Inhibition of erythrocyte phosphate transport by high pressures.

abstract：:A vitamin D(3) metabolite in intestine more polar than 25-hydroxy-vitamin D(3)(25-OH D(3)) has been detected by countercurrent distribution. The intestinal metabolite is found also after administration of labeled hydroxy D(3), indicating that it arises from vitamin D(3) via the intermediate 25-hydroxy derivative. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haussler MR,Boyce DW,Littledike ET,Rasmussen H

更新日期：1971-01-01 00:00:00

abstract：:When an algorithm in dimension one is extended to dimension d, in nearly every case its computational cost is taken to the power d. This fundamental difficulty is the single greatest impediment to solving many important problems and has been dubbed the curse of dimensionality. For numerical analysis in dimension d, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beylkin G,Mohlenkamp MJ

更新日期：2002-08-06 00:00:00

abstract：:MscS is a mechanosensitive channel that is ubiquitous among bacteria. Recent progress in the genome projects has revealed that homologs of MscS are also present in eukaryotes, but whether they operate as ion channels is unknown. In this study we cloned MSC1, a homolog of MscS in Chlamydomonas, and examined its functio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakayama Y,Fujiu K,Sokabe M,Yoshimura K

更新日期：2007-04-03 00:00:00

abstract：:The Notch signaling pathway defines an evolutionarily conserved cell-cell interaction mechanism that throughout development controls the ability of precursor cells to respond to developmental signals. Here we show that Notch signaling regulates the expression of the master control genes eyeless, vestigial, and Distal-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kurata S,Go MJ,Artavanis-Tsakonas S,Gehring WJ

更新日期：2000-02-29 00:00:00

abstract：:The acquisition of cell-surface urokinase plasminogen activator activity is a hallmark of malignancy. We generated an engineered anthrax toxin that is activated by cell-surface urokinase in vivo and displays limited toxicity to normal tissue but broad and potent tumoricidal activity. Native anthrax toxin protective an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Aaronson H,Mitola DJ,Leppla SH,Bugge TH

更新日期：2003-01-21 00:00:00

abstract：:Endosymbiotic acquisition of bacteria by a protist, with subsequent evolution of the bacteria into mitochondria and plastids, had a transformative impact on eukaryotic biology. Reconstructing events that created a stable association between endosymbiont and host during the process of organellogenesis--including establ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nowack EC,Grossman AR

更新日期：2012-04-03 00:00:00

abstract：:Two major DNA double-strand break repair pathways exist in all eukaryotes, nonhomologous DNA end joining (NHEJ) and homologous recombination (HR). Although both pathways can function throughout the cell cycle, NHEJ predominates in G0/G1) (when a replicated sister chromatid is unavailable), whereas HR makes a more subs...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Convery E,Shin EK,Ding Q,Wang W,Douglas P,Davis LS,Nickoloff JA,Lees-Miller SP,Meek K

更新日期：2005-02-01 00:00:00

abstract：:A major goal of tumor immunotherapy is the effective eradication of established metastases associated with the induction of a T cell-mediated protective immunity. We achieved this in a poorly immunogenic murine neuroblastoma model by gene therapy with a single chain interleukin 12 (scIL-12) fusion protein that assures...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lode HN,Dreier T,Xiang R,Varki NM,Kang AS,Reisfeld RA

更新日期：1998-03-03 00:00:00

abstract：:Sea urchins are a major component of recent marine communities where they exert a key role as grazers and benthic predators. However, their impact on past marine organisms, such as crinoids, is hard to infer in the fossil record. Analysis of bite mark frequencies on crinoid columnals and comprehensive genus-level dive...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gorzelak P,Salamon MA,Baumiller TK

更新日期：2012-05-01 00:00:00

abstract：:Self-assembled monolayer-protected nanoparticles are promising candidates for applications, such as sensing and drug delivery, in which the molecular ligands' interactions with the surrounding environment play a crucial role. We recently showed that, when gold nanoparticles are coated with a binary mixture of immiscib...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Centrone A,Penzo E,Sharma M,Myerson JW,Jackson AM,Marzari N,Stellacci F

更新日期：2008-07-22 00:00:00

abstract：:Homologs of the chromatin-bound yeast silent information regulator 2 (SIR2) protein are found in organisms from all biological kingdoms. SIR2 itself was originally discovered to influence mating-type control in haploid cells by locus-specific transcriptional silencing. Since then, SIR2 and its homologs have been sugge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Landry J,Sutton A,Tafrov ST,Heller RC,Stebbins J,Pillus L,Sternglanz R

