The age-specific force of natural selection and biodemographic walls of death.

abstract：:Miraculin (MCL) is a homodimeric protein isolated from the red berries of Richadella dulcifica. MCL, although flat in taste at neutral pH, has taste-modifying activity to convert sour stimuli to sweetness. Once MCL is held on the tongue, strong sweetness is sensed over 1 h each time we taste a sour solution. Neverthel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koizumi A,Tsuchiya A,Nakajima K,Ito K,Terada T,Shimizu-Ibuka A,Briand L,Asakura T,Misaka T,Abe K

更新日期：2011-10-04 00:00:00

abstract：:In the troposphere, methanol (CH3OH) is present ubiquitously and second in abundance among organic gases after methane. In the surface ocean, methanol represents a supply of energy and carbon for marine microbes. Here we report direct measurements of air-sea methanol transfer along a ∼10,000-km north-south transect of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang M,Nightingale PD,Beale R,Liss PS,Blomquist B,Fairall C

更新日期：2013-12-10 00:00:00

abstract：:The application of boron neutron capture therapy to rheumatoid arthritis requires the selective delivery of the boron-10 isotope to the synovitic tissue. The use of liposomes as a boron delivery method has been explored through the measurement of the time course biodistribution of boron in rats with collagen-induced a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watson-Clark RA,Banquerigo ML,Shelly K,Hawthorne MF,Brahn E

更新日期：1998-03-03 00:00:00

abstract：:Coordinated changes in gene expression underlie the early patterning and cell-type specification of the central nervous system. However, much less is known about how such changes contribute to later stages of circuit assembly and refinement. In this study, we employ single-cell RNA sequencing to develop a detailed, wh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalish BT,Cheadle L,Hrvatin S,Nagy MA,Rivera S,Crow M,Gillis J,Kirchner R,Greenberg ME

更新日期：2018-01-30 00:00:00

abstract：:Amyloid beta-protein (Abeta) is linked to neuronal injury and death in Alzheimer's disease (AD). Of particular relevance for elucidating the role of Abeta in AD is new evidence that oligomeric forms of Abeta are potent neurotoxins that play a major role in neurodegeneration and the strong association of the 42-residue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bitan G,Kirkitadze MD,Lomakin A,Vollers SS,Benedek GB,Teplow DB

更新日期：2003-01-07 00:00:00

abstract：:The cellular models generally used in the in vitro evaluation of anti-human immunodeficiency virus compounds are dividing cells. A model constituted by resting lymphocytes may more accurately reflect a drug's future efficacy in humans, since viral DNA synthesis is known to take place in quiescent cells, creating a res...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malley SD,Grange JM,Hamedi-Sangsari F,Vila JR

更新日期：1994-11-08 00:00:00

abstract：:Genetic polymorphism in the H-2:Qa:Tla region of chromosome 17 is associated with constitutive variation of bodily odor phenotypes which permit individual olfactory recognition among mice. To determine whether known genes in the H-2:Qa:Tla complex are concerned in the constitution of odor phenotypes, mice were tested ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamazaki K,Beauchamp GK,Egorov IK,Bard J,Thomas L,Boyse EA

更新日期：1983-09-01 00:00:00

abstract：:Parts of the primary structure of the NAD-specific glutamate dehydrogenase [L-glutamate:NAD oxidoreductase (deaminating), EC 1.4.1.2] from Neurospora crassa are presented. Segments of the sequence representing 886 unique amino-acid residues have been determined; the largest contains 267 residues. There are only short ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Austen BM,Nyc JF,Degani Y,Smith EL

更新日期：1975-12-01 00:00:00

abstract：:When we reach toward objects, we easily avoid potential obstacles located in the workspace. Previous studies suggest that obstacle avoidance relies on mechanisms in the dorsal visual stream in the posterior parietal cortex. One fundamental question that remains unanswered is where the visual inputs to these dorsal-str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Striemer CL,Chapman CS,Goodale MA

