Abstract:
:A recombinant plasmid containing sequences complementary to human pro-alpha l(I) collagen mRNA was used for the chromosomal assignment of the pro-alpha l(I) collagen gene. Restriction endonuclease analysis of DNA from mouse-human and Chinese hamster-human somatic cell hybrids revealed cosegregation with human chromosome 17. Hybrids containing derivative chromosomes with a t(2;17)(q14;q21) translocation showed cosegregation of the pro-alpha l(I) gene with the segment 17q21 leads to qter. In situ hybridization on human metaphasic chromosomes confirmed this conclusion.
journal_name
Proc Natl Acad Sci U S Aauthors
Huerre C,Junien C,Weil D,Chu ML,Morabito M,Van Cong N,Myers JC,Foubert C,Gross MS,Prockop DJ,Boué A,Kaplan JC,de la Chapelle A,Ramirez Fdoi
10.1073/pnas.79.21.6627subject
Has Abstractpub_date
1982-11-01 00:00:00pages
6627-30issue
21eissn
0027-8424issn
1091-6490journal_volume
79pub_type
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