Energy dissipation bounds for autonomous thermodynamic cycles.

abstract：:HLA-A and -B antigens are phosphorylated in transformed lymphoblastoid cells and peripheral blood lymphocytes, both incubated with 32Pi. The phosphate group is attached to HLA-A and -B heavy chain (p44) as identified by immunoprecipitation with anti-beta2-microglobulin IgG, sodium dodecyl sulfate/polyacrylamide gel el...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pober JS,Guild BC,Strominger JL

更新日期：1978-12-01 00:00:00

abstract：:Sparse 3T3 cells, in excess serum, become quiescent in the early G(1) (or G(0)) phase of the cell cycle if the cells are cultured in low concentrations of amino acids, glucose, or phosphate ion. These quiescent cells then initiate DNA synthesis if the concentration of the limiting nutrient is increased. In normal medi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Holley RW,Kiernan JA

更新日期：1974-08-01 00:00:00

abstract：:Portable, single-sided NMR sensors can operate under conditions inaccessible to conventional NMR while featuring lower cost, portability, and the ability to analyze arbitrary-sized objects. Such sensors can nondestructively probe the interior of samples by collecting images and measuring relaxation and diffusion const...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Paulsen JL,Bouchard LS,Graziani D,Blümich B,Pines A

更新日期：2008-12-30 00:00:00

abstract：:Alcohol exposure during development can cause brain malformations and neurobehavioral abnormalities. In view of the teratogenicity of ethanol, identification of molecules that could counteract the neurotoxic effects of alcohol deserves high priority. Here, we report that pituitary adenylate cyclase-activating polypept...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vaudry D,Rousselle C,Basille M,Falluel-Morel A,Pamantung TF,Fontaine M,Fournier A,Vaudry H,Gonzalez BJ

更新日期：2002-04-30 00:00:00

abstract：:Maximum likelihood analysis for linkage between autosomal dominant aniridia and 12 biochemical and serological markers in a single large family showed a probable linkage between autosomal dominant aniridia and the enzyme acid phosphatase-1. The presence of an autosomal dominant aniridia gene linked to acid phosphatase...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ferrell RE,Chakravarti A,Hittner HM,Riccardi VM

更新日期：1980-03-01 00:00:00

abstract：:The content of elongation factor Tu in E. coli B has been determined both by radioimmune assay and by GDP binding. The two assays gave comparable results: cells growing at 2 doublings per hour contained about 8 molecules of Tu per ribosome, whereas those growing at 0.22 doublings per hour contained about 14 molecules ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furano AV

更新日期：1975-12-01 00:00:00

abstract：:Synthesis of the 31-amino acid, inner membrane protein MgtS (formerly denoted YneM) is induced by very low Mg2+ in a PhoPQ-dependent manner in Escherichia coli Here we report that MgtS acts to increase intracellular Mg2+ levels and maintain cell integrity upon Mg2+ depletion. Upon development of a functional tagged de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang H,Yin X,Wu Orr M,Dambach M,Curtis R,Storz G

更新日期：2017-05-30 00:00:00

abstract：:Previous research has implicated a large network of brain regions in the processing of risk during decision making. However, it has not yet been determined if activity in these regions is predictive of choices on future risky decisions. Here, we examined functional MRI data from a large sample of healthy subjects perf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Helfinstein SM,Schonberg T,Congdon E,Karlsgodt KH,Mumford JA,Sabb FW,Cannon TD,London ED,Bilder RM,Poldrack RA

更新日期：2014-02-18 00:00:00

abstract：:Mutations of the VHL tumor suppressor gene occur in patients with VHL disease and in the majority of sporadic clear cell renal carcinomas (VHL(-/-) RCC). Loss of VHL protein function is associated with constitutive expression of mRNAs encoding hypoxia-inducible proteins, such as vascular endothelial growth factor. Ove...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Paulsen N,Brychzy A,Fournier MC,Klausner RD,Gnarra JR,Pause A,Lee S

更新日期：2001-02-13 00:00:00

abstract：:Immigration and demographic change have become highly salient in American politics, partly because of the 2016 campaign of Donald Trump. Previous research indicates that local influxes of immigrants or unfamiliar ethnic groups can generate threatened responses, but has either focused on nonelectoral outcomes or analyz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill SJ,Hopkins DJ,Huber GA

