Nuclear resonance vibrational spectroscopic and computational study of high-valent diiron complexes relevant to enzyme intermediates.

abstract：:DNA methylation at CpG dinucleotides is an important epigenetic regulator common to virtually all mammalian cell types, but recent evidence indicates that during early postnatal development neuronal genomes also accumulate uniquely high levels of two alternative forms of methylation, non-CpG methylation and hydroxymet...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kinde B,Gabel HW,Gilbert CS,Griffith EC,Greenberg ME

更新日期：2015-06-02 00:00:00

abstract：:By selective attachment of a DNA cleavage agent to specific residues in the yeast TATA box binding protein (yTBP), we demonstrate that, in solution, yTBP binds to the TATA boxes of both the adenovirus major late promoter and the yeast CYC1 promoter with only a modest preference in orientation and binds well to several...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cox JM,Hayward MM,Sanchez JF,Gegnas LD,van der Zee S,Dennis JH,Sigler PB,Schepartz A

更新日期：1997-12-09 00:00:00

abstract：:Acid-sensing ion channels (ASICs) are trimeric cation-selective ion channels activated by protons in the physiological range. Recent reports have revealed that postsynaptically localized ASICs contribute to the excitatory postsynaptic current by responding to the transient acidification of the synaptic cleft that acco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： MacLean DM,Jayaraman V

更新日期：2017-03-21 00:00:00

abstract：:Viral hepatitis is a disease of antiquity, but evidence for more than one etiologic agent has been recognized only since the 1940s, when two viruses (hepatitis A virus and hepatitis B virus) were thought to account for all disease. In the past 20 years, three additional hepatitis agents (hepatitis C virus, hepatitis D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purcell RH

更新日期：1994-03-29 00:00:00

abstract：:We analyzed the relationship of genetic factors determining the expression of endogenous type-C RNA tumor viruses and other host-gene markers to tumorigenesis. A hybridization experiment was performed with mice of strains AKR/J and C57L, the first filial (F(1)) generation hybrids, the second filial (F(2)) generation h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meier H,Taylor BA,Cherry M,Buebner RJ

更新日期：1973-05-01 00:00:00

abstract：:Phylogenetic differences in acetylcholine receptors from skeletal neuromuscular synapses of various species of snakes and lizards have been investigated, using the snake venom alpha-neurotoxins alpha-atratoxin (cobrotoxin) and alpha-bungarotoxin. The acetylcholine receptors of the phylogenetically primitive lizards, l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burden SJ,Hartzell HC,Yoshikami D

更新日期：1975-08-01 00:00:00

abstract：:The observation that the age-specific incidence curve of many carcinomas is approximately linear on a double logarithmic plot has led to much speculation regarding the number and nature of the critical events involved in carcinogenesis. By a consideration of colorectal and pancreatic cancers in the Surveillance Epidem...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meza R,Jeon J,Moolgavkar SH,Luebeck EG

更新日期：2008-10-21 00:00:00

abstract：:The mammalian anx7 gene codes for a Ca(2+)-activated GTPase, which supports Ca(2+)/GTP-dependent secretion events and Ca(2+) channel activities in vitro and in vivo. To test whether anx7 might be involved in Ca(2+) signaling in secreting pancreatic beta cells, we knocked out the anx7 gene in the mouse and tested the i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Srivastava M,Atwater I,Glasman M,Leighton X,Goping G,Caohuy H,Miller G,Pichel J,Westphal H,Mears D,Rojas E,Pollard HB

更新日期：1999-11-23 00:00:00

abstract：:The transcription factor caudal-type homeobox 1 (CDX1) is a key regulator of differentiation in the normal colon and in colorectal cancer (CRC). CDX1 activates the expression of enterocyte genes, but it is not clear how the concomitant silencing of stem cell genes is achieved. MicroRNAs (miRNAs) are important mediator...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones MF,Hara T,Francis P,Li XL,Bilke S,Zhu Y,Pineda M,Subramanian M,Bodmer WF,Lal A

更新日期：2015-03-31 00:00:00

abstract：:USF1 and USF2 are ubiquitously expressed transcription factors implicated as antagonists of the c-Myc protooncoprotein in the control of cellular proliferation. To determine the biological role of the USF proteins, mutant mice were generated by homologous recombination in embryonic stem cells. USF1-null mice were viab...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sirito M,Lin Q,Deng JM,Behringer RR,Sawadogo M

