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The glycine synaptic receptor: evidence that strychnine binding is associated with the ionic conductance mechanism.

Abstract：

:The ability of a series of anions to inhibit [(3)H]strychnine binding to spinal cord synaptic membranes correlates closely with their neurophysiologic capacity to reverse inhibitory postsynaptic potentials in the mammalian spinal cord. Seven neurophysiologically active anions are also effective inhibitors of [(3)H]strychnine binding with mean effective doses ranging from 160 to 620 mM. Seven other anions that are ineffective neurophysiologically also fail to alter strychnine binding. Chloride inhibits strychnine binding in a noncompetitive fashion. Hill plots of the displacement of [(3)H]strychnine by chloride give coefficients of 2.3-2.7. The inhibition of strychnine binding by these anions suggests that strychnine binding is closely associated with the ionic conductance mechanism for chloride in the glycine receptor.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Young AB,Snyder SH

doi

10.1073/pnas.71.10.4002

subject

Has Abstract

pub_date

1974-10-01 00:00:00

pages

4002-5

issue

10

eissn

0027-8424

issn

1091-6490

journal_volume

71

pub_type

杂志文章

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