更新日期：2019-12-10 00:00:00

abstract：:Several findings suggest that signals from tyrosine kinases are transduced, at least in part, through ras proteins. These findings include (i) blockage of the transforming activity of constitutively active tyrosine kinases by inhibiting ras function and (ii) genetic screens in Caenorhabditis elegans and in Drosophila ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bowtell D,Fu P,Simon M,Senior P

更新日期：1992-07-15 00:00:00

abstract：:A stable complex between pentaammineruthenium(III) and histidine-33 in horse heart ferricytochrome c is formed in the reaction between aquopentaammineruthenium(II) and the protein at pH 7. HPLC of the tryptic hydrolysate of the modified protein was employed to identify the pentaammineruthenium binding site. Spectrosco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yocom KM,Shelton JB,Shelton JR,Schroeder WA,Worosila G,Isied SS,Bordignon E,Gray HB

更新日期：1982-11-01 00:00:00

abstract：:When two phases of water are at equilibrium, the ratio of hydrogen isotopes in each is slightly altered because of their different phase affinities. This isotopic fractionation process can be utilized to analyze water's movement in the world's climate. Here we show that equilibrium fractionation ratios, an entirely qu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markland TE,Berne BJ

更新日期：2012-05-22 00:00:00

abstract：:Activation of p53 tumor suppressor by antagonizing its negative regulator murine double minute (MDM)2 has been considered an attractive strategy for cancer therapy and several classes of p53-MDM2 binding inhibitors have been developed. However, these compounds do not inhibit the p53-MDMX interaction, and their effecti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves B,Thompson T,Xia M,Janson C,Lukacs C,Deo D,Di Lello P,Fry D,Garvie C,Huang KS,Gao L,Tovar C,Lovey A,Wanner J,Vassilev LT

更新日期：2012-07-17 00:00:00

abstract：:We have constructed and characterized a polyoma virus-based plasmid that is maintained as an autonomously replicating extrachromosomal element (episome) in mouse embryonic stem (ES) cells. Plasmid pMGD20neo contains the polyoma origin of replication harboring a mutated enhancer (PyF101), a modified polyoma early regio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gassmann M,Donoho G,Berg P

更新日期：1995-02-28 00:00:00

abstract：:Multiple biological processes involve the stretching of nucleic acids (NAs). Stretching forces induce local changes in the molecule structure, inhibiting or promoting the binding of proteins, which ultimately affects their functionality. Understanding how a force induces changes in the structure of NAs at the atomic l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marin-Gonzalez A,Vilhena JG,Perez R,Moreno-Herrero F

更新日期：2017-07-03 00:00:00

abstract：:In the prostate gland of adult mammals, most epithelial cells are in a state of proliferative quiescence. Androgens regulate this effect by inducing cell cycle arrest in the G(0)/G(1) phase. Potential mediators of this androgen-induced proliferative shutoff were identified by means of subtracted cDNA libraries. The ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Geck P,Maffini MV,Szelei J,Sonnenschein C,Soto AM

更新日期：2000-08-29 00:00:00

abstract：:The recombinant plasmid p102 based on pBR322 carrying approximately equal to 50% of the replicator proximal early region of simian virus 40 (SV40) DNA, including the viral origin of replication, has been constructed. It lacks a major part of the large tumor (T) antigen 3'-coding region, the T-antigen termination codon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horst J,Weckler C,Jacob E,Aulehla-Scholz C,Deppert W

更新日期：1982-08-01 00:00:00

abstract：:Eukaryotic transcriptional activators may function by stimulating formation of RNA polymerase II preinitiation complexes at the core promoter of genes. In this case, their mode of action will intrinsically depend on how these complexes assemble on promoters in living cells, an issue that remains largely unexplored. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez-Couto E,Klages N,Strubin M

更新日期：1997-07-22 00:00:00

abstract：:By using differential display PCR, we have identified 98 cDNA fragments from the rat dorsal hippocampus that are expressed differentially between the fast learners and slow learners in the water maze learning task. One of these cDNA fragments encodes the rat serum- and glucocorticoid-inducible kinase (sgk) gene. North...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsai KJ,Chen SK,Ma YL,Hsu WL,Lee EH