更新日期：1998-03-31 00:00:00

abstract：:The localized maternal RNA Vg1 resides in the cortical region of the vegetal pole of fully grown Xenopus oocytes and is inherited by only a subset of blastomeres in the early embryo [Weeks, D. L. & Melton, D. A. (1987) Cell 51, 861-867]. Because RNA-cytoskeletal interactions may play a role in RNA localization, we hav...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pondel MD,King ML

更新日期：1988-10-01 00:00:00

abstract：:The G protein-coupled m1 and m3 muscarinic acetylcholine receptors increase tyrosine phosphorylation of several proteins, including the focal adhesion-associated proteins paxillin and focal adhesion kinase (FAK), but the mechanism is not understood. Activation of integrins during adhesion of cells to extracellular mat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slack BE

更新日期：1998-06-23 00:00:00

abstract：:Phosphatidylinositol 3,4,5-triphosphate (PIP3) plays a key role in neuronal polarization and axon formation. PIP3-containing vesicles are transported to axon tips by the kinesin KIF13B via an adaptor protein, centaurin α1 (CENTA1). KIF13B interacts with CENTA1 through its forkhead-associated (FHA) domain. We solved th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tong Y,Tempel W,Wang H,Yamada K,Shen L,Senisterra GA,MacKenzie F,Chishti AH,Park HW

更新日期：2010-11-23 00:00:00

abstract：:Viral shells are self-assembled protein nanocontainers with remarkable material properties. They combine simplicity of construction with toughness and complex functionality. These properties make them interesting for bionanotechnology. To date we know little about how virus structure determines assembly pathways and s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivanovska IL,Miranda R,Carrascosa JL,Wuite GJ,Schmidt CF

更新日期：2011-08-02 00:00:00

abstract：:Invariant natural killer T (iNKT) cells recognize lipid antigens presented by CD1d and play a central role in regulating immunity and inflammation in peripheral tissues. However, the mechanisms which govern iNKT cell homeostasis after thymic emigration are incompletely understood. Here we demonstrate that microsomal t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeissig S,Peuker K,Iyer S,Gensollen T,Dougan SK,Olszak T,Kaser A,Blumberg RS

更新日期：2017-09-26 00:00:00

abstract：:An inductive interaction between the sevenless (sev) transmembrane tyrosine kinase receptor and the bride of sevenless (boss) transmembrane ligand is required for the development of the R7 photoreceptor neuron in the compound eye of Drosophila melanogaster. The boss protein is proposed to contain a large N-terminal ex...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hart AC,Harrison SD,Van Vactor DL Jr,Rubin GM,Zipursky SL

更新日期：1993-06-01 00:00:00

abstract：:Rodless retina (gene symbol, r) was discovered in mice by Keeler 70 years ago and was first described in this journal as an autosomal recessive mutation leading to "the absence of the visual cells (rods), the external nuclear layer, and the external molecular layer" [Keeler, C. E. (1924) Proc. Natl. Acad. Sci. USA 10,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pittler SJ,Keeler CE,Sidman RL,Baehr W

更新日期：1993-10-15 00:00:00

abstract：:Somatic LINE-1 (L1) retrotransposition has been detected in early embryos, adult brains, and the gastrointestinal (GI) tract, and many cancers, including epithelial GI tumors. We previously found numerous somatic L1 insertions in paired normal and GI cancerous tissues. Here, using a modified method of single-cell anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yamaguchi K,Soares AO,Goff LA,Talasila A,Choi JA,Ivenitsky D,Karma S,Brophy B,Devine SE,Meltzer SJ,Kazazian HH Jr

更新日期：2020-12-22 00:00:00

abstract：:The possible role of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) in protein synthesis by Escherichia coli ribosomes and protein factors was examined. Although pppGpp could effectively substitute for GTP in reactions catalyzed by initiation factor 2 (ribosomal binding of fMet-tRNA and formation of N-formylmethion...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hamel E,Cashel M

更新日期：1973-11-01 00:00:00

abstract：:The Watson-Crick model for DNA duplex duplication proposes that the two parental chains separate and that each directs the synthesis of a complementary chain with which it is found associated after the duplication act. Previous experiments have left unchallenged alternative models which propose that in any single act ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Russo VE,Stahl MM,Stahl FW

