Pautot S,Weitz DA,Xie XS

更新日期：2003-08-19 00:00:00

abstract：:The fifth exons of major histocompatibility complex (MHC) class I genes encode a transmembrane domain (TM) that is largely responsible for class I antigen cell-surface expression usually through conventional hydrophobic amino acid-membrane interactions or, less often, through phosphatidylinositol linkage. In this repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crew MD,Filipowsky ME,Neshat MS,Smith GS,Walford RL

更新日期：1991-06-01 00:00:00

abstract：:We used a sensitive and specific cDNA polymerase chain reaction assay to detect hepatitis C virus (HCV) RNA in serum samples from 128 unselected southern African Blacks with hepatocellular carcinoma (HCC) and found HCV RNA in 26 (20.3%) of these patients. Antibodies to HCV (anti-HCV) were detected in 59 patients (46.1...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bukh J,Miller RH,Kew MC,Purcell RH

更新日期：1993-03-01 00:00:00

abstract：:T helper 17 (TH17) cells represent a discrete TH cell subset instrumental in the immune response to extracellular bacteria and fungi. However, TH17 cells are considered to be detrimentally involved in autoimmune diseases like multiple sclerosis (MS). In contrast to TH17 cells, regulatory T (Treg) cells were shown to b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ulges A,Witsch EJ,Pramanik G,Klein M,Birkner K,Bühler U,Wasser B,Luessi F,Stergiou N,Dietzen S,Brühl TJ,Bohn T,Bündgen G,Kunz H,Waisman A,Schild H,Schmitt E,Zipp F,Bopp T

更新日期：2016-09-06 00:00:00

abstract：:The extracellular hemoglobin of Ascaris has an extremely high oxygen affinity (P50 = 0.004 mmHg). It consists of eight identical subunits of molecular weight 40,600. Their sequence, determined by protein chemistry, shows two tandemly linked globin-like sequences and an 18-residue C-terminal extension. Two N-linked gly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Baere I,Liu L,Moens L,Van Beeumen J,Gielens C,Richelle J,Trotman C,Finch J,Gerstein M,Perutz M

更新日期：1992-05-15 00:00:00

abstract：:Newborns are at increased risk of jaundice, a condition in which excess bilirubin accumulates in blood. Left untreated, jaundice can lead to neurological impairment and death. Jaundice resulting from unconjugated hyperbilirubinemia is easily treated with exposure to blue light, and phototherapy systems have been devel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Keahey PA,Simeral ML,Schroder KJ,Bond MM,Mtenthaonnga PJ,Miros RH,Dube Q,Richards-Kortum RR

更新日期：2017-12-19 00:00:00

abstract：:Viruses are the most common biological entities in the oceans by an order of magnitude. However, very little is known about their diversity. Here we report a genomic analysis of two uncultured marine viral communities. Over 65% of the sequences were not significantly similar to previously reported sequences, suggestin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Breitbart M,Salamon P,Andresen B,Mahaffy JM,Segall AM,Mead D,Azam F,Rohwer F

更新日期：2002-10-29 00:00:00

abstract：:Metal cation homeostasis is essential for plant nutrition and resistance to toxic heavy metals. Many plant metal transporters remain to be identified at the molecular level. In the present study, we have isolated AtNramp cDNAs from Arabidopsis and show that these genes complement the phenotype of a metal uptake defici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomine S,Wang R,Ward JM,Crawford NM,Schroeder JI

更新日期：2000-04-25 00:00:00

abstract：:Many synthetic or natural fibers are produced via the transformation of a liquid solution into a solid filament, which allows the wet processing of high molecular weight polymers, proteins, or inorganic particles. Synthetic wet-spun fibers are used in our everyday life from clothing to composite reinforcement applicat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mercader C,Lucas A,Derré A,Zakri C,Moisan S,Maugey M,Poulin P

更新日期：2010-10-26 00:00:00

abstract：:Freezing avoidance conferred by different types of antifreeze proteins in various polar and subpolar fishes represents a remarkable example of cold adaptation, but how these unique proteins arose is unknown. We have found that the antifreeze glycoproteins (AFGPs) of the predominant Antarctic fish taxon, the notothenio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen L,DeVries AL,Cheng CH

