Weak compactness and control measures in the space of unbounded measures.

abstract：:Half-cystine peptic peptides representing the intrachain disulfide bonds of the light chain from an apparently homogeneous rabbit anti-p-azobenzoate antibody were isolated in good yields after reduction and alkylation with [(14)C]iodoacetate, and their sequences were determined. The sequence of the first 21 amino-term...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Appella E,Chersi A,Roholt OA,Pressman D

更新日期：1971-10-01 00:00:00

abstract：:A cell line has been developed from the imaginal wing discs of the lepidopteran insect Trichoplusia ni (Hübner). The cells grow in suspension as fluid-filled, multicellular vesicles. The cell line has been designated IAL-TND1. Two-dimensional electrophoresis (isoelectric focusing and sodium dodecyl sulfate/polyacrylam...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lynn DE,Miller SG,Oberlander H

更新日期：1982-04-01 00:00:00

abstract：:The density of cells and neurons in the neocortex of many mammals varies across cortical areas and regions. This variability is, perhaps, most pronounced in primates. Nonuniformity in the composition of cortex suggests regions of the cortex have different specializations. Specifically, regions with densely packed neur...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Collins CE,Turner EC,Sawyer EK,Reed JL,Young NA,Flaherty DK,Kaas JH

更新日期：2016-01-19 00:00:00

abstract：:Suppressor T cells have been shown to be much more radiosensitive than other lymphoïd cells, and we have tried to reduce tumor growth by low-dose irradiation. Syngeneic DBA/2 mice received whole-body irradiation (150 rads; 1 rad = 0.01 J/kg) 6 days after P815 tumor inoculation. Tumor growth is significantly reduced in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tilkin AF,Schaaf-Lafontaine N,Van Acker A,Boccadoro M,Urbain J

更新日期：1981-03-01 00:00:00

abstract：:Melanopsin, the photopigment of the "circadian" receptors that regulate the biological clock and the pupillary reflex in mammals, is homologous to invertebrate rhodopsins. Evidence supporting the involvement of phosphoinositides in light-signaling has been garnered, but the downstream effectors that control the light-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Peinado G,Osorno T,Gomez Mdel P,Nasi E

更新日期：2015-06-23 00:00:00

abstract：:Voltage-gated sodium (Na(V)) and potassium (K(V)) channels are critical components of neuronal action potential generation and propagation. Here, we report that Na(V)β1 encoded by SCN1b, an integral subunit of Na(V) channels, coassembles with and modulates the biophysical properties of K(V)1 and K(V)7 channels, but no...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nguyen HM,Miyazaki H,Hoshi N,Smith BJ,Nukina N,Goldin AL,Chandy KG

更新日期：2012-11-06 00:00:00

abstract：:Previous studies have failed to detect an interaction between monomeric soluble CD4 (sCD4) and class II major histocompatibility complex (MHC) proteins, suggesting that oligomerization of CD4 on the cell surface may be required to form a stable class II MHC binding site. To test this possibility, we transfected the F4...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sakihama T,Smolyar A,Reinherz EL

更新日期：1995-07-03 00:00:00

abstract：:The ability of a series of anions to inhibit [(3)H]strychnine binding to spinal cord synaptic membranes correlates closely with their neurophysiologic capacity to reverse inhibitory postsynaptic potentials in the mammalian spinal cord. Seven neurophysiologically active anions are also effective inhibitors of [(3)H]str...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Young AB,Snyder SH

更新日期：1974-10-01 00:00:00

abstract：:G-protein-coupled receptors (GPCRs) have recently joined the list of cell surface receptors that dimerize. Dimerization has been shown to alter the ligand-binding, signaling, and trafficking properties of these receptors. Recent studies have shown that GPCRs heterodimerize with closely related members, resulting in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jordan BA,Trapaidze N,Gomes I,Nivarthi R,Devi LA

更新日期：2001-01-02 00:00:00

abstract：:Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a potent endogenous activator of the cell death pathway and functions by activating the cell surface death receptors 4 and 5 (DR4 and DR5). TRAIL is nontoxic in vivo and preferentially kills neoplastically transformed cells over normal cells by an unde...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chinnaiyan AM,Prasad U,Shankar S,Hamstra DA,Shanaiah M,Chenevert TL,Ross BD,Rehemtulla A

