The age-specific force of natural selection and biodemographic walls of death.

Abstract:

:W. D. Hamilton's celebrated formula for the age-specific force of natural selection furnishes predictions for senescent mortality due to mutation accumulation, at the price of reliance on a linear approximation. Applying to Hamilton's setting the full nonlinear demographic model for mutation accumulation recently developed by Evans, Steinsaltz, and Wachter, we find surprising differences. Nonlinear interactions cause the collapse of Hamilton-style predictions in the most commonly studied case, refine predictions in other cases, and allow walls of death at ages before the end of reproduction. Haldane's principle for genetic load has an exact but unfamiliar generalization.

authors

Wachter KW,Evans SN,Steinsaltz D

doi

10.1073/pnas.1306656110

subject

Has Abstract

pub_date

2013-06-18 00:00:00

pages

10141-6

issue

25

eissn

0027-8424

issn

1091-6490

pii

1306656110

journal_volume

110

pub_type

杂志文章
  • Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.

    abstract::The use of proteasome inhibitors to target cancer's dependence on altered protein homeostasis has been greatly limited by intrinsic and acquired resistance. Analyzing data from thousands of cancer lines and tumors, we find that those with suppressed expression of one or more 19S proteasome subunits show intrinsic prot...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1619067114

    authors: Tsvetkov P,Sokol E,Jin D,Brune Z,Thiru P,Ghandi M,Garraway LA,Gupta PB,Santagata S,Whitesell L,Lindquist S

    更新日期:2017-01-10 00:00:00

  • NinaB combines carotenoid oxygenase and retinoid isomerase activity in a single polypeptide.

    abstract::In animals, successful production of the visual chromophore (11-cis-retinal or derivatives thereof such as 11-cis-3-hydroxy-retinal) is essential for photoreceptor cell function and survival. These carotenoid-derived compounds must combine with a protein moiety (the opsin) to establish functional visual pigments. Evid...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0807805105

    authors: Oberhauser V,Voolstra O,Bangert A,von Lintig J,Vogt K

    更新日期:2008-12-02 00:00:00

  • Electron tunneling through alkanedithiol self-assembled monolayers in large-area molecular junctions.

    abstract::The electrical transport through self-assembled monolayers of alkanedithiols was studied in large-area molecular junctions and described by the Simmons model [Simmons JG (1963) J Appl Phys 34:1793-1803 and 2581-2590] for tunneling through a practical barrier, i.e., a rectangular barrier with the image potential includ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章,评审

    doi:10.1073/pnas.0701472104

    authors: Akkerman HB,Naber RC,Jongbloed B,van Hal PA,Blom PW,de Leeuw DM,de Boer B

    更新日期:2007-07-03 00:00:00

  • Structural changes of tailless bacteriophage ΦX174 during penetration of bacterial cell walls.

    abstract::Unlike tailed bacteriophages, which use a preformed tail for transporting their genomes into a host bacterium, the ssDNA bacteriophage ΦX174 is tailless. Using cryo-electron microscopy and time-resolved small-angle X-ray scattering, we show that lipopolysaccharides (LPS) form bilayers that interact with ΦX174 at an ic...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1716614114

    authors: Sun Y,Roznowski AP,Tokuda JM,Klose T,Mauney A,Pollack L,Fane BA,Rossmann MG

    更新日期:2017-12-26 00:00:00

  • Evolution of models to support community and policy action with science: Balancing pastoral livelihoods and wildlife conservation in savannas of East Africa.

    abstract::We developed a "continual engagement" model to better integrate knowledge from policy makers, communities, and researchers with the goal of promoting more effective action to balance poverty alleviation and wildlife conservation in 4 pastoral ecosystems of East Africa. The model involved the creation of a core boundar...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0900313106

    authors: Reid RS,Nkedianye D,Said MY,Kaelo D,Neselle M,Makui O,Onetu L,Kiruswa S,Kamuaro NO,Kristjanson P,Ogutu J,BurnSilver SB,Goldman MJ,Boone RB,Galvin KA,Dickson NM,Clark WC

    更新日期:2016-04-26 00:00:00

  • Vitamin D metabolism during pregnancy and lactation in the rat.

    abstract::The plasma concentration of the major vitamin D metabolites; 25-hydroxyvitamin D, 1,25-dihydroxyvitamin D, and 24,25-dihydroxyvitamin D were measured during pregnancy and lactation in the adult female rat. The concentrations of these metabolites were also measured in rat pups during lactation and after weaning. The pl...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.76.11.5549

    authors: Halloran BP,Barthell EN,DeLuca HF

    更新日期:1979-11-01 00:00:00

  • Experimental constraints on mate preferences in Drosophila pseudoobscura decrease offspring viability and fitness of mated pairs.

