Humans, water, and the colonization of Australia.

Abstract:

:The Pleistocene global dispersal of modern humans required the transit of arid and semiarid regions where the distribution of potable water provided a primary constraint on dispersal pathways. Here, we provide a spatially explicit continental-scale assessment of the opportunities for Pleistocene human occupation of Australia, the driest inhabited continent on Earth. We establish the location and connectedness of persistent water in the landscape using the Australian Water Observations from Space dataset combined with the distribution of small permanent water bodies (springs, gnammas, native wells, waterholes, and rockholes). Results demonstrate a high degree of directed landscape connectivity during wet periods and a high density of permanent water points widely but unevenly distributed across the continental interior. A connected network representing the least-cost distance between water bodies and graded according to terrain cost shows that 84% of archaeological sites >30,000 y old are within 20 km of modern permanent water. We further show that multiple, well-watered routes into the semiarid and arid continental interior were available throughout the period of early human occupation. Depletion of high-ranked resources over time in these paleohydrological corridors potentially drove a wave of dispersal farther along well-watered routes to patches with higher foraging returns.

authors

Bird MI,O'Grady D,Ulm S

doi

10.1073/pnas.1608470113

subject

Has Abstract

pub_date

2016-10-11 00:00:00

pages

11477-11482

issue

41

eissn

0027-8424

issn

1091-6490

pii

1608470113

journal_volume

113

pub_type

杂志文章
  • Ocean sentinel albatrosses locate illegal vessels and provide the first estimate of the extent of nondeclared fishing.

    abstract::With threats to nature becoming increasingly prominent, in order for biodiversity levels to persist, there is a critical need to improve implementation of conservation measures. In the oceans, the surveillance of fisheries is complex and inadequate, such that quantifying and locating nondeclared and illegal fisheries ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1915499117

    authors: Weimerskirch H,Collet J,Corbeau A,Pajot A,Hoarau F,Marteau C,Filippi D,Patrick SC

    更新日期:2020-02-11 00:00:00

  • Mu and kappa opioids inhibit transmitter release by different mechanisms.

    abstract::The actions of various opioids were examined on calcium action potentials in the cell somata of guinea pig myenteric neurones and on the release of acetylcholine at synapses onto these cells. The opioids morphine, normorphine, and [D-Ala2, MePhe4, Met5(O)]enkephalin-ol caused membrane hyperpolarizations resulting from...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.82.6.1860

    authors: Cherubini E,North RA

    更新日期:1985-03-01 00:00:00

  • Evidence for thymopoietin and thymopoietin/alpha-bungarotoxin/nicotinic receptors within the brain.

    abstract::Thymopoietin, a polypeptide hormone of the thymus that has pleiotropic actions on the immune, endocrine, and nervous systems, potently interacts with the neuromuscular nicotinic acetylcholine receptor. Thymopoietin binds to the nicotinic alpha-bungarotoxin (alpha-BGT) receptor in muscle and, like alpha-BGT, inhibits c...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章,收录出版

    doi:10.1073/pnas.88.6.2603

    authors: Quik M,Babu U,Audhya T,Goldstein G

    更新日期:1991-03-15 00:00:00

  • Antibody-dependent enhancement of influenza disease promoted by increase in hemagglutinin stem flexibility and virus fusion kinetics.

    abstract::Several next-generation (universal) influenza vaccines and broadly neutralizing antibodies (bNAbs) are in clinical development. Some of these mediate inhibitions of virus replication at the postentry stage or use Fc-dependent mechanisms. Nonneutralizing antibodies have the potential to mediate enhancement of viral inf...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1821317116

    authors: Winarski KL,Tang J,Klenow L,Lee J,Coyle EM,Manischewitz J,Turner HL,Takeda K,Ward AB,Golding H,Khurana S

    更新日期:2019-07-23 00:00:00

  • Homology and functional similarity of an hrp-linked pathogenicity locus, dspEF, of Erwinia amylovora and the avirulence locus avrE of Pseudomonas syringae pathovar tomato.

    abstract::The "disease-specific" (dsp) region next to the hrp gene cluster of Erwinia amylovora is required for pathogenicity but not for elicitation of the hypersensitive reaction. A 6.6-kb apparent operon, dspEF, was found responsible for this phenotype. The operon contains genes dspE and dspF and is positively regulated by h...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.95.3.1325

    authors: Bogdanove AJ,Kim JF,Wei Z,Kolchinsky P,Charkowski AO,Conlin AK,Collmer A,Beer SV

    更新日期:1998-02-03 00:00:00

  • Structural characterization of the D290V mutation site in hnRNPA2 low-complexity-domain polymers.

