Dihydropyridine receptor of L-type Ca2+ channels: identification of binding domains for [3H](+)-PN200-110 and [3H]azidopine within the alpha 1 subunit.

abstract：:Chemosensory proteins (CSPs) have been proposed to transport hydrophobic chemicals from air to olfactory or taste receptors. They have been isolated from several sensory organs of a wide range of insect species. The x-ray structure of CSPMbraA6, a 112-aa antennal protein from the moth Mamestra brassicae (Mbra), was sh...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Campanacci V,Lartigue A,Hällberg BM,Jones TA,Giudici-Orticoni MT,Tegoni M,Cambillau C

更新日期：2003-04-29 00:00:00

abstract：:Antibodies against an inositol phospholipid-specific phospholipase C purified from bovine brain were used to screen rat brain lambda gt11 expression cDNA libraries. Complete sequences of three cDNA inserts yielded a cumulative sequence of 5106 base pairs. The deduced protein had 1289 amino acids with a calculated mole...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Suh PG,Ryu SH,Moon KH,Suh HW,Rhee SG

更新日期：1988-08-01 00:00:00

abstract：:Agricultural foods and technologies are thought to have eased the mechanical demands of diet-how often or how hard one had to chew-in human populations worldwide. Some evidence suggests correspondingly worldwide changes in skull shape and form across the agricultural transition, although these changes have proved diff...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Katz DC,Grote MN,Weaver TD

更新日期：2017-08-22 00:00:00

abstract：:The chemokine stromal cell-derived factor 1, SDF-1, is an important regulator of leukocyte and hematopoietic precursor migration and pre-B cell proliferation. The receptor for SDF-1, CXCR4, also functions as a coreceptor for T-tropic HIV-1 entry. We find that mice deficient for CXCR4 die perinatally and display profou...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ma Q,Jones D,Borghesani PR,Segal RA,Nagasawa T,Kishimoto T,Bronson RT,Springer TA

更新日期：1998-08-04 00:00:00

abstract：:Sprouty proteins act as intracellular inhibitors of receptor tyrosine kinase signaling. Here we show that the mammalian Sprouty2 protein contains an iron-sulfur complex that can exist in an oxidized, reduced, or nitrosylated state. Purified Sprouty2 assembles into large monodisperse spheres containing approximately 24...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Alexander PB,He Y,Kikkawa M,Vogel PD,McKnight SL

更新日期：2005-09-27 00:00:00

abstract：:A computational model is presented that can be used as a tool in the design of safer chemicals. This model predicts the rate of hydrogen-atom abstraction by cytochrome P450 enzymes. Excellent correlations between biotransformation rates and the calculated activation energies (delta Hact) of the cytochrome P450-mediate...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yin H,Anders MW,Korzekwa KR,Higgins L,Thummel KE,Kharasch ED,Jones JP

更新日期：1995-11-21 00:00:00

abstract：:Efficient 3'-end processing of cell cycle-regulated mammalian histone premessenger RNAs (pre-mRNAs) requires an upstream stem-loop and a histone downstream element (HDE) that base pairs with the U7 small ribonucleoprotein. Insertions between these elements have two effects: the site of cleavage moves in concert with t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scharl EC,Steitz JA

更新日期：1996-12-10 00:00:00

abstract：:The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of immunosuppression. We show that in human peripheral blood cells, more than 30% of Treg up-regulate CCR8 following activation in the presence of CCL1. This interaction induces STAT3-dependent up-regulation of FOXp3, CD39, IL-10, and granzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barsheshet Y,Wildbaum G,Levy E,Vitenshtein A,Akinseye C,Griggs J,Lira SA,Karin N

更新日期：2017-06-06 00:00:00

abstract：:This communication reports an analysis of Tn5/IS50 target site selection by using an extensive collection of Tn5 and IS50 insertions in two relatively small regions of DNA (less than 1 kb each). For both regions data were collected resulting from in vitro and in vivo transposition events. Since the data sets are consi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goryshin IY,Miller JA,Kil YV,Lanzov VA,Reznikoff WS

更新日期：1998-09-01 00:00:00

abstract：:We studied visual perception using an annular random-dot motion stimulus called the racetrack. We recorded neural activity using magnetoencephalography while subjects viewed variants of this stimulus that contained no inherent motion or various degrees of embedded motion. Subjects reported seeing rotary motion during ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Crowe DA,Leuthold AC,Georgopoulos AP

