Two contemporaneous mitogenomes from terminal Pleistocene burials in eastern Beringia.

Abstract:

:Pleistocene residential sites with multiple contemporaneous human burials are extremely rare in the Americas. We report mitochondrial genomic variation in the first multiple mitochondrial genomes from a single prehistoric population: two infant burials (USR1 and USR2) from a common interment at the Upward Sun River Site in central Alaska dating to ∼11,500 cal B.P. Using a targeted capture method and next-generation sequencing, we determined that the USR1 infant possessed variants that define mitochondrial lineage C1b, whereas the USR2 genome falls at the root of lineage B2, allowing us to refine younger coalescence age estimates for these two clades. C1b and B2 are rare to absent in modern populations of northern North America. Documentation of these lineages at this location in the Late Pleistocene provides evidence for the extent of mitochondrial diversity in early Beringian populations, which supports the expectations of the Beringian Standstill Model.

authors

Tackney JC,Potter BA,Raff J,Powers M,Watkins WS,Warner D,Reuther JD,Irish JD,O'Rourke DH

doi

10.1073/pnas.1511903112

subject

Has Abstract

pub_date

2015-11-10 00:00:00

pages

13833-8

issue

45

eissn

0027-8424

issn

1091-6490

pii

1511903112

journal_volume

112

pub_type

历史文章,杂志文章
  • Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson's disease and DLB.

    abstract::Hyperphosphorylated α-synuclein in Lewy bodies and Lewy neurites is a characteristic neuropathological feature of Parkinson's disease (PD) and Dementia with Lewy bodies (DLB). The catalytic subunit of the specific phosphatase, protein phosphatase 2A (PP2A) that dephosphorylates α-synuclein, is hypomethylated in these ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1813365115

    authors: Yan R,Zhang J,Park HJ,Park ES,Oh S,Zheng H,Junn E,Voronkov M,Stock JB,Mouradian MM

    更新日期:2018-12-18 00:00:00

  • Persistent HIV-1 infection of natural killer cells in patients receiving highly active antiretroviral therapy.

    abstract::We have identified a subset of CD56(+)CD3(-) human natural killer (NK) cells that express CD4 and the HIV coreceptors CCR5 and CXCR4. These cells can be productively infected in vitro by both CCR5- and CXCR4-using molecular clones of HIV-1 in a CD4-dependent manner. Analysis of HIV-infected persons showed that viral D...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.102672999

    authors: Valentin A,Rosati M,Patenaude DJ,Hatzakis A,Kostrikis LG,Lazanas M,Wyvill KM,Yarchoan R,Pavlakis GN

    更新日期:2002-05-14 00:00:00

  • Dual role of lignin in plant litter decomposition in terrestrial ecosystems.

    abstract::Plant litter decomposition is a critical step in the formation of soil organic matter, the mineralization of organic nutrients, and the carbon balance in terrestrial ecosystems. Biotic decomposition in mesic ecosystems is generally negatively correlated with the concentration of lignin, a group of complex aromatic pol...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0909396107

    authors: Austin AT,Ballaré CL

    更新日期:2010-03-09 00:00:00

  • Role of cell surface immunoglobulin in B-lymphocyte activation.

    abstract::The role of cell surface immunoglobulin in helper T-cell-dependent B-cell activation was analyzed using a B-cell lymphoma, CH12, with known antigen specificity and activation properties similar to those of a resting B cell. Two sources of helper T cells were used, both selected such that they interact with H-2-encoded...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.81.8.2466

    authors: LoCascio NJ,Haughton G,Arnold LW,Corley RB

    更新日期:1984-04-01 00:00:00

  • Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.

    abstract::The Escherichia coli mutS gene product is involved in mismatch correction in this organism. We have purified a biologically active form of the 97,000 Mr protein to near homogeneity from an overproducing strain. Enzymatic and chemical protection ("footprinting") experiments have demonstrated that mutS-encoded protein s...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.83.14.5057

    authors: Su SS,Modrich P

    更新日期:1986-07-01 00:00:00

  • Dynamics of avian haemosporidian assemblages through millennial time scales inferred from insular biotas of the West Indies.

    abstract::Although introduced hemosporidian (malaria) parasites (Apicomplexa: Haemosporida) have hastened the extinction of endemic bird species in the Hawaiian Islands and perhaps elsewhere, little is known about the temporal dynamics of endemic malaria parasite populations. Haemosporidian parasites do not leave informative fo...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1702512114

    authors: Soares L,Latta SC,Ricklefs RE

    更新日期:2017-06-20 00:00:00

  • Subcellular distribution of Lck during CD4 T-cell maturation in the thymic medulla regulates the T-cell activation threshold.

