Abstract:
:W. D. Hamilton's celebrated formula for the age-specific force of natural selection furnishes predictions for senescent mortality due to mutation accumulation, at the price of reliance on a linear approximation. Applying to Hamilton's setting the full nonlinear demographic model for mutation accumulation recently developed by Evans, Steinsaltz, and Wachter, we find surprising differences. Nonlinear interactions cause the collapse of Hamilton-style predictions in the most commonly studied case, refine predictions in other cases, and allow walls of death at ages before the end of reproduction. Haldane's principle for genetic load has an exact but unfamiliar generalization.
journal_name
Proc Natl Acad Sci U S Aauthors
Wachter KW,Evans SN,Steinsaltz Ddoi
10.1073/pnas.1306656110subject
Has Abstractpub_date
2013-06-18 00:00:00pages
10141-6issue
25eissn
0027-8424issn
1091-6490pii
1306656110journal_volume
110pub_type
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