Two contemporaneous mitogenomes from terminal Pleistocene burials in eastern Beringia.

abstract：:Numerous studies have shown that high olive oil intake reduces blood pressure (BP). These positive effects of olive oil have frequently been ascribed to its minor components, such as alpha-tocopherol, polyphenols, and other phenolic compounds that are not present in other oils. However, in this study we demonstrate th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Terés S,Barceló-Coblijn G,Benet M,Alvarez R,Bressani R,Halver JE,Escribá PV

更新日期：2008-09-16 00:00:00

abstract：:Metastasis, the truly lethal aspect of cancer, occurs when metastatic cancer cells in a tumor break through the basement membrane and penetrate the extracellular matrix. We show that MDA-MB-231 metastatic breast cancer cells cooperatively invade a 3D collagen matrix while following a glucose gradient. The invasion fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu L,Duclos G,Sun B,Lee J,Wu A,Kam Y,Sontag ED,Stone HA,Sturm JC,Gatenby RA,Austin RH

更新日期：2013-01-29 00:00:00

abstract：:The major protein extracted from anyloid deposits induced in mice by injection of either Candida albicans cells or sodium caseinate was found to have chromatographic and electrophoretic properties and an amino-acid compostiion characteristic of the AA class of amyloid proteins. The homology of the mouse protein with p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eriksen N,Ericsson LH,Pearsall N,Lagunoff D,Benditt EP

更新日期：1976-03-01 00:00:00

abstract：:Saccharomyces cerevisiae strains harboring a nonreciprocal, bridge-induced translocation (BIT) between chromosomes VIII and XV exhibited an abnormal phenotype comprising elongated buds and multibudded, unevenly nucleated pseudohyphae. In these cells, we found evidence of molecular effects elicited by the translocation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nikitin D,Tosato V,Zavec AB,Bruschi CV

更新日期：2008-07-15 00:00:00

abstract：:Prostaglandin E1 and the beta-adrenergic hormone l-isoproterenol stimulated cyclic AMP formation in both nucleated and enucleated myeloid leukemic cells that could be induced to differentiate normally to mature cells by the macrophage- and granulocyte-inducing protein MGI (MGI+D+ cells). Enucleated as well as nucleate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simantov R,Shkolnik T,Sachs L

更新日期：1980-08-01 00:00:00

abstract：:Since their discovery as key regulators of early animal development, microRNAs now are recognized as widespread regulators of gene expression. Despite their abundance, little is known regarding the regulation of microRNA biogenesis. We show that three highly conserved muscle-specific microRNAs, miR-1, miR-133 and miR-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rao PK,Kumar RM,Farkhondeh M,Baskerville S,Lodish HF

更新日期：2006-06-06 00:00:00

abstract：:Increasing evidence highlights a role for the immune system in the pathogenesis of autism spectrum disorder (ASD), as immune dysregulation is observed in the brain, periphery, and gastrointestinal tract of ASD individuals. Furthermore, maternal infection (maternal immune activation, MIA) is a risk factor for ASD. Mode...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hsiao EY,McBride SW,Chow J,Mazmanian SK,Patterson PH

更新日期：2012-07-31 00:00:00

abstract：:The Pyrococcus furiosus (PF) ornithine carbamoyltransferase (OTCase; EC 2.1.3.3) is an extremely heat-stable enzyme that maintains about 50% of its activity after heat treatment for 60 min at 100 degrees C. To understand the molecular basis of thermostability of this enzyme, we have determined its three-dimensional st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Villeret V,Clantin B,Tricot C,Legrain C,Roovers M,Stalon V,Glansdorff N,Van Beeumen J

更新日期：1998-03-17 00:00:00

abstract：:Light activates rod outer segment (ROS) phosphodiesterase (PDEase), as shown by previous biochemical and physiological studies. We have further investigated the role of PDEase in this system by injecting trypsin-activated PDEase, purified from bovine ROS, into single ROS of the isolated retina of the toad Bufo marinus...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shimoda Y,Hurley JB,Miller WH

更新日期：1984-01-01 00:00:00

abstract：:Epithelial barrier disruption is a major cause of inflammatory bowel disease (IBD); however, the cellular and molecular regulation of intestinal epithelial homeostasis remains largely undefined. Here, we show that the C-type lectin receptor LSECtin (Clec4g) on macrophages is required for protection against dextran sul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang Z,Li Q,Wang X,Jiang X,Zhao D,Lin X,He F,Tang L

