Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy.

abstract：:Oriented assemblies of small crystals forming larger structures are common in nature and crucial for forthcoming technologies as they circumvent the difficulties of structural manipulation at microscopic scale. We have discovered two distinctive concentric assemblies of zinc oxide rods, wherein each rod has an intrins...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gautam UK,Imura M,Rout CS,Bando Y,Fang X,Dierre B,Sakharov L,Govindaraj A,Sekiguchi T,Golberg D,Rao CN

更新日期：2010-08-03 00:00:00

abstract：:Soot particles produced by incomplete combustion processes are one of the major components of urban air pollution. Chemistry at their surfaces lead to the heterogeneous conversion of several key trace gases; for example NO(2) interacts with soot and is converted into HONO, which rapidly photodissociates to form OH in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Monge ME,D'Anna B,Mazri L,Giroir-Fendler A,Ammann M,Donaldson DJ,George C

更新日期：2010-04-13 00:00:00

abstract：:In the presence of the nucleotide analog adenosine 5'-[gamma-thio]triphosphate (ATP[gamma S]), effects of Ca2+ on stiffness and equatorial x-ray diffraction patterns of single skinned fibers of the rabbit psoas muscle were studied. It is shown that cross-bridges in the presence of ATP[gamma S] have properties of the w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraft T,Yu LC,Kuhn HJ,Brenner B

更新日期：1992-12-01 00:00:00

abstract：:Complement membrane attack complexes (MACs) promote inflammatory functions in endothelial cells (ECs) by stabilizing NF-κB-inducing kinase (NIK) and activating noncanonical NF-κB signaling. Here we report a novel endosome-based signaling complex induced by MACs to stabilize NIK. We found that, in contrast to cytokine-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jane-wit D,Surovtseva YV,Qin L,Li G,Liu R,Clark P,Manes TD,Wang C,Kashgarian M,Kirkiles-Smith NC,Tellides G,Pober JS

更新日期：2015-08-04 00:00:00

abstract：:We report a simplified method for culturing fetal central nervous system cells predominantly inducing neurons that grow, differentiate, and live in vitro for as long as 10 weeks. These central nervous system cells form a confluent cell culture in which about 80% of the cells are fully differentiated neurons producing ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sotelo J,Gibbs CJ Jr,Gajdusek DC,Toh BH,Wurth M

更新日期：1980-01-01 00:00:00

abstract：:Staphylococcus aureus colonizes the skin of the majority of patients with atopic dermatitis (AD), and its presence increases disease severity. Adhesion of S. aureus to corneocytes in the stratum corneum is a key initial event in colonization, but the bacterial and host factors contributing to this process have not bee...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Towell AM,Feuillie C,Vitry P,Da Costa TM,Mathelié-Guinlet M,Kezic S,Fleury OM,McAleer MA,Dufrêne YF,Irvine AD,Geoghegan JA

更新日期：2021-01-05 00:00:00

abstract：:The image that best expresses Darwin's thinking is the tree of life. However, Darwin's human evolutionary tree lacked almost everything because only the Neanderthals were known at the time and they were considered one extreme expression of our own species. Darwin believed that the root of the human tree was very deep ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arsuaga JL

更新日期：2010-05-11 00:00:00

abstract：:What can be done to reduce unhealthy eating among adolescents? It was hypothesized that aligning healthy eating with important and widely shared adolescent values would produce the needed motivation. A double-blind, randomized, placebo-controlled experiment with eighth graders (total n = 536) evaluated the impact of a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bryan CJ,Yeager DS,Hinojosa CP,Chabot A,Bergen H,Kawamura M,Steubing F

更新日期：2016-09-27 00:00:00

abstract：:The soil-transmitted helminths or nematodes (hookworms, whipworms, and Ascaris) are roundworms that infect more than 1 billion of the poorest peoples and are leading causes of morbidity worldwide. Few anthelmintics are available for treatment, and only one is commonly used in mass drug administrations. New anthelminti...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu Y,Platzer EG,Bellier A,Aroian RV

更新日期：2010-03-30 00:00:00

abstract：:Cells of the human embryonic stem (hES) cell line H9, when cultured in the form of embryoid bodies, give rise to cells with markers of the keratinocyte of stratified squamous epithelia. Keratinocytes also form in nodules produced in scid mice by injected H9 cells; the hES-derived keratinocytes could be recovered in cu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Iuchi S,Dabelsteen S,Easley K,Rheinwald JG,Green H

