A molecular profile of the mouse gastric parietal cell with and without exposure to Helicobacter pylori.

abstract：:Compositeness of the electron may show up in a very small deviation of the measured electron g factor from one calculated for a point electron by quantum electrodynamics. The precision of our g measurements is currently limited by an interaction of the cyclotron motion with standing waves in the trap cavity containing...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dehmelt H,Van Dyck R Jr,Palmer F

更新日期：1992-03-01 00:00:00

abstract：:By selective attachment of a DNA cleavage agent to specific residues in the yeast TATA box binding protein (yTBP), we demonstrate that, in solution, yTBP binds to the TATA boxes of both the adenovirus major late promoter and the yeast CYC1 promoter with only a modest preference in orientation and binds well to several...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox JM,Hayward MM,Sanchez JF,Gegnas LD,van der Zee S,Dennis JH,Sigler PB,Schepartz A

更新日期：1997-12-09 00:00:00

abstract：:Intact squid axons were injected with aequorin and bathed in 3 mM Ca seawater (a concentration close to that of squid blood). Sodium and potassium currents were pharmacologically blocked and repetitive voltage-clamp pulses of a duration of 1.5 ms were applied (to simulate the duration of an action potential) at amplit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mullins LJ,Requena J,Whittembury J

更新日期：1985-03-01 00:00:00

abstract：:Dendritic spines are of major importance in information processing and memory formation in central neurons. Estradiol has been shown to induce an increase of dendritic spine density on hippocampal neurons in vivo and in vitro. The neurotrophin brain-derived neurotrophic factor (BDNF) recently has been implicated in ne...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murphy DD,Cole NB,Segal M

更新日期：1998-09-15 00:00:00

abstract：:The conserved two-component regulatory system GacS/GacA determines the expression of extracellular products and virulence factors in a variety of Gram-negative bacteria. In the biocontrol strain CHA0 of Pseudomonas fluorescens, the response regulator GacA is essential for the synthesis of extracellular protease (AprA)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Blumer C,Heeb S,Pessi G,Haas D

更新日期：1999-11-23 00:00:00

abstract：:We have found that three Escherichia coli heat shock proteins, DnaK (the hsp70 homolog), DnaJ, and GrpE, function in oriP1 DNA replication in vitro solely to activate DNA binding by the replication initiator protein RepA. Activation results from the conversion of P1 or P7 RepA dimers to monomers that bind with high af...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wickner S,Skowyra D,Hoskins J,McKenney K

更新日期：1992-11-01 00:00:00

abstract：:Modern European genetic structure demonstrates strong correlations with geography, while genetic analysis of prehistoric humans has indicated at least two major waves of immigration from outside the continent during periods of cultural change. However, population-level genome data that could shed light on the demograp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Veeramah KR,Rott A,Groß M,van Dorp L,López S,Kirsanow K,Sell C,Blöcher J,Wegmann D,Link V,Hofmanová Z,Peters J,Trautmann B,Gairhos A,Haberstroh J,Päffgen B,Hellenthal G,Haas-Gebhard B,Harbeck M,Burger J

更新日期：2018-03-27 00:00:00

abstract：:Jasmonoyl-isoleucine (JA-Ile), the active form of the plant hormone jasmonate (JA), is sensed by the F-box protein CORONATINE INSENSITIVE 1 (COI1), a component of a functional Skp-Cullin-F-box E3 ubiquitin ligase complex. Sensing of JA-Ile by COI1 rapidly triggers genome-wide transcriptional changes that are largely r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： An C,Li L,Zhai Q,You Y,Deng L,Wu F,Chen R,Jiang H,Wang H,Chen Q,Li C

更新日期：2017-10-17 00:00:00

abstract：:This study quantifies and maps the water footprint (WF) of humanity at a high spatial resolution. It reports on consumptive use of rainwater (green WF) and ground and surface water (blue WF) and volumes of water polluted (gray WF). Water footprints are estimated per nation from both a production and consumption perspe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoekstra AY,Mekonnen MM

更新日期：2012-02-28 00:00:00

abstract：:In the last 60,000 y humans have expanded across the globe and now occupy a wider range than any other terrestrial species. Our ability to successfully adapt to such a diverse range of habitats is often explained in terms of our cognitive ability. Humans have relatively bigger brains and more computing power than othe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Boyd R,Richerson PJ,Henrich J

