Persistence of learning-induced synapses depends on neurotrophic priming of glucocorticoid receptors.

abstract：:The bacterial hibernating 100S ribosome is a poorly understood form of the dimeric 70S particle that has been linked to pathogenesis, translational repression, starvation responses, and ribosome turnover. In the opportunistic pathogen Staphylococcus aureus and most other bacteria, hibernation-promoting factor (HPF) ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Basu A,Yap MN

更新日期：2017-09-26 00:00:00

abstract：:The cat tongue is covered in sharp, rear-facing spines called papillae, the precise function of which is a mystery. In this combined experimental and theoretical study, we use high-speed film, grooming force measurements, and computed tomography (CT) scanning to elucidate the mechanism by which papillae are used to gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noel AC,Hu DL

更新日期：2018-12-04 00:00:00

abstract：:Using antibodies that react selectively with peptide sequences unique to endothelial nitric oxide synthase (eNOS), we demonstrate localizations to neuronal populations in the brain. In some brain regions, such as the cerebellum and olfactory bulb, eNOS and neuronal NOS (nNOS) occur in the same cell populations, though...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dinerman JL,Dawson TM,Schell MJ,Snowman A,Snyder SH

更新日期：1994-05-10 00:00:00

abstract：:According to a current "RNA first" model for the origin of life, RNA emerged in some form on early Earth to become the first biopolymer to support Darwinism here. Threose nucleic acid (TNA) and other polyelectrolytes are also considered as the possible first Darwinian biopolymer(s). This model is being developed by re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim HJ,Benner SA

更新日期：2017-10-24 00:00:00

abstract：:Phytochrome is the photoreceptor that controls red light-mediated morphogenesis in higher plants. It exists in two photointerconvertible forms, a red light-absorbing form, Pr, and a far-red light-absorbing form, Pfr. Because photoconversion of Pr to Pfr by a brief light pulse decreases the in vivo half-life of this ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shanklin J,Jabben M,Vierstra RD

更新日期：1987-01-01 00:00:00

abstract：:Avian reovirus S1133 penetrates and uncoats in suspension cultures of mouse L cells. The multiple species of viral transcripts are produced in the cytoplasm of the infected cell, but they fail to associate with polysomes, consistent with the absence of viral protein synthesis. The selective block in avian virus mRNA t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Benavente J,Shatkin AJ

更新日期：1988-06-01 00:00:00

abstract：:We have previously identified and purified a cell surface glycoprotein from retina and brain, called neural cell adhesion molecule or N-CAM, that appears to be involved in neural cell--cell adhesion, the fasciculation of neurites, and the formation of normal tissue patterns in the retina. The present studies reveal th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rutishauser U,Hoffman S,Edelman GM

更新日期：1982-01-01 00:00:00

abstract：:By using clones of murine T cells reactive with alloantigens as well as soluble antigens, it has been possible to demonstrate that Ia antigens, Ir gene phenomena (defined as the ability of immune T cells to recognize antigen), and mixed lymphocyte reaction (MLR)-stimulating determinants encoded within the I-A subregio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fathman CG,Kimoto M,Melvold R,David CS

更新日期：1981-03-01 00:00:00

abstract：:Due to intrinsic aggressiveness and lack of effective therapies, prognosis of pancreatic cancer remains dismal. Because the only molecular targeted drug approved for pancreatic ductal adenocarcinoma is a kinase inhibitor specific to the epidermal growth factor receptor (EGFR), and this receptor collaborates with anoth...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maron R,Schechter B,Mancini M,Mahlknecht G,Yarden Y,Sela M

更新日期：2013-09-17 00:00:00

abstract：:We propose and test a theoretical perspective in which a universal hallmark of successful literacy acquisition is the convergence of the speech and orthographic processing systems onto a common network of neural structures, regardless of how spoken words are represented orthographically in a writing system. During fun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rueckl JG,Paz-Alonso PM,Molfese PJ,Kuo WJ,Bick A,Frost SJ,Hancock R,Wu DH,Mencl WE,Duñabeitia JA,Lee JR,Oliver M,Zevin JD,Hoeft F,Carreiras M,Tzeng OJ,Pugh KR,Frost R

