Central nervous system activity associated with the pain evoked by bradykinin and its alteration by morphine and aspirin.

abstract：:We have used expression cloning in Xenopus oocytes to isolate two different cDNAs encoding functional N-methyl-D-aspartate (NMDA) receptor subunits. The two receptors (NMDA-R1A and -R1B) display different pharmacologic properties as a consequence of alternative exon addition within the putative ligand-binding domain. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakanishi N,Axel R,Shneider NA

更新日期：1992-09-15 00:00:00

abstract：:Transforming growth factor alpha (TGF-alpha) is generated by cleavage of a membrane-anchored precursor protein, proTGF-alpha. ProTGF-alpha is cleaved at a slow rate and accumulates on the cell surface, thereby mediating cell-cell adhesion and mitogenic stimulation. We show here that cleavage of membrane proTGF-alpha b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pandiella A,Massagué J

更新日期：1991-03-01 00:00:00

abstract：:Mind wandering represents the human capacity for internally focused thought and relies upon the brain's default network and its interactions with attentional networks. Studies have characterized mind wandering in healthy people, yet there is limited understanding of how this capacity is affected in clinical population...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Callaghan C,Shine JM,Hodges JR,Andrews-Hanna JR,Irish M

更新日期：2019-02-19 00:00:00

abstract：:Infection of the mouse trigeminal ganglia (TG) is the most commonly used model for the study of herpes simplex virus type 1 (HSV-1) latency. Its popularity is caused, at least in part, by the perception that latent infection can be studied in this system in the absence of spontaneous viral reactivation. However, this ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Feldman LT,Ellison AR,Voytek CC,Yang L,Krause P,Margolis TP

更新日期：2002-01-22 00:00:00

abstract：:Container-shaped molecules provide structured environments that impart geometric bounds on the motions and conformations of smaller molecular occupants. Moreover, they provide "solvation" that is constrained in time and space. When inwardly directed functional groups are present, they can interact chemically with the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purse BW,Rebek J Jr

更新日期：2005-08-02 00:00:00

abstract：:As a consequence of recent developments in molecular phylogenomics, all extant orders of placental mammals have been grouped into 3 lineages: Afrotheria, Xenarthra, and Boreotheria, which originated in Africa, South America, and Laurasia, respectively. Despite this advancement, the order of divergence of these 3 linea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nishihara H,Maruyama S,Okada N

更新日期：2009-03-31 00:00:00

abstract：:Computational and biochemical studies implicate the blue-light sensor cryptochrome (CRY) as an endogenous light-dependent magnetosensor enabling migratory birds to navigate using the Earth's magnetic field. Validation of such a mechanism has been hampered by the absence of structures of vertebrate CRYs that have funct...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zoltowski BD,Chelliah Y,Wickramaratne A,Jarocha L,Karki N,Xu W,Mouritsen H,Hore PJ,Hibbs RE,Green CB,Takahashi JS

更新日期：2019-09-24 00:00:00

abstract：:Two human B-cell differentiation antigens, Bp35 and Bp50, apparently play distinct roles as signal receptors in B-cell activation. Monoclonal antibodies (mAbs) to either Bp35 or Bp50 deliver positive signals to B cells that stimulate their transition through the cell cycle. mAb to Bp35, like anti-immunoglobulin antibo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clark EA,Ledbetter JA

更新日期：1986-06-01 00:00:00

abstract：:We present data that demonstrate that three MR elements isolated from wild populations of Drosophila melanogaster on two continents can cause large deletions of the X chromosome in males. The deleted chromosomes, termed mini-X chromosomes, are induced at a frequency of approximately 1:4000 in chromosomes that are init...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green MM,Yamamoto MT,Miklos GL

更新日期：1987-07-01 00:00:00

abstract：:The cellular form of the Prion protein (PrPC) is necessary for prion replication in mice. To determine whether it is also sufficient, we expressed PrP under the control of various cell- or tissue-specific regulatory elements in PrP knockout mice. The interferon regulatory factor-1 promoter/Emu enhancer led to high PrP...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raeber AJ,Sailer A,Hegyi I,Klein MA,Rülicke T,Fischer M,Brandner S,Aguzzi A,Weissmann C