更新日期：1997-04-15 00:00:00

abstract：:Emerging genetic and clinical evidence suggests a link between Gaucher disease and the synucleinopathies Parkinson disease and dementia with Lewy bodies. Here, we provide evidence that a mouse model of Gaucher disease (Gba1(D409V/D409V)) exhibits characteristics of synucleinopathies, including progressive accumulation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sardi SP,Clarke J,Kinnecom C,Tamsett TJ,Li L,Stanek LM,Passini MA,Grabowski GA,Schlossmacher MG,Sidman RL,Cheng SH,Shihabuddin LS

更新日期：2011-07-19 00:00:00

abstract：:We show that the motion of a slightly compressible fluid is near that of an incompressible fluid. That is, for a given initial velocity field, the motion of a compressible fluid with large sound speed is near to that of an idealized incompressible fluid. We consider the compressible fluid motion in Lagrangian coordina...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ebin DG

更新日期：1975-02-01 00:00:00

abstract：:A sensitive assay for detection of eukaryotic RNA polymerase II has been developed. This assay depends on the ability of polymerase II to elongate a small RNA primer, oligo(U), hybridized to a single-stranded homopolymeric DNA template, poly(dA). The poly(dA).oligo(U)-dependent RNA polymerase II from calf thymus has b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fradkin LG,Leong K,Morrow CD,Berk AJ,Dasgupta A

更新日期：1985-12-01 00:00:00

abstract：:Biochemical and genetic studies have implicated alpha-gustducin as a key component in the transduction of both bitter or sweet taste. Yet, alpha-gustducin-null mice are not completely unresponsive to bitter or sweet compounds. To gain insights into how gustducin mediates responses to bitter and sweet compounds, and to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ruiz-Avila L,Wong GT,Damak S,Margolskee RF

更新日期：2001-07-17 00:00:00

abstract：:Specific rearrangement of internal chromosomal regions occurs during development of the somatic macronucleus in Tetrahymena thermophila and results in elimination of germ-line (micronuclear) DNA sequences. The timing and mechanism of genome rearrangement within one particular 9.3-kilobase region, which contains three ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austerberry CF,Allis CD,Yao MC

更新日期：1984-12-01 00:00:00

abstract：:A pH-dependent transition between delocalized and trapped mixed valence states of an engineered CuA center in azurin has been investigated by UV-visible absorption and electron paramagnetic resonance spectroscopic techniques. At pH 7.0, the CuA azurin displays a typical delocalized mixed valence dinuclear [Cu(1.5).......

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang HJ,Lu Y

更新日期：2004-08-31 00:00:00

abstract：:Time series data on arthropod populations are critical for understanding the magnitude, direction, and drivers of change. However, most arthropod monitoring programs are short-lived and restricted in taxonomic resolution. Monitoring data from the Arctic are especially underrepresented, yet critical to uncovering and u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Høye TT,Loboda S,Koltz AM,Gillespie MAK,Bowden JJ,Schmidt NM

更新日期：2021-01-12 00:00:00

abstract：:Several domains of the human immunodeficiency virus type 1 (HIV-1) envelope glycoprotein have been identified that are involved in HIV-1-mediated membrane fusion. One domain that is involved in membrane fusion is the hydrophobic amino terminus of the HIV-1 transmembrane glycoprotein gp41. Here we show that a polar sub...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Freed EO,Delwart EL,Buchschacher GL Jr,Panganiban AT

更新日期：1992-01-01 00:00:00

abstract：:The binding of invariant chain to major histocompatibility complex (MHC) proteins is an important step in processing of MHC class II proteins and in antigen presentation. The question of how invariant chain can bind to all MHC class II proteins is central to understanding these processes. We have employed molecular mo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee C,McConnell HM

更新日期：1995-08-29 00:00:00

abstract：:Surface topography profoundly influences cell adhesion, differentiation, and stem cell fate control. Numerous studies using a variety of materials demonstrate that nanoscale topographies change the intracellular organization of actin cytoskeleton and therefore a broad range of cellular dynamics in live cells. However,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lou HY,Zhao W,Li X,Duan L,Powers A,Akamatsu M,Santoro F,McGuire AF,Cui Y,Drubin DG,Cui B

更新日期：2019-11-12 00:00:00