Inactivation of cardiotrophin-like cytokine, a second ligand for ciliary neurotrophic factor receptor, leads to cold-induced sweating syndrome in a patient.

abstract：:Vascular endothelial cells (ECs) sense and respond to hemodynamic shear stress, which is critical for circulatory homeostasis and the pathophysiology of vascular diseases. The mechanisms of shear stress mechanotransduction, however, remain elusive. We previously demonstrated a direct role of mitochondria in the purine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamamoto K,Nogimori Y,Imamura H,Ando J

更新日期：2020-12-29 00:00:00

abstract：:Despite their relative simplicity, bacteria have complex anatomy at the subcellular level. At the cell poles of Caulobacter crescentus, a 177-amino acid (aa) protein called PopZ self-assembles into 3D polymeric superstructures. Remarkably, we find that this assemblage interacts directly with at least eight different p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holmes JA,Follett SE,Wang H,Meadows CP,Varga K,Bowman GR

更新日期：2016-11-01 00:00:00

abstract：:Tumor necrosis factor (TNF) receptor-associated factor 6 (TRAF6) plays a vital role in immune signal transduction pathways by acting as a ubiquitin ligase (E3) for Lys63-linked polyubiquitin chain synthesis. However, the detailed mechanism by which the TRAF6 RING dimer promotes ubiquitin transfer was unknown. Through ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fu TM,Shen C,Li Q,Zhang P,Wu H

更新日期：2018-02-20 00:00:00

abstract：:Differential rates of AIDS development and/or T4 lymphocyte depletion in HIV-1-infected individuals remain unexplained. The hypothesis that qualitative differences in selection pressure in vivo may account for different rates of disease progression was addressed in nine eligible study participants from a cohort of 315...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang WK,Essex M,McLane MF,Mayer KH,Hsieh CC,Brumblay HG,Seage G,Lee TH

更新日期：1996-06-25 00:00:00

abstract：:Micron-scale robots require systems that can morph into arbitrary target configurations controlled by external agents such as heat, light, electricity, and chemical environment. Achieving this behavior using conventional approaches is challenging because the available materials at these scales are not programmable lik...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agrawal M,Glotzer SC

更新日期：2020-04-21 00:00:00

abstract：:The synthesis of cytoplasmic proteins from quiescent and serum-stimulated Swiss 3T3 cells was compared by two-dimensional polyacrylamide gel electrophoresis. Four new proteins of Mrs 26,000, 28,000, 45,000, and 47,000 designated N26, N28, N45, and N47, which were not detectable in quiescent cells, appeared 60 min afte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomas G,Thomas G,Luther H

更新日期：1981-09-01 00:00:00

abstract：:Mitochondrial function and ambulatory activity were monitored after feeding old rats acetyl-L-carnitine (ALCAR). Young (3-5 mo) and old (22-28 mo) rats were given a 1.5% (wt/vol) solution of ALCAR in their drinking water for 1 mo, were sacrificed, and their liver parenchymal cells were isolated. ALCAR supplementation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hagen TM,Ingersoll RT,Wehr CM,Lykkesfeldt J,Vinarsky V,Bartholomew JC,Song MH,Ames BN

更新日期：1998-08-04 00:00:00

abstract：:A single-nucleotide polymorphism in the human arylamine N-acetyltransferase 2 (Nat2) gene has recently been identified as associated with insulin resistance in humans. To understand the cellular and molecular mechanisms by which alterations in Nat2 activity might cause insulin resistance, we examined murine ortholog N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Camporez JP,Wang Y,Faarkrog K,Chukijrungroat N,Petersen KF,Shulman GI

更新日期：2017-12-26 00:00:00

abstract：:Acquired immunity to Streptococcus pneumoniae (pneumococcus) has long been assumed to depend on the presence of anticapsular antibodies. We found, however, that colonization with live pneumococci of serotypes 6B, 7F, or 14 protected mice against recolonization by any of the serotypes and that protection from acquisiti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malley R,Trzcinski K,Srivastava A,Thompson CM,Anderson PW,Lipsitch M

更新日期：2005-03-29 00:00:00

abstract：:Broken-cell preparations of Salmonella typhimurium rapidly incorporated 75Se from 75SeO3(2-) into tRNA by an ATP-dependent process. Selenium incorporation in the presence of 50 microM 75SeO3(2-) (0.8-1 pmol per A260 unit) was enhanced by the selenocysteine precursor, O-acetyl-L-serine (to 3.7 pmol per A260 unit). This...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veres Z,Tsai L,Politino M,Stadtman TC