更新日期：2011-06-28 00:00:00

abstract：:Using a HeLa cell line stably transfected with the tat gene from human immunodeficiency virus type 1, we have found that the expression of the regulatory Tat protein suppresses the expression of cellular Mn-containing superoxide dismutase (Mn-SOD). This enzyme is one of the cell's primary defenses against oxygen-deriv...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Flores SC,Marecki JC,Harper KP,Bose SK,Nelson SK,McCord JM

更新日期：1993-08-15 00:00:00

abstract：:Molecular agitation more rapid than thermal Brownian motion is reported for cellular environments, motor proteins, synthetic molecular motors, enzymes, and common chemical reactions, yet that chemical activity coupled to molecular motion contrasts with generations of accumulated knowledge about diffusion at equilibriu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jee AY,Tlusty T,Granick S

更新日期：2020-11-24 00:00:00

abstract：:The self-adjoint algebra of operators generated by the semigroup of translation operators acting on the Hilbert space of functions supported on the half-line is studied. A real-valued index is introduced and is used to determine the spectrum of the Wiener-Hopf integral operators with distribution kernel having an almo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coburn LA,Douglas RG

更新日期：1969-04-01 00:00:00

abstract：:An artificial charge pair buried in the hydrophobic core of staphylococcal nuclease was engineered by making the V23E and L36K substitutions. Buried individually, Glu-23 and Lys-36 both titrate with pKa values near 7. When buried together their pKa values appear to be normal. The ionizable moieties of the buried Glu-L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robinson AC,Castañeda CA,Schlessman JL,García-Moreno EB

更新日期：2014-08-12 00:00:00

abstract：:Epidemics, flame propagation, and cardiac rhythms are classic examples of reaction-diffusion waves that describe a switch from one alternative state to another. Only two types of waves are known: pulled, driven by the leading edge, and pushed, driven by the bulk of the wave. Here, we report a distinct class of semipus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Birzu G,Hallatschek O,Korolev KS

更新日期：2018-04-17 00:00:00

abstract：:Nucleotide excision repair (NER) prevents skin cancer by eliminating highly genotoxic cyclobutane pyrimidine dimers (CPDs) induced in DNA by the UVB component of sunlight. NER consists of two distinct but overlapping subpathways, i.e., global NER, which removes CPD from the genome overall, and transcription-coupled NE...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mathonnet G,Leger C,Desnoyers J,Drouin R,Therrien JP,Drobetsky EA

更新日期：2003-06-10 00:00:00

abstract：:The human gut is home to trillions of microbes, thousands of bacterial phylotypes, as well as hydrogen-consuming methanogenic archaea. Studies in gnotobiotic mice indicate that Methanobrevibacter smithii, the dominant archaeon in the human gut ecosystem, affects the specificity and efficiency of bacterial digestion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Samuel BS,Hansen EE,Manchester JK,Coutinho PM,Henrissat B,Fulton R,Latreille P,Kim K,Wilson RK,Gordon JI

更新日期：2007-06-19 00:00:00

abstract：:T-cell anergy is a state of T cells that is hyporesponsive to stimulation via the T-cell receptor and costimulatory molecules and is thought to be important for self-tolerance. How T-cell anergy is regulated is still poorly understood. We report here that tuberous sclerosis (TSC)1 is critical for T-cell anergy. Defici...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xie DL,Wu J,Lou YL,Zhong XP

更新日期：2012-08-28 00:00:00

abstract：:The molecular and cellular basis of selective motor neuron (MN) vulnerability in amyotrophic lateral sclerosis (ALS) is not known. In genetically distinct mouse models of familial ALS expressing mutant superoxide dismutase-1 (SOD1), TAR DNA-binding protein 43 (TDP-43), and fused in sarcoma (FUS), we demonstrate select...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lalancette-Hebert M,Sharma A,Lyashchenko AK,Shneider NA

更新日期：2016-12-20 00:00:00

abstract：:The feeling of being observed or merely participating in an experiment can affect individuals' behavior. Referred to as the Hawthorne effect, this inconsistently observed phenomenon can both provide insight into individuals' behavior and confound the interpretation of experimental manipulations. Here, we pursue both t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schwartz D,Fischhoff B,Krishnamurti T,Sowell F