更新日期：2000-05-23 00:00:00

abstract：:We have previously identified by cDNA cloning 5 mRNAs that appear in resting BALB/c 3T3 cells soon after growth stimulation by serum or platelet-derived growth factor. Five additional mRNAs of this class are described in this report. The mRNAs reached peak levels between 40 and 120 min after serum addition and rapidly...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lau LF,Nathans D

更新日期：1987-03-01 00:00:00

abstract：:The ability to analyze and isolate cells based on the expression of specific surface markers has increased our understanding of cell biology and produced numerous applications for biomedicine. However, established cell-sorting platforms rely on labels that are limited in number due to biophysical constraints, such as ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dahotre SN,Chang YM,Wieland A,Stammen SR,Kwong GA

更新日期：2018-04-24 00:00:00

abstract：:The CD4 receptor contributes to T-cell activation by coligating major histocompatibility complex class II on antigen presenting cells with the T-cell receptor (TCR)/CD3 complex, and triggering a cascade of signaling events including tyrosine phosphorylation of intracellular proteins. Paradoxically, CD3 cross-linking p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Desbarats J,Freed JH,Campbell PA,Newell MK

更新日期：1996-10-01 00:00:00

abstract：:Studies by several investigators have shown that 12-0-tetradecanoylphorbol-13-acetate (TPA) is an extraordinarily potent stimulator of differentiation of cultured human promyelocytic leukemia cells in vitro. In the present study, TPA was administered to humans by i.v. infusion without irreversible toxicity, and it was...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Han ZT,Zhu XX,Yang RY,Sun JZ,Tian GF,Liu XJ,Cao GS,Newmark HL,Conney AH,Chang RL

更新日期：1998-04-28 00:00:00

abstract：:Mach bands, the illusory brightness maxima and minima perceived at the initiation and termination of luminance gradients, respectively, are generally considered a direct perceptual manifestation of lateral inhibitory interactions among retinal or other lower order visual neurons. Here we examine an alternative explana...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lotto RB,Williams SM,Purves D

更新日期：1999-04-27 00:00:00

abstract：:Exposure of Escherichia coli to alkylating agents activates expression of AidB in addition to DNA repair proteins Ada, AlkA, and AlkB. AidB was recently shown to possess a flavin adenine dinucleotide (FAD) cofactor and to bind to dsDNA, implicating it as a flavin-dependent DNA repair enzyme. However, the molecular mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowles T,Metz AH,O'Quin J,Wawrzak Z,Eichman BF

更新日期：2008-10-07 00:00:00

abstract：:Escherichia coli is a model laboratory bacterium, a species that is widely distributed in the environment, as well as a mutualist and pathogen in its human hosts. As such, E. coli represents an attractive organism to study how environment impacts microbial genome structure and function. Uropathogenic E. coli (UPEC) mu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen SL,Hung CS,Xu J,Reigstad CS,Magrini V,Sabo A,Blasiar D,Bieri T,Meyer RR,Ozersky P,Armstrong JR,Fulton RS,Latreille JP,Spieth J,Hooton TM,Mardis ER,Hultgren SJ,Gordon JI

更新日期：2006-04-11 00:00:00

abstract：:Rat liver membrane adenylate cyclase (EC 4.6.1.1) that has been stimulated more than 10-fold by cholera toxin (choleragen) has a 3-fold greater sensitivity to stimulation by glucagon. Choleragen similarly increases the sensitivity of cyclase to other peptide (ACTH, vasoactive intestinal polypeptide) and nonpeptide (ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bennett V,O'Keefe E,Cuatrecasaş P

更新日期：1975-01-01 00:00:00

abstract：:The highly ordered and reproducible structure of the fungal prion HET-s makes it an excellent model system for studying the inherent properties of prions, self-propagating infectious proteins that have been implicated in a number of fatal diseases. In particular, the HET-s prion-forming domain readily folds into a rel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wan W,Stubbs G

更新日期：2014-04-08 00:00:00

abstract：:Treatment of the third component of human complement (C3) with methylamine results in a loss of hemolytic function and the appearance of a thiol group. Studies with [14C]methylamine have indicatd a stoichiometric and covalent reaction with the native protein. Hydrazine-inactivated C3 and C3b prepared with bovine tryps...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tack BF,Harrison RA,Janatova J,Thomas ML,Prahl JW

