Peroxisome proliferator-binding protein: identification and partial characterization of nafenopin-, clofibric acid-, and ciprofibrate-binding proteins from rat liver.

abstract：:Ice-core records show that climate changes in the past have been large, rapid, and synchronous over broad areas extending into low latitudes, with less variability over historical times. These ice-core records come from high mountain glaciers and the polar regions, including small ice caps and the large ice sheets of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alley RB

更新日期：2000-02-15 00:00:00

abstract：:Huntington disease (HD) is caused by an expansion mutation of the N-terminal polyglutamine of huntingtin (mHTT). mHTT is ubiquitously present, but it induces noticeable damage to the brain's striatum, thereby affecting motor, psychiatric, and cognitive functions. The striatal damage and progression of HD are associate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sharma M,Rajendrarao S,Shahani N,Ramírez-Jarquín UN,Subramaniam S

更新日期：2020-07-07 00:00:00

abstract：:Alternative adaptations-different adaptive phenotypes maintained in the same life stage and the same population but not necessarily simultaneously expressed in the same individual-represent contrasting character sets produced by the same genome, in effect allowing a single species to occupy more than one sympatric nic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： West-Eberhard MJ

更新日期：1986-03-01 00:00:00

abstract：:Individuals homozygous for the C-C chemokine receptor type 5 gene with 32-bp deletions (CCR5Δ32) are resistant to HIV-1 infection. In this study, we generated induced pluripotent stem cells (iPSCs) homozygous for the naturally occurring CCR5Δ32 mutation through genome editing of wild-type iPSCs using a combination of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ye L,Wang J,Beyer AI,Teque F,Cradick TJ,Qi Z,Chang JC,Bao G,Muench MO,Yu J,Levy JA,Kan YW

更新日期：2014-07-01 00:00:00

abstract：:Cytosine methylation at CpG dinucleotides contributes to the epigenetic maintenance of gene silencing. Dynamic reprogramming of DNA methylation patterns is believed to play a key role during development and differentiation in vertebrates. The mechanisms of DNA demethylation remain unclear and controversial. Here, we p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kress C,Thomassin H,Grange T

更新日期：2006-07-25 00:00:00

abstract：:Most human cancers are of monoclonal origin and display many genetic alterations. In an effort to determine whether clonal expansion itself could account for the large number of genetic alterations, we compared spontaneous transformation in cloned and uncloned populations of NIH 3T3 cells. We have reported that progre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chow M,Rubin H

更新日期：2000-01-04 00:00:00

abstract：:The relative abundance of individual proteins shared among clones of lymphocytes provides a meaningful basis for cellular classification. Twelve clones of T cells (obtained by limiting dilution) were analyzed by two-dimensional gel electrophoresis for polypeptide content and then evaluated by the computational techniq...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lefkovits I,Kuhn L,Valiron O,Merle A,Kettman J

更新日期：1988-05-01 00:00:00

abstract：:Histone mRNAs are naturally intronless and accumulate efficiently in the cytoplasm. To learn whether there are cis-acting sequences within histone genes that allow efficient cytoplasmic accumulation of RNAs, we made recombinant constructs in which sequences from the mouse H2a gene were cloned into a human beta-globin ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang Y,Carmichael GG

更新日期：1997-09-16 00:00:00

abstract：:Drosophila melanogaster CRYPTOCHROME (CRY) mediates behavioral and electrophysiological responses to blue light coded by circadian and arousal neurons. However, spectroscopic and biochemical assays of heterologously expressed CRY suggest that CRY may mediate functional responses to UV-A (ultraviolet A) light as well. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baik LS,Fogle KJ,Roberts L,Galschiodt AM,Chevez JA,Recinos Y,Nguy V,Holmes TC

更新日期：2017-01-24 00:00:00

abstract：:The Arabidopsis thaliana SOS2 and SOS3 genes are required for intracellular Na(+) and K(+) homeostasis and plant tolerance to high Na(+) and low K(+) environments. SOS3 is an EF hand type calcium-binding protein having sequence similarities with animal neuronal calcium sensors and the yeast calcineurin B. SOS2 is a se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halfter U,Ishitani M,Zhu JK