更新日期：1999-03-30 00:00:00

abstract：:The araCBAD regulatory region of Escherichia coli contains two divergently oriented promoters and three sites to which AraC, the regulatory protein of the operon, can bind. This paper presents the results of in vivo dimethyl sulfate "footprinting" experiments to monitor occupancy of the three AraC sites and measuremen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huo L,Martin KJ,Schleif R

更新日期：1988-08-01 00:00:00

abstract：:Interpretation of empirical results based on a taxa's lifetime distribution shows apparently conflicting results. Species' lifetime is reported to be exponentially distributed, whereas higher-order taxa, such as families or genera, follow a broader distribution, compatible with power-law decay. We show that both forms...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pigolotti S,Flammini A,Marsili M,Maritan A

更新日期：2005-11-01 00:00:00

abstract：:Normal monkeys and monkeys with lesions of the hippocampal formation and adjacent cortex (the H+ lesion) were trained on the delayed nonmatching to sample (DNMS) task with a delay of 0.5 s between the sample and the choice. The animals with H+ lesions learned the task normally at this short delay and also exhibited th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alvarez P,Zola-Morgan S,Squire LR

更新日期：1994-06-07 00:00:00

abstract：:The Schiff base adducts of glyceraldehyde with hemoglobin undergo Amadori rearrangement to form stable ketoamine structures; this reaction is similar to the nonenzymic glucosylation of proteins. In the present studies the analogous rearrangement of the Schiff base adducts of glycolaldehyde with proteins has been demon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Acharya AS,Manning JM

更新日期：1983-06-01 00:00:00

abstract：:We have carried out free energy perturbation calculations on DNA double-stranded hexanucleotides. The sequence d(CGCGCG)2 has been "mutated" into d(CGTGCG).d(CGCACG) with the oligonucleotide in the A, B, and Z structural forms, both in vacuo and in aqueous solution. In addition, model free energy calculations have bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dang LX,Pearlman DA,Kollman PA

更新日期：1990-06-01 00:00:00

abstract：:Prion disease is characterized by the alpha-->beta structural conversion of the cellular prion protein (PrP(C)) into the misfolded and aggregated "scrapie" (PrP(Sc)) isoform. It has been speculated that methionine (Met) oxidation in PrP(C) may have a special role in this process, but has not been detailed and assigned...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wolschner C,Giese A,Kretzschmar HA,Huber R,Moroder L,Budisa N

更新日期：2009-05-12 00:00:00

abstract：:Metallophilicity is defined as the interaction among closed-shell metal centers, the origin of which remains controversial, particularly for the roles of spd orbital hybridization (mixing of the spd atomic orbitals of the metal atom in the molecular orbitals of metal complex) and the relativistic effect. Our studies r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wan Q,Yang J,To WP,Che CM

更新日期：2021-01-05 00:00:00

abstract：:The importance of proper ion channel trafficking is underpinned by a number of channel-linked genetic diseases whose defect is associated with failure to reach the cell surface. Conceptually, it is reasonable to suggest that the function of ion channels depends critically on the precise subcellular localization and th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lu L,Timofeyev V,Li N,Rafizadeh S,Singapuri A,Harris TR,Chiamvimonvat N

更新日期：2009-10-27 00:00:00

abstract：:α-SNAP [soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein] and NSF proteins are conserved across eukaryotes and sustain cellular vesicle trafficking by mediating disassembly and reuse of SNARE protein complexes, which facilitate fusion of vesicles to target membranes. However, certain haplotypes of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bayless AM,Smith JM,Song J,McMinn PH,Teillet A,August BK,Bent AF

更新日期：2016-11-22 00:00:00

abstract：:The recent success of antibody-drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubule-destabilizing agents. Here, we determined the high-resolution crystal structure of the complex between tubulin and maytansine, which is part of an ADC that is approved by the US Food and Drug A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Prota AE,Bargsten K,Diaz JF,Marsh M,Cuevas C,Liniger M,Neuhaus C,Andreu JM,Altmann KH,Steinmetz MO

更新日期：2014-09-23 00:00:00

abstract：:Polyketides represent an extremely diverse class of secondary metabolites often explored for their bioactive traits. These molecules are also attractive building blocks for chemical catalysis and polymerization. However, the use of polyketides in larger scale chemistry applications is stymied by limited titers and yie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markham KA,Palmer CM,Chwatko M,Wagner JM,Murray C,Vazquez S,Swaminathan A,Chakravarty I,Lynd NA,Alper HS