更新日期：1980-10-01 00:00:00

abstract：:The Paramyxoviridae family of enveloped viruses enters cells through the concerted action of two viral glycoproteins. The receptor-binding protein, hemagglutinin-neuraminidase (HN), H, or G, binds its cellular receptor and activates the fusion protein, F, which, through an extensive refolding event, brings viral and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bose S,Zokarkar A,Welch BD,Leser GP,Jardetzky TS,Lamb RA

更新日期：2012-09-25 00:00:00

abstract：:Large mandibular defects are clinically challenging to reconstruct due to the complex anatomy of the jaw and the limited availability of appropriate tissue for repair. We envision leveraging current advances in fabrication and biomaterials to create implantable devices that generate bone within the patients themselves...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatara AM,Koons GL,Watson E,Piepergerdes TC,Shah SR,Smith BT,Shum J,Melville JC,Hanna IA,Demian N,Ho T,Ratcliffe A,van den Beucken JJJP,Jansen JA,Wong ME,Mikos AG

更新日期：2019-04-02 00:00:00

abstract：:Humans speak, monkeys grunt, and ducks quack. How do we come to know which vocalizations animals produce? Here we explore this question by asking whether young infants expect humans, but not other animals, to produce speech, and further, whether infants have similarly restricted expectations about the sources of vocal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vouloumanos A,Druhen MJ,Hauser MD,Huizink AT

更新日期：2009-11-03 00:00:00

abstract：:The polymerase chain reaction was used to amplify DNA surrounding the codon 12 region of the c-Ki-ras gene from C3H/10T1/2 cells and from a number of 3-methylcholanthrene (MCA)-transformed derivatives of these cells. Sequence analysis demonstrated that tumorigenic MCAC116/39 cells, known by DNA-mediated transfection t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen AC,Herschman HR

更新日期：1989-03-01 00:00:00

abstract：:Aryloxyphenoxypropionates, inhibitors of the plastid acetyl-CoA carboxylase (ACC) of grasses, also inhibit Toxoplasma gondii ACC. Clodinafop, the most effective of the herbicides tested, inhibits growth of T. gondii in human fibroblasts by 70% at 10 microM in 2 days and effectively eliminates the parasite in 2-4 days ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zuther E,Johnson JJ,Haselkorn R,McLeod R,Gornicki P

更新日期：1999-11-09 00:00:00

abstract：:Heterochromatin protein 1 (HP1), first discovered in Drosophila melanogaster, is a highly conserved chromosomal protein implicated in both heterochromatin formation and gene silencing. We report here characterization of an HP1-interacting protein, heterochromatin protein 2 (HP2), which codistributes with HP1 in the pe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shaffer CD,Stephens GE,Thompson BA,Funches L,Bernat JA,Craig CA,Elgin SC

更新日期：2002-10-29 00:00:00

abstract：:Biogeochemical reactions occur unevenly in space and time, but this heterogeneity is often simplified as a linear average due to sparse data, especially in subsurface environments where access is limited. For example, little is known about the spatial variability of groundwater denitrification, an important process in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kolbe T,de Dreuzy JR,Abbott BW,Aquilina L,Babey T,Green CT,Fleckenstein JH,Labasque T,Laverman AM,Marçais J,Peiffer S,Thomas Z,Pinay G

更新日期：2019-02-12 00:00:00

abstract：:The C2 domain containing protein extended synaptotagmin (E-Syt) plays important roles in both lipid homeostasis and the intracellular signaling; however, its role in physiology remains largely unknown. Here, we show that hypothalamic E-Syt3 plays a critical role in diet-induced obesity (DIO). E-Syt3 is characteristica...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang Y,Guan Y,Pan S,Yan L,Wang P,Chen Z,Shen Q,Zhao F,Zhang X,Li J,Li J,Cai D,Zhang G

更新日期：2020-08-18 00:00:00

abstract：:The recent intensification of agriculture, and the prospects of future intensification, will have major detrimental impacts on the nonagricultural terrestrial and aquatic ecosystems of the world. The doubling of agricultural food production during the past 35 years was associated with a 6.87-fold increase in nitrogen ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilman D

更新日期：1999-05-25 00:00:00