    abstract::Human genetic studies have given evidence of familial, disease-causing mutations in the analogous amino acid residue shared by three related RNA binding proteins causative of three neurological diseases. Alteration of aspartic acid residue 290 of hnRNPA2 to valine is believed to predispose patients to multisystem prot...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1806174115

    authors: Murray DT,Zhou X,Kato M,Xiang S,Tycko R,McKnight SL

    更新日期:2018-10-16 00:00:00

  • Dynamics of transient pores in stretched vesicles.

    abstract::We image macroscopic transient pores in mechanically stretched giant vesicles. Holes open above a critical radius r(c1), grow up to a radius r(c2), and close. We interpret the upper limit r(c2) by a relaxation of the membrane tension as the holes expand. The closing of the holes is caused by a further relaxation of th...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.19.10591

    authors: Sandre O,Moreaux L,Brochard-Wyart F

    更新日期:1999-09-14 00:00:00

  • Structural and biochemical studies of p21Ras S-nitrosylation and nitric oxide-mediated guanine nucleotide exchange.

    abstract::Ras is a guanine nucleotide-binding protein that cycles between inactive GDP-bound and active GTP-bound states to regulate a diverse array of cellular processes, including cell growth, apoptosis, and differentiation. The guanine nucleotide-bound state of Ras is tightly maintained by regulatory factors to promote regul...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1037299100

    authors: Williams JG,Pappu K,Campbell SL

    更新日期:2003-05-27 00:00:00

  • Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men.

    abstract::Type 2 diabetes mellitus (T2DM) is strongly associated with obesity in most, but not all, ethnic groups, suggesting important ethnic differences in disease susceptibility. Although it is clear that insulin resistance plays a major role in the pathogenesis of T2DM and that insulin resistance is strongly associated with...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0608537103

    authors: Petersen KF,Dufour S,Feng J,Befroy D,Dziura J,Dalla Man C,Cobelli C,Shulman GI

    更新日期:2006-11-28 00:00:00

  • Giving is self-rewarding for monkeys.

    abstract::Helping and sharing among humans is often motivated by empathy and accompanied by a sense of satisfaction. To determine whether similar self-rewarding mechanisms may underpin assistance among nonhuman primates, eight female brown capuchin monkeys (Cebus apella) underwent testing in a simple choice paradigm. Paired wit...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0807060105

    authors: de Waal FB,Leimgruber K,Greenberg AR

    更新日期:2008-09-09 00:00:00

  • Housing growth in and near United States protected areas limits their conservation value.

    abstract::Protected areas are crucial for biodiversity conservation because they provide safe havens for species threatened by land-use change and resulting habitat loss. However, protected areas are only effective when they stop habitat loss within their boundaries, and are connected via corridors to other wild areas. The effe...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0911131107

    authors: Radeloff VC,Stewart SI,Hawbaker TJ,Gimmi U,Pidgeon AM,Flather CH,Hammer RB,Helmers DP

    更新日期:2010-01-12 00:00:00

  • A fetal protein in chromatin of Novikoff hepatoma and Walker 256 carcinosarcoma tumors that is absent from normal and regenerating rat liver.

    abstract::Antibodies to chromatin proteins of Novikoff hepatoma cells formed precipitin bands in the double-diffusion immunoprecipitation assay with chromatin proteins of Novikoff hepatoma, Walker 256 carcinosarcoma, and 18-day fetal rat liver. The antigen used for preparation of antiserum was the chromatin proteins initially e...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.73.9.3258

    authors: Yeoman LC,Jordan JJ,Busch RK,Taylor CW,Savage HE,Busch H

    更新日期:1976-09-01 00:00:00

  • Increased tyrosine kinase activity associated with the protein encoded by the activated neu oncogene.

    abstract::A single mutation altering the transmembrane domain of the receptor-like p185 protein encoded by the rat neu gene converts the normal neu gene into a potent oncogene. The biochemical consequences of this mutation were studied by examining phosphorylation of the normal and transforming p185 molecules in membrane prepar...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.85.15.5394

    authors: Bargmann CI,Weinberg RA

    更新日期:1988-08-01 00:00:00

  • Host plant peptides elicit a transcriptional response to control the Sinorhizobium meliloti cell cycle during symbiosis.

    abstract::The α-proteobacterium Sinorhizobium meliloti establishes a chronic intracellular infection during the symbiosis with its legume hosts. Within specialized host cells, S. meliloti differentiates into highly polyploid, enlarged nitrogen-fixing bacteroids. This differentiation is driven by host cells through the productio...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1400450111

    authors: Penterman J,Abo RP,De Nisco NJ,Arnold MF,Longhi R,Zanda M,Walker GC

    更新日期:2014-03-04 00:00:00

  • Does a neuroimmune interaction contribute to the genesis of painful peripheral neuropathies?