更新日期：2015-12-15 00:00:00

abstract：:When fibers of fibrin clots or fragments of fibrinogen pellets are negatively stained they exhibit in the electron microscope characteristic patterns of cross-striations or bands. Those found in pellet material are indistinguishable from those seen in thrombin-induced fibrin fibers. The pattern seen in fibrin from bov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams RC

更新日期：1983-03-01 00:00:00

abstract：:Cyclooxygenase-2 (COX-2) expression is induced by mitogenic and proinflammatory factors. Its overexpression plays a causal role in inflammation and tumorigenesis. COX-2 expression is tightly regulated, but the mechanisms are largely unclear. Here we show the control of COX-2 expression by an endogenous tryptophan meta...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheng HH,Kuo CC,Yan JL,Chen HL,Lin WC,Wang KH,Tsai KK,Guvén H,Flaberg E,Szekely L,Klein G,Wu KK

更新日期：2012-08-14 00:00:00

abstract：:Replication of plasmid DNA molecules containing the simian virus 40 (SV40) origin of DNA replication has been reconstituted with seven highly purified cellular proteins plus the SV40 large tumor (T) antigen. Initiation of DNA synthesis is absolutely dependent upon T antigen, replication protein A, and the DNA polymera...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weinberg DH,Collins KL,Simancek P,Russo A,Wold MS,Virshup DM,Kelly TJ

更新日期：1990-11-01 00:00:00

abstract：:Phage phi 29 DNA cannot be phosphorylated with polynucleotide kinase and [gamma-32P]ATP because of the presence of a viral protein covalently linked to the 5' termini. The 5' ends can, however, be made susceptible to phosphorylation by treatment with alkali and alkaline phosphatase. Restriction fragments Hpa II C and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Escarmís C,Salas M

更新日期：1981-03-01 00:00:00

abstract：:The early steps in the biosynthesis of Taxol involve the cyclization of geranylgeranyl diphosphate to taxa-4(5),11(12)-diene followed by cytochrome P450-mediated hydroxylation at C5, acetylation of this intermediate, and a second cytochrome P450-dependent hydroxylation at C10 to yield taxadien-5 alpha-acetoxy-10 beta-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schoendorf A,Rithner CD,Williams RM,Croteau RB

更新日期：2001-02-13 00:00:00

abstract：:Inflammatory bowel diseases (IBDs), including Crohn's disease and ulcerative colitis, are associated with dysbiosis of the gut microbiome. Emerging evidence suggests that small-molecule metabolites derived from bacterial breakdown of a variety of dietary nutrients confer a wide array of host benefits, including amelio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scott SA,Fu J,Chang PV

更新日期：2020-08-11 00:00:00

abstract：:Rotifers of the asexual class Bdelloidea are unusual in possessing two or more divergent copies of every gene that has been examined. Phylogenetic analysis of the heat-shock gene hsp82 and the TATA-box-binding protein gene tbp in multiple bdelloid species suggested that for each gene, each copy belonged to one of two ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mark Welch DB,Cummings MP,Hillis DM,Meselson M

更新日期：2004-02-10 00:00:00

abstract：:Calcium/phospholipid-dependent protein kinase (protein kinase C, PKC) has been suggested to play a role in the sensitivity of gamma-aminobutyrate type A (GABAA) receptors to ethanol. We tested a line of null mutant mice that lacks the gamma isoform of PKC (PKC gamma) to determine the role of this brain-specific isoenz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Harris RA,McQuilkin SJ,Paylor R,Abeliovich A,Tonegawa S,Wehner JM

更新日期：1995-04-25 00:00:00

abstract：:Mechanisms by which the extracellular domain of Notch1 controls Notch1 signaling are not well defined. Here, we show that the O-fucose glycan in the Notch1 ligand-binding domain regulates the strength of Notch1 signaling during embryogenesis, postweaning growth, and T cell development in the mouse. Heterozygotes carry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ge C,Stanley P

更新日期：2008-02-05 00:00:00

abstract：:Fifty cats with feline leukemia virus (FeLV) infection and leukemia-lymphoma complex were treated by ex vivo immunoadsorption with Staphylococcus protein A-bound filters. Most cats responded to therapy. Twelve showed tumor regression, including disappearance of tumor cells, but died later of other complications. Three...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu WT,Engelman RW,Trang LQ,Hau K,Good RA,Day NK