更新日期：1990-08-01 00:00:00

abstract：:Many substances in the plant kingdom and in man's diet occur as glycosides. Recent studies have indicated that many glycosides that are not mutagenic in tests such as the Salmonella test become mutagenic upon hydrolysis of the glycosidic linkages. The Salmonella test utilizes a liver homogenate to approximate mammalia...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tamura G,Gold C,Ferro-Luzzi A,Ames BN

更新日期：1980-08-01 00:00:00

abstract：:DNA repair alkyltransferases protect organisms against the cytotoxic, mutagenic, and carcinogenic effects of alkylating agents by transferring alkyl adducts from DNA to an active cysteine on the protein, thereby restoring the native DNA structure. We used random sequence substitutions to gain structure-function inform...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Christians FC,Loeb LA

更新日期：1996-06-11 00:00:00

abstract：:Tyrosine kinases of the Janus kinase family initiate cellular responses through their association with receptors for alpha-helical cytokines. In addition to a tyrosine kinase domain, these enzymes possess a kinase-like (KL) domain, whose function remains elusive. To investigate the role of the KL domain of Tyk2 in int...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeh TC,Dondi E,Uze G,Pellegrini S

更新日期：2000-08-01 00:00:00

abstract：:Protein misfolding is the molecular basis for several human diseases. How the primary amino acid sequence triggers misfolding and determines the benign or toxic character of the misfolded protein remains largely obscure. Among proteins that misfold, polyglutamine (polyQ) expansion proteins provide an interesting case:...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duennwald ML,Jagadish S,Muchowski PJ,Lindquist S

更新日期：2006-07-18 00:00:00

abstract：:Major changes in global rainfall patterns accompanied a northward shift of Earth's thermal equator at the onset of an abrupt climate change 14.6 kya. This northward pull of Earth's wind and rain belts stemmed from disintegration of North Atlantic winter sea ice cover, which steepened the interhemispheric meridional te...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Broecker WS,Putnam AE

更新日期：2013-10-15 00:00:00

abstract：:Splenic lymphocytes from a Lewis rat, immunized with purified estradiol-receptor complex of calf uterine nuclei, were fused with cells of three different mouse myeloma lines (P3-X63-Ag8, P3-NSI/I-Ag4-1, and Sp2/0-Ag14) to yield hybridoma cultures, 9% of which produced antibodies to the receptor protein (estrophilin). ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greene GL,Fitch FW,Jensen EV

更新日期：1980-01-01 00:00:00

abstract：:Staphylococcus aureus surface protein SasG promotes cell-cell adhesion during the accumulation phase of biofilm formation, but the molecular basis of this interaction remains poorly understood. Here, we unravel the mechanical properties of SasG on the surface of living bacteria, that is, in its native cellular environ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Formosa-Dague C,Speziale P,Foster TJ,Geoghegan JA,Dufrêne YF

更新日期：2016-01-12 00:00:00

abstract：:Many aspects of plant development, including patterning and tropisms, are largely dependent on the asymmetric distribution of the plant signaling molecule auxin. Auxin transport inhibitors (ATIs), which interfere with directional auxin transport, have been essential tools in formulating this concept. However, despite ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dhonukshe P,Grigoriev I,Fischer R,Tominaga M,Robinson DG,Hasek J,Paciorek T,Petrásek J,Seifertová D,Tejos R,Meisel LA,Zazímalová E,Gadella TW Jr,Stierhof YD,Ueda T,Oiwa K,Akhmanova A,Brock R,Spang A,Friml J

更新日期：2008-03-18 00:00:00

abstract：:Vibrational modes in mechanical resonators provide a promising candidate to interface and manipulate classical and quantum information. The observation of coherent dynamics between distant mechanical resonators can be a key step toward scalable phonon-based applications. Here we report tunable coherent phonon dynamics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang ZZ,Song XX,Luo G,Su ZJ,Wang KL,Cao G,Li HO,Xiao M,Guo GC,Tian L,Deng GW,Guo GP