更新日期：2018-02-27 00:00:00

abstract：:When we grasp and manipulate an object, populations of tactile nerve fibers become activated and convey information about the shape, size, and texture of the object and its motion across the skin. The response properties of tactile fibers have been extensively characterized in single-unit recordings, yielding importan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saal HP,Delhaye BP,Rayhaun BC,Bensmaia SJ

更新日期：2017-07-11 00:00:00

abstract：:PTEN is an important tumor-suppressor gene associated with many cancers. Through expression profiling of glioblastoma tissue samples and prostate cancer xenografts, we identified a molecular signature for loss of the PTEN tumor suppressor in glioblastoma and prostate tumors. The PTEN signature consists of a minimum of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mehrian-Shai R,Chen CD,Shi T,Horvath S,Nelson SF,Reichardt JK,Sawyers CL

更新日期：2007-03-27 00:00:00

abstract：:The role of the Ca2+/phospholipid-dependent, diacylglycerol-activated enzyme protein kinase C (PKC) in rabbit eyelid conditioning was examined. PKC was partially purified from the CA1 region of hippocampal slices from naive, pseudoconditioned, and conditioned rabbits 24 hr after the rabbits were well conditioned. Crud...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bank B,DeWeer A,Kuzirian AM,Rasmussen H,Alkon DL

更新日期：1988-03-01 00:00:00

abstract：:Tumor growth requires neoangiogenesis. VEGF is the most potent proangiogenic factor. Dysregulation of hypoxia-inducible factor (HIF) or cytokine stimuli such as those involving the chemokine receptor 4/stromal-derived cell factor 1 (CXCR4/SDF-1) axis are the major cause of ectopic overexpression of VEGF in tumors. Alt...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： de Nigris F,Crudele V,Giovane A,Casamassimi A,Giordano A,Garban HJ,Cacciatore F,Pentimalli F,Marquez-Garban DC,Petrillo A,Cito L,Sommese L,Fiore A,Petrillo M,Siani A,Barbieri A,Arra C,Rengo F,Hayashi T,Al-Omran M,

更新日期：2010-08-10 00:00:00

abstract：:For more than 50 y ecologists have believed that spatial heterogeneity in habitat conditions promotes species richness by increasing opportunities for niche partitioning. However, a recent stochastic model combining the main elements of niche theory and island biogeography theory suggests that environmental heterogene...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Allouche O,Kalyuzhny M,Moreno-Rueda G,Pizarro M,Kadmon R

更新日期：2012-10-23 00:00:00

abstract：:How did human cooperation evolve? Recent evidence shows that many people are willing to engage in altruistic punishment, voluntarily paying a cost to punish noncooperators. Although this behavior helps to explain how cooperation can persist, it creates an important puzzle. If altruistic punishment provides benefits to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fowler JH

更新日期：2005-05-10 00:00:00

abstract：:In a previous paper we described the induction by x-irradiation or radiation-induced leukemia virus-inoculation of two classes of lymphoid T-cell neoplasms: The first class, designated T-cell lymphoblastoma (TCLB), consists of growth-factor-dependent eudiploid cells that home to the spleen and give rise to splenic tum...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Haas M,Altman A,Rothenberg E,Bogart MH,Jones OW

更新日期：1984-03-01 00:00:00

abstract：:Purified NADPH:cytochrome c (P-450) reductase (FpT; NADPH-ferrihemoprotein oxidoreductase, EC 1.6.2.4) can reductively activate mitomycin antibiotics through a one-electron reduction to species that alkylate DNA. To assess the involvement of FpT in the intracellular activation of the mitomycins, transfectants overexpr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Belcourt MF,Hodnick WF,Rockwell S,Sartorelli AC

更新日期：1996-01-09 00:00:00

abstract：:Dead and dying cells release nucleic acids. These extracellular RNAs and DNAs can be taken up by inflammatory cells and activate multiple nucleic acid-sensing toll-like receptors (TLR3, 7, 8, and 9). The inappropriate activation of these TLRs can engender a variety of inflammatory and autoimmune diseases. The redundan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee J,Sohn JW,Zhang Y,Leong KW,Pisetsky D,Sullenger BA

更新日期：2011-08-23 00:00:00