Ultrasensitive detection of waste products in water using fluorescence emission cavity-enhanced spectroscopy.

abstract：:As new disease threats arise and existing pathogens grow resistant to conventional interventions, attention increasingly focuses on the development of vaccines to induce protective immune responses. Given their admirable safety records, protein subunit vaccines are attractive for widespread immunization, but their dis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen DJ,Osterrieder N,Metzger SM,Buckles E,Doody AM,DeLisa MP,Putnam D

更新日期：2010-02-16 00:00:00

abstract：:Comparisons of exon II HLA-DR beta sequences have shown that nucleotide variations are principally clustered within the following three regions: V1 (amino acid 8-15), V2 (25-32), and V3 (70-77). V1, V2, and V3-derived 24-mers have been synthesized, the DR beta sequences coming from DR1, DR3, Drw6, DR4, DR5, and DRw53 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Le Gall I,Millasseau P,Dausset J,Cohen D

更新日期：1986-10-01 00:00:00

abstract：:Calcium sensitivity of myosin cross-bridge activation in striated muscles commonly varies during ontogeny and in response to alterations in muscle usage, but the consequences for whole-organism physiology are not well known. Here we show that the relative abundances of alternatively spliced transcripts of the calcium ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marden JH,Fitzhugh GH,Wolf MR,Arnold KD,Rowan B

更新日期：1999-12-21 00:00:00

abstract：:Protein framework alterations in heritable Cu, Zn superoxide dismutase (SOD) mutants cause misassembly and aggregation in cells affected by the motor neuron disease ALS. However, the mechanistic relationship between superoxide dismutase 1 (SOD1) mutations and human disease is controversial, with many hypotheses postul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pratt AJ,Shin DS,Merz GE,Rambo RP,Lancaster WA,Dyer KN,Borbat PP,Poole FL 2nd,Adams MW,Freed JH,Crane BR,Tainer JA,Getzoff ED

更新日期：2014-10-28 00:00:00

abstract：:Metazoan embryogenesis is controlled by a limited number of signaling modules that are used repetitively at successive developmental stages. The development of social amoebas shows similar reiterated use of cAMP-mediated signaling. In the model Dictyostelium discoideum, secreted cAMP acting on 4 cAMP receptors (cARs1-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawabe Y,Morio T,James JL,Prescott AR,Tanaka Y,Schaap P

更新日期：2009-04-28 00:00:00

abstract：:The 20S proteasome core particle (20S CP) plays an integral role in cellular homeostasis by degrading proteins no longer required for function. The process is, in part, controlled via gating residues localized to the ends of the heptameric barrel-like CP structure that occlude substrate entry pores, preventing unregul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang R,Pérez F,Kay LE

更新日期：2017-11-14 00:00:00

abstract：:A cell line has been developed from the imaginal wing discs of the lepidopteran insect Trichoplusia ni (Hübner). The cells grow in suspension as fluid-filled, multicellular vesicles. The cell line has been designated IAL-TND1. Two-dimensional electrophoresis (isoelectric focusing and sodium dodecyl sulfate/polyacrylam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynn DE,Miller SG,Oberlander H

更新日期：1982-04-01 00:00:00

abstract：:Bacterial populations are subject to complex processes of diversification that involve mutation and horizontal DNA transfer mediated by transformation, transduction, or conjugation. Tracing the evolutionary events leading to genetic changes allows us to infer the history of a microbe. Here, we combine experimental and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brochet M,Rusniok C,Couvé E,Dramsi S,Poyart C,Trieu-Cuot P,Kunst F,Glaser P

更新日期：2008-10-14 00:00:00

abstract：:Crystals of magnetite (Fe(3)O(4)) and periclase (MgO) in Fe-Mg-Ca carbonate in the Martian meteorite Allan Hills 84001 were studied by using transmission electron microscopy to understand their origin and evaluate claims that the magnetites were made by Martian microorganisms. In magnesian carbonate, periclase occurs ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barber DJ,Scott ER

更新日期：2002-05-14 00:00:00

abstract：:Stressful events evoke long-term changes in behavioral responses; however, the underlying mechanisms in the brain are not well understood. Previous work has shown that epigenetic changes and immediate-early gene (IEG) induction in stress-activated dentate gyrus (DG) granule neurons play a crucial role in these behavio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saunderson EA,Spiers H,Mifsud KR,Gutierrez-Mecinas M,Trollope AF,Shaikh A,Mill J,Reul JM

