E-box function in a period gene repressed by light.

abstract：:Little is known about genetic regulation of the development of white matter. This knowledge is critical in understanding the pathophysiology of neurodevelopmental syndromes associated with altered cognition as well as in elucidating the genetics of normal human cognition. The hemideletion of approximately 25 genes on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Marenco S,Siuta MA,Kippenhan JS,Grodofsky S,Chang WL,Kohn P,Mervis CB,Morris CA,Weinberger DR,Meyer-Lindenberg A,Pierpaoli C,Berman KF

更新日期：2007-09-18 00:00:00

abstract：:The distribution of proenkephalin and [Met]enkephalin immunoreactivities in the bovine hypothalamo-neurohypophyseal system was studied by use of specific antisera. Proenkephalin and [Met]enkephalin immunoreactivities were found in magnocellular neuronal cell bodies in the dorsal part of the supraoptic nuclei and in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vanderhaeghen JJ,Lotstra F,Liston DR,Rossier J

更新日期：1983-08-01 00:00:00

abstract：:The DC and DX subregions of the human major histocompatibility complex (MHC) have been cloned from a cosmid library made from a human B-cell line, Priess. The DC subregion, 48 kilobases, includes the DC alpha and DC beta genes. A second DC-like region, the DX subregion, 35 kilobases, contains the DX alpha gene and a n...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okada K,Boss JM,Prentice H,Spies T,Mengler R,Auffray C,Lillie J,Grossberger D,Strominger JL

更新日期：1985-05-01 00:00:00

abstract：:Plasma of normal human individuals was shown to contain an inhibitor of Trypanosoma cruzi neuraminidase (NAase; acylneuraminyl hydrolase, sialidase, EC 3.2.1.18). The inhibitor has been purified to homogeneity by PEG precipitation, CM Affi-Gel Blue Sepharose chromatography, and gel filtration. The purified preparation...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prioli RP,Rosenberg I,Pereira ME

更新日期：1987-05-01 00:00:00

abstract：:Fast axoplasmic transport was studied in dorsal root ganglion cells of the cat. Proteins carried in the fast axoplasmic flow were labeled after an intraganglionic injection of (L)-[4,5-(3)H]leucine. The rate of transport was 380 +/- 26 mm/day in both the central and peripheral branches of the bifurcating axons that ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Anderson LE,McClure WO

更新日期：1973-05-01 00:00:00

abstract：:Wnts regulate important intracellular signaling events, and dysregulation of the Wnt pathway has been linked to human disease. Here, we uncover numerous Wnt canonical effectors in human platelets where Wnts, their receptors, and downstream signaling components have not been previously described. We demonstrate that th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Steele BM,Harper MT,Macaulay IC,Morrell CN,Perez-Tamayo A,Foy M,Habas R,Poole AW,Fitzgerald DJ,Maguire PB

更新日期：2009-11-24 00:00:00

abstract：:A general theory of the structure of complexes of the transition metals is developed on the basis of the enneacovalence of the metals and the requirements of the electroneutrality principle. An extra orbital may be provided through the small but not negligible amount of f and g character of spd bond orbitals, and an e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pauling L

更新日期：1977-12-01 00:00:00

abstract：:The reversible phosphorylation of tyrosine residues is an important mechanism for modulating biological processes such as cellular signaling, differentiation, and growth, and if deregulated, can result in various types of cancer. Therefore, an understanding of these dynamic cellular processes at the molecular level re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salomon AR,Ficarro SB,Brill LM,Brinker A,Phung QT,Ericson C,Sauer K,Brock A,Horn DM,Schultz PG,Peters EC

更新日期：2003-01-21 00:00:00

abstract：:The design principles of spider dragline silk, nature's high-performance fiber, are still largely unknown, in particular for the noncrystalline glycine-rich domains, which form the bulk of the material. Here we apply two-dimensional solid-state NMR to determine the distribution of the backbone torsion angles (phi,psi)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： van Beek JD,Hess S,Vollrath F,Meier BH

更新日期：2002-08-06 00:00:00

abstract：:For a series of different proteins, including a structural protein, enzyme, inhibitor, protein marker, and a charge-transfer system, we have quantified the higher affinity of Na+ over K+ to the protein surface by means of molecular dynamics simulations and conductivity measurements. Both approaches show that sodium bi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vrbka L,Vondrásek J,Jagoda-Cwiklik B,Vácha R,Jungwirth P