更新日期：1984-06-01 00:00:00

abstract：:To efficiently represent all of the possible rewards in the world, dopaminergic midbrain neurons dynamically adapt their coding range to the momentarily available rewards. Specifically, these neurons increase their activity for an outcome that is better than expected and decrease it for an outcome worse than expected,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park SQ,Kahnt T,Talmi D,Rieskamp J,Dolan RJ,Heekeren HR

更新日期：2012-03-13 00:00:00

abstract：:The remarkable strength of glasses is examined using the random first order transition theory of the glass transition. The theory predicts that strength depends on elastic modulus but also on the configurational energy frozen in when the glass is prepared. The stress catalysis of cooperative rearrangements of the type...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wisitsorasak A,Wolynes PG

更新日期：2012-10-02 00:00:00

abstract：:We use alternating-laser excitation to achieve fluorescence-aided molecule sorting (FAMS) and enable simultaneous analysis of biomolecular structure and interactions at the level of single molecules. This was performed by labeling biomolecules with fluorophores that serve as donor-acceptor pairs for Förster resonance ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kapanidis AN,Lee NK,Laurence TA,Doose S,Margeat E,Weiss S

更新日期：2004-06-15 00:00:00

abstract：:We have used expression cloning in Xenopus oocytes to isolate two different cDNAs encoding functional N-methyl-D-aspartate (NMDA) receptor subunits. The two receptors (NMDA-R1A and -R1B) display different pharmacologic properties as a consequence of alternative exon addition within the putative ligand-binding domain. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakanishi N,Axel R,Shneider NA

更新日期：1992-09-15 00:00:00

abstract：:Guanosine tetraphosphate, recently discovered to mediate the regulatory relationship between protein synthesis and RNA accumulation in various bacteria, has been synthesized in vitro in large quantities and analyzed by natural-abundance (13)C nuclear magnetic resonance spectroscopy in order to confirm its structure an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Que L Jr,Willie GR,Cashel M,Bodley JW,Gray GR

更新日期：1973-09-01 00:00:00

abstract：:The homotypic fusion of endoplasmic reticulum (ER) membranes is mediated by atlastin (ATL), which consists of an N-terminal cytosolic domain containing a GTPase module and a three-helix bundle followed by two transmembrane (TM) segments and a C-terminal tail (CT). Fusion depends on a GTP hydrolysis-induced conformatio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu TY,Bian X,Sun S,Hu X,Klemm RW,Prinz WA,Rapoport TA,Hu J

更新日期：2012-08-07 00:00:00

abstract：:An early and a late histone H2B gene from the sea urchin Stronglyocentrotus purpuratus were linked in a single plasmid and injected into the eggs of the sea urchin Lytechinus pictus. The levels of transcripts of injected early and late genes and of endogenous early genes were monitored during development by a ribonucl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Colin AM,Catlin TL,Kidson SH,Maxson R

更新日期：1988-01-01 00:00:00

abstract：:Flagellar polypeptides of Chlamydomonas reinhardtii were analyzed in two-dimensions by isoelectric focusing and electrophoresis in the presence of sodium dodecyl sulfate. In addition to flagellar tubulin, over 130 polypeptides were resolved and 100 of these were identified as axonemal components in wild-type organisms...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Piperno G,Huang B,Luck DJ

更新日期：1977-04-01 00:00:00

abstract：:The MHC class I antigen presentation pathway allows the immune system to distinguish between self and nonself. Despite extensive research on the processing of antigenic peptides, little is known about their origin. Here, we show that mRNAs carrying premature stop codons that prevent the production of full-length prote...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Apcher S,Daskalogianni C,Lejeune F,Manoury B,Imhoos G,Heslop L,Fåhraeus R

更新日期：2011-07-12 00:00:00

abstract：:A rat model of hereditary renal carcinoma (RC) was found in a rat colony of the Sprague-Dawley strain in Japan and named the "Nihon" rat. In heterozygotes, RCs, predominantly the clear cell type, develop from early preneoplastic lesions, which began to appear as early as 3 weeks of age, to adenocarcinomas by the age o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okimoto K,Sakurai J,Kobayashi T,Mitani H,Hirayama Y,Nickerson ML,Warren MB,Zbar B,Schmidt LS,Hino O

更新日期：2004-02-17 00:00:00