更新日期：2000-02-15 00:00:00

abstract：:The helicity in water has been determined for several series of alanine-rich peptides that contain single lysine residues and that are N-terminally linked to a helix-inducing and reporting template termed Ac-Hel1. The helix-propagating constant for alanine (sAla value) that best fits the properties of these peptides l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Groebke K,Renold P,Tsang KY,Allen TJ,McClure KF,Kemp DS

更新日期：1996-04-30 00:00:00

abstract：:Clostridium perfringens iota-toxin (Ia) mono-ADP ribosylates Arg177 of actin, leading to cytoskeletal disorganization and cell death. To fully understand the reaction mechanism of arginine-specific mono-ADP ribosyl transferase, the structure of the toxin-substrate protein complex must be characterized. Recently, we so...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tsurumura T,Tsumori Y,Qiu H,Oda M,Sakurai J,Nagahama M,Tsuge H

更新日期：2013-03-12 00:00:00

abstract：:Here we test the hypothesis that high-altitude native resident Tibetan women with genotypes for high oxygen saturation of hemoglobin, and thus less physiological hypoxic stress, have higher Darwinian fitness than women with low oxygen saturation genotypes. Oxygen saturation and genealogical data were collected from re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beall CM,Song K,Elston RC,Goldstein MC

更新日期：2004-09-28 00:00:00

abstract：:The mammalian innate immune system uses several sensors of double-stranded RNA (dsRNA) to develop the interferon response. Among these sensors are dsRNA-activated oligoadenylate synthetases (OAS), which produce signaling 2',5'-linked RNA molecules (2-5A) that activate regulated RNA decay in mammalian tissues. Differen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Donovan J,Whitney G,Rath S,Korennykh A

更新日期：2015-03-31 00:00:00

abstract：:Microtubules (MTs) are polymers assembled from αβ-tubulin heterodimers that display the hallmark behavior of dynamic instability. MT dynamics are driven by GTP hydrolysis within the MT lattice, and are highly regulated by a number of MT-associated proteins (MAPs). How MAPs affect MTs is still not fully understood, par...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang R,LaFrance B,Nogales E

更新日期：2018-07-03 00:00:00

abstract：:In this study we sought to better understand the role of the glycoprotein quality control machinery in the assembly of MHC class I molecules with high-affinity peptides. The lectin-like chaperone calreticulin (CRT) and the thiol oxidoreductase ERp57 participate in the final step of this process as part of the peptide-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wearsch PA,Peaper DR,Cresswell P

更新日期：2011-03-22 00:00:00

abstract：:In the antennal lobe of Drosophila, information about odors is transferred from olfactory receptor neurons (ORNs) to projection neurons (PNs), which then send axons to neurons in the lateral horn of the protocerebrum (LHNs) and to Kenyon cells (KCs) in the mushroom body. The transformation from ORN to PN responses can...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Luo SX,Axel R,Abbott LF

更新日期：2010-06-08 00:00:00

abstract：:Low-dimensional objects such as molecular strands, ladders, and sheets have intrinsic features that affect their propensity to fold into 3D objects. Understanding this relationship remains a challenge for de novo design of functional structures. Using molecular dynamics simulations, we investigate the refolding of the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dodd PM,Damasceno PF,Glotzer SC

更新日期：2018-07-17 00:00:00

abstract：:The ability to control drops and their movements on phobic surfaces is important in printing or patterning, microfluidic devices, and water-repellent materials. These materials are always micro-/nanotextured, and a natural limitation of repellency occurs when drops are small enough (as in a dew) to get trapped in the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Q,Yao X,Liu H,Quéré D,Jiang L

更新日期：2015-07-28 00:00:00

abstract：:The major late transcriptional unit of adenovirus type 2 has served as a model for studying transcription in eukaryotes. We report that pausing and premature termination are intrinsic to the transcription of this transcriptional unit by RNA polymerase II. In vivo and in isolated nuclei, transcription pauses at discret...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maderious A,Chen-Kiang S

更新日期：1984-10-01 00:00:00

abstract：:Grasslands cover more than 20% of the Earth's terrestrial surface, and their rise to dominance is one of the most dramatic events of biome evolution in Earth history. Grasses possess two main photosynthetic pathways: the C(3) pathway that is typical of most plants and a specialized C(4) pathway that minimizes photores...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Edwards EJ,Smith SA

