Abstract:
:Like all aliphatic amines, the polyamines spermine and spermidine are physical quenchers of singlet molecular oxygen (1O2*). The rate constants of these processes were determined in vitro with photochemically generated 1O2* and the hydrocarbon rubrene as substrate, in pyridine. At millimolar concentration, spermine and spermidine should quench 1O2* in vivo and prevent it from damaging DNA. It is proposed that a biological function of polyamines is the protection of replicating DNA against oxidative damage.
journal_name
Proc Natl Acad Sci U S Aauthors
Khan AU,Mei YH,Wilson Tdoi
10.1073/pnas.89.23.11426keywords:
subject
Has Abstractpub_date
1992-12-01 00:00:00pages
11426-7issue
23eissn
0027-8424issn
1091-6490journal_volume
89pub_type
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