更新日期：2002-03-19 00:00:00

abstract：:In this era of continued emergence of zoonotic virus infections, the rapid development of rodent models represents a critical barrier to public health preparedness, including the testing of antivirus therapy and vaccines. The Middle East respiratory syndrome coronavirus (MERS-CoV) was recently identified as the causat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao J,Li K,Wohlford-Lenane C,Agnihothram SS,Fett C,Zhao J,Gale MJ Jr,Baric RS,Enjuanes L,Gallagher T,McCray PB Jr,Perlman S

更新日期：2014-04-01 00:00:00

abstract：:W. D. Hamilton's celebrated formula for the age-specific force of natural selection furnishes predictions for senescent mortality due to mutation accumulation, at the price of reliance on a linear approximation. Applying to Hamilton's setting the full nonlinear demographic model for mutation accumulation recently deve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wachter KW,Evans SN,Steinsaltz D

更新日期：2013-06-18 00:00:00

abstract：:Thymidine dinucleotide (pTpT) stimulates melanogenesis in mammalian pigment cells and intact skin, mimicking the effects of UV irradiation and UV-mimetic DNA damage. Here it is shown that, in addition to tanning, pTpT induces a second photoprotective response, enhanced repair of UV-induced DNA damage. This enhanced re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eller MS,Maeda T,Magnoni C,Atwal D,Gilchrest BA

更新日期：1997-11-11 00:00:00

abstract：:The Fas/APO-1 cytotoxic pathway plays an important role in the regulation of peripheral immunity. Recent evidence indicates that this regulatory function operates through deletion of activated T and B lymphocytes by CD4+ T cells expressing the Fas ligand. Because macrophages play a key role in peripheral immunity, we ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ashany D,Song X,Lacy E,Nikolic-Zugic J,Friedman SM,Elkon KB

更新日期：1995-11-21 00:00:00

abstract：:The class II transactivator (CIITA) is the master integrator of expression of MHC class II genes. It interacts with variety of basal transcription factors to initiate and elongate transcription of these genes. Among others, it recruits positive transcription elongation factor b (P-TEFb) to MHC class II promoters. In c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kohoutek J,Blazek D,Peterlin BM

更新日期：2006-11-14 00:00:00

abstract：:When T cells become infected by the parasite Theileria parva, they acquire a transformed phenotype and no longer require antigen-specific stimulation or exogenous growth factors. This is accompanied by constitutive interleukin 2 (IL-2) and IL-2 receptor expression. Transformation can be reversed entirely by eliminatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galley Y,Hagens G,Glaser I,Davis W,Eichhorn M,Dobbelaere D

更新日期：1997-05-13 00:00:00

abstract：:Misfolded proteins are an emerging hallmark of cardiac diseases. Although some misfolded proteins, such as desmin, are associated with mutations in the genes encoding these disease-associated proteins, little is known regarding more general mechanisms that contribute to the generation of misfolded proteins in the hear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu Y,Satz JS,Vo MN,Nangle LA,Schimmel P,Ackerman SL

更新日期：2014-12-09 00:00:00

abstract：:The parietal cell (PC) plays an important role in normal gastric physiology and in common diseases of the stomach. Although the genes involved in acid secretion are well known, there is limited molecular information about other aspects of PC function. We have generated a comprehensive database of genes expressed prefe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mills JC,Syder AJ,Hong CV,Guruge JL,Raaii F,Gordon JI

更新日期：2001-11-20 00:00:00

abstract：:Expression of the transcription factor FOXC2 is induced and necessary for successful epithelial-mesenchymal transition, a developmental program that when activated in cancer endows cells with metastatic potential and the properties of stem cells. As such, identifying agents that inhibit the growth of FOXC2-transformed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bollong MJ,Pietilä M,Pearson AD,Sarkar TR,Ahmad I,Soundararajan R,Lyssiotis CA,Mani SA,Schultz PG,Lairson LL

更新日期：2017-11-14 00:00:00

abstract：:CCAAT/enhancer binding protein (C/EBP) epsilon is a recently cloned member of the C/EBP family of transcription factors and is expressed exclusively in cells of hematopoietic origin. The human C/EBPepsilon gene is transcribed by two alternative promoters, Palpha and Pbeta. A combination of differential splicing and al...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamanaka R,Kim GD,Radomska HS,Lekstrom-Himes J,Smith LT,Antonson P,Tenen DG,Xanthopoulos KG

更新日期：1997-06-10 00:00:00