更新日期：2016-04-26 00:00:00

abstract：:To characterize the region on human IgG1 responsible for its high-affinity interaction with the human Fc gamma receptor class I (Fc gamma RI), we have analyzed the binding properties of a series of genetically engineered chimeric antidinitrophenyl antibodies with identical murine antibody combining sites and hybrid Ig...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chappel MS,Isenman DE,Everett M,Xu YY,Dorrington KJ,Klein MH

更新日期：1991-10-15 00:00:00

abstract：:The S100A8/S100A9 heterodimer calprotectin (CP) functions in the host response to pathogens through a mechanism termed "nutritional immunity." CP binds Mn(2+) and Zn(2+) with high affinity and starves bacteria of these essential nutrients. Combining biophysical, structural, and microbiological analysis, we identified ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damo SM,Kehl-Fie TE,Sugitani N,Holt ME,Rathi S,Murphy WJ,Zhang Y,Betz C,Hench L,Fritz G,Skaar EP,Chazin WJ

更新日期：2013-03-05 00:00:00

abstract：:Glaucoma is a common cause of vision loss or blindness and reduction of intraocular pressure (IOP) has been proven beneficial in a large fraction of glaucoma patients. The IOP is maintained by the trabecular meshwork (TM) and the elevation of IOP in open-angle glaucoma is associated with dysfunction and loss of the po...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhu W,Gramlich OW,Laboissonniere L,Jain A,Sheffield VC,Trimarchi JM,Tucker BA,Kuehn MH

更新日期：2016-06-21 00:00:00

abstract：:DNA methylation may be a component of a multilevel control mechanism that regulates eukaryotic gene expression. We used synthetic oligonucleotides to investigate the effect of cytosine methylation on the binding of the transcription factor Sp1 to its target sequence (a G + C-rich sequence known as a "GC box"). Concate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harrington MA,Jones PA,Imagawa M,Karin M

更新日期：1988-04-01 00:00:00

abstract：:Lufenuron is an insect growth regulator insecticide mainly used for the control of the cat flea. To understand mechanisms of resistance to lufenuron, we have characterized lufenuron resistance in a natural population of Drosophila melanogaster. In this study we have used precise genetic mapping to identify a mechanism...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bogwitz MR,Chung H,Magoc L,Rigby S,Wong W,O'Keefe M,McKenzie JA,Batterham P,Daborn PJ

更新日期：2005-09-06 00:00:00

abstract：:Virus-specific or group-specific antibody probes to potyviruses can be produced by targeting the immune response to the virus-specific, N-terminal region of the capsid protein (29-95 amino acids depending on the virus) or to the conserved core region (216 amino acids) of the capsid protein, respectively. Immunochemica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shukla DD,Tribbick G,Mason TJ,Hewish DR,Geysen HM,Ward CW

更新日期：1989-11-01 00:00:00

abstract：:Progressive myoclonus epilepsy of Univerricht-Lundborg type is a clinically defined entity among the progressive myoclonus epilepsies. It is an autosomal recessive disorder. The underlying biochemical defect is unknown. We used linkage analysis to localize the gene in 12 families with the aid of polymorphic DNA marker...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lehesjoki AE,Koskiniemi M,Sistonen P,Miao J,Hästbacka J,Norio R,de la Chapelle A

更新日期：1991-05-01 00:00:00

abstract：:RNA synthesis in isolated brain nuclei was analyzed 2.5 hr after the intravenous administration of d-lysergic acid diethylamide (LSD) to young rabbits. The drug stimulated transcription by 54% in brain stem nuclei and by 13% in cerebral hemisphere nuclei expressed over saline controls. Both nucleoplasmic and nucleolar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown IR

更新日期：1975-03-01 00:00:00

abstract：:The phosphorylation of protein I, a specific neuronal protein, has been found to be regulated both by cyclic AMP (cAMP) and by calcium, in intact as well as in lysed synaptosome preparations from rat brain. In order to determine the phosphorylation site(s) of protein I that were regulated by cAMP and calcium, protein ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huttner WB,Greengard P

更新日期：1979-10-01 00:00:00

abstract：:Global declines in biodiversity are altering disease dynamics in complex and multifaceted ways. Changes in biodiversity can have several outcomes on disease risk, including dilution and amplification effects, both of which can have a profound influence on the effects of disease in a community. The dilution effect occu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Searle CL,Biga LM,Spatafora JW,Blaustein AR

