Class I histocompatibility antigens and insulin receptors: evidence for interactions.

abstract：:Shiverer (shi) is an autosomal recessive mutation in the mouse characterized by an almost total lack of central nervous system myelin. While small amounts of other myelin components are present in the brain of the shi mouse, the four forms of myelin basic protein (MBP) are not detectable. Previous investigations by us...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Molineaux SM,Engh H,de Ferra F,Hudson L,Lazzarini RA

更新日期：1986-10-01 00:00:00

abstract：:The rate of leucine incorporation into a specific estrogen-induced protein of immature rat isolated by gel electrophoresis declines rapidly between 2-4 hr after estrogen stimulation in vivo followed by incubation in vitro. Actinomycin D present during the in vitro phase prevents this decline, and elicits a "superinduc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： DeAngelo AB,Fujimoto GI

更新日期：1973-01-01 00:00:00

abstract：:Branching morphogenesis in the mammary gland is achieved by the migration of epithelial cells through a microenvironment consisting of stromal cells and extracellular matrix (ECM). Here we show that galectin-1 (Gal-1), an endogenous lectin that recognizes glycans bearing N-acetyllactosamine (LacNAc) epitopes, induces ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bhat R,Belardi B,Mori H,Kuo P,Tam A,Hines WC,Le QT,Bertozzi CR,Bissell MJ

更新日期：2016-08-16 00:00:00

abstract：:The araCBAD regulatory region of Escherichia coli contains two divergently oriented promoters and three sites to which AraC, the regulatory protein of the operon, can bind. This paper presents the results of in vivo dimethyl sulfate "footprinting" experiments to monitor occupancy of the three AraC sites and measuremen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huo L,Martin KJ,Schleif R

更新日期：1988-08-01 00:00:00

abstract：:We previously demonstrated that the primary region of factor IX and IXa responsible for saturable specific binding to bovine aortic endothelial cells resides in residues 3-11 at the amino terminus of factor IX. We also demonstrated that mutations of lysine to alanine at residue 5, factor IX K5A, or valine to lysine at...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung WF,van den Born J,Kühn K,Kjellén L,Hudson BG,Stafford DW

更新日期：1996-10-01 00:00:00

abstract：:In many plants, osmotic stress induces a rapid accumulation of proline through de novo synthesis from glutamate. This response is thought to play a pivotal role in osmotic stress tolerance [Kishor, P. B. K., Hong, Z., Miao, G.-H., Hu, C.-A. A. and Verma, D. P. S. (1995) Plant Physiol. 108, 1387-1394]. During recovery ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Verbruggen N,Hua XJ,May M,Van Montagu M

更新日期：1996-08-06 00:00:00

abstract：:The Arabidopsis thaliana SOS1 protein is a putative Na+/H+ antiporter that functions in Na+ extrusion and is essential for the NaCl tolerance of plants. sos1 mutant plants share phenotypic similarities with mutants lacking the protein kinase SOS2 and the Ca2+ sensor SOS3. To investigate whether the three SOS proteins ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quintero FJ,Ohta M,Shi H,Zhu JK,Pardo JM

更新日期：2002-06-25 00:00:00

abstract：:Strongylocentrotus intermedius (A. Agassiz, 1863) is an economically important sea urchin inhabiting the northwest Pacific region of Asia. The northern Primorye (Sea of Japan) populations of S. intermedius consist of two sympatric morphological forms, "usual" (U) and "gray" (G). The two forms are significantly differe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Balakirev ES,Pavlyuchkov VA,Ayala FJ

更新日期：2008-10-21 00:00:00

abstract：:Patients with primary (AL) cardiac amyloidosis suffer from progressive cardiomyopathy with a median survival of less than 8 months and a 5-year survival of <10%. Contributing to this poor prognosis is the fact that these patients generally do not tolerate standard heart failure therapies. The molecular mechanisms unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shi J,Guan J,Jiang B,Brenner DA,Del Monte F,Ward JE,Connors LH,Sawyer DB,Semigran MJ,Macgillivray TE,Seldin DC,Falk R,Liao R

更新日期：2010-03-02 00:00:00

abstract：:Exposing primary cultures of cerebellar granule neurons to 100 nM phorbol 12-myristate 13-acetate (PMA) for 24 hr decreases the Ca2+/phosphatidylserine/diolein-dependent protein kinase C (PKC; ATP:protein phosphotransferase, EC 2.7.1.37) by approximately 90% in the 100,000 x g supernatant and pellet fractions of neuro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Favaron M,Manev H,Siman R,Bertolino M,Szekely AM,DeErausquin G,Guidotti A,Costa E

