Identification of the Fc gamma receptor class I binding site in human IgG through the use of recombinant IgG1/IgG2 hybrid and point-mutated antibodies.

abstract：:Treatment strategies for severe cases of pandemic influenza have focused on antiviral therapies. In contrast, passive immunotherapy with convalescent blood products has received limited attention. We consider the hypothesis that a passive-immunotherapy program that collects plasma from a small percentage of recovered ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu JT,Lee CK,Cowling BJ,Yuen KY

更新日期：2010-02-16 00:00:00

abstract：:Discrete state models are a common tool of modeling in many areas. E.g., Markov state models as a particular representative of this model family became one of the major instruments for analysis and understanding of processes in molecular dynamics (MD). Here we extend the scope of discrete state models to the case of s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerber S,Horenko I

更新日期：2014-10-14 00:00:00

abstract：:The nucleus accumbens is considered a critical target of the action of drugs of abuse. In this nucleus a "shell" and a "core" have been distinguished on the basis of anatomical and histochemical criteria. The present study investigated the effect in freely moving rats of intravenous cocaine, amphetamine, and morphine ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pontieri FE,Tanda G,Di Chiara G

更新日期：1995-12-19 00:00:00

abstract：:In HL-60 cells, a human promyelocytic leukemia cell line, the human c-myc gene, designated MYC, is amplified about 16-fold. On differentiation of the HL-60 cells into granulocytes induced by several inhibitors of poly(ADP-ribose) polymerase [NAD+ poly(adenosine diphosphate D-ribose)ADP-D-ribosyltransferase, EC 2.4.2.3...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shima H,Nakayasu M,Aonuma S,Sugimura T,Nagao M

更新日期：1989-10-01 00:00:00

abstract：:Global increases in population, consumption, and gross domestic product raise concerns about the sustainability of the current and future use of natural resources. The human appropriation of net primary production (HANPP) provides a useful measure of human intervention into the biosphere. The productive capacity of la...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Krausmann F,Erb KH,Gingrich S,Haberl H,Bondeau A,Gaube V,Lauk C,Plutzar C,Searchinger TD

更新日期：2013-06-18 00:00:00

abstract：:Transcriptional interference between genes and the regulatory elements of simple eukaryotes such as Saccharomyces cerevisiae is an unavoidable consequence of their compressed genetic arrangement. We have shown previously that with the tandem arranged genes GAL10 and GAL7, inefficient transcriptional termination of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prescott EM,Proudfoot NJ

更新日期：2002-06-25 00:00:00

abstract：:Cellular differentiation leading to formation of the bradyzoite tissue cyst stage is the underlying cause of chronic toxoplasmosis. Consequently, mechanisms responsible for controlling development in the Toxoplasma intermediate life cycle have long been sought. Here, we identified 15 Toxoplasma mRNAs induced in early ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Radke JB,Lucas O,De Silva EK,Ma Y,Sullivan WJ Jr,Weiss LM,Llinas M,White MW

更新日期：2013-04-23 00:00:00

abstract：:Adeno-associated virus (AAV)-mediated gene therapy is currently being pursued as a treatment for the monogenic disorder α-1-antitrypsin (AAT) deficiency. Results from phase I and II studies have shown relatively stable and dose-dependent increases in transgene-derived wild-type AAT after local intramuscular vector adm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Calcedo R,Somanathan S,Qin Q,Betts MR,Rech AJ,Vonderheide RH,Mueller C,Flotte TR,Wilson JM

更新日期：2017-02-14 00:00:00

abstract：:Monkeypox virus (MPV) is a virulent human pathogen that has gained increased attention because of its potential use as a bioterrorism agent and inadvertent introduction into North America in 2003. The US outbreak also provided an important opportunity to study MPV-specific T cell immunity. Although MPV-specific CD4(+)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hammarlund E,Dasgupta A,Pinilla C,Norori P,Früh K,Slifka MK

更新日期：2008-09-23 00:00:00

abstract：:Protein kinase C (PKC) and Syk protein tyrosine kinase play critical roles in immune cell activation including that through the high-affinity IgE receptor, FcepsilonRI. Mechanisms by which PKC activation leads to the activation of Ras, a family of GTPases essential for immune cell activation, have been elusive. We pre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kawakami Y,Kitaura J,Yao L,McHenry RW,Kawakami Y,Newton AC,Kang S,Kato RM,Leitges M,Rawlings DJ,Kawakami T