更新日期：2006-02-07 00:00:00

abstract：:Functional activity of N-methyl-D-aspartate (NMDA) receptors requires both glutamate binding and the binding of an endogenous coagonist that has been presumed to be glycine, although D-serine is a more potent agonist. Localizations of D-serine and it biosynthetic enzyme serine racemase approximate the distribution of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mothet JP,Parent AT,Wolosker H,Brady RO Jr,Linden DJ,Ferris CD,Rogawski MA,Snyder SH

更新日期：2000-04-25 00:00:00

abstract：:The detection, stabilization, and repair of stress-induced damage are essential requirements for cellular life. All cells respond to osmotic stress-induced water loss with increased expression of genes that mediate accumulation of organic osmolytes, solutes that function as chemical chaperones and restore osmotic home...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lamitina T,Huang CG,Strange K

更新日期：2006-08-08 00:00:00

abstract：:The structure of the proline-specific aminopeptidase (EC 3.4.11.9) from Escherichia coli has been solved and refined for crystals of the native enzyme at a 2.0-A resolution, for a dipeptide-inhibited complex at 2.3-A resolution, and for a low-pH inactive form at 2.7-A resolution. The protein crystallizes as a tetramer...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wilce MC,Bond CS,Dixon NE,Freeman HC,Guss JM,Lilley PE,Wilce JA

更新日期：1998-03-31 00:00:00

abstract：:Animals treated with potent gamma-glutamyl transpeptidase inhibitors and a patient with severe gamma-glutamyl transpeptidase deficiency excrete much larger than normal amounts of glutathione, gamma-glutamylcysteine, and cysteine in their urine; these compounds were found in disulfide forms. The findings indicate that ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffith OW,Meister A

更新日期：1980-06-01 00:00:00

abstract：:High-quality and high-throughput prediction of enzyme commission (EC) numbers is essential for accurate understanding of enzyme functions, which have many implications in pathologies and industrial biotechnology. Several EC number prediction tools are currently available, but their prediction performance needs to be f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ryu JY,Kim HU,Lee SY

更新日期：2019-07-09 00:00:00

abstract：:We used electron cryotomography and subtomogram averaging to determine the in situ structures of mitochondrial ATP synthase dimers from two organisms belonging to the phylum euglenozoa: Trypanosoma brucei, a lethal human parasite, and Euglena gracilis, a photosynthetic protist. At a resolution of 32.5 Å and 27.5 Å, re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mühleip AW,Dewar CE,Schnaufer A,Kühlbrandt W,Davies KM

更新日期：2017-01-31 00:00:00

abstract：:There are defined medullary, mesencephalic, hypothalamic, and thalamic functions in regulation of respiration, but knowledge of cortical control and the elements subserving the consciousness of breathlessness and air hunger is limited. In nine young adults, air hunger was produced acutely by CO(2) inhalation. Comparis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brannan S,Liotti M,Egan G,Shade R,Madden L,Robillard R,Abplanalp B,Stofer K,Denton D,Fox PT

更新日期：2001-02-13 00:00:00

abstract：:Neuromelanin (NM) isolated from the substantia nigra region of the human brain was studied by scanning probe and photoelectron emission microscopies. Atomic force microscopy reveals that NM granules are comprised of spherical structures with a diameter of approximately 30 nm, similar to that observed for Sepia cuttlef...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bush WD,Garguilo J,Zucca FA,Albertini A,Zecca L,Edwards GS,Nemanich RJ,Simon JD

更新日期：2006-10-03 00:00:00

abstract：:Recombinant human erythropoietin (rHuEpo) has been used successfully in the treatment of cancer-related anemia. Clinical observations with several patients with multiple-myeloma treated with rHuEpo has shown, in addition to the improved quality of life, a longer survival than expected, considering the poor prognostic ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mittelman M,Neumann D,Peled A,Kanter P,Haran-Ghera N

更新日期：2001-04-24 00:00:00

abstract：:Two anti-tumor monoclonal antibodies, L6 (anticarcinoma) and 1F5 (anti-B lymphoma), were covalently linked to alkaline phosphatase (AP), forming conjugates that could bind to the surface of antigen-positive tumor cells. The conjugates were capable of converting a relatively noncytotoxic prodrug, etoposide phosphate (E...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Senter PD,Saulnier MG,Schreiber GJ,Hirschberg DL,Brown JP,Hellström I,Hellström KE