更新日期：1990-03-01 00:00:00

abstract：:Rev-Erbβ is a nuclear receptor that couples circadian rhythm, metabolism, and inflammation. Heme binding to the protein modulates its function as a repressor, its stability, its ability to bind other proteins, and its activity in gas sensing. Rev-Erbβ binds Fe3+-heme more tightly than Fe2+-heme, suggesting its activit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sarkar A,Carter EL,Harland JB,Speelman AL,Lehnert N,Ragsdale SW

更新日期：2021-01-19 00:00:00

abstract：:The synthetic polypeptide antigen poly(LTyr, LGlu)-poly(DLAl)- -poly(LLys)[T,G)-A- -L] was covalently linked to N-acetylmuramyl-L-alanyl-D-isoglutamine (MDP), which is the minimal adjuvant-active structure that can substitute for Mycobacteria in complete Freund's adjuvant. When injected in aqueous solution into mice, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mozes E,Sela M,Chedid L

更新日期：1980-08-01 00:00:00

abstract：:We investigated the ability of targeted immunomicelles to detect and assess macrophages in atherosclerotic plaque using MRI in vivo. There is a large clinical need for a noninvasive tool to assess atherosclerosis from a molecular and cellular standpoint. Macrophages play a central role in atherosclerosis and are assoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Amirbekian V,Lipinski MJ,Briley-Saebo KC,Amirbekian S,Aguinaldo JG,Weinreb DB,Vucic E,Frias JC,Hyafil F,Mani V,Fisher EA,Fayad ZA

更新日期：2007-01-16 00:00:00

abstract：:The ATP-dependent enzyme dethiobiotin synthetase from Escherichia coli catalyses the formation of dethiobiotin from CO2 and 7, 8-diaminopelargonic acid. The reaction is initiated by the formation of a carbamate and proceeds through a phosphorylated intermediate, a mixed carbamic phosphoric anhydride. Here, we report t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Käck H,Gibson KJ,Lindqvist Y,Schneider G

更新日期：1998-05-12 00:00:00

abstract：:In the present article we describe the design and evaluation of a synthetic receptor that binds to the exterior surface of chymotrypsin and disrupts its interaction with proteinaceous inhibitors, such as soybean trypsin inhibitor, basic pancreatic trypsin inhibitor, ovomucoid turkey inhibitor, and Bowman-Birk inhibito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park HS,Lin Q,Hamilton AD

更新日期：2002-04-16 00:00:00

abstract：:Ezrin and moesin are components of actin-rich cell surface structures that are thought to function as membrane-cytoskeletal linking proteins. Here we show that a stable complex of ezrin and moesin can be isolated from cultured cells by immunoprecipitation with specific antibodies. The capacity of these two proteins to...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gary R,Bretscher A

更新日期：1993-11-15 00:00:00

abstract：:The fah1 mutant of Arabidopsis is defective in the accumulation of sinapic acid-derived metabolites, including the guaiacyl-syringyl lignin typical of angiosperms. Earlier results indicated that the FAH1 locus encodes ferulate-5-hydroxylase (F5H), a cytochrome P450-dependent monooxygenase (P450) of the general phenylp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer K,Cusumano JC,Somerville C,Chapple CC

更新日期：1996-07-09 00:00:00

abstract：:The synthesis of the proteins laminin and collagen IV is stimulated approximately equal to 20-fold in F9 mouse teratocarcinoma stem cells after treatment of the cells with retinoic acid and N6, O2'-dibutyryl-cAMP (Bt2cAMP). A cDNA library from F9 cells treated with retinoic acid, Bt2cAMP, and theophylline (F9-R + DBC ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang SY,Gudas LJ

更新日期：1983-10-01 00:00:00

abstract：:Humans are consciously aware of some memories and can make verbal reports about these memories. Other memories cannot be brought to consciousness, even though they influence behavior. This conspicuous difference in access to memories is central in taxonomies of human memory systems but has been difficult to document i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hampton RR

更新日期：2001-04-24 00:00:00

abstract：:Protein synthesis in all living organisms occurs on ribonucleoprotein particles, called ribosomes. Despite the universality of this process, eukaryotic ribosomes are significantly larger in size than their bacterial counterparts due in part to the presence of 80 r proteins rather than 54 in bacteria. Using cryoelectro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Armache JP,Jarasch A,Anger AM,Villa E,Becker T,Bhushan S,Jossinet F,Habeck M,Dindar G,Franckenberg S,Marquez V,Mielke T,Thomm M,Berninghausen O,Beatrix B,Söding J,Westhof E,Wilson DN,Beckmann R