更新日期：2003-08-05 00:00:00

abstract：:Bufonid anurans of the genus Atelopus contain both steroidal bufadienolides and various guanidinium alkaloids of the tetrodotoxin class. The former inhibit sodium-potassium ATPases, whereas the latter block voltage-dependent sodium channels. The structure of one guanidinium alkaloid, zetekitoxin AB, has remained a mys...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yotsu-Yamashita M,Kim YH,Dudley SC Jr,Choudhary G,Pfahnl A,Oshima Y,Daly JW

更新日期：2004-03-30 00:00:00

abstract：:Cells of the human embryonic stem (hES) cell line H9, when cultured in the form of embryoid bodies, give rise to cells with markers of the keratinocyte of stratified squamous epithelia. Keratinocytes also form in nodules produced in scid mice by injected H9 cells; the hES-derived keratinocytes could be recovered in cu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iuchi S,Dabelsteen S,Easley K,Rheinwald JG,Green H

更新日期：2006-02-07 00:00:00

abstract：:A posttranslational protein O-mannosylation process resembling that found in fungi and animals has been reported in the major human pathogen Mycobacterium tuberculosis (Mtb) and related actinobacteria. However, the role and incidence of this process, which is essential in eukaryotes, have never been explored in Mtb. W...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu CF,Tonini L,Malaga W,Beau M,Stella A,Bouyssié D,Jackson MC,Nigou J,Puzo G,Guilhot C,Burlet-Schiltz O,Rivière M

更新日期：2013-04-16 00:00:00

abstract：:An open question remains as to what coordinates cell behavior during organogenesis, permitting organs to reach their appropriate size and shape. The Arabidopsis gene STRUBBELIG (SUB) defines a receptor-mediated signaling pathway in plants. SUB encodes a putative leucine-rich repeat transmembrane receptor-like kinase. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chevalier D,Batoux M,Fulton L,Pfister K,Yadav RK,Schellenberg M,Schneitz K

更新日期：2005-06-21 00:00:00

abstract：:A low molecular weight toxin isolated from the venom of the digger wasp Philanthus triangulum, first noted by T. Piek, is a potent antagonist of transmission at quisqualate-sensitive glutamate synapses of locust leg muscle. This philanthotoxin 433 (PTX-433) has been purified, chemically characterized, and subsequently...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eldefrawi AT,Eldefrawi ME,Konno K,Mansour NA,Nakanishi K,Oltz E,Usherwood PN

更新日期：1988-07-01 00:00:00

abstract：:Hydrothermal vent ecosystems support diverse life forms, many of which rely on symbiotic associations to perform functions integral to survival in these extreme physicochemical environments. Epsilonproteobacteria, found free-living and in intimate associations with vent invertebrates, are the predominant vent-associat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grzymski JJ,Murray AE,Campbell BJ,Kaplarevic M,Gao GR,Lee C,Daniel R,Ghadiri A,Feldman RA,Cary SC

更新日期：2008-11-11 00:00:00

abstract：:Mathematical models have been developed to explore the population dynamics of viral diseases among wildlife. However, assessing the predictions stemming from these models with wildlife databases adequate in size and temporal duration is uncommon. An epizootic of raccoon rabies that began in the mid-Atlantic region of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Childs JE,Curns AT,Dey ME,Real LA,Feinstein L,Bjørnstad ON,Krebs JW

更新日期：2000-12-05 00:00:00

abstract：:The cellular form of the Prion protein (PrPC) is necessary for prion replication in mice. To determine whether it is also sufficient, we expressed PrP under the control of various cell- or tissue-specific regulatory elements in PrP knockout mice. The interferon regulatory factor-1 promoter/Emu enhancer led to high PrP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raeber AJ,Sailer A,Hegyi I,Klein MA,Rülicke T,Fischer M,Brandner S,Aguzzi A,Weissmann C

更新日期：1999-03-30 00:00:00

abstract：:Proparathyroid hormone (calcemic fraction-A) is a biosynthetic precursor of parathyroid hormone in bovine glands. Limited amounts of the isolated prohormone have been obtained for the purpose of initial structural studies. The results of automated sequence analysis on two separate preparations indicate that the N-term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamilton JW,Niall HD,Jacobs JW,Keutmann HT,Potts JT Jr,Cohn DV

