Abstract:
:Chromosomal instability (CIN) is a defining characteristic of most human cancers. Mutation of CIN genes increases the probability that whole chromosomes or large fractions of chromosomes are gained or lost during cell division. The consequence of CIN is an imbalance in the number of chromosomes per cell (aneuploidy) and an enhanced rate of loss of heterozygosity. A major question of cancer genetics is to what extent CIN, or any genetic instability, is an early event and consequently a driving force for tumor progression. In this article, we develop a mathematical framework for studying the effect of CIN on the somatic evolution of cancer. Specifically, we calculate the conditions for CIN to initiate the process of colorectal tumorigenesis before the inactivation of tumor suppressor genes.
journal_name
Proc Natl Acad Sci U S Aauthors
Nowak MA,Komarova NL,Sengupta A,Jallepalli PV,Shih IeM,Vogelstein B,Lengauer Cdoi
10.1073/pnas.202617399keywords:
subject
Has Abstractpub_date
2002-12-10 00:00:00pages
16226-31issue
25eissn
0027-8424issn
1091-6490pii
202617399journal_volume
99pub_type
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