更新日期：2000-03-28 00:00:00

abstract：:The number of large intramembrane particles associated with sites of synaptic vesicle release at the squid giant synapse was determined and compared to the average maximal presynaptic calcium current in order to derive an estimate of the conductance each particle would have if it were a calcium channel. This value, 0....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pumplin DW,Reese TS,Llinás R

更新日期：1981-11-01 00:00:00

abstract：:Entropic effects have often been invoked to explain the extraordinary catalytic power of enzymes. In particular, the hypothesis that enzymes can use part of the substrate-binding free energy to reduce the entropic penalty associated with the subsequent chemical transformation has been very influential. The enzymatic r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kazemi M,Himo F,Åqvist J

更新日期：2016-03-01 00:00:00

abstract：:Human immunodeficiency virus type 1 (HIV-1) viral DNA synthesis in quiescent and activated peripheral blood lymphocytes (PBLs) was studied. Incomplete viral DNA (previously demonstrated to be associated with HIV-1 virions) is carried by HIV-1 virions into quiescent and activated PBLs, contributing to the formation of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gao WY,Cara A,Gallo RC,Lori F

更新日期：1993-10-01 00:00:00

abstract：:The hammerhead ribozyme, as engineered by J. Haseloff and W. L. Gerlach [(1988) Nature (London) 334, 585-591], is an RNA molecule containing two regions of conserved nucleotides, a double helix, called helix II, which connects the two conserved regions, and flanking arms of variable sequence, which hybridize the riboz...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCall MJ,Hendry P,Jennings PA

更新日期：1992-07-01 00:00:00

abstract：:Sessile marine organisms are prolific sources of biologically active natural products. However, these compounds are often found in highly variable amounts, with the abiotic and biotic factors governing their production remaining poorly understood. We present an approach that permits monitoring of in vivo natural produ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Esquenazi E,Jones AC,Byrum T,Dorrestein PC,Gerwick WH

更新日期：2011-03-29 00:00:00

abstract：:Modification by covalent attachment of polyethylene glycol (PEG) can reduce the immunogenicity and prolong the circulating life of proteins, but the utility of this approach for any protein is restricted by the number and distribution of PEG attachment sites (e.g., epsilon-amino groups of lysine residues). We have dev...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hershfield MS,Chaffee S,Koro-Johnson L,Mary A,Smith AA,Short SA

更新日期：1991-08-15 00:00:00

abstract：:There exists a properly embedded minimal surface of genus one with a single end asymptotic to the end of the helicoid. This genus-one helicoid is constructed as the limit of a continuous one-parameter family of screw-motion invariant minimal surfaces, also asymptotic to the helicoid, that have genus equal to one in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weber M,Hoffman D,Wolf M

更新日期：2005-11-15 00:00:00

abstract：:Autism spectrum disorder (ASD) is characterized by impaired social interactions and communication. The pathogenesis of ASD is not known, but it involves activation of microglia. We had shown that the peptide neurotensin (NT) is increased in the serum of children with ASD and stimulates cultured adult human microglia t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsilioni I,Pantazopoulos H,Conti P,Leeman SE,Theoharides TC

更新日期：2020-07-14 00:00:00

abstract：:Humans choose actions based on both habit and planning. Habitual control is computationally frugal but adapts slowly to novel circumstances, whereas planning is computationally expensive but can adapt swiftly. Current research emphasizes the competition between habits and plans for behavioral control, yet many complex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cushman F,Morris A

更新日期：2015-11-10 00:00:00

abstract：:Ferritin has a protein shell of 5 X 10(6) Da consisting of 24 subunits of two types, a heavier (H) chain of 21,000 Da and a lighter (L) chain of 19,000 Da. A cDNA clone of the messenger for the L subunit has been isolated from a human monocyte-like leukemia cell line. The clone contains an open reading frame of 522 nu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dörner MH,Salfeld J,Will H,Leibold EA,Vass JK,Munro HN

更新日期：1985-05-01 00:00:00

abstract：:Photoadaptation, the ability to attenuate a light response on prolonged light exposure while remaining sensitive to escalating changes in light intensity, is essential for organisms to decipher time information appropriately, yet the underlying molecular mechanisms are poorly understood. In Neurospora crassa, VIVID (V...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen CH,DeMay BS,Gladfelter AS,Dunlap JC,Loros JJ