更新日期：2009-09-15 00:00:00

abstract：:(2'-5')Oligoadenylate synthetase [(2'-5')A synthetase], which synthesizes a series of oligoadenylates ppp-(A2'p)n5'A [collectively referred to as (2'-5')A], has been described previously in rat liver cells, where its concentration varied with the growth status of this organ--i.e., it decreased during the early phase o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etienne-Smekens M,Vandenbussche P,Content J,Dumont JE

更新日期：1983-08-01 00:00:00

abstract：:A detailed conformational analysis of the known crystal structures of vitamin A, carotenoid, and xanthenoid derivatives has been made. These studies suggest that the visual chromophore 11-cis retinal and its isomers may each occur in several different conformational states, which would be expected to have different li...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sundaralingam M,Beddell C

更新日期：1972-06-01 00:00:00

abstract：:Several proteins have been identified that protect Drosophila telomeres from fusion events. They include UbcD1, HP1, HOAP, the components of the Mre11-Rad50-Nbs (MRN) complex, the ATM kinase, and the putative transcription factor Woc. Of these proteins, only HOAP has been shown to localize specifically at telomeres. H...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raffa GD,Siriaco G,Cugusi S,Ciapponi L,Cenci G,Wojcik E,Gatti M

更新日期：2009-02-17 00:00:00

abstract：:The composition of biologic molecules isolated from biominerals suggests that control of mineral growth is linked to biochemical features. Here, we define a systematic relationship between the ability of biomolecules in solution to promote the growth of calcite (CaCO3) and their net negative molecular charge and hydro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Elhadj S,De Yoreo JJ,Hoyer JR,Dove PM

更新日期：2006-12-19 00:00:00

abstract：:Autoantibodies directed against the cell surface receptors for insulin are found in some patients with extreme insulin resistance. These antibodies specifically inhibit the binding of insulin to its receptor. A purified IgG fraction from one patient's plasma was labeled with 125I. The 125I-labeled antireceptor antibod...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarrett DB,Roth J,Kahn CR,Flier JS

更新日期：1976-11-01 00:00:00

abstract：:Neurons in macaque ventral premotor cortex and inferior parietal lobe discharge during both the observation and the execution of motor acts. It has been claimed that these so-called mirror neurons form the basis of action understanding by matching the visual input with the corresponding motor program (direct matching)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lingnau A,Gesierich B,Caramazza A

更新日期：2009-06-16 00:00:00

abstract：:Health care is a crucial factor in US economic growth, because growing health care costs have made US corporations less competitive than their counterparts in countries where central governments assume most of those costs. In this paper we illustrate a second, possibly more powerful, effect of health care expenditures...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Manton KG,Gu XL,Ullian A,Tolley HD,Headen AE Jr,Lowrimore G

更新日期：2009-12-15 00:00:00

abstract：:Protein ubiquitination plays an important role in ATP-dependent protein turnover, and it also may regulate other cellular events. Covalent attachment of ubiquitin to other proteins is catalyzed by three different enzymes, E1, E2, and E3. We have previously shown that protein ubiquitination can be regulated by phosphor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kong SK,Chock PB

更新日期：1994-11-22 00:00:00

abstract：:Efforts to delineate the advent of many enzymes essential to protein translation are often limited by the fact that the modern genetic code evolved before divergence of the tree of life. Glutaminyl-tRNA synthetase (GlnRS) is one noteworthy exception to the universality of the translation apparatus. In eukaryotes and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Skouloubris S,Ribas de Pouplana L,De Reuse H,Hendrickson TL

更新日期：2003-09-30 00:00:00

abstract：:The neighbor-exclusion principle is one of the most general and interesting rules describing intercalative DNA binding by small molecules. It suggests that such binding can only occur at every other base-pair site, reflecting a very large negative cooperativity in the binding process. We have carried out molecular mec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao SN,Kollman PA

更新日期：1987-08-01 00:00:00

abstract：:Streptococcus pneumoniae can cause disease in various human tissues and organs, including the ear, the brain, the blood, and the lung, and thus in highly diverse and dynamic environments. It is challenging to study how pneumococci control virulence factor expression, because cues of natural environments and the presen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sorg RA,Gallay C,Van Maele L,Sirard JC,Veening JW