更新日期：2018-10-23 00:00:00

abstract：:Bacteria in the human oral cavity often grow in an attached multispecies biofilm community. Members of this community display defined interactions that have an impact on the physiology of the individual and the group. Here, we show that during coculture growth with streptococci, the oral pathogen Aggregatibacter actin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramsey MM,Whiteley M

更新日期：2009-02-03 00:00:00

abstract：:DNA methylation is an epigenetic mark that silences transposable elements (TEs) and repeats. Whereas the establishment and maintenance of DNA methylation are relatively well understood, little is known about their dynamics and biological relevance in plant and animal innate immunity. Here, we show that some TEs are de...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu A,Lepère G,Jay F,Wang J,Bapaume L,Wang Y,Abraham AL,Penterman J,Fischer RL,Voinnet O,Navarro L

更新日期：2013-02-05 00:00:00

abstract：:Chromogranin A (CGA) is a secretory protein present in the adrenal medulla and in a variety of endocrine organs. This protein may serve as precursor for pancreastatin (PST) and for other biologically active peptides. Recently, chromostatin (CST), a CGA derivative, has been identified that possesses high biological act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cetin Y,Aunis D,Bader MF,Galindo E,Jörns A,Bargsten G,Grube D

更新日期：1993-03-15 00:00:00

abstract：:Docosahexaenoic acid (DCHA), a major polyunsaturated acid component of fish lipid, is not a substrate for prostaglandin synthetase from ram seminal vesicles but is a strong competitive inhibitor (Ki, 0.36 microM) of the conversion by this enzyme of arachidonate (Km, 5.9 microM) to prostaglandins. In contrast, DCHA exh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Corey EJ,Shih C,Cashman JR

更新日期：1983-06-01 00:00:00

abstract：:The Na(+)/I(-) symporter (NIS) is a key plasma membrane protein that mediates active I(-) uptake in the thyroid, lactating breast, and other tissues with an electrogenic stoichiometry of 2 Na(+) per I(-). In the thyroid, NIS-mediated I(-) uptake is the first step in the biosynthesis of the iodine-containing thyroid ho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dohán O,Portulano C,Basquin C,Reyna-Neyra A,Amzel LM,Carrasco N

更新日期：2007-12-18 00:00:00

abstract：:Positively acting, rate-limiting regulatory factors that influence tissue-specific expression of the human cardiac alpha-actin gene in a mouse muscle cell line are shown by in vivo competition and gel mobility-shift assays to bind to upstream regions of its promoter but to neither vector DNA nor a beta-globin promoter...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miwa T,Boxer LM,Kedes L

更新日期：1987-10-01 00:00:00

abstract：:To identify genes important for hair-cell function, we conducted a mutagenic screen in zebrafish. Larvae from one mutant line, ru848, were unresponsive to acoustic stimuli and unable to balance. The mutation results in a 90% reduction in hair-cell number and partial retinal degeneration by 5 days postfertilization. We...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Starr CJ,Kappler JA,Chan DK,Kollmar R,Hudspeth AJ

更新日期：2004-02-24 00:00:00

abstract：:By the use of a rat kidney cell line infected with a temperature-sensitive Rous sarcoma virus, we have shown that, at permissive temperatures where the cells are transformed, concanavalin A induces a clustering of its cell membrane receptors into patches, and the intracellular smooth muscle myosin-like protein is in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ash JF,Vogt PK,Singer SJ

更新日期：1976-10-01 00:00:00

abstract：:Neural crest stem cells can be isolated from differentiated cultures of human pluripotent stem cells, but the process is inefficient and requires cell sorting to obtain a highly enriched population. No specific method for directed differentiation of human pluripotent cells toward neural crest stem cells has yet been r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Menendez L,Yatskievych TA,Antin PB,Dalton S

更新日期：2011-11-29 00:00:00

abstract：:Mouse myeloma cells were pulse-labeled in vitro with (3)H-D-glucosamine and (14)C-L-leucine. Analysis on sucrose gradients revealed incorporation of both isotopes into polyribosomes and release of most of such radioactivity after treatment of labeled cells in vitro with puromycin. A mixing experiment excluded the in v...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sherr CJ,Uhr JW

更新日期：1969-09-01 00:00:00

abstract：:Intracellular electrophysiological recordings were obtained from a specialized class of "starburst" amacrine cells by using an isolated superperfused retina-eyecup preparation of the rabbit. These cells were injected intracellularly with horseradish peroxidase and identified with light microscopy. A computer-controlle...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller RF,Bloomfield SA

