Rhesus monkeys know when they remember.

abstract：:The mechanism of phosphosylation and dephosphorylation of spectrin from human erythrocyte membranes has been examined under closely physiological conditions. The results support the hypothesis that spectrin is an autophosphorylating and dephosphorylating system. (i) Extraction from ghosts of up to 85% of the kinase (c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Imhof BA,Acha-Orbea HJ,Libermann TA,Reber BF,Lanz JH,Winterhalter KH,Birchmeier W

更新日期：1980-06-01 00:00:00

abstract：:Using an antibody highly specific for D-serine conjugated to glutaraldehyde, we have localized endogenous D-serine in rat brain. Highest levels of D-serine immunoreactivity occur in the gray matter of the cerebral cortex, hippocampus, anterior olfactory nucleus, olfactory tubercle, and amygdala. Localizations of D-ser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schell MJ,Molliver ME,Snyder SH

更新日期：1995-04-25 00:00:00

abstract：:We have investigated whether glycosylation of membrane glycoproteins is a determinant of the site of maturation of enveloped viruses in Madin-Darby canine kidney (MDCK) cells. In MDCK cell monolayers, vesicular stomatitis virus buds exclusively from the basal or lateral plasma membranes and contains a sialylated glyco...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Roth MG,Fitzpatrick JP,Compans RW

更新日期：1979-12-01 00:00:00

abstract：:Global change drivers (GCDs) are expected to alter community structure and consequently, the services that ecosystems provide. Yet, few experimental investigations have examined effects of GCDs on plant community structure across multiple ecosystem types, and those that do exist present conflicting patterns. In an unp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Komatsu KJ,Avolio ML,Lemoine NP,Isbell F,Grman E,Houseman GR,Koerner SE,Johnson DS,Wilcox KR,Alatalo JM,Anderson JP,Aerts R,Baer SG,Baldwin AH,Bates J,Beierkuhnlein C,Belote RT,Blair J,Bloor JMG,Bohlen PJ,Bork EW

更新日期：2019-09-03 00:00:00

abstract：:Oxidative stress is known to cause tumorigenesis through induction of DNA and lipid damage. It also promotes cancer progression through a largely unknown mechanism. Sulfiredoxin (Srx) is a novel oxidative stress-induced antioxidant protein whose function in tumorigenesis and cancer progression has not been well studie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wei Q,Jiang H,Xiao Z,Baker A,Young MR,Veenstra TD,Colburn NH

更新日期：2011-04-26 00:00:00

abstract：:Calcium oscillations suppress mitochondrial movements along the microtubules to support on-demand distribution of mitochondria. To activate this mechanism, Ca(2+) targets a yet unidentified cytoplasmic factor that does not seem to be a microtubular motor or a kinase/phosphatase. Here, we have studied the dependence of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saotome M,Safiulina D,Szabadkai G,Das S,Fransson A,Aspenstrom P,Rizzuto R,Hajnóczky G

更新日期：2008-12-30 00:00:00

abstract：:This perspective addresses recent advances in lipid transport across the Gram-negative inner and outer membranes. While we include a summary of previously existing literature regarding this topic, we focus on the maintenance of lipid asymmetry (Mla) pathway. Discovered in 2009 by the Silhavy group [J. C. Malinverni, T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Powers MJ,Trent MS

更新日期：2019-08-27 00:00:00

abstract：:The sources of human germline mutations are poorly understood. Part of the difficulty is that mutations occur very rarely, and so direct pedigree-based approaches remain limited in the numbers that they can examine. To address this problem, we consider the spectrum of low-frequency variants in a dataset (Genome Aggreg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Agarwal I,Przeworski M

更新日期：2019-09-03 00:00:00

abstract：:Epilepsy, a disease characterized by abnormal brain activity, is a disabling and potentially life-threatening condition for nearly 1% of the world population. Unfortunately, modulation of brain excitability using available antiepileptic drugs can have serious side effects, especially in the developing brain, and some ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Baraban SC,Southwell DG,Estrada RC,Jones DL,Sebe JY,Alfaro-Cervello C,García-Verdugo JM,Rubenstein JL,Alvarez-Buylla A

更新日期：2009-09-08 00:00:00

abstract：:Dictyostelium myosin II is activated by phosphorylation of its regulatory light chain by myosin light chain kinase A (MLCK-A), an unconventional MLCK that is not regulated by Ca2+/calmodulin. MLCK-A is activated by autophosphorylation of threonine-289 outside of the catalytic domain and by phosphorylation of threonine...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silveira LA,Smith JL,Tan JL,Spudich JA

