Developmentally regulated expression by Trypanosoma cruzi of molecules that accelerate the decay of complement C3 convertases.

abstract：:Recent studies with fibroblasts have shown that peptidylhydroxyproline formation begins toward the end of the log phase of growth and is an expression of the activity of the enzyme, collagen proline hydroxylase, which increase in late log-phase cells. This communication reports a two- to fivefold increase in hydroxyla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Comstock JP,Udenfriend S

更新日期：1970-06-01 00:00:00

abstract：:In order to define the protease domain of human immunodeficiency virus 1, various regions of the pol open reading frame were cloned and expressed in Escherichia coli. Antiserum directed against the conserved retroviral protease active site was used to identify pol precursor and processed species containing the presume...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves MC,Lim JJ,Heimer EP,Kramer RA

更新日期：1988-04-01 00:00:00

abstract：:The maytansinoid drug DM1 is 100- to 1000-fold more cytotoxic than anticancer drugs that are currently in clinical use. The immunoconjugate C242-DM1 was prepared by conjugating DM1 to the monoclonal antibody C242, which recognizes a mucin-type glycoprotein expressed to various extents by human colorectal cancers. C242...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu C,Tadayoni BM,Bourret LA,Mattocks KM,Derr SM,Widdison WC,Kedersha NL,Ariniello PD,Goldmacher VS,Lambert JM,Blättler WA,Chari RV

更新日期：1996-08-06 00:00:00

abstract：:We provide evidence for an interaction between mouse class I major histocompatibility complex antigens and insulin receptors. Antibodies against class I but not class II major histocompatibility complex antigens immunoprecipitate photoaffinity-labeled hepatic insulin receptors. Haplotype specificity is demonstrated by...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Phillips ML,Moule ML,Delovitch TL,Yip CC

更新日期：1986-05-01 00:00:00

abstract：:Filipin, digitonin, and saponin react with membrane cholesterol to produce unique membrane alterations (sterol-specific complexes) that are easily discernible in freeze-fracture replicas. We have treated both noninnervated and innervated Xenopus embryonic muscle cells in culture with these agents. Freeze-fracture of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bridgman PC,Nakajima Y

更新日期：1981-02-01 00:00:00

abstract：:The configuration of the heme-carbonyl group upon binding of carbon monoxide to sperm whale myoglobin (Mb) in crystals is evaluated on the basis of infrared spectroscopic methods. Multiplets of the totally symmetric C-O stretching mode are observed for the heme-bound ligand near 1933, 1944, and 1967 cm-1, correspondin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Makinen MW,Houtchens RA,Caughey WS

更新日期：1979-12-01 00:00:00

abstract：:We have previously shown that the isometric tension of a fully calcium-activated skinned rabbit psoas muscle fiber is reversibly depressed by increased hydrostatic pressure. We report here the characterization of tension transients induced by a rapid (less than 1-ms) release of increased pressure at 12 degrees C. The ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fortune NS,Geeves MA,Ranatunga KW

更新日期：1991-08-15 00:00:00

abstract：:Aging and disease processes may be due to deleterious and irreversible changes produced by free radical reactions. The enzyme copper-zinc superoxide dismutase (Cu-Zn SOD; superoxide:superoxide oxidoreductase, EC 1.15.1.1) performs a protective function by scavenging superoxide radicals. The Cu-Zn SOD gene (Sod) cloned...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seto NO,Hayashi S,Tener GM

更新日期：1990-06-01 00:00:00

abstract：:This paper is a theoretical study of dynamic self assembly in a system of millimeter-sized magnetized disks floating at a liquid-air interface and spinning under the influence of a rotating magnetic field. Equations of motions are derived that account for the hydrodynamic and magnetic forces acting in the system. Nume...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grzybowski BA,Stone HA,Whitesides GM

更新日期：2002-04-02 00:00:00

abstract：:Transthyretin (TTR) is a globular tetrameric transport protein in plasma. Nearly 140 single amino acid substitutions in TTR cause life-threatening amyloid disease. We report a one-of-a-kind pathological variant featuring a Glu51, Ser52 duplication mutation (Glu51_Ser52dup). The proband, heterozygous for the mutation, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Klimtchuk ES,Prokaeva T,Frame NM,Abdullahi HA,Spencer B,Dasari S,Cui H,Berk JL,Kurtin PJ,Connors LH,Gursky O