更新日期：2010-09-21 00:00:00

abstract：:Interfacial zones between tissues provide specialized, transitional junctions central to normal tissue function. Regenerative medicine strategies focused on multiple cell types and/or bi/tri-layered scaffolds do not provide continuously graded interfaces, severely limiting the integration and biological performance of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips JE,Burns KL,Le Doux JM,Guldberg RE,García AJ

更新日期：2008-08-26 00:00:00

abstract：:Mammalian centromere function depends upon a specialized chromatin organization where distinct domains of CENP-A and dimethyl K4 histone H3, forming centric chromatin, are uniquely positioned on or near the surface of the chromosome. These distinct domains are embedded in pericentric heterochromatin (characterized by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Greaves IK,Rangasamy D,Ridgway P,Tremethick DJ

更新日期：2007-01-09 00:00:00

abstract：:For the design of potent subunit vaccines, it is of paramount importance to identify all antigens immunologically recognized by a patient population infected with a pathogen. We have developed a rapid and efficient procedure to identify such commonly recognized antigens, and here we provide a comprehensive in vivo ant...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Etz H,Minh DB,Henics T,Dryla A,Winkler B,Triska C,Boyd AP,Söllner J,Schmidt W,von Ahsen U,Buschle M,Gill SR,Kolonay J,Khalak H,Fraser CM,von Gabain A,Nagy E,Meinke A

更新日期：2002-05-14 00:00:00

abstract：:We investigate the role of identity and self-image consideration under "pay-what-you-want" pricing. Results from three field experiments show that often, when granted the opportunity to name the price of a product, fewer consumers choose to buy it than when the price is fixed and low. We show that this opt-out behavio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gneezy A,Gneezy U,Riener G,Nelson LD

更新日期：2012-05-08 00:00:00

abstract：:Previous studies have shown that Delta-mediated Notch signaling regulates the number of early differentiating neurons. However, the role of Notch activation and Jagged-mediated signaling during late neurogenesis remains poorly defined. In the developing spinal cord of zebrafish, GABAergic Kolmer-Agduhr (KA'') cells an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yeo SY,Chitnis AB

更新日期：2007-04-03 00:00:00

abstract：:Equine arteritis virus (EAV) is a positive-strand RNA virus that uses a discontinuous transcription mechanism to generate a nested set of six subgenomic mRNAs from which its structural genes are expressed. A stable bacterial plasmid (pEAV030) containing a full-length cDNA copy of the 12.7-kb EAV genome was constructed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Dinten LC,den Boon JA,Wassenaar AL,Spaan WJ,Snijder EJ

更新日期：1997-02-04 00:00:00

abstract：:Using brain transcriptomic profiles from 853 individual honey bees exhibiting 48 distinct behavioral phenotypes in naturalistic contexts, we report that behavior-specific neurogenomic states can be inferred from the coordinated action of transcription factors (TFs) and their predicted target genes. Unsupervised hierar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chandrasekaran S,Ament SA,Eddy JA,Rodriguez-Zas SL,Schatz BR,Price ND,Robinson GE

更新日期：2011-11-01 00:00:00

abstract：:The nuclear lamina is a network of structural filaments, the A and B type lamins, located at the nuclear envelope and throughout the nucleus. Lamin filaments provide the nucleus with mechanical stability and support many basic activities, including gene regulation. Mutations in LMNA, the gene encoding A type lamins, c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dahl KN,Scaffidi P,Islam MF,Yodh AG,Wilson KL,Misteli T

更新日期：2006-07-05 00:00:00

abstract：:Serpentine barrens represent extreme hazards for plant colonists. These sites are characterized by high porosity leading to drought, lack of essential mineral nutrients, and phytotoxic levels of metals. Nevertheless, nature forged populations adapted to these challenges. Here, we use a population-based evolutionary ge...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arnold BJ,Lahner B,DaCosta JM,Weisman CM,Hollister JD,Salt DE,Bomblies K,Yant L

更新日期：2016-07-19 00:00:00