更新日期：1988-07-01 00:00:00

abstract：:A series of small peptides corresponding to the amino termini of the fibrin alpha- and beta-chains has been synthesized. The peptides glycyl-L-prolyl-L-arginyl-L-proline and glycyl-L-prolyl-L-arginylsarcosine are potent inhibitors of fibrin polymerization. Moreover, these peptides have a natural stability stemming fro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laudano AP,Doolittle RF

更新日期：1978-07-01 00:00:00

abstract：:Although it is well described in model membranes, little is known about phase separation in biological membranes. Here, we provide evidence for a coexistence of at least two different lipid bilayer phases in the apical plasma membrane of epithelial cells. Phase connectivity was assessed by measuring long-range diffusi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meder D,Moreno MJ,Verkade P,Vaz WL,Simons K

更新日期：2006-01-10 00:00:00

abstract：:Interphotoreceptor retinoid-binding protein (IRBP) has been hypothesized to function as an intercellular shuttle in the vertebrate eye, serving to transport retinoids between the retinal pigment epithelium (RPE) and photoreceptors in the process by which visual pigment is regenerated after photolysis. This hypothesis ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Okajima TI,Pepperberg DR,Ripps H,Wiggert B,Chader GJ

更新日期：1990-09-01 00:00:00

abstract：:Sensory neurons perceive environmental cues and are important of organismal survival. Peripheral sensory neurons interact intimately with glial cells. While the function of axonal ensheathment by glia is well studied, less is known about the functional significance of glial interaction with the somatodendritic compart...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yadav S,Younger SH,Zhang L,Thompson-Peer KL,Li T,Jan LY,Jan YN

更新日期：2019-03-12 00:00:00

abstract：:Charge transport (CT) through the DNA base pairs provides a means to promote redox reactions at a remote site and potentially to effect signaling between molecules bound to DNA. Here we describe the oxidation of a cell-cycle regulatory protein, p53, from a distance through DNA-mediated CT. A consensus p53 binding site...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Augustyn KE,Merino EJ,Barton JK

更新日期：2007-11-27 00:00:00

abstract：:By patch-clamp analysis, we have shown that chronic, intermittent mechanical strain (CMS) increases the activity of stretch-activated cation channels of osteoblast-like UMR-106.01 cells. CMS also produces a swelling-activated whole-cell conductance (Gm) regulated by varying strain levels. We questioned whether the swe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Duncan RL,Kizer N,Barry EL,Friedman PA,Hruska KA

更新日期：1996-03-05 00:00:00

abstract：:Colloquium talks at prestigious universities both create and reflect academic researchers' reputations. Gender disparities in colloquium talks can arise through a variety of mechanisms. The current study examines gender differences in colloquium speakers at 50 prestigious US colleges and universities in 2013-2014. Usi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nittrouer CL,Hebl MR,Ashburn-Nardo L,Trump-Steele RCE,Lane DM,Valian V

更新日期：2018-01-02 00:00:00

abstract：:How genome divergence eventually leads to speciation is a topic of prime evolutionary interest. Genomic islands of elevated divergence are frequently reported between diverging lineages, and their size is expected to increase with time and gene flow under the speciation-with-gene-flow model. However, such islands can ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma T,Wang K,Hu Q,Xi Z,Wan D,Wang Q,Feng J,Jiang D,Ahani H,Abbott RJ,Lascoux M,Nevo E,Liu J

更新日期：2018-01-09 00:00:00

abstract：:We propose approaching prediction from a framework grounded in the theoretical correct prediction rate of a variable set as a parameter of interest. This framework allows us to define a measure of predictivity that enables assessing variable sets for, preferably high, predictivity. We first define the prediction rate ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lo A,Chernoff H,Zheng T,Lo SH

更新日期：2016-12-13 00:00:00

abstract：:Invariant natural killer T cell (NKT) cells (iNKT cells) produce both T-helper 1 (Th1) and T-helper 2 cytokines in response to α-Galactosylceramide (α-GalCer) stimulation and are thought to be the important effectors in the regulation of both innate and adaptive immunity involved in autoimmune disorders, microbial inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu TN,Lin KH,Chang YJ,Huang JR,Cheng JY,Yu AL,Wong CH

更新日期：2011-10-18 00:00:00