更新日期：2010-12-28 00:00:00

abstract：:The ability of a specialized herbivore to overcome the chemical defense of a particular plant taxon not only makes it accessible as a food source but may also provide metabolites to be exploited for communication or chemical defense. Phyllotreta flea beetles are adapted to crucifer plants (Brassicales) that are defend...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Beran F,Pauchet Y,Kunert G,Reichelt M,Wielsch N,Vogel H,Reinecke A,Svatoš A,Mewis I,Schmid D,Ramasamy S,Ulrichs C,Hansson BS,Gershenzon J,Heckel DG

更新日期：2014-05-20 00:00:00

abstract：:Freezing avoidance conferred by different types of antifreeze proteins in various polar and subpolar fishes represents a remarkable example of cold adaptation, but how these unique proteins arose is unknown. We have found that the antifreeze glycoproteins (AFGPs) of the predominant Antarctic fish taxon, the notothenio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen L,DeVries AL,Cheng CH

更新日期：1997-04-15 00:00:00

abstract：:Epilepsy is the most common neurological disorder of young humans. Each year 150,000 children in the United States experience their first seizure. Antiepileptic drugs (AEDs), used to treat seizures in children, infants, and pregnant women, cause cognitive impairment, microcephaly, and birth defects. The cause of unwan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bittigau P,Sifringer M,Genz K,Reith E,Pospischil D,Govindarajalu S,Dzietko M,Pesditschek S,Mai I,Dikranian K,Olney JW,Ikonomidou C

更新日期：2002-11-12 00:00:00

abstract：:RNA helicases play roles in various essential biological processes such as RNA splicing and editing. Recent in vitro studies show that RNA helicases are involved in immune responses toward viruses, serving as viral RNA sensors or immune signaling adaptors. However, there is still a lack of in vivo data to support the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang Y,He K,Sheng B,Lei X,Tao W,Zhu X,Wei Z,Fu R,Wang A,Bai S,Zhang Z,Hong N,Ye C,Tian Y,Wang J,Li M,Zhang K,Li L,Yang H,Li HB,Flavell RA,Zhu S

更新日期：2021-01-26 00:00:00

abstract：:Under typical conditions, medial prefrontal cortex (mPFC) connections with the amygdala are immature during childhood and become adult-like during adolescence. Rodent models show that maternal deprivation accelerates this development, prompting examination of human amygdala-mPFC phenotypes following maternal deprivati...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gee DG,Gabard-Durnam LJ,Flannery J,Goff B,Humphreys KL,Telzer EH,Hare TA,Bookheimer SY,Tottenham N

更新日期：2013-09-24 00:00:00

abstract：:Adenylate cyclase [ATP pyrophosphate-lyase (cyclizing), EC 4.6.1.1] was solubilized from a rat brain homogenate with sodium deoxycholate. This solubilized preparation had no detectable enzymic activity with either Mg-ATP or Mn-ATP as substrate. The activity could be restored by addition of either nonionic detergent or...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hebdon GM,LeVine H 3rd,Sahyoun NE,Schmitges CJ,Cuatrecasas P

更新日期：1981-01-01 00:00:00

abstract：:Phosphorylation of purified microtubule-associated proteins (MAPs) inhibits the rate and extent of MAP-stimulated microtubule assembly. The extent of microtubule assembly is reduced as a result of a decrease in the fraction of tubulin polymerized, without a significant change in the critical protein concentration. The...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jameson L,Caplow M

更新日期：1981-06-01 00:00:00

abstract：:Toll-like receptor signaling and subsequent activation of NF-κB- and MAPK-dependent genes during infection play an important role in antimicrobial host defense. The YopJ protein of pathogenic Yersinia species inhibits NF-κB and MAPK signaling, resulting in blockade of NF-κB-dependent cytokine production and target cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Philip NH,Dillon CP,Snyder AG,Fitzgerald P,Wynosky-Dolfi MA,Zwack EE,Hu B,Fitzgerald L,Mauldin EA,Copenhaver AM,Shin S,Wei L,Parker M,Zhang J,Oberst A,Green DR,Brodsky IE

更新日期：2014-05-20 00:00:00

abstract：:The transition to pulmonary respiration after birth requires rapid alterations in the structure of the mammalian cardiovascular system. One dramatic change that occurs is the closure of the ductus arteriosus (DA), an arterial connection in the fetus that directs blood flow away from the pulmonary circulation. Two memb...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Levet S,Ouarné M,Ciais D,Coutton C,Subileau M,Mallet C,Ricard N,Bidart M,Debillon T,Faravelli F,Rooryck C,Feige JJ,Tillet E,Bailly S