更新日期：1998-10-27 00:00:00

abstract：:Plant morphogenesis requires coordinated cytoplasmic growth, oriented cell wall extension, and cell cycle progression, but it is debated which of these processes are primary drivers for tissue growth and directly targeted by developmental genes. Here, we used ChIP high-throughput sequencing combined with transcriptome...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schiessl K,Muiño JM,Sablowski R

更新日期：2014-02-18 00:00:00

abstract：:Listeria monocytogenes is an intracellular parasite that can readily infect the macrophage-like cell line J774 and the kidney epithelial cell PtK2. After being ingested, the organism escapes from the phagolysosome into the host-cell cytoplasm. N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)-phallacidin, a specific stain for act...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dabiri GA,Sanger JM,Portnoy DA,Southwick FS

更新日期：1990-08-01 00:00:00

abstract：:Cry proteins produced by Bacillus thuringiensis are selective biodegradable insecticides used increasingly in bacterial insecticides and transgenic plants as alternatives to synthetic chemical insecticides. However, the potential for development of resistance and cross-resistance in target insect populations to Cry pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wirth MC,Georghiou GP,Federici BA

更新日期：1997-09-30 00:00:00

abstract：:Cooperativity in oligonucleotide-directed sequence-specific recognition of DNA by triple helix formation can be enhanced by the addition of discrete dimerization domains. The equilibrium association constants for cooperative binding of oligonucleotides that dimerize by Watson-Crick hydrogen bonds and occupy adjacent s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Distefano MD,Dervan PB

更新日期：1993-02-15 00:00:00

abstract：:Regulation of the turnover of triglycerides in adipose tissue requires the continuous provision of 3-glycerophosphate, which may be supplied by the metabolism of glucose or by glyceroneogenesis, the de novo synthesis of 3-glycerophosphate from sources other than hexoses or glycerol. The importance of glyceroneogenesis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Olswang Y,Cohen H,Papo O,Cassuto H,Croniger CM,Hakimi P,Tilghman SM,Hanson RW,Reshef L

更新日期：2002-01-22 00:00:00

abstract：:The human epidermal growth factor receptor (EGFR) is a key representative of tyrosine kinase receptors, ubiquitous actors in cell signaling, proliferation, differentiation, and migration. Although the receptor is well-studied, a central issue remains: How does the compositional diversity and functional diversity of th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coskun Ü,Grzybek M,Drechsel D,Simons K

更新日期：2011-05-31 00:00:00

abstract：:Cyclophilins are a family of proteins that bind cyclosporin A (CsA) and possess peptidyl-prolyl cis-trans isomerase activity. In addition, they are secreted by activated cells and act in a cytokine-like manner, presumably via signaling through a cell surface cyclophilin receptor. More recently, host-derived cyclophili...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sherry B,Zybarth G,Alfano M,Dubrovsky L,Mitchell R,Rich D,Ulrich P,Bucala R,Cerami A,Bukrinsky M

更新日期：1998-02-17 00:00:00

abstract：:Egg activation is the process in which mature oocytes are released from developmental arrest and gain competency for embryonic development. In Drosophila and other arthropods, eggs are activated by mechanical pressure in the female reproductive tract, whereas in most other species, eggs are activated by fertilization....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Q,Wolfner MF

更新日期：2019-09-17 00:00:00

abstract：:Identifying potentially unique features of the human cerebral cortex is a first step to understanding how evolution has shaped the brain in our species. By analyzing MR images obtained from 177 humans and 73 chimpanzees, we observed a human-specific asymmetry in the superior temporal sulcus at the heart of the communi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Leroy F,Cai Q,Bogart SL,Dubois J,Coulon O,Monzalvo K,Fischer C,Glasel H,Van der Haegen L,Bénézit A,Lin CP,Kennedy DN,Ihara AS,Hertz-Pannier L,Moutard ML,Poupon C,Brysbaert M,Roberts N,Hopkins WD,Mangin JF,Dehaene-

更新日期：2015-01-27 00:00:00

abstract：:Alphavirus envelope proteins, organized as trimers of E2-E1 heterodimers on the surface of the pathogenic alphavirus, mediate the low pH-triggered fusion of viral and endosomal membranes in human cells. The lack of specific treatment for alphaviral infections motivates our exploration of potential antiviral approaches...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeng X,Mukhopadhyay S,Brooks CL 3rd