更新日期：1970-02-01 00:00:00

abstract：:Sequence comparisons of genomes or expressed sequence tags (ESTs) from related organisms provide insight into functional conservation and diversification. We compare the sequences of ESTs from the male accessory gland of Drosophila simulans to their orthologs in its close relative Drosophila melanogaster, and demonstr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Swanson WJ,Clark AG,Waldrip-Dail HM,Wolfner MF,Aquadro CF

更新日期：2001-06-19 00:00:00

abstract：:Systemic inflammation occurring around the course of tumor progression and treatment are often correlated with adverse oncological outcomes. As such, it is suspected that neutrophils, the first line of defense against infection, may play important roles in linking inflammation and metastatic seeding. To decipher the d...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen MB,Hajal C,Benjamin DC,Yu C,Azizgolshani H,Hynes RO,Kamm RD

更新日期：2018-07-03 00:00:00

abstract：:Selected aspects of the evolutionary process and more specifically of the genetic variation are considered, with an emphasis in studies performed by my group. One key aspect of evolution seems to be the concomitant occurrence of dichotomic, contradictory (dialect) processes. Genetic variation is structured, and the dy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salzano FM

更新日期：2000-05-09 00:00:00

abstract：:The developmental plasticity of plants relies on the remarkable ability of the meristems to integrate nutrient and energy availability with environmental signals. Meristems in root and shoot apexes share highly similar molecular players but are spatially separated by soil. Whether and how these two meristematic tissue...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Cai W,Liu Y,Li H,Fu L,Liu Z,Xu L,Liu H,Xu T,Xiong Y

更新日期：2017-03-07 00:00:00

abstract：:Whereas 234(92)U142 and other actinon nuclei have ground-state bands that indicate that each nucleus consists of a sphere and a single revolving cluster with constant composition and with only a steady increase in the moment of inertia with increase in J, the angular-momentum quantum number, many of the lanthanon grou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1991-02-01 00:00:00

abstract：:The polymerase chain reaction was used to amplify DNA surrounding the codon 12 region of the c-Ki-ras gene from C3H/10T1/2 cells and from a number of 3-methylcholanthrene (MCA)-transformed derivatives of these cells. Sequence analysis demonstrated that tumorigenic MCAC116/39 cells, known by DNA-mediated transfection t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen AC,Herschman HR

更新日期：1989-03-01 00:00:00

abstract：:A surprising example of interspecies competition is the production by certain bacteria of hydrogen peroxide at concentrations that are lethal for others. A case in point is the displacement of Staphylococcus aureus by Streptococcus pneumoniae in the nasopharynx, which is of considerable clinical significance. How it i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Selva L,Viana D,Regev-Yochay G,Trzcinski K,Corpa JM,Lasa I,Novick RP,Penadés JR

更新日期：2009-01-27 00:00:00

abstract：:The hormone gibberellin (GA) is a key regulator of plant growth. Many of the components of the gibberellin signal transduction [e.g., GIBBERELLIN INSENSITIVE DWARF 1 (GID1) and DELLA], biosynthesis [e.g., GA 20-oxidase (GA20ox) and GA3ox], and deactivation pathways have been identified. Gibberellin binds its receptor,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Middleton AM,Úbeda-Tomás S,Griffiths J,Holman T,Hedden P,Thomas SG,Phillips AL,Holdsworth MJ,Bennett MJ,King JR,Owen MR

更新日期：2012-05-08 00:00:00

abstract：:A series of monoclonal antibodies was used to define three discrete stages of human intrathymic T-cell differentiation. The earliest stage was confined to <10% of thymocytes, which were.reactive with both OKT9 and OKT10. Subsequently, approximately 70% of human thymocytes acquired a thymocyte-restricted antigen, OKT6,...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reinherz EL,Kung PC,Goldstein G,Levey RH,Schlossman SF

更新日期：1980-03-01 00:00:00

abstract：:We studied visual perception using an annular random-dot motion stimulus called the racetrack. We recorded neural activity using magnetoencephalography while subjects viewed variants of this stimulus that contained no inherent motion or various degrees of embedded motion. Subjects reported seeing rotary motion during ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crowe DA,Leuthold AC,Georgopoulos AP

更新日期：2010-12-28 00:00:00