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Increasing intracellular magnesium levels with the 31-amino acid MgtS protein.

Abstract：

:Synthesis of the 31-amino acid, inner membrane protein MgtS (formerly denoted YneM) is induced by very low Mg2+ in a PhoPQ-dependent manner in Escherichia coli Here we report that MgtS acts to increase intracellular Mg2+ levels and maintain cell integrity upon Mg2+ depletion. Upon development of a functional tagged derivative of MgtS, we found that MgtS interacts with MgtA to increase the levels of this P-type ATPase Mg2+ transporter under Mg2+-limiting conditions. Correspondingly, the effects of MgtS upon Mg2+ limitation are lost in a ∆mgtA mutant, and MgtA overexpression can suppress the ∆mgtS phenotype. MgtS stabilization of MgtA provides an additional layer of regulation of this tightly controlled Mg2+ transporter and adds to the list of small proteins that regulate inner membrane transporters.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Wang H,Yin X,Wu Orr M,Dambach M,Curtis R,Storz G

doi

10.1073/pnas.1703415114

subject

Has Abstract

pub_date

2017-05-30 00:00:00

pages

5689-5694

issue

22

eissn

0027-8424

issn

1091-6490

pii

1703415114

journal_volume

114

pub_type

杂志文章

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