更新日期：2015-02-17 00:00:00

abstract：:Interaction of syntaxin 1 with the alpha(1D) subunit of the voltage-gated L type Ca(2+) channel was investigated in the pancreatic beta cell. Coexpression of the enhanced green fluorescent protein-linked alpha(1D) subunit with the enhanced blue fluorescent protein-linked syntaxin 1 and Western blot analysis together w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang SN,Larsson O,Bränström R,Bertorello AM,Leibiger B,Leibiger IB,Moede T,Köhler M,Meister B,Berggren PO

更新日期：1999-08-31 00:00:00

abstract：:Nuclear lamins are components of the nuclear lamina, a structural scaffolding for the cell nucleus. Defects in lamins A and C cause an array of human diseases, including muscular dystrophy, lipodystrophy, and progeria, but no diseases have been linked to the loss of lamins B1 or B2. To explore the functional relevance...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Coffinier C,Chang SY,Nobumori C,Tu Y,Farber EA,Toth JI,Fong LG,Young SG

更新日期：2010-03-16 00:00:00

abstract：:Antisense RNA to the 27/32-kDa rat liver gap junction (GJ) protein was used to explore the role of GJs in preimplantation embryos. When all blastomeres of two- and four-cell embryos were injected with GJ antisense RNA, the percentage of embryos compacted at 60 hr of development was reduced to less than 20%, while 90% ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bevilacqua A,Loch-Caruso R,Erickson RP

更新日期：1989-07-01 00:00:00

abstract：:Calcium signaling pathways control a variety of cellular events such as gene transcription, protein phosphorylation, nucleotide metabolism, and ion transport. These pathways often involve a large number of calcium-binding proteins collectively known as the calmodulin or EF-hand protein superfamily. Many EF-hand protei...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ikura M,Ames JB

更新日期：2006-01-31 00:00:00

abstract：:Groundwater-dependent species are among the least-known components of global biodiversity, as well as some of the most vulnerable because of rapid groundwater depletion at regional and global scales. The karstic Edwards-Trinity aquifer system of west-central Texas is one of the most species-rich groundwater systems in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Devitt TJ,Wright AM,Cannatella DC,Hillis DM

更新日期：2019-02-12 00:00:00

abstract：:The DNA-binding domain of c-Myb consists of three homologous tandem repeats of 52 amino acids. The structure of the third (C-terminal) repeat obtained by NMR analysis has a conformation related to the helix-turn-helix motif. To identify the role of each repeat in the sequence recognition of DNA, we analyzed specific i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tanikawa J,Yasukawa T,Enari M,Ogata K,Nishimura Y,Ishii S,Sarai A

更新日期：1993-10-15 00:00:00

abstract：:Conflict between groups of individuals is a prevalent feature in human societies. A common theoretical explanation for intergroup conflict is that it provides benefits to individuals within groups in the form of reproduction-enhancing resources, such as food, territory, or mates. However, it is not always the case tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Henriques GJB,Simon B,Ispolatov Y,Doebeli M

更新日期：2019-07-09 00:00:00

abstract：:Polycyclic aromatic hydrocarbons and related species have been suggested to play a key role in the astrochemical evolution of the interstellar medium, but the formation mechanism of even their simplest building block--the aromatic benzene molecule--has remained elusive for decades. Here we demonstrate in crossed molec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones BM,Zhang F,Kaiser RI,Jamal A,Mebel AM,Cordiner MA,Charnley SB

更新日期：2011-01-11 00:00:00

abstract：:Mechanical injury to the adult mammalian spinal cord results in permanent loss of structural integrity at the lesion site and of the brain-controlled function distal to the lesion. Some of these consequences were permanently averted by altering the cellular constituents at the lesion site with x-irradiation delivered ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kalderon N,Fuks Z

更新日期：1996-10-01 00:00:00

abstract：:Benzophenones are among the most useful photocrosslinking agents in biology. We have evolved an orthogonal aminoacyl-tRNA synthetase/tRNA pair that makes possible the in vivo incorporation of p-benzoyl-l-phenylalanine into proteins in Escherichia coli in response to the amber codon, TAG. This unnatural amino acid was ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chin JW,Martin AB,King DS,Wang L,Schultz PG

更新日期：2002-08-20 00:00:00