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Transplantation of iPSC-derived TM cells rescues glaucoma phenotypes in vivo.

Abstract：

:Glaucoma is a common cause of vision loss or blindness and reduction of intraocular pressure (IOP) has been proven beneficial in a large fraction of glaucoma patients. The IOP is maintained by the trabecular meshwork (TM) and the elevation of IOP in open-angle glaucoma is associated with dysfunction and loss of the postmitotic cells residing within this tissue. To determine if IOP control can be maintained by replacing lost TM cells, we transplanted TM-like cells derived from induced pluripotent stem cells into the anterior chamber of a transgenic mouse model of glaucoma. Transplantation led to significantly reduced IOP and improved aqueous humor outflow facility, which was sustained for at least 9 wk. The ability to maintain normal IOP engendered survival of retinal ganglion cells, whose loss is ultimately the cause for reduced vision in glaucoma. In vivo and in vitro analyses demonstrated higher TM cellularity in treated mice compared with littermate controls and indicated that this increase is primarily because of a proliferative response of endogenous TM cells. Thus, our study provides in vivo demonstration that regeneration of the glaucomatous TM is possible and points toward novel approaches in the treatment of this disease.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Zhu W,Gramlich OW,Laboissonniere L,Jain A,Sheffield VC,Trimarchi JM,Tucker BA,Kuehn MH

doi

10.1073/pnas.1604153113

subject

Has Abstract

pub_date

2016-06-21 00:00:00

pages

E3492-500

issue

25

eissn

0027-8424

issn

1091-6490

pii

1604153113

journal_volume

113

pub_type

杂志文章

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