更新日期：2010-02-09 00:00:00

abstract：:In the replication of human immunodeficiency virus type 1 (HIV-1), gag MA (matrix), a major structural protein of the virus, carries out opposing targeting functions. During virus assembly, gag MA is cotranslationally myristoylated, a modification required for membrane targeting of gag polyproteins. During virus infec...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bukrinskaya AG,Ghorpade A,Heinzinger NK,Smithgall TE,Lewis RE,Stevenson M

更新日期：1996-01-09 00:00:00

abstract：:The fluorescence of the supposedly buried tryptophan in ribonuclease T1 has been found to be collisionally quenched by acrylamide with a rate constant of 3 X 10(8) M--1 sec--1. Only a slight decrease in the quenching rate is observed upon a 5-fold increase in the viscosity of the solution. For this to be the case, the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eftink MR,Ghiron CA

更新日期：1975-09-01 00:00:00

abstract：:A major function of innate immune receptors is to recognize pathogen-associated molecular patterns and then evoke immune responses appropriate to the nature of the invading pathogen(s). Because innate immune cells express various types of these receptors, distinct combinations of signaling pathways are activated in re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Negishi H,Matsuki K,Endo N,Sarashina H,Miki S,Matsuda A,Fukazawa K,Taguchi-Atarashi N,Ikushima H,Yanai H,Nishio J,Honda K,Fujioka Y,Ohba Y,Noda T,Taniguchi S,Nishida E,Zhang Y,Chi H,Flavell RA,Taniguchi T

更新日期：2013-12-03 00:00:00

abstract：:The [A] allele of SNP rs965513 in 9q22 has been consistently shown to be highly associated with increased papillary thyroid cancer (PTC) risk with an odds ratio of ∼1.8 as determined by genome-wide association studies, yet the molecular mechanisms remain poorly understood. Previously, we noted that the expression of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： He H,Li W,Liyanarachchi S,Srinivas M,Wang Y,Akagi K,Wang Y,Wu D,Wang Q,Jin V,Symer DE,Shen R,Phay J,Nagy R,de la Chapelle A

更新日期：2015-05-12 00:00:00

abstract：:L-Fucose and D-galactose in low concentrations (0.27 or 2.7 mM) inhibited the induction of active Na+ channels in mouse and human neuroblastoma cells when the monosaccharides were added to the culture medium for 4 days with the inducing agent dimethyl sulfoxide. Active Na+ ionophores were determined by measurement of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giovanni MY,Kessel D,Glick MC

更新日期：1981-02-01 00:00:00

abstract：:Acetylcholinesterase of intact red blood cell membranes and the acetylcholine receptor at the neuromuscular junction of whole-frog sartorius muscle have been irreversibly inactivated by photo-affinity labeling with two quaternary ammonium aryl azides. The inactivation requires that the azides, at the time of their pho...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kiefer H,Lindstrom J,Lennox ES,Singer SJ

更新日期：1970-12-01 00:00:00

abstract：:Selected aspects of the evolutionary process and more specifically of the genetic variation are considered, with an emphasis in studies performed by my group. One key aspect of evolution seems to be the concomitant occurrence of dichotomic, contradictory (dialect) processes. Genetic variation is structured, and the dy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Salzano FM

更新日期：2000-05-09 00:00:00

abstract：:The yeast SIN1 protein is a nuclear protein that together with other proteins behaves as a transcriptional repressor of a family of genes. In addition, sin1 mutants are defective in proper mitotic chromosome segregation. In an effort to understand the basis for these phenotypes, we employed the yeast two-hybrid system...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shpungin S,Liberzon A,Bangio H,Yona E,Katcoff DJ

更新日期：1996-08-06 00:00:00

abstract：:We simulated the behavior of suspended carbon nanotube resonators over a broad range of temperatures to explore the physics of semiflexible polymers in underdamped environments. We find that thermal fluctuations induce strong coupling between resonance modes. This effect leads to spectral fluctuations that readily acc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barnard AW,Sazonova V,van der Zande AM,McEuen PL

更新日期：2012-11-20 00:00:00