更新日期：2018-07-10 00:00:00

abstract：:The bottom-up design of protein-based signaling networks is a key goal of synthetic biology; yet, it remains elusive due to our inability to tailor-make signal transducers and receptors that can be readily compiled into defined signaling networks. Here, we report a generic approach for the construction of protein-base...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stein V,Alexandrov K

更新日期：2014-11-11 00:00:00

abstract：:Toll like receptors (TLRs) use Toll-IL-1 receptor (TIR) domain-containing adapters, such as myeloid differentiation primary response gene 88 (MyD88) and TIR domain-containing adapter inducing IFN-β (TRIF), to induce activation of transcription factors, including NF-κB, MAP kinases, and IFN regulatory factors. TLR sign...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Troutman TD,Hu W,Fulenchek S,Yamazaki T,Kurosaki T,Bazan JF,Pasare C

更新日期：2012-01-03 00:00:00

abstract：:We have isolated several lines of rat embryo cells transformed by simian virus 40. All these lines are fully transformed with regard to saturation density and serum sensitivity, but they differ greatly in their anchorage dependence, as assayed by efficiency of plating in methyl cellulose suspension. This set of lines ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pollack R,Risser R,Conlon S,Rifkin D

更新日期：1974-12-01 00:00:00

abstract：:The chloroplast stromal proteins from spinach condense the two heterocyclic moieties of vitamin B1--4-methyl-5-(beta-hydroxyethyl)thiazole and 2-methyl-4-amino-5-hydroxymethylpyrimidine--in the presence of MgATP. We have taken advantage of this observation to study thiazole synthesis. We present data indicating that p...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Julliard JH,Douce R

更新日期：1991-03-15 00:00:00

abstract：:Two factors that contribute to the progression of Parkinson disease are a brain defect in mitochondrial respiration and the generation of hydrogen peroxide (H2O2) by monoamine oxidase (MAO). Here we show that the two are linked. Metabolism of the neurotransmitter dopamine, or other monoamines (benzylamine, tyramine), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cohen G,Farooqui R,Kesler N

更新日期：1997-05-13 00:00:00

abstract：:We stabilize nematic droplets with handles against surface tension-driven instabilities, using a yield-stress material as outer fluid, and study the complex nematic textures and defect structures that result from the competition between topological constraints and the elasticity of the nematic liquid crystal. We uncov...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pairam E,Vallamkondu J,Koning V,van Zuiden BC,Ellis PW,Bates MA,Vitelli V,Fernandez-Nieves A

更新日期：2013-06-04 00:00:00

abstract：:Tc1-like transposable elements from teleost fish have been phylogenetically examined to determine the mechanisms involved in their evolution and conserved domains of function. We identified two new functional domains in these elements. The first is a bipartite nuclear localization signal, indicating that transposons c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ivics Z,Izsvak Z,Minter A,Hackett PB

更新日期：1996-05-14 00:00:00

abstract：:Due to the small size of a nanoconfinement, the property of water contained inside is rather challenging to probe. Herein, we measured the amount of water molecules released during the folding of individual G-quadruplex and i-motif structures, from which water activities are estimated in the DNA nanocages prepared by ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jonchhe S,Pandey S,Emura T,Hidaka K,Hossain MA,Shrestha P,Sugiyama H,Endo M,Mao H

更新日期：2018-09-18 00:00:00

abstract：:RNA movements and localization pervade biology, from embryonic development to disease. To identify RNAs at specific locations, we developed a strategy in which a uridine-adding enzyme is anchored to subcellular sites, where it directly marks RNAs with 3' terminal uridines. This localized RNA recording approach yields ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Medina-Munoz HC,Lapointe CP,Porter DF,Wickens M

更新日期：2020-09-22 00:00:00

abstract：:Oxidative stress is a ubiquitous threat to all aerobic organisms and has been implicated in numerous pathological conditions such as cancer. Here we demonstrate a pivotal role for E2F1, a cell cycle regulatory transcription factor, in cell tolerance of oxidative stress. Cells lacking E2F1 are hypersensitive to oxidati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Graves JD,Lee YJ,Liu K,Li G,Lin FT,Lin WC