更新日期：2020-11-03 00:00:00

abstract：:The endoplasmic reticulum (ER) plays an important role in peroxisome biogenesis; some peroxisomal membrane proteins are inserted into the ER and trafficked to peroxisomes in vesicles. These vesicles could also provide the phospholipids required for the growth of peroxisomal membranes, because peroxisomes lack phosphol...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raychaudhuri S,Prinz WA

更新日期：2008-10-14 00:00:00

abstract：:The lineage-determining transcription factor CCAAT enhancer binding protein alpha (C/EBPalpha) is required for myeloid differentiation. Decreased function or expression of C/EBPalpha is often found in human acute myeloid leukemia. However, the precise impact of C/EBPalpha deficiency on the maturation arrest in leukemo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wagner K,Zhang P,Rosenbauer F,Drescher B,Kobayashi S,Radomska HS,Kutok JL,Gilliland DG,Krauter J,Tenen DG

更新日期：2006-04-18 00:00:00

abstract：:Transgenic overexpression of Cu(+2)/Zn(+2) superoxide dismutase 1 (SOD1) harboring an amyotrophic lateral sclerosis (ALS)-linked familial genetic mutation (SOD1(G93A)) in a Sprague-Dawley rat results in ALS-like motor neuron disease. Motor neuron disease in these rats depended on high levels of mutant SOD1 expression,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Howland DS,Liu J,She Y,Goad B,Maragakis NJ,Kim B,Erickson J,Kulik J,DeVito L,Psaltis G,DeGennaro LJ,Cleveland DW,Rothstein JD

更新日期：2002-02-05 00:00:00

abstract：:The template for transcription and replication of negative-stranded RNA viruses is a ribonucleoprotein structure, the nucleocapsid. We have developed a system that supports assembly of the negative-stranded RNA genome of a defective interfering (DI) particle of vesicular stomatitis virus (VSV) into a nucleocapsid in v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mirakhur B,Peluso RW

更新日期：1988-10-01 00:00:00

abstract：:A general theory of the structure of complexes of the transition metals is developed on the basis of the enneacovalence of the metals and the requirements of the electroneutrality principle. An extra orbital may be provided through the small but not negligible amount of f and g character of spd bond orbitals, and an e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1977-12-01 00:00:00

abstract：:The land plants and their immediate green algal ancestors, the charophytes, form the Streptophyta. There is evidence that both the chloroplast DNA (cpDNA) and mitochondrial DNA (mtDNA) underwent substantial changes in their architecture (intron insertions, gene losses, scrambling in gene order, and genome expansion in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Turmel M,Otis C,Lemieux C

更新日期：2002-08-20 00:00:00

abstract：:Rat hepatoma cells infected with mouse mammary tumor virus contain multiple forms of unintegrated viral DNA when grown in the presence of glucocorticoids. Using the DNA transfer procedure of Southern, we have prepared restriction endonuclease fragment maps of these forms of viral DNA. The maps indicate that: (i) the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shank PR,Cohen JC,Varmus HE,Yamamoto KR,Ringold GM

更新日期：1978-05-01 00:00:00

abstract：:If H denotes the classical Hilbert transform and Hu(x) = v(x), then the functions u(x) and v(x) are the values on the real axis of a pair of conjugate functions, harmonic in the upper half-plane. This note gives a generalization of the above concepts in which the Laplace equation Deltau = 0 is replaced by the Yukawa e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duffin RJ

更新日期：1972-12-01 00:00:00

abstract：:Membrane binding of Gag, a crucial step in HIV-1 assembly, is facilitated by bipartite signals within the matrix (MA) domain: N-terminal myristoyl moiety and the highly basic region (HBR). We and others have shown that Gag interacts with a plasma-membrane-specific acidic phospholipid, phosphatidylinositol-(4,5)-bispho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chukkapalli V,Oh SJ,Ono A

更新日期：2010-01-26 00:00:00

abstract：:The designed assembly of proteins into well-defined supramolecular architectures not only tests our understanding of protein-protein interactions, but it also provides an opportunity to tailor materials with new physical and chemical properties. Previously, we described that RIDC3, a designed variant of the monomeric ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brodin JD,Carr JR,Sontz PA,Tezcan FA

更新日期：2014-02-25 00:00:00