Abstract:
:Portable, single-sided NMR sensors can operate under conditions inaccessible to conventional NMR while featuring lower cost, portability, and the ability to analyze arbitrary-sized objects. Such sensors can nondestructively probe the interior of samples by collecting images and measuring relaxation and diffusion constants, and, given careful shimming schemes, even perform chemical analysis. The inherently strong magnetic-field gradients of single-sided sensors developed so far has prevented imaging of materials with high water content, such as biological tissues, over large volumes whereas designs with more homogeneous fields suffer from low field strength and typically cannot probe volumes larger than approximately 10 cm(3). We present a design with a continuously adjustable sensitive volume, enabling the effective volume to be enlarged several fold. This capability allows for imaging in reasonable times of much bigger objects and opens the door to the possibility of clinical imaging with portable sensors. We demonstrate MRI in axial and sagittal planes, at different depths of the sensitive volume and T(1)-weighted contrast in a tissue sample.
journal_name
Proc Natl Acad Sci U S Aauthors
Paulsen JL,Bouchard LS,Graziani D,Blümich B,Pines Adoi
10.1073/pnas.0811222106subject
Has Abstractpub_date
2008-12-30 00:00:00pages
20601-4issue
52eissn
0027-8424issn
1091-6490pii
0811222106journal_volume
105pub_type
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