    abstract::Using Drosophila pseudoobscura, we tested the hypothesis that social constraints on the free expression of mate preferences, by both females and males, decrease offspring viability and reproductive success of mating pairs. Mate preference arenas eliminated intrasexual combat and intersexual coercion. The time female a...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0611152104

    authors: Anderson WW,Kim YK,Gowaty PA

    更新日期:2007-03-13 00:00:00

  • Secondary structure of eukaryotic cytoplasmic 5S ribosomal RNA.

    abstract::A five-helix secondary structural model is proposed for eukaryotic cytoplasmic 5S rRNA. All available sequence data are consistent with this model including those from Chlorella 5S rRNA whose sequence is revised by data included here. Various architectural features of eukaryotic 5S rRNA are summarized in terms of this...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.78.4.2150

    authors: Luehrsen KR,Fox GE

    更新日期:1981-04-01 00:00:00

  • Measurements of the concentration and composition of nuclei for cirrus formation.

    abstract::This article addresses the need for new data on indirect effects of natural and anthropogenic aerosol particles on atmospheric ice clouds. Simultaneous measurements of the concentration and composition of tropospheric aerosol particles capable of initiating ice in cold (cirrus) clouds are reported. Measurements suppor...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2532677100

    authors: DeMott PJ,Cziczo DJ,Prenni AJ,Murphy DM,Kreidenweis SM,Thomson DS,Borys R,Rogers DC

    更新日期:2003-12-09 00:00:00

  • Prostaglandin synthesis in isolated rat kidney glomeruli.

    abstract::Isolated rat kidney glomeruli converted octatritiated arachidonic acid to several prostaglandins whose production was inhibited by meclofenamate. These were, in order of decreasing abundance, prostaglandin F2 alpha, prostaglandin E2, 6-oxo-prostaglandin F1 alpha, thromboxane B2, and prostaglandin D2. These products we...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.76.3.1155

    authors: Hassid A,Konieczkowski M,Dunn MJ

    更新日期:1979-03-01 00:00:00

  • Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin Cry1Ab in the silkworm, Bombyx mori.

    abstract::Bt toxins derived from the arthropod bacterial pathogen Bacillus thuringiensis are widely used for insect control as insecticides or in transgenic crops. Bt resistance has been found in field populations of several lepidopteran pests and in laboratory strains selected with Bt toxin. Widespread planting of crops expres...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1120698109

    authors: Atsumi S,Miyamoto K,Yamamoto K,Narukawa J,Kawai S,Sezutsu H,Kobayashi I,Uchino K,Tamura T,Mita K,Kadono-Okuda K,Wada S,Kanda K,Goldsmith MR,Noda H

    更新日期:2012-06-19 00:00:00

  • RNA-directed DNA polymerase from human leukemic blood cells and from primate type-C virus-producing cells: high- and low-molecular-weight forms with variant biochemical and immunological properties.

    abstract::RNA-directed DNA polymerase (reverse transcriptase) from leukocytes of individual leukemic patients can be grouped by velocity gradient analyses into two distinct classes, a low-molecular-weight (LMW) class of approximately 70,000 and a high-molecular-weight (HMW) class of 130,000 to 140,000. The reverse transcriptase...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.72.3.1194

    authors: Mondal H,Gallagher RE,Gallo RC

    更新日期:1975-03-01 00:00:00

  • Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β.

    abstract::Nanoparticles are increasingly used in various fields, including biomedicine and electronics. One application utilizes the opacifying effect of nano-TiO(2), which is frequently used as pigment in cosmetics. Although TiO(2) is believed to be biologically inert, an emerging literature reports increased incidence of resp...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1008155107

    authors: Yazdi AS,Guarda G,Riteau N,Drexler SK,Tardivel A,Couillin I,Tschopp J

    更新日期:2010-11-09 00:00:00

  • A feedback circuit involving let-7-family miRNAs and DAF-12 integrates environmental signals and developmental timing in Caenorhabditis elegans.

    abstract::Animal development is remarkably robust; cell fates are specified with spatial and temporal precision despite physiological and environmental contingencies. Favorable conditions cause Caenorhabditis elegans to develop rapidly through four larval stages (L1-L4) to the reproductive adult. In unfavorable conditions, L2 l...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0908131106

    authors: Hammell CM,Karp X,Ambros V

    更新日期:2009-11-03 00:00:00

  • Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models.

