Abstract:
:The environmental topology of complex structures is used by Escherichia coli to create traveling waves of high cell density, a prelude to quorum sensing. When cells are grown to a moderate density within a confining microenvironment, these traveling waves of cell density allow the cells to find and collapse into confining topologies, which are unstable to population fluctuations above a critical threshold. This was first observed in mazes designed to mimic complex environments, then more clearly in a simpler geometry consisting of a large open area surrounding a square (250 x 250 microm) with a narrow opening of 10-30 microm. Our results thus show that under nutrient-deprived conditions bacteria search out each other in a collective manner and that the bacteria can dynamically confine themselves to highly enclosed spaces.
journal_name
Proc Natl Acad Sci U S Aauthors
Park S,Wolanin PM,Yuzbashyan EA,Lin H,Darnton NC,Stock JB,Silberzan P,Austin Rdoi
10.1073/pnas.1935975100keywords:
subject
Has Abstractpub_date
2003-11-25 00:00:00pages
13910-5issue
24eissn
0027-8424issn
1091-6490pii
1935975100journal_volume
100pub_type
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