Abstract:
:Monkeypox virus (MPV) is a virulent human pathogen that has gained increased attention because of its potential use as a bioterrorism agent and inadvertent introduction into North America in 2003. The US outbreak also provided an important opportunity to study MPV-specific T cell immunity. Although MPV-specific CD4(+) and CD8(+) T cells could recognize vaccinia virus (VV)-infected monocytes and produce inflammatory cytokines such as IFNgamma and TNFalpha, they were largely incapable of responding to autologous MPV-infected cells. Further analysis revealed that, unlike cowpox virus (CPV), MPV did not interfere with MHC expression or intracellular transport of MHC molecules. Instead, MPV-infected cells were capable of preventing T cell receptor (TcR)-mediated T cell activation in trans. The ability to trigger a state of nonresponsiveness represents a unique MHC-independent mechanism for blocking antiviral T cell activation and inflammatory cytokine production and is likely an important attribute involved with viral dissemination in the infected host.
journal_name
Proc Natl Acad Sci U S Aauthors
Hammarlund E,Dasgupta A,Pinilla C,Norori P,Früh K,Slifka MKdoi
10.1073/pnas.0800589105subject
Has Abstractpub_date
2008-09-23 00:00:00pages
14567-72issue
38eissn
0027-8424issn
1091-6490pii
0800589105journal_volume
105pub_type
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