    abstract::To examine the role of breast cancer stem cells (BCSCs) in metastasis, we generated human-in-mouse breast cancer orthotopic models using patient tumor specimens, labeled with optical reporter fusion genes. These models recapitulate human cancer features not captured with previous models, including spontaneous metastas...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1006732107

    authors: Liu H,Patel MR,Prescher JA,Patsialou A,Qian D,Lin J,Wen S,Chang YF,Bachmann MH,Shimono Y,Dalerba P,Adorno M,Lobo N,Bueno J,Dirbas FM,Goswami S,Somlo G,Condeelis J,Contag CH,Gambhir SS,Clarke MF

    更新日期:2010-10-19 00:00:00

  • Constitutively active Notch4 receptor elicits brain arteriovenous malformations through enlargement of capillary-like vessels.

    abstract::Arteriovenous (AV) malformation (AVM) is a devastating condition characterized by focal lesions of enlarged, tangled vessels that shunt blood from arteries directly to veins. AVMs can form anywhere in the body and can cause debilitating ischemia and life-threatening hemorrhagic stroke. The mechanisms that underlie AVM...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1415316111

    authors: Murphy PA,Kim TN,Huang L,Nielsen CM,Lawton MT,Adams RH,Schaffer CB,Wang RA

    更新日期:2014-12-16 00:00:00

  • Mosquito transferrin, an acute-phase protein that is up-regulated upon infection.

    abstract::When treated with heat-killed bacterial cells, mosquito cells in culture respond by up-regulating several proteins. Among these is a 66-kDa protein (p66) that is secreted from cells derived from both Aedes aegypti and Aedes albopictus. p66 was degraded by proteolysis and gave a virtually identical pattern of peptide p...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.94.23.12337

    authors: Yoshiga T,Hernandez VP,Fallon AM,Law JH

    更新日期:1997-11-11 00:00:00

  • Stimulatory and inhibitory protein kinase C consensus sequences regulate the cystic fibrosis transmembrane conductance regulator.

    abstract::Protein kinase C (PKC) phosphorylation stimulates the cystic fibrosis transmembrane conductance regulator (CFTR) channel and enhances its activation by protein kinase A (PKA) through mechanisms that remain poorly understood. We have examined the effects of mutating consensus sequences for PKC phosphorylation and repor...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0303411101

    authors: Chappe V,Hinkson DA,Howell LD,Evagelidis A,Liao J,Chang XB,Riordan JR,Hanrahan JW

    更新日期:2004-01-06 00:00:00

  • Genetic code origins: tRNAs older than their synthetases?

    abstract::We present a phylogenetic analysis to determine whether a given tRNA molecule was established in evolution before its cognate aminoacyl-tRNA synthetase. The earlier appearance of tRNA versus their metabolically related enzymes is a prediction of the RNA world theory, but the available synthetase and tRNA sequences pre...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.95.19.11295

    authors: Ribas de Pouplana L,Turner RJ,Steer BA,Schimmel P

    更新日期:1998-09-15 00:00:00

  • Signaling via beta1 integrins and mitogen-activated protein kinase determines human epidermal stem cell fate in vitro.

    abstract::Human epidermal stem cells express higher levels of beta1 integrins and are more adhesive than keratinocytes that are destined to differentiate. To investigate whether high beta1 integrin expression and adhesiveness are essential for maintaining keratinocytes in the stem cell compartment, we introduced a dominant-nega...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.12.6728

    authors: Zhu AJ,Haase I,Watt FM

    更新日期:1999-06-08 00:00:00

  • The natural center of chromaticity space is not always achromatic: a new look at color induction.

    abstract::Although current theories of color vision differ in many respects, they all assume the existence of a uniquely defined neutral point in chromaticity space. It generally is assumed that this point satisfies several criteria simultaneously. One of these criteria is that it is perceived as achromatic. A further criterion...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.192216699

    authors: Ekroll V,Faul F,Niederée R,Richter E

    更新日期:2002-10-01 00:00:00

  • Hypomorphic Notch 3 alleles link Notch signaling to ischemic cerebral small-vessel disease.

    abstract::The most common monogenic cause of small-vessel disease leading to ischemic stroke and vascular dementia is the neurodegenerative syndrome cerebral autosomal-dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), which is associated with mutations in the Notch 3 receptor. CADASIL pathology ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1101964108

    authors: Arboleda-Velasquez JF,Manent J,Lee JH,Tikka S,Ospina C,Vanderburg CR,Frosch MP,Rodríguez-Falcón M,Villen J,Gygi S,Lopera F,Kalimo H,Moskowitz MA,Ayata C,Louvi A,Artavanis-Tsakonas S