更新日期：2020-06-30 00:00:00

abstract：:Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. This increased risk cannot be fully explained by classic risk factors. One of the key features of shift workers is that their behavioral and environmental cycles are typically misaligned relative to their endogenous circadian syste...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morris CJ,Purvis TE,Hu K,Scheer FA

更新日期：2016-03-08 00:00:00

abstract：:In the last decade, a number of quantitative epidemiological studies of specific diseases have been done in developing countries that for the first time allow estimation of the total burden of disease (mortality and morbidity) attributable to use of solid fuels in adult women and young children, who jointly receive th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smith KR

更新日期：2000-11-21 00:00:00

abstract：:We present a synthesis theorem for a family of locally equivalent measures defined on a ring of sets. This theorem is then used to exhibit a control measure for weakly compact sets of unbounded measures. In addition, the existence of a local control measure for locally strongly bounded vector measures is proved by mea...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brooks JK,Dinculeanu N

更新日期：1972-05-01 00:00:00

abstract：:The mechanical properties of engineering structures continuously weaken during service life because of material fatigue or degradation. By contrast, living organisms are able to strengthen their mechanical properties by regenerating parts of their structures. For example, plants strengthen their cell structures by tra...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu K,Feng Z,Du H,Xin A,Lee KH,Li K,Su Y,Wang Q,Fang NX,Daraio C

更新日期：2021-01-19 00:00:00

abstract：:Current theoretical models of the commons assert that common-pool resources can only be managed sustainably with clearly defined boundaries around both communities and the resources that they use. In these theoretical models, open access inevitably leads to a tragedy of the commons. However, in many open-access system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Moritz M,Behnke R,Beitl CM,Bliege Bird R,Chiaravalloti RM,Clark JK,Crabtree SA,Downey SS,Hamilton IM,Phang SC,Scholte P,Wilson JA

更新日期：2018-12-18 00:00:00

abstract：:Determining the principal energy-transfer pathways responsible for allosteric communication in biomolecules remains challenging, partially due to the intrinsic complexity of the systems and the lack of effective characterization methods. In this work, we introduce the eigenvector centrality metric based on mutual info...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Negre CFA,Morzan UN,Hendrickson HP,Pal R,Lisi GP,Loria JP,Rivalta I,Ho J,Batista VS

更新日期：2018-12-26 00:00:00

abstract：:The dramatic increase in healthcare cost has become a significant burden to the world. Many patients are denied the accessibility of medication because of the high price of drugs. Total biosynthesis of chiral drug intermediates is an environmentally friendly approach that helps provide more affordable pharmaceuticals....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang K,Li H,Cho KM,Liao JC

更新日期：2010-04-06 00:00:00

abstract：:Viral hepatitis is a disease of antiquity, but evidence for more than one etiologic agent has been recognized only since the 1940s, when two viruses (hepatitis A virus and hepatitis B virus) were thought to account for all disease. In the past 20 years, three additional hepatitis agents (hepatitis C virus, hepatitis D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Purcell RH

更新日期：1994-03-29 00:00:00

abstract：:Lethal factor, the principal virulence factor of Bacillus anthracis, inhibits mitogen-activated protein kinase (MAPK) signaling by proteolytically cleaving MAPK kinases. Edema factor, another component of anthrax toxin, is an adenylate cyclase, which increases intracellular cAMP. Inhibition of MAPK signaling with eith...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koo HM,VanBrocklin M,McWilliams MJ,Leppla SH,Duesbery NS,Vande Woude GF

更新日期：2002-03-05 00:00:00

abstract：:Rat skeletal muscle selenoprotein W cDNA was isolated and sequenced. The isolation strategy involved design of degenerate PCR primers from reverse translation of a partial peptide sequence. A reverse transcription-coupled PCR product from rat muscle mRNA was used to screen a muscle cDNA library prepared from selenium-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vendeland SC,Beilstein MA,Yeh JY,Ream W,Whanger PD

更新日期：1995-09-12 00:00:00