更新日期：2020-03-17 00:00:00

abstract：:Immunoprecipitation of proteins extracted from metabolically labeled human glioblastoma and fibrosarcoma cells with antiserum to platelet-derived growth factor (PDGF) showed that these cells express and secrete proteins that are recognized specifically by the antiserum. The molecular masses of immunoprecipitated prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pantazis P,Pelicci PG,Dalla-Favera R,Antoniades HN

更新日期：1985-04-01 00:00:00

abstract：:There exists a properly embedded minimal surface of genus one with a single end asymptotic to the end of the helicoid. This genus-one helicoid is constructed as the limit of a continuous one-parameter family of screw-motion invariant minimal surfaces, also asymptotic to the helicoid, that have genus equal to one in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber M,Hoffman D,Wolf M

更新日期：2005-11-15 00:00:00

abstract：:Epidermal growth factor (EGF), transforming growth factor alpha (TGF-alpha), and amphiregulin are structurally and functionally related growth regulatory proteins. These secreted polypeptides all bind to the 170-kDa cell-surface EGF receptor, activating its intrinsic kinase activity. However, amphiregulin exhibits dif...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Plowman GD,Whitney GS,Neubauer MG,Green JM,McDonald VL,Todaro GJ,Shoyab M

更新日期：1990-07-01 00:00:00

abstract：:Unconventional mRNA splicing on the endoplasmic reticulum (ER) membrane is the sole conserved mechanism in eukaryotes to transmit information regarding misfolded protein accumulation to the nucleus to activate the stress response. In metazoans, the unspliced form of X-box-binding protein 1 (XBP1u) mRNA is recruited to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kanda S,Yanagitani K,Yokota Y,Esaki Y,Kohno K

更新日期：2016-10-04 00:00:00

abstract：:In electron microscopy studies of the endothelial vesicles in frog mesenteric capillaries, an accidental observation was made concerning vesicular organization. When tannic acid was added to already fixed tissue, the mordant reached apparently free vesicles in the cytoplasm under conditions in which vesicular movement...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bundgaard M,Frøkjaer-Jensen J,Crone C

更新日期：1979-12-01 00:00:00

abstract：:High molecular weight RNA (35S) isolated from avian myeloblastosis virus directs the cell-free synthesis of two prominent polypeptides of 180,000 and 76,000 molecular weight. The latter polypeptide has previously been identified as the precursor to the group-specific antigens of the virus ("gag" proteins) [Vogt, V. M....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paterson BM,Marciani DJ,Papas TS

更新日期：1977-11-01 00:00:00

abstract：:Olfactory transduction is thought to take place in the outer dendritic membrane of insect olfactory receptor neurons. Here we show that the outer dendritic plasma membrane of silkmoth olfactory receptor neurons seems to be exclusively equipped with a specific ion channel activated by low concentrations of the species-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zufall F,Hatt H

更新日期：1991-10-01 00:00:00

abstract：:HIV infection leads to a state of chronic immune activation and progressive deterioration in immune function, manifested most recognizably by the progressive depletion of CD4+ T cells. A substantial percentage of natural killer (NK) cells from patients with HIV infection are activated and express the natural cytotoxic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vieillard V,Strominger JL,Debré P

更新日期：2005-08-02 00:00:00

abstract：:Mutations in the low density lipoprotein (LDL) receptor (LDLR) cause hypercholesterolemia because of inefficient LDL clearance from the circulation. In addition, there is a paradoxical oversecretion of the metabolic precursor of LDL, very low density lipoprotein (VLDL). We recently demonstrated that the LDLR mediates ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gillian-Daniel DL,Bates PW,Tebon A,Attie AD

更新日期：2002-04-02 00:00:00

abstract：:In many cell-signaling pathways, information is transmitted by the diffusion of messenger molecules. Diffusion coefficients characterize the messenger's spatial range and the characteristic times of signal propagation. Inside cells, particles usually diffuse in the presence of immobile binding sites (or traps). It is ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pando B,Dawson SP,Mak DO,Pearson JE

更新日期：2006-04-04 00:00:00

abstract：:Bacteriorhodopsin from Halobacterium halobium has been solubilized in the nonionic detergent Triton X-100. The circular dichroic spectrum and hydrodynamic properties indicate that the structure of this protein in the detergent is not significantly altered from that of the native membrane-bound form. Bacteriorhodopsin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reyenolds JA,Stoeckenius W

更新日期：1977-07-01 00:00:00