更新日期：2015-06-23 00:00:00

abstract：:Acquired resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKIs) is inevitable in metastatic EGFR-mutant lung cancers. Here, we modeled disease progression using EGFR-mutant human tumor cell lines. Although five of six models displayed alterations already found in humans, one harbored an unexpected seconda...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ohashi K,Sequist LV,Arcila ME,Moran T,Chmielecki J,Lin YL,Pan Y,Wang L,de Stanchina E,Shien K,Aoe K,Toyooka S,Kiura K,Fernandez-Cuesta L,Fidias P,Yang JC,Miller VA,Riely GJ,Kris MG,Engelman JA,Vnencak-Jones CL,D

更新日期：2012-07-31 00:00:00

abstract：:This is a multinanosecond molecular dynamics study of a bio-nano complex formed by a carbon nanoparticle, a buckyball C(60), and a biological molecule, an antibody, with high binding affinity and specificity. In the simulation, the ball is completely desolvated by the binding site of the antibody by means of a nearly ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noon WH,Kong Y,Ma J

更新日期：2002-04-30 00:00:00

abstract：:The human genome is made up of long DNA segments, the isochores, which are compositionally homogeneous and can be subdivided into a small number of families characterized by different G+C levels. Chromosome in situ suppression hybridization (in which excess unlabeled human DNA is added to suppress hybridization of rep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Saccone S,De Sario A,Wiegant J,Raap AK,Della Valle G,Bernardi G

更新日期：1993-12-15 00:00:00

abstract：:This presentation reviews Chandra's major contribution to the understanding of nearby galaxies. After a brief summary on significant advances in characterizing various types of discrete x-ray sources, the presentation focuses on the global hot gas in and around galaxies, especially normal ones like our own. The hot ga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wang QD

更新日期：2010-04-20 00:00:00

abstract：:Canonical Wnt signaling plays an important role in development and disease, regulating transcription of target genes and stabilizing many proteins phosphorylated by glycogen synthase kinase 3 (GSK3). We observed that the MiT family of transcription factors, which includes the melanoma oncogene MITF (micropthalmia-asso...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ploper D,Taelman VF,Robert L,Perez BS,Titz B,Chen HW,Graeber TG,von Euw E,Ribas A,De Robertis EM

更新日期：2015-02-03 00:00:00

abstract：:The relative importance of local ecological and larger-scale historical processes in causing differences in species richness across the globe remains keenly debated. To gain insight into these questions, we investigated the assembly of plant diversity in the Cerrado in South America, the world's most species-rich trop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simon MF,Grether R,de Queiroz LP,Skema C,Pennington RT,Hughes CE

更新日期：2009-12-01 00:00:00

abstract：:A perversion in an otherwise uniform helical structure, such as a climbing plant tendril, refers to a kink that connects two helices with opposite chiralities. Such singularity structures are widely seen in natural and artificial mechanical systems, and they provide the fundamental mechanism of helical symmetry breaki...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu S,Yao Z,Chiou K,Stupp SI,Olvera de la Cruz M

更新日期：2016-06-28 00:00:00

abstract：:Staphylococcus aureus is a major cause of community-acquired and nosocomial infections including the life-threatening conditions endocarditis, necrotizing pneumonia, necrotizing fasciitis, and septicemia. Toll-like receptor (TLR)-2, a membrane-bound microbial sensor, detects staphylococcal components, but macrophages ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hruz P,Zinkernagel AS,Jenikova G,Botwin GJ,Hugot JP,Karin M,Nizet V,Eckmann L

更新日期：2009-08-04 00:00:00

abstract：:To examine the hypothesis that bone marrow consists of discrete stem cell regulatory volumes or domains, we studied spleen colony-forming unit (CFU-S) population growth kinetics in unirradiated WBB6F1-W/Wv mice receiving various doses of +/+ bone marrow cells. Assay of femoral marrow CFU-S content in the eight recipie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maloney MA,Lamela RA,Banda MJ,Patt HM

更新日期：1982-02-01 00:00:00

abstract：:In Drosophila, heterochromatin protein 1 (HP1) suppresses the expression of euchromatic genes that are artificially translocated adjacent to heterochromatin by expanding heterochromatin structure into neighboring euchromatin. The purpose of this study was to determine whether HP1 functions as a transcriptional repress...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hwang KK,Eissenberg JC,Worman HJ

更新日期：2001-09-25 00:00:00

abstract：:Opitz syndrome (OS) is a genetically heterogeneous disorder characterized by defects of the ventral midline, including hypertelorism, cleft lip and palate, heart defects, and mental retardation. We recently identified the gene responsible for X-linked OS. The ubiquitously expressed gene product, MID1, is a member of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schweiger S,Foerster J,Lehmann T,Suckow V,Muller YA,Walter G,Davies T,Porter H,van Bokhoven H,Lunt PW,Traub P,Ropers HH

更新日期：1999-03-16 00:00:00