    更新日期:2011-05-24 00:00:00

  • Characterization of the chicken vimentin gene: single copy gene producing multiple mRNAs.

    abstract::Genomic clones and cDNA plasmids were isolated for the intermediate filament protein vimentin from chicken. The identity of the various clones was determined both by mRNA selection [Paterson, B. M. & Roberts, B. E. (1981) in Gene Amplification and Analysis, Structural Analysis or Nucleic Acids, eds. Chirikjian, J. G. ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.80.4.911

    authors: Zehner ZE,Paterson BM

    更新日期:1983-02-01 00:00:00

  • Genome fragment of Wolbachia endosymbiont transferred to X chromosome of host insect.

    abstract::The adzuki bean beetle, Callosobruchus chinensis, is triple-infected with distinct lineages of Wolbachia endosymbiont, wBruCon, wBruOri, and wBruAus, which were identified by their wsp (Wolbachia surface protein) gene sequences. Whereas wBruCon and wBruOri caused cytoplasmic incompatibility of the host insect, wBruAus...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.222228199

    authors: Kondo N,Nikoh N,Ijichi N,Shimada M,Fukatsu T

    更新日期:2002-10-29 00:00:00

  • Detection and isolation of a new DNA polymerase from human breast tumor cell line HBT-3 by (dT)12-18-cellulose chromatography.

    abstract::Column chromatography on (dT)(12-18)-cellulose was used to detect and isolate a novel DNA polymerase activity from human breast tumor cell line HBT-3. The new enzyme is similar to those of mammalian RNA tumor viruses in its molecular size, preference for poly(A).(dT)(12-18) as compared to either poly(dA).(dT)(12-18) o...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.70.8.2453

    authors: Gerwin BI,Bassin RH

    更新日期:1973-08-01 00:00:00

  • Phenotypic and functional characterization of adult brain neuropoiesis.

    abstract::The modern concept of neurogenesis in the adult brain is predicated on the premise that multipotent glial cells give rise to new neurons throughout life. Although extensive evidence exists indicating that this is the case, the transition from glial to neuronal phenotype remains poorly understood. A unique monolayer ce...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0503965102

    authors: Scheffler B,Walton NM,Lin DD,Goetz AK,Enikolopov G,Roper SN,Steindler DA

    更新日期:2005-06-28 00:00:00

  • Targeting of Ras-mediated FGF signaling suppresses Pten-deficient skin tumor.

    abstract::Deficiency in PTEN (phosphatase and tensin homolog deleted on chromosome 10) is the underlying cause of PTEN hamartoma tumor syndrome and a wide variety of human cancers. In skin epidermis, we have previously identified an autocrine FGF signaling induced by loss of Pten in keratinocytes. In this study, we demonstrate ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1604450113

    authors: Mathew G,Hannan A,Hertzler-Schaefer K,Wang F,Feng GS,Zhong J,Zhao JJ,Downward J,Zhang X

    更新日期:2016-11-15 00:00:00

  • Sequence requirements for cleavage activation of influenza virus hemagglutinin expressed in mammalian cells.

    abstract::Cleavage of the hemagglutinin (HA) in tissue culture systems has been correlated with virulence of avian influenza viruses. To examine the structural requirements for cleavage of the HA, the HA gene from a virulent H5 influenza virus was expressed in mammalian cells (CV-1), and the cleavage site of the HA was explored...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.85.2.324

    authors: Kawaoka Y,Webster RG

    更新日期:1988-01-01 00:00:00

  • Legionella pneumophila glucosyltransferase inhibits host elongation factor 1A.

    abstract::Legionella pneumophila, the causal agent of Legionnaires' disease, is an intracellular parasite and invades and proliferates within different eukaryotic cells, including human alveolar macrophages. After several 100-fold multiplication within host cells, the pathogens are released for new invasion by induction of apop...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0601562103

    authors: Belyi Y,Niggeweg R,Opitz B,Vogelsgesang M,Hippenstiel S,Wilm M,Aktories K

    更新日期:2006-11-07 00:00:00

  • Template requirements for the initiation of adenovirus DNA replication.

    abstract::The first step in the replication of the adenovirus genome is the covalent attachment of the 5'-terminal nucleotide, dCMP, to the virus-encoded terminal protein precursor (pTP). This reaction can be observed in vitro and has been previously shown to be dependent upon either viral DNA or linearized plasmid DNA containi...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.81.1.100

    authors: Challberg MD,Rawlins DR

    更新日期:1984-01-01 00:00:00