Abstract:
:Little is known about genetic regulation of the development of white matter. This knowledge is critical in understanding the pathophysiology of neurodevelopmental syndromes associated with altered cognition as well as in elucidating the genetics of normal human cognition. The hemideletion of approximately 25 genes on chromosome 7q11.23 that causes Williams syndrome (WS) includes genes that regulate cytoskeletal dynamics in neurons, especially LIMK1 and CYLN2, and therefore offers the opportunity to investigate the role of these genes in the formation of white matter tracts. We used diffusion tensor imaging to demonstrate alteration in white matter fiber directionality, deviation in posterior fiber tract course, and reduced lateralization of fiber coherence in WS. These abnormalities are consistent with an alteration of the late stages of neuronal migration, define alterations of white matter structures underlying dissociable behavioral phenotypes in WS, and provide human in vivo information about genetic control of white matter tract formation.
journal_name
Proc Natl Acad Sci U S Aauthors
Marenco S,Siuta MA,Kippenhan JS,Grodofsky S,Chang WL,Kohn P,Mervis CB,Morris CA,Weinberger DR,Meyer-Lindenberg A,Pierpaoli C,Berman KFdoi
10.1073/pnas.0704311104subject
Has Abstractpub_date
2007-09-18 00:00:00pages
15117-22issue
38eissn
0027-8424issn
1091-6490pii
0704311104journal_volume
104pub_type
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