更新日期：1983-05-01 00:00:00

abstract：:During tRNA biosynthesis the 5'-leader sequences in precursor tRNAs are removed by the ribonucleoprotein RNase P, an enzyme whose RNA moiety is required for activity. To clarify some aspects of the enzyme mechanism, we examined substrate binding and product formation with mutant precursor tRNAs. Mutations G-1----A or ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nichols M,Söll D,Willis I

更新日期：1988-03-01 00:00:00

abstract：:Horse heart cytochrome c can be split with cyanogen bromide into a heme peptide (residues 1-65) and a nonheme peptide (residues 66-104). In a process involving (i) complex formation between the two fragments and (ii) restoration of the severed peptide linkage, a fully active cytochrome c preparation can be re-formed. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barstow LE,Young RS,Yakali E,Sharp JJ,O'Brien JC,Berman PW,Harbury HA

更新日期：1977-10-01 00:00:00

abstract：:The principal sequence feature responsible for intrinsic DNA curvature is generally assumed to be runs of adenines. However, according to the wedge model of DNA curvature, each dinucleotide step is associated with a characteristic deflection of the local helix axis. Thus, an important test of a more general view of se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolshoy A,McNamara P,Harrington RE,Trifonov EN

更新日期：1991-03-15 00:00:00

abstract：:In the antennal lobe of Drosophila, information about odors is transferred from olfactory receptor neurons (ORNs) to projection neurons (PNs), which then send axons to neurons in the lateral horn of the protocerebrum (LHNs) and to Kenyon cells (KCs) in the mushroom body. The transformation from ORN to PN responses can...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo SX,Axel R,Abbott LF

更新日期：2010-06-08 00:00:00

abstract：:Cyclin-dependent kinase 4/6 (CDK4/6) inhibitors are an established treatment in estrogen receptor-positive breast cancer and are currently in clinical development in melanoma, a tumor that exhibits high rates of CDK4 activation. We analyzed melanoma cells with acquired resistance to the CDK4/6 inhibitor palbociclib an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： AbuHammad S,Cullinane C,Martin C,Bacolas Z,Ward T,Chen H,Slater A,Ardley K,Kirby L,Chan KT,Brajanovski N,Smith LK,Rao AD,Lelliott EJ,Kleinschmidt M,Vergara IA,Papenfuss AT,Lau P,Ghosh P,Haupt S,Haupt Y,Sanij E,

更新日期：2019-09-03 00:00:00

abstract：:The cingulate gyri in 37 subjects with and without early dementia of the Alzheimer type (DAT) were studied by using MRI at 1.0 mm3 isotropic resolution. Groups were segregated into young controls (n = 10), age-matched normal controls (n = 10), very mild DAT (n = 8), and mild DAT (n = 9). By using automated Bayesian se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller MI,Hosakere M,Barker AR,Priebe CE,Lee N,Ratnanather JT,Wang L,Gado M,Morris JC,Csernansky JG

更新日期：2003-12-09 00:00:00

abstract：:A detailed phenomenology of low energy excitations is a crucial starting point for microscopic understanding of complex materials, such as the cuprate high-temperature superconductors. Because of its unique momentum-space discrimination, angle-resolved photoemission spectroscopy (ARPES) is ideally suited for this task...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vishik IM,Hashimoto M,He RH,Lee WS,Schmitt F,Lu D,Moore RG,Zhang C,Meevasana W,Sasagawa T,Uchida S,Fujita K,Ishida S,Ishikado M,Yoshida Y,Eisaki H,Hussain Z,Devereaux TP,Shen ZX

更新日期：2012-11-06 00:00:00

abstract：:p-Coumaric acid is the precursor of phenylpropanoids, which are plant secondary metabolites that are beneficial to human health. Tyrosine ammonia lyase catalyzes the production of p-coumaric acid from tyrosine. Because of their photosynthetic ability and biosynthetic versatility, cyanobacteria are promising candidates...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xue Y,Zhang Y,Cheng D,Daddy S,He Q

更新日期：2014-07-01 00:00:00

abstract：:Alcohol dependence has traditionally been considered a brain disorder. Alteration in the composition of the gut microbiota has recently been shown to be present in psychiatric disorders, which suggests the possibility of gut-to-brain interactions in the development of alcohol dependence. The aim of the present study w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leclercq S,Matamoros S,Cani PD,Neyrinck AM,Jamar F,Stärkel P,Windey K,Tremaroli V,Bäckhed F,Verbeke K,de Timary P,Delzenne NM

更新日期：2014-10-21 00:00:00