更新日期：2010-11-16 00:00:00

abstract：:V79 Chinese hamster fibroblasts are widely used for mutagenicity testing but have the serious limitation that they do not express cytochromes P-450, which are needed for the activation of many promutagens to mutagenic metabolites. A full-length cDNA clone encoding the monooxygenase cytochrome P-450IIB1 under control o...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Doehmer J,Dogra S,Friedberg T,Monier S,Adesnik M,Glatt H,Oesch F

更新日期：1988-08-01 00:00:00

abstract：:A tetramer of the Mu transposase (MuA) pairs the recombination sites, cleaves the donor DNA, and joins these ends to a target DNA by strand transfer. Juxtaposition of the recombination sites is accomplished by the assembly of a stable synaptic complex of MuA protein and Mu DNA. This initial critical step is facilitate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Clubb RT,Mizuuchi M,Huth JR,Omichinski JG,Savilahti H,Mizuuchi K,Clore GM,Gronenborn AM

更新日期：1996-02-06 00:00:00

abstract：:The scaling of respiratory metabolism with body mass is one of the most pervasive phenomena in biology. Using a single allometric equation to characterize empirical scaling relationships and to evaluate alternative hypotheses about mechanisms has been controversial. We developed a method to directly measure respiratio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mori S,Yamaji K,Ishida A,Prokushkin SG,Masyagina OV,Hagihara A,Hoque AT,Suwa R,Osawa A,Nishizono T,Ueda T,Kinjo M,Miyagi T,Kajimoto T,Koike T,Matsuura Y,Toma T,Zyryanova OA,Abaimov AP,Awaya Y,Araki MG,Kawasaki T

更新日期：2010-01-26 00:00:00

abstract：:The phytochrome family of informational photoreceptors has a central role in regulating light-responsive gene expression, but the mechanism of intracellular signal transduction has remained elusive. In a genetic screen for T DNA-tagged Arabidopsis mutants affected in early signaling intermediates, we identified poc1 (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halliday KJ,Hudson M,Ni M,Qin M,Quail PH

更新日期：1999-05-11 00:00:00

abstract：:Severe burn trauma is generally followed by a catabolic response that leads to muscle wasting and weakness affecting skeletal musculature. Here, we perform whole-genome expression and in vivo NMR spectroscopy studies to define respectively the full set of burn-induced changes in skeletal muscle gene expression and the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Padfield KE,Astrakas LG,Zhang Q,Gopalan S,Dai G,Mindrinos MN,Tompkins RG,Rahme LG,Tzika AA

更新日期：2005-04-12 00:00:00

abstract：:Prenatal unilateral enucleation in mammals causes an extensive anatomical reorganization of visual pathways. The remaining eye innervates the entire extent of visual subcortical and cortical areas. Electrophysiological recordings have shown that the retino-geniculate connections are retinotopically organized and genic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bisti S,Trimarchi C

更新日期：1993-12-01 00:00:00

abstract：:To investigate the earliest steps of the intrinsic clotting pathway, Hageman factor (Factor XII) was exposed to Sephadex gels to which ellagic acid had been adsorbed; Hageman factor was then separated from the gels and studied in the fluid phase. Sephadex-ellagic acid-exposed Hageman factor, whether purified or in pla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ratnoff OD,Saito H

更新日期：1979-02-01 00:00:00

abstract：:The all-cis hexose D-allose, fed to hamster fibroblast cultures over 14-20 hr, brings about a striking down-regulation of hexose transport. This down-regulation by allose is inhibited by 2,4-dinitrophenol. By using D-[14C]allose and thin-layer chromatography, two types of products accumulated that have been identified...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ullrey DB,Kalckar HM

更新日期：1991-02-15 00:00:00

abstract：:The matrix 2 (M2) protein from influenza A virus is a proton channel that uses His37 as a selectivity filter. Here we report high-resolution (1.10 Å) cryogenic crystallographic structures of the transmembrane domain of M2 at low and high pH. These structures reveal that waters within the pore form hydrogen-bonded netw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomaston JL,Alfonso-Prieto M,Woldeyes RA,Fraser JS,Klein ML,Fiorin G,DeGrado WF

更新日期：2015-11-17 00:00:00

abstract：:Hybridoma technology was used for preparation of murine monoclonal antibodies of high titer against bone-Gla protein and osteonectin. A procedure of immunization and hybridization similar to that already described [Katzmann, J.A., Nesheim, M.E., Hibbard, L.S. & Mann, K.G. (1981) Proc. Natl. Acad. Sci. USA 78, 162-166;...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stenner DD,Romberg RW,Tracy RP,Katzmann JA,Riggs BL,Mann KG

更新日期：1984-05-01 00:00:00