    abstract::Painful peripheral neuropathies are precipitated by nerve injury from disease or trauma. All such injuries will be accompanied by an inflammatory reaction, a neuritis, that will mobilize the immune system. The role of the inflammation itself is difficult to determine in the presence of structural damage to the nerve. ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.96.14.7737

    authors: Bennett GJ

    更新日期:1999-07-06 00:00:00

  • Alternative DNA loops regulate the arabinose operon in Escherichia coli.

    abstract::The araCBAD regulatory region of Escherichia coli contains two divergently oriented promoters and three sites to which AraC, the regulatory protein of the operon, can bind. This paper presents the results of in vivo dimethyl sulfate "footprinting" experiments to monitor occupancy of the three AraC sites and measuremen...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.85.15.5444

    authors: Huo L,Martin KJ,Schleif R

    更新日期:1988-08-01 00:00:00

  • Ultrafast energy relaxation in single light-harvesting complexes.

    abstract::Energy relaxation in light-harvesting complexes has been extensively studied by various ultrafast spectroscopic techniques, the fastest processes being in the sub-100-fs range. At the same time, much slower dynamics have been observed in individual complexes by single-molecule fluorescence spectroscopy (SMS). In this ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1522265113

    authors: Malý P,Gruber JM,Cogdell RJ,Mančal T,van Grondelle R

    更新日期:2016-03-15 00:00:00

  • Discovery and validation of small-molecule heat-shock protein 90 inhibitors through multimodality molecular imaging in living subjects.

    abstract::Up-regulation of the folding machinery of the heat-shock protein 90 (Hsp90) chaperone protein is crucial for cancer progression. The two Hsp90 isoforms (α and β) play different roles in response to chemotherapy. To identify isoform-selective inhibitors of Hsp90(α/β)/cochaperone p23 interactions, we developed a dual-lu...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1205459109

    authors: Chan CT,Reeves RE,Geller R,Yaghoubi SS,Hoehne A,Solow-Cordero DE,Chiosis G,Massoud TF,Paulmurugan R,Gambhir SS

    更新日期:2012-09-11 00:00:00

  • Differential effects of Hsc70 and Hsp70 on the intracellular trafficking and functional expression of epithelial sodium channels.

    abstract::The members of the cytoplasmic 70-kDa heat shock protein family are involved in appropriate folding and trafficking of newly synthesized proteins in the cell. Hsc70, which is expressed constitutively, and Hsp70, the expression of which is stress- and heat shock-induced, are often considered to have similar cellular fu...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0507903103

    authors: Goldfarb SB,Kashlan OB,Watkins JN,Suaud L,Yan W,Kleyman TR,Rubenstein RC

    更新日期:2006-04-11 00:00:00

  • Targeted disruption of Pax1 defines its null phenotype and proves haploinsufficiency.

    abstract::The murine paired box-containing gene Pax1 is required for normal development of the vertebral column, the sternum, and the scapula. Previous studies have shown that three natural Pax1 mouse mutants, the undulated alleles, exhibit phenotypes of different severity in these skeletal elements. Nevertheless, these analyse...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.95.15.8692

    authors: Wilm B,Dahl E,Peters H,Balling R,Imai K

    更新日期:1998-07-21 00:00:00

  • Platelet and osteoclast beta3 integrins are critical for bone metastasis.

    abstract::Mice with a targeted deletion of beta3 integrin were used to examine the process by which tumor cells metastasize and destroy bone. Injection of B16 melanoma cells into the left cardiac ventricle resulted in osteolytic bone metastasis in 74% of beta3+/+ mice by 14 days. In contrast, only 4% of beta3-/- mice developed ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2234372100

    authors: Bakewell SJ,Nestor P,Prasad S,Tomasson MH,Dowland N,Mehrotra M,Scarborough R,Kanter J,Abe K,Phillips D,Weilbaecher KN

    更新日期:2003-11-25 00:00:00

  • Acid-base chemical reaction model for nucleation rates in the polluted atmospheric boundary layer.

    abstract::Climate models show that particles formed by nucleation can affect cloud cover and, therefore, the earth's radiation budget. Measurements worldwide show that nucleation rates in the atmospheric boundary layer are positively correlated with concentrations of sulfuric acid vapor. However, current nucleation theories do ...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1210285109

    authors: Chen M,Titcombe M,Jiang J,Jen C,Kuang C,Fischer ML,Eisele FL,Siepmann JI,Hanson DR,Zhao J,McMurry PH