    abstract::Mature peripheral T cells respond to foreign but not to self-antigens. During development in the thymus, deletion of high-affinity self-reactive immature thymocytes contributes to tolerance of mature T cells. However, double-positive thymocytes are positively selected to survive if they respond to self-peptide-MHC com...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1119272109

    authors: Stephen TL,Wilson BS,Laufer TM

    更新日期:2012-05-08 00:00:00

  • Lewis base catalysis of bromo- and iodolactonization, and cycloetherification.

    abstract::Lewis base catalyzed bromo- and iodolactonization reactions have been developed and the effects of catalyst structure on rate and cyclization selectivity have been systematically explored. The effects of substrate structure on halolactonization reactions and the interaction of those effects with the effects of catalys...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1005296107

    authors: Denmark SE,Burk MT

    更新日期:2010-11-30 00:00:00

  • Major diversification of voltage-gated K+ channels occurred in ancestral parahoxozoans.

    abstract::We examined the origins and functional evolution of the Shaker and KCNQ families of voltage-gated K(+) channels to better understand how neuronal excitability evolved. In bilaterians, the Shaker family consists of four functionally distinct gene families (Shaker, Shab, Shal, and Shaw) that share a subunit structure co...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1422941112

    authors: Li X,Liu H,Chu Luo J,Rhodes SA,Trigg LM,van Rossum DB,Anishkin A,Diatta FH,Sassic JK,Simmons DK,Kamel B,Medina M,Martindale MQ,Jegla T

    更新日期:2015-03-03 00:00:00

  • Monte Carlo studies of surface chemistry and nonthermal desorption involving interstellar grains.

    abstract::Although still poorly understood, the chemistry that occurs on the surfaces of interstellar dust particles profoundly affects the growth of molecules in the interstellar medium. The most important surface reaction is the conversion of atomic to molecular hydrogen, which is a precursor for all subsequent molecular deve...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0601556103

    authors: Herbst E,Cuppen HM

    更新日期:2006-08-15 00:00:00

  • Cell-free synthesis of the precursor polypeptide for avian myeloblastosis virus DNA polymerase.

    abstract::High molecular weight RNA (35S) isolated from avian myeloblastosis virus directs the cell-free synthesis of two prominent polypeptides of 180,000 and 76,000 molecular weight. The latter polypeptide has previously been identified as the precursor to the group-specific antigens of the virus ("gag" proteins) [Vogt, V. M....

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.74.11.4951

    authors: Paterson BM,Marciani DJ,Papas TS

    更新日期:1977-11-01 00:00:00

  • Analysis of 81 genes from 64 plastid genomes resolves relationships in angiosperms and identifies genome-scale evolutionary patterns.

    abstract::Angiosperms are the largest and most successful clade of land plants with >250,000 species distributed in nearly every terrestrial habitat. Many phylogenetic studies have been based on DNA sequences of one to several genes, but, despite decades of intensive efforts, relationships among early diverging lineages and sev...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0709121104

    authors: Jansen RK,Cai Z,Raubeson LA,Daniell H,Depamphilis CW,Leebens-Mack J,Müller KF,Guisinger-Bellian M,Haberle RC,Hansen AK,Chumley TW,Lee SB,Peery R,McNeal JR,Kuehl JV,Boore JL

    更新日期:2007-12-04 00:00:00

  • STRUBBELIG defines a receptor kinase-mediated signaling pathway regulating organ development in Arabidopsis.

    abstract::An open question remains as to what coordinates cell behavior during organogenesis, permitting organs to reach their appropriate size and shape. The Arabidopsis gene STRUBBELIG (SUB) defines a receptor-mediated signaling pathway in plants. SUB encodes a putative leucine-rich repeat transmembrane receptor-like kinase. ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0503526102

    authors: Chevalier D,Batoux M,Fulton L,Pfister K,Yadav RK,Schellenberg M,Schneitz K

    更新日期:2005-06-21 00:00:00

  • Migratory arrest of gonadotropin-releasing hormone neurons in transgenic mice.

    abstract::Gonadotropin-releasing hormone (GnRH) is important in reproduction, although the mechanism of central hypogonadism in humans remains unclear. Because the GnRH neuron originates from the olfactory placode and migrates to the hypothalamus during development, central hypogonadism in humans could be caused by failure in n...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.88.8.3402

    authors: Radovick S,Wray S,Lee E,Nicols DK,Nakayama Y,Weintraub BD,Westphal H,Cutler GB Jr,Wondisford FE