更新日期：2011-09-27 00:00:00

abstract：:The temporal distribution of the major extinctions over the past 250 million years has been investigated statistically using various forms of time series analysis. The analyzed record is based on variation in extinction intensity for fossil families of marine vertebrates, invertebrates, and protozoans and contains 12 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raup DM,Sepkoski JJ Jr

更新日期：1984-02-01 00:00:00

abstract：:Iodine is an important nutrient and a significant sink of tropospheric ozone, a climate-forcing gas and air pollutant. Ozone interacts with seawater iodide, leading to volatile inorganic iodine release that likely represents the largest source of atmospheric iodine. Increasing ozone concentrations since the preindustr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Legrand M,McConnell JR,Preunkert S,Arienzo M,Chellman N,Gleason K,Sherwen T,Evans MJ,Carpenter LJ

更新日期：2018-11-27 00:00:00

abstract：:Long-term memory relies on modulation of synaptic connections in response to experience. This plasticity involves trafficking of AMPA receptors (AMPAR) and alteration of spine morphology. Arc, a gene induced by synaptic activity, mediates the endocytosis of AMPA receptors and is required for both long-term and homeost...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peebles CL,Yoo J,Thwin MT,Palop JJ,Noebels JL,Finkbeiner S

更新日期：2010-10-19 00:00:00

abstract：:Hypertonicity-induced binding of the transcription factor TonEBP/OREBP to its cognate DNA element, ORE/TonE, is associated with increased transcription of several osmotically regulated genes. Previously, it was found that hypertonicity rapidly causes nuclear translocation and phosphorylation of TonEBP/OREBP and, more ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferraris JD,Williams CK,Persaud P,Zhang Z,Chen Y,Burg MB

更新日期：2002-01-22 00:00:00

abstract：:Cell-mediated immunity is critical for host resistance to tuberculosis. T lymphocytes recognizing antigens presented by the major histocompatibility complex (MHC) class I and class II molecules have been found to be necessary for control of mycobacterial infection. Mice genetically deficient in the generation of MHC c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teitelbaum R,Cammer M,Maitland ML,Freitag NE,Condeelis J,Bloom BR

更新日期：1999-12-21 00:00:00

abstract：:Molecular beacons are DNA probes that form a stem-and-loop structure and possess an internally quenched fluorophore. When they bind to complementary nucleic acids, they undergo a conformational transition that switches on their fluorescence. These probes recognize their targets with higher specificity than probes that...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonnet G,Tyagi S,Libchaber A,Kramer FR

更新日期：1999-05-25 00:00:00

abstract：:Normal neural development is essential for the formation of neuronal networks and brain function. Cutaneous T cell lymphoma-associated antigen 5 (cTAGE5)/meningioma expressed antigen 6 (MEA6) plays a critical role in the secretion of proteins. However, its roles in the transport of nonsecretory cellular components and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang F,Wang Y,Wang T,Yao L,Lam SM,Huang X,Fan J,Wang Q,Liu L,Jiang Y,Zhang H,Shi L,Yu M,Shui G,Wang Y,Gao F,Zhang X,Xu Z

更新日期：2018-10-02 00:00:00

abstract：:Biodistribution studies of a water-soluble radioactive metallofullerene compound have been conducted using BALB/c mice. To this end, a sample containing Hox@C82 (x = 1, 2) was purified and derivatized to prepare the water-soluble metallofullerol, Hox@C82(OH)y. This metallofullerol was then neutron-activated (165Ho[n,g...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cagle DW,Kennel SJ,Mirzadeh S,Alford JM,Wilson LJ

更新日期：1999-04-27 00:00:00

abstract：:A gene encoding steroid 18-hydroxylase (P-450C18) was isolated from a human genomic DNA library. It was identified as CYP11B2, which was previously postulated to be a pseudogene or a less active gene closely related to CYP11B1, the gene encoding steroid 11 beta-hydroxylase (P-45011 beta) [Mornet, E., Dupont, J., Vitek...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawamoto T,Mitsuuchi Y,Toda K,Yokoyama Y,Miyahara K,Miura S,Ohnishi T,Ichikawa Y,Nakao K,Imura H

更新日期：1992-02-15 00:00:00

abstract：:Epithelia are planar tissues that undergo major morphogenetic movements during development. These movements must work in the context of the mechanical properties of epithelia. Surprisingly little is known about these mechanical properties at the time and length scales of morphogenetic processes. We show that at a time...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luu O,David R,Ninomiya H,Winklbauer R

更新日期：2011-03-08 00:00:00