    更新日期:2012-11-13 00:00:00

  • Genome-wide identification of cis-regulatory motifs and modules underlying gene coregulation using statistics and phylogeny.

    abstract::Cell fate determination depends in part on the establishment of specific transcriptional programs of gene expression. These programs result from the interpretation of the genomic cis-regulatory information by sequence-specific factors. Decoding this information in sequenced genomes is an important issue. Here, we deve...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1002876107

    authors: Rouault H,Mazouni K,Couturier L,Hakim V,Schweisguth F

    更新日期:2010-08-17 00:00:00

  • Export of an N-terminal fragment of Escherichia coli flagellin by a flagellum-specific pathway.

    abstract::Flagellin and several other external components of the bacterial flagellum are thought to be exported, not by the general N-terminal signal peptide-dependent pathway, but by a flagellum-specific pathway involving a central channel in the flagellum itself. We have constructed a variety of mutant alleles of the Escheric...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.86.13.4953

    authors: Kuwajima G,Kawagishi I,Homma M,Asaka J,Kondo E,Macnab RM

    更新日期:1989-07-01 00:00:00

  • Direct kinetic fingerprinting and digital counting of single protein molecules.

    abstract::The sensitive and accurate quantification of protein biomarkers plays important roles in clinical diagnostics and biomedical research. Sandwich ELISA and its variants accomplish the capture and detection of a target protein via two antibodies that tightly bind at least two distinct epitopes of the same antigen and hav...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2008312117

    authors: Chatterjee T,Knappik A,Sandford E,Tewari M,Choi SW,Strong WB,Thrush EP,Oh KJ,Liu N,Walter NG,Johnson-Buck A

    更新日期:2020-09-15 00:00:00

  • Candidate tumor suppressor BTG3 maintains genomic stability by promoting Lys63-linked ubiquitination and activation of the checkpoint kinase CHK1.

    abstract::B-cell translocation gene 3 (BTG3) is a member of the antiproliferative BTG/ Transducer of ErbB2 gene family and is induced by genotoxic stress in a p53- and Checkpoint kinase 1 (CHK1)-dependent manner. Down-regulation of BTG3 has been observed in human cancers, suggesting that it plays an important role in tumor supp...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1220635110

    authors: Cheng YC,Lin TY,Shieh SY

    更新日期:2013-04-09 00:00:00

  • The organization of orientation and spatial frequency in primary visual cortex.

    abstract::Many studies have demonstrated that the primary visual cortex contains multiple functional maps of visual properties (e.g., ocular dominance, orientation preference, and spatial-frequency preference), but as yet no consistent picture has emerged as to how these maps are related to one another. Three divergent, prior o...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0407450101

    authors: Sirovich L,Uglesich R

    更新日期:2004-11-30 00:00:00

  • Multiplex assessment of the positions of odorant receptor-specific glomeruli in the mouse olfactory bulb by serial two-photon tomography.

    abstract::In the mouse, axons of olfactory sensory neurons (OSNs) that express the same odorant receptor (OR) gene coalesce into one or a few glomeruli in the olfactory bulb. The positions of OR-specific glomeruli are traditionally described as stereotyped. Here, we have assessed quantitatively the positions of OR-specific glom...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.1512135112

    authors: Zapiec B,Mombaerts P

    更新日期:2015-10-27 00:00:00

  • Genome-wide transcriptional analysis of flagellar regeneration in Chlamydomonas reinhardtii identifies orthologs of ciliary disease genes.

    abstract::The important role that cilia and flagella play in human disease creates an urgent need to identify genes involved in ciliary assembly and function. The strong and specific induction of flagellar-coding genes during flagellar regeneration in Chlamydomonas reinhardtii suggests that transcriptional profiling of such cel...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.0408358102

    authors: Stolc V,Samanta MP,Tongprasit W,Marshall WF

    更新日期:2005-03-08 00:00:00

  • Restoration of fragmentary Babylonian texts using recurrent neural networks.

    abstract::The main sources of information regarding ancient Mesopotamian history and culture are clay cuneiform tablets. Many of these tablets are damaged, leading to missing information. Currently, the missing text is manually reconstructed by experts. We investigate the possibility of assisting scholars, by modeling the langu...

    journal_title:Proceedings of the National Academy of Sciences of the United States of America

    pub_type: 杂志文章

    doi:10.1073/pnas.2003794117

    authors: Fetaya E,Lifshitz Y,Aaron E,Gordin S

    更新日期:2020-09-15 00:00:00