Abstract:
:The functions of neurotransmitters in fetal development are poorly understood. Genetic observations have suggested a role for the inhibitory amino acid neurotransmitter gamma-aminobutyric acid (GABA) in the normal development of the mouse palate. Mice homozygous for mutations in the beta-3 GABAA receptor subunit develop a cleft secondary palate. GABA, the ligand for this receptor, is synthesized by the enzyme glutamic acid decarboxylase. We have disrupted one of the two mouse Gad genes by gene targeting and also find defects in the formation of the palate. The striking similarity in phenotype between the receptor and ligand mutations clearly demonstrates a role for GABA signaling in normal palate development.
journal_name
Proc Natl Acad Sci U S Aauthors
Condie BG,Bain G,Gottlieb DI,Capecchi MRdoi
10.1073/pnas.94.21.11451subject
Has Abstractpub_date
1997-10-14 00:00:00pages
11451-5issue
21eissn
0027-8424issn
1091-6490journal_volume
94pub_type
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