更新日期：2006-10-17 00:00:00

abstract：:Cholera and enterotoxigenic Escherichia coli (ETEC) are among the most common causes of acute infantile gastroenteritis globally. We previously developed a rice-based vaccine that expressed cholera toxin B subunit (MucoRice-CTB) and had the advantages of being cold chain-free and providing protection against cholera t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tokuhara D,Yuki Y,Nochi T,Kodama T,Mejima M,Kurokawa S,Takahashi Y,Nanno M,Nakanishi U,Takaiwa F,Honda T,Kiyono H

更新日期：2010-05-11 00:00:00

abstract：:Nucleotide sequences that direct transcription of the human 5-lipoxygenase gene have been examined by ligation to the chloramphenicol acetyltransferase gene and determination of chloramphenicol acetyltransferase activity in transfected HeLa and HL-60 cells. Various lengths of 5'-flanking sequences up to 5.9 kilobase p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoshiko S,Rådmark O,Samuelsson B

更新日期：1990-12-01 00:00:00

abstract：:A whole genome cattle-hamster radiation hybrid cell panel was used to construct a map of 54 markers located on bovine chromosome 5 (BTA5). Of the 54 markers, 34 are microsatellites selected from the cattle linkage map and 20 are genes. Among the 20 mapped genes, 10 are new assignments that were made by using the compa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ozawa A,Band MR,Larson JH,Donovan J,Green CA,Womack JE,Lewin HA

更新日期：2000-04-11 00:00:00

abstract：:Visual transduction in Drosophila is a G protein-coupled phospholipase C-mediated process that leads to depolarization via activation of the transient receptor potential (TRP) calcium channel. Inactivation-no-afterpotential D (INAD) is an adaptor protein containing PDZ domains known to interact with TRP. Immunoprecipi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shieh BH,Zhu MY,Lee JK,Kelly IM,Bahiraei F

更新日期：1997-11-11 00:00:00

abstract：:The structure of the gene encoding human hexabrachion (tenascin) has been determined from overlapping clones isolated from a human genomic bacteriophage library. The genomic inserts were characterized by restriction mapping, Southern blot analysis, PCR, and DNA sequencing. The coding region of the hexabrachion gene sp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gulcher JR,Nies DE,Alexakos MJ,Ravikant NA,Sturgill ME,Marton LS,Stefansson K

更新日期：1991-11-01 00:00:00

abstract：:Much of the success of Plasmodium falciparum in establishing persistent infections is attributed to immune evasion through antigenic variation. This process involves periodically exchanging variants of the major surface antigen PfEMP1, a protein also responsible for parasite cytoadherence. PfEMP1 is encoded by genes o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ralph SA,Scheidig-Benatar C,Scherf A

更新日期：2005-04-12 00:00:00

abstract：:Usher syndrome type 1 (USH1) patients suffer from sensorineuronal deafness, vestibular dysfunction, and visual impairment. Several genetic loci have been linked to USH1, and four of the relevant genes have been identified. They encode the unconventional myosin VIIa, the PDZ-domain protein harmonin, and the putative ad...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Siemens J,Kazmierczak P,Reynolds A,Sticker M,Littlewood-Evans A,Müller U

更新日期：2002-11-12 00:00:00

abstract：:HIV-1 envelope glycoprotein is the primary target for HIV-1-specific antibodies. The native HIV-1 envelope spike on the virion surface is a trimer, but trimeric gp140 and monomeric gp120 currently are believed to induce comparable immune responses. Indeed, most studies on the immunogenicity of HIV-1 envelope oligomers...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovacs JM,Nkolola JP,Peng H,Cheung A,Perry J,Miller CA,Seaman MS,Barouch DH,Chen B

更新日期：2012-07-24 00:00:00

abstract：:Adrenocorticotropic hormone (ACTH) inhibited [3H]thymidine incorporation in normal adrenocortical cells of adult rats in culture, with a concomitant increase in corticosterone production and a characteristic retraction of cells. Both dibutyryl cyclic AMP and an analog of ACTH, which produces virtually no cyclic AMP, i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ramachandran J,Suyama AT

更新日期：1975-01-01 00:00:00

abstract：:This investigation was undertaken to determine the possible role of growth hormone (GH) in the hormonal regulation of hepatic low density lipoprotein (LDL) receptor expression. Treatment of normal rats with estrogen (ethynylestradiol, 5 mg/kg per day) increased the number of hepatic LDL receptors, and the LDL receptor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rudling M,Norstedt G,Olivecrona H,Reihnér E,Gustafsson JA,Angelin B