更新日期：2013-09-17 00:00:00

abstract：:The S100A8/S100A9 heterodimer calprotectin (CP) functions in the host response to pathogens through a mechanism termed "nutritional immunity." CP binds Mn(2+) and Zn(2+) with high affinity and starves bacteria of these essential nutrients. Combining biophysical, structural, and microbiological analysis, we identified ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Damo SM,Kehl-Fie TE,Sugitani N,Holt ME,Rathi S,Murphy WJ,Zhang Y,Betz C,Hench L,Fritz G,Skaar EP,Chazin WJ

更新日期：2013-03-05 00:00:00

abstract：:A bone-resorbing factor, comparable to the osteoclast-activating factor (OAF) produced from peripheral blood leukocytes, is shown to be produced by murine spleen cells activated with the T-cell mitogen Con A. Murine OAF is demonstrated here as being a product of the interaction between thymus-derived T lymphocytes and...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horowitz M,Vignery A,Gershon RK,Baron R

更新日期：1984-04-01 00:00:00

abstract：:Nipah virus (NiV) and Hendra virus are the type species of the highly pathogenic paramyxovirus genus Henipavirus, which can cause severe respiratory disease and fatal encephalitis infections in humans, with case fatality rates approaching 75%. NiV contains two envelope glycoproteins, the receptor-binding G glycoprotei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu K,Rajashankar KR,Chan YP,Himanen JP,Broder CC,Nikolov DB

更新日期：2008-07-22 00:00:00

abstract：:Cytochrome ba3 from Thermus thermophilus reacts slowly with excess HCN at pH 7.4 to create a form of the enzyme in which CuA, cytochrome b, and CuB remain oxidized, while cytochrome a3 is reduced by one electron, presumably with the formation of cyanogen. We have examined this form of the enzyme by UV-visible, resonan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Surerus KK,Oertling WA,Fan C,Gurbiel RJ,Einarsdóttir O,Antholine WE,Dyer RB,Hoffman BM,Woodruff WH,Fee JA

更新日期：1992-04-15 00:00:00

abstract：:Deregulation of microRNA (miRNA) expression can lead to cancer initiation and progression. However, limited information exists on the function of miRNAs in cancer maintenance. We examined these issues in the case of myeloproliferative diseases and neoplasms (MPN), a collection of hematopoietic neoplasms regarded as pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Guo S,Bai H,Megyola CM,Halene S,Krause DS,Scadden DT,Lu J

更新日期：2012-10-09 00:00:00

abstract：:Disruption of Rauscher leukemia virus (RLV) with low levels of Nonidet P-40 yielded "immature" cores. These cores have a diameter of about 920 A, as opposed to the 1300-A diameter of RLV, possess knob-like protuberances, and contain a concentrically coiled internal strand apposed to the core shell. The two major polyp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yoshinaka Y,Luftig RB

更新日期：1977-08-01 00:00:00

abstract：:Genetic deletion studies have shown that haploinsufficiency of Delta-like ligand (Dll) 4, a transmembrane ligand for the Notch family of receptors, results in major vascular defects and embryonic lethality. To better define the role of Dll4 during vascular growth and differentiation, we selected the postnatal retina a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lobov IB,Renard RA,Papadopoulos N,Gale NW,Thurston G,Yancopoulos GD,Wiegand SJ

更新日期：2007-02-27 00:00:00

abstract：:Mutations in the potassium channel gene KCNQ4 underlie DFNA2, an autosomal dominant form of progressive hearing loss in humans. In the mouse cochlea, the transcript has been found exclusively in the outer hair cells. By using specific antibodies, we now show that KCNQ4 is situated at the basal membrane of these sensor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kharkovets T,Hardelin JP,Safieddine S,Schweizer M,El-Amraoui A,Petit C,Jentsch TJ

更新日期：2000-04-11 00:00:00

abstract：:The minimal size of the recombination site required for efficient FLP recombinase-catalyzed recombination in vitro is no more than 28 base pairs, which includes parts of two 13-base-pair inverted repeats and all of an 8-base-pair spacer. The FLP recombinase cleaves the DNA at the boundaries of the spacer, becomes cova...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Senecoff JF,Bruckner RC,Cox MM

更新日期：1985-11-01 00:00:00

abstract：:We have obtained the resonance Raman spectrum of bacteriorhodopsin's primary photoproduct K with a novel low-temperature spinning sample technique. Purple membrane at 77 K is illuminated with spatially separated actinic (pump) and probe laser beams. The 514-nm pump beam produces a photostationary steady-state mixture ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Braiman M,Mathies R

更新日期：1982-01-01 00:00:00