更新日期：1974-03-01 00:00:00

abstract：:Activation of the RET (rearranged during transfection) receptor by glial cell-line-derived neurotrophic factor (GDNF) has been identified as an important differentiation and survival factor for dopaminergic neurons of the midbrain in preclinical experiments. These encouraging results have led to clinical trials of GDN...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kowsky S,Pöppelmeyer C,Kramer ER,Falkenburger BH,Kruse A,Klein R,Schulz JB

更新日期：2007-12-11 00:00:00

abstract：:Engaging mammalian Toll-like receptors (TLRs) activate both the NF-kappaB and mitogen-activated protein kinase signaling pathways. Here we establish that mitogen-activated protein 3 kinase Tpl2, levels of which are markedly reduced in nfkb1(-/-) cells, is required for extracellular signal-regulated kinase (ERK) activa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Banerjee A,Gugasyan R,McMahon M,Gerondakis S

更新日期：2006-02-28 00:00:00

abstract：:Grain growth under shear annealing is crucial for controlling the properties of polycrystalline materials. However, their microscopic kinetics are not well understood because individual atomic trajectories are difficult to track. Here, we study grain growth with single-particle kinetics in colloidal polycrystals using...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Peng Y,Zhang Y,Still T,Yodh AG,Han Y

更新日期：2020-09-29 00:00:00

abstract：:It is well established that assimilatory nitrate reductase (ANR) activity in soil is inhibited by ammonium (NH4+). To elucidate the mechanism of this inhibition, we studied the effect of L-methionine sulfoximine (MSX), an inhibitor of NH4+ assimilation by microorganisms, on assimilatory reduction of nitrate (NO3-) in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCarty GW,Bremner JM

更新日期：1992-01-15 00:00:00

abstract：:The ability of cocaine to inhibit the dopamine transporter (DAT) appears to be crucial for its reinforcing properties. The potential use of drugs that produce long-lasting inhibition of the DAT as a mean of preventing the "high" and reducing drug-seeking behavior has become a major strategy in medication development. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volkow ND,Wang GJ,Fowler JS,Gatley SJ,Ding YS,Logan J,Dewey SL,Hitzemann R,Lieberman J

更新日期：1996-09-17 00:00:00

abstract：:The toxicological significance of exposures to synthetic chemicals is examined in the context of exposures to naturally occurring chemicals. We calculate that 99.99% (by weight) of the pesticides in the American diet are chemicals that plants produce to defend themselves. Only 52 natural pesticides have been tested in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ames BN,Profet M,Gold LS

更新日期：1990-10-01 00:00:00

abstract：:Chicken erythrocyte nuclei have been labeled in the active regions of the chromosome by using the nick translation reaction. In this procedure, accessible areas of the genome are preferentially nicked by the action of pancreatic DNase I and subsequently labeled by using DNA polymerase I from Escherichia coli. These nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gazit B,Panet A,Cedar H

更新日期：1980-04-01 00:00:00

abstract：:Pressures of 200-1000 atmospheres (20-100 MPa) are found to decrease significantly the amount of phosphate (H32PO4-2)transported into the rabbit erythrocyte under otherwise physiological conditions. Such compression does not cause irreversible morphological changes or result in membrane disruption. The findings are in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy RB,Libby WF

更新日期：1976-08-01 00:00:00

abstract：:We have developed a modified rhodamine (Rho) staining procedure to study uptake and efflux in murine hematopoietic stem cells. Distinct populations of Rho++ (bright), Rho+ (dull), and Rho- (negative) cells could be discriminated. Sorted Rho- cells were subjected to a second Rho staining procedure with the P-glycoprote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zijlmans JM,Visser JW,Kleiverda K,Kluin PM,Willemze R,Fibbe WE

更新日期：1995-09-12 00:00:00

abstract：:Hydrogenases catalyze the reversible reaction 2H(+) + 2e(-) ↔ H(2) with an equilibrium constant that is dependent on the reducing potential of electrons carried by their redox partner. To examine the possibility of increasing the photobiological production of hydrogen within cyanobacterial cultures, we expressed the [...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ducat DC,Sachdeva G,Silver PA

更新日期：2011-03-08 00:00:00

abstract：:Inhibitory gamma-aminobutyric acid-mediated synaptic currents were studied in dissociated primary cultures of neonatal rat cortex with the whole-cell patch-clamp technique. Immunocytochemical staining of the cultures showed the presence of a large number of glutamic acid decarboxylase-containing neurons, and electrica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vicini S,Alho H,Costa E,Mienville JM,Santi MR,Vaccarino FM

更新日期：1986-12-01 00:00:00