更新日期：1992-08-01 00:00:00

abstract：:Sunlight exposure is strongly indicated as one of the important etiologic agents in human cutaneous malignant melanoma. However, because of the absence of good animal models, it has not been possible to estimate the wavelengths or wavelength regions involved. We have developed a useful animal model from crosses and ba...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Setlow RB,Woodhead AD,Grist E

更新日期：1989-11-01 00:00:00

abstract：:Oil spills can lead to irreversible environmental degradation and are a potential hazard to human health. We study how onshore oil spills affect neonatal and infant mortality by combining spatial data from the Nigerian Oil Spill Monitor with Demographic and Health Surveys. To identify a causal effect, we compare sibli...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruederle A,Hodler R

更新日期：2019-03-19 00:00:00

abstract：:Hsubc9, a human gene encoding a ubiquitin-conjugating enzyme, has been cloned. The 18-kDa HsUbc9 protein is homologous to the ubiquitin-conjugating enzymes Hus5 of Schizosaccharomyces pombe and Ubc9 of Saccharomyces cerevisiae. The Hsubc9 gene complements a ubc9 mutation of S. cerevisiae. It has been mapped to chromos...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kovalenko OV,Plug AW,Haaf T,Gonda DK,Ashley T,Ward DC,Radding CM,Golub EI

更新日期：1996-04-02 00:00:00

abstract：:Neuronal specificity in retinal ganglion cells of Xenopus subserves the orderly connections of the optic nerve fibers in the tectum. This specificity derives from positional information acquired by the developing retina at embryonic stages 28-31. Here we report that ganglion cells of embryonic stage 28 eyes can acquir...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hunt RK,Jacobson M

更新日期：1972-04-01 00:00:00

abstract：:Earlier Monte Carlo studies on a single-helix model of the GTP cap at the end of a microtubule are extended here to a more realistic five-start helix model of the microtubule end. As in the earlier work, phase changes occur at the microtubule end: the end is either capped with GTP and growing slowly or uncapped and sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen YD,Hill TL

更新日期：1985-02-01 00:00:00

abstract：:We have isolated rat brain cDNA clones encoding AE2, a homologue of the erythrocyte anion exchanger, band 3 (AE1). Immunocytochemistry and in situ hybridization reveal that, in brain, AE2 expression is restricted to the basolateral membrane of the choroid plexus epithelium. Expression of a full-length mouse AE2 cDNA i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindsey AE,Schneider K,Simmons DM,Baron R,Lee BS,Kopito RR

更新日期：1990-07-01 00:00:00

abstract：:The high-affinity receptor for human granulocyte/macrophage colony-stimulating factor (hGM-CSF) is composed of two subunits, alpha and beta. The alpha subunit binds GM-CSF with low affinity, whereas the beta subunit does not bind GM-CSF by itself. The alpha and beta subunits together form the high-affinity GM-CSF rece...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitamura T,Hayashida K,Sakamaki K,Yokota T,Arai K,Miyajima A

更新日期：1991-06-15 00:00:00

abstract：:The glycoprotein I complex, consisting of two polypeptides of Mr 210,000 and 150,000, was isolated from human platelet membranes by wheat germ lectin affinity chromatography. Glycocalicin, a soluble loosely bound membrane glycoprotein of Mr 150,000 related to the glycoprotein I system, was also purified. The isolated ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nachman RL,Kinoshita T,Ferris B

更新日期：1979-06-01 00:00:00

abstract：:To define the gene content of the HLA class I region, cDNA selection was applied to three overlapping yeast artificial chromosomes (YACs) that spanned 1 megabase (Mb) of this region of the human major histocompatibility complex. These YACs extended from the region centromeric to HLA-E to the region telomeric to HLA-F....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei H,Fan WF,Xu H,Parimoo S,Shukla H,Chaplin DD,Weissman SM

更新日期：1993-12-15 00:00:00

abstract：:Many marine bacteria have evolved to grow optimally at either high (copiotrophic) or low (oligotrophic) nutrient concentrations, enabling different species to colonize distinct trophic habitats in the oceans. Here, we compare the genome sequences of two bacteria, Photobacterium angustum S14 and Sphingopyxis alaskensis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lauro FM,McDougald D,Thomas T,Williams TJ,Egan S,Rice S,DeMaere MZ,Ting L,Ertan H,Johnson J,Ferriera S,Lapidus A,Anderson I,Kyrpides N,Munk AC,Detter C,Han CS,Brown MV,Robb FT,Kjelleberg S,Cavicchioli R

更新日期：2009-09-15 00:00:00