    更新日期:1991-04-15 00:00:00

  • Evolution of Drosophila sex comb length illustrates the inextricable interplay between selection and variation.

    abstract::In spite of the diversity of possible biological forms observed in nature, a limited range of morphospace is frequently occupied for a given trait. Several mechanisms have been proposed to explain this bias in the distribution of phenotypes including selection, drift, and developmental constraints. Despite extensive w...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1322342111

    authors: Malagón JN,Ahuja A,Sivapatham G,Hung J,Lee J,Muñoz-Gómez SA,Atallah J,Singh RS,Larsen E

    更新日期:2014-09-30 00:00:00

  • Human vision fails to distinguish widespread sexual dichromatism among sexually "monochromatic" birds.

    abstract::Historical scenarios of evolution of avian plumage coloration have been called into question with the discoveries that most birds can see UV light (which normal humans cannot), and that UV-reflecting plumages are widespread in birds. Several examples of sexual dichromatism not detectable with human visual capabilities...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0501891102

    authors: Eaton MD

    更新日期:2005-08-02 00:00:00

  • Structured clustering of the glycosphingolipid GM1 is required for membrane curvature induced by cholera toxin.

    abstract::AB5 bacterial toxins and polyomaviruses induce membrane curvature as a mechanism to facilitate their entry into host cells. How membrane bending is accomplished is not yet fully understood but has been linked to the simultaneous binding of the pentameric B subunit to multiple copies of glycosphingolipid receptors. Her...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2001119117

    authors: Kabbani AM,Raghunathan K,Lencer WI,Kenworthy AK,Kelly CV

    更新日期:2020-06-30 00:00:00

  • Pheromone-induced anisotropy in yeast plasma membrane phosphatidylinositol-4,5-bisphosphate distribution is required for MAPK signaling.

    abstract::During response of budding yeast to peptide mating pheromone, the cell becomes markedly polarized and MAPK scaffold protein Ste5 localizes to the resulting projection (shmoo tip). We demonstrated before that this recruitment is essential for sustained MAPK signaling and requires interaction of a pleckstrin homology (P...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1005817107

    authors: Garrenton LS,Stefan CJ,McMurray MA,Emr SD,Thorner J

    更新日期:2010-06-29 00:00:00

  • Diversity of immune strategies explained by adaptation to pathogen statistics.

    abstract::Biological organisms have evolved a wide range of immune mechanisms to defend themselves against pathogens. Beyond molecular details, these mechanisms differ in how protection is acquired, processed, and passed on to subsequent generations-differences that may be essential to long-term survival. Here, we introduce a m...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1600663113

    authors: Mayer A,Mora T,Rivoire O,Walczak AM

    更新日期:2016-08-02 00:00:00

  • Populations of auditory cortical neurons can accurately encode acoustic space across stimulus intensity.

    abstract::The auditory cortex is critical for perceiving a sound's location. However, there is no topographic representation of acoustic space, and individual auditory cortical neurons are often broadly tuned to stimulus location. It thus remains unclear how acoustic space is represented in the mammalian cerebral cortex and how...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0901023106

    authors: Miller LM,Recanzone GH

    更新日期:2009-04-07 00:00:00

  • Anchored clathrate waters bind antifreeze proteins to ice.

    abstract::The mechanism by which antifreeze proteins (AFPs) irreversibly bind to ice has not yet been resolved. The ice-binding site of an AFP is relatively hydrophobic, but also contains many potential hydrogen bond donors/acceptors. The extent to which hydrogen bonding and the hydrophobic effect contribute to ice binding has ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1100429108

    authors: Garnham CP,Campbell RL,Davies PL

    更新日期:2011-05-03 00:00:00

  • Mutation, specialization, and hypersensitivity in highly optimized tolerance.

    abstract::We introduce a model of evolution in which competing organisms are represented by percolation lattice models. Fitness is based on the number of occupied sites remaining after removing a cluster connected to a randomly selected site. High-fitness individuals arising through mutation and selection must trade off density...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.261714399

    authors: Zhou T,Carlson JM,Doyle J

    更新日期:2002-02-19 00:00:00

  • Selective NaV1.1 activation rescues Dravet syndrome mice from seizures and premature death.

    abstract::Dravet syndrome is a catastrophic, pharmacoresistant epileptic encephalopathy. Disease onset occurs in the first year of life, followed by developmental delay with cognitive and behavioral dysfunction and substantially elevated risk of premature death. The majority of affected individuals harbor a loss-of-function mut...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1804764115

    authors: Richards KL,Milligan CJ,Richardson RJ,Jancovski N,Grunnet M,Jacobson LH,Undheim EAB,Mobli M,Chow CY,Herzig V,Csoti A,Panyi G,Reid CA,King GF,Petrou S

    更新日期:2018-08-21 00:00:00

  • Refolding of Escherichia coli dihydrofolate reductase: sequential formation of substrate binding sites.

    abstract::The kinetics of refolding of Escherichia coli dihydrofolate reductase (EC 1.5.1.3) have been examined upon dilution of unfolded enzyme in 4.5 M urea to 1.29 M urea in 0.02 M phosphate buffer (pH 7.2) at 10 degrees C. Changes in the intrinsic protein fluorescence on refolding are characterized by four phases. Based on ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.87.12.4413

    authors: Frieden C

    更新日期:1990-06-01 00:00:00

  • Histone deacetylase inhibitor treatment dramatically reduces cholesterol accumulation in Niemann-Pick type C1 mutant human fibroblasts.

    abstract::Niemann-Pick type C (NPC) disease is predominantly caused by mutations in the NPC1 protein that affect intracellular cholesterol trafficking and cause accumulation of unesterified cholesterol and other lipids in lysosomal storage organelles. We report the use of a series of small molecule histone deacetylase (HDAC) in...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1014890108

    authors: Pipalia NH,Cosner CC,Huang A,Chatterjee A,Bourbon P,Farley N,Helquist P,Wiest O,Maxfield FR

    更新日期:2011-04-05 00:00:00

  • Exploring monovalent copper compounds with oxygen and hydrogen.

    abstract::New important applications of copper metal, e.g., in the areas of hydrogen production, fuel cell operation, and spent nuclear fuel disposal, require accurate knowledge of the physical and chemical properties of stable and metastable copper compounds. Among the copper(I) compounds with oxygen and hydrogen, cuprous oxid...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1115834109

    authors: Korzhavyi PA,Soroka IL,Isaev EI,Lilja C,Johansson B

    更新日期:2012-01-17 00:00:00

  • Bradyrhizobium japonicum rhizobitoxine genes and putative enzyme functions: expression requires a translational frameshift.

    abstract::Some strains of Bradyrhizobium japonicum produce rhizobitoxine, a phytotoxin that causes foliar chlorosis on susceptible host plants. We have previously obtained Tn5-induced rhizobitoxine null mutants of B. japonicum. DNA sequence analysis of the region surrounding two Tn5 insertions identifies two overlapping open re...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.7.2641

    authors: Ruan X,Zhang C,Peters NK

    更新日期:1993-04-01 00:00:00

  • Favorable outcome of experimental islet xenotransplantation without immunosuppression in a nonhuman primate model of diabetes.

    abstract::Transplantation of pancreatic islets for treating type 1 diabetes is restricted to patients with critical metabolic lability resulting from the need for immunosuppression and the shortage of donor organs. To overcome these barriers, we developed a strategy to macroencapsulate islets from different sources that allow t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1708420114

    authors: Ludwig B,Ludwig S,Steffen A,Knauf Y,Zimerman B,Heinke S,Lehmann S,Schubert U,Schmid J,Bleyer M,Schönmann U,Colton CK,Bonifacio E,Solimena M,Reichel A,Schally AV,Rotem A,Barkai U,Grinberg-Rashi H,Kaup FJ,Avni Y,J

    更新日期:2017-10-31 00:00:00

  • Synthesis of (-)-longithorone A: using organic synthesis to probe a proposed biosynthesis.

    abstract::We present a full report of our enantioselective synthesis of (-)-longithorone A (1). The synthesis was designed to test the feasibility of the biosynthetic proposal for 1 put forward by Schmitz involving intermolecular and transannular Diels-Alder reactions of two [12]-paracyclophane quinones. We have found that if t...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0401952101

    authors: Morales CA,Layton ME,Shair MD

    更新日期:2004-08-17 00:00:00

  • In vitro selection of optimal DNA substrates for T4 RNA ligase.

    abstract::We have used in vitro selection techniques to characterize DNA sequences that are ligated efficiently by T4 RNA ligase. We find that the ensemble of selected sequences ligated about 10 times as efficiently as the random mixture of sequences used as the input for selection. Surprisingly, the majority of the selected se...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.90.4.1576

    authors: Harada K,Orgel LE

    更新日期:1993-02-15 00:00:00