Molecular modulation of calcium oxalate crystallization by osteopontin and citrate.

abstract：:The antigenic mosaic of the Archaebacterium Methanobacterium thermoautotrophicum, strain delta H, was analyzed with a panel of six monoclonal antibodies. Five antigenic determinants were identified. One contains N-acetyl-D-glucosamine, another contains N-acetyl-D-galactosamine, and a third contains gamma-glutamylalani...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Conway de Macario E,Macario AJ,Magariños MC,König H,Kandler O

更新日期：1983-10-01 00:00:00

abstract：:A cancer DNA phenotype, identical to the DNA structure of tumors, has been identified in the prostate glands of certain healthy men over 55 years of age. We now show that the same DNA signature exists in normal tissues adjacent to tumors. This finding implies that the phenotype is maintained in normal prostate cells f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Malins DC,Gilman NK,Green VM,Wheeler TM,Barker EA,Anderson KM

更新日期：2005-12-27 00:00:00

abstract：:Apolipoprotein A-I (apo A-I), the major apolipoprotein in human high density lipoproteins, is involved in the disease atherosclerosis. Cloned apo A-I cDNA (pA1-3) was used as a probe in chromosome mapping studies to detect the human apo A-I structural gene sequence in human-Chinese hamster cell hybrids. Southern blot ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheung P,Kao FT,Law ML,Jones C,Puck TT,Chan L

更新日期：1984-01-01 00:00:00

abstract：:Two functional human dUTP pyrophosphatase (dUTPase; EC 3.6.1.23) cDNAs were isolated from a cDNA expression library by genetic complementation in Escherichia coli. These cDNAs differed in size but exhibited a common overlapping DNA sequence. Contained within this sequence was a single long open reading frame sufficien...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McIntosh EM,Ager DD,Gadsden MH,Haynes RH

更新日期：1992-09-01 00:00:00

abstract：:The 20S proteasome core particle (20S CP) plays an integral role in cellular homeostasis by degrading proteins no longer required for function. The process is, in part, controlled via gating residues localized to the ends of the heptameric barrel-like CP structure that occlude substrate entry pores, preventing unregul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang R,Pérez F,Kay LE

更新日期：2017-11-14 00:00:00

abstract：:Reconnections of coherent filamentary structures play a key role in the dynamics of fluids, redistributing energy and helicity among the length scales, triggering dissipative effects, and inducing fine-scale mixing. Unlike ordinary (classical) fluids where vorticity is a continuous field, in superfluid helium and in a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Galantucci L,Baggaley AW,Parker NG,Barenghi CF

更新日期：2019-06-18 00:00:00

abstract：:Novel organismal structures in metazoans are often undergirded by complex gene regulatory networks; as such, understanding the emergence of new structures through evolution requires reconstructing the series of evolutionary steps leading to these underlying networks. Here, we reconstruct the step-by-step assembly of t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Irimia M,Denuc A,Burguera D,Somorjai I,Martín-Durán JM,Genikhovich G,Jimenez-Delgado S,Technau U,Roy SW,Marfany G,Garcia-Fernàndez J

更新日期：2011-03-29 00:00:00

abstract：:In neurotransmission synaptotagmin-1 tethers synaptic vesicles to the presynaptic plasma membrane by binding to acidic membrane lipids and SNAREs and promotes rapid SNARE-mediated fusion upon Ca(2+) triggering. However, recent studies suggested that upon membrane contact synaptotagmin may not only bind in trans to the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vennekate W,Schröder S,Lin CC,van den Bogaart G,Grunwald M,Jahn R,Walla PJ

更新日期：2012-07-03 00:00:00

abstract：:Normal myeloid precursors and MGI(+)D(+) myeloid leukemic cells can be induced to differentiate to mature cells by the normal protein inducer MGI. The sequence of differentiation is the induction of C3 and Fc rosettes, C3 and Fc immune phagocytosis (IP), synthesis and secretion of lysozyme, and formation of mature mac...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lotem J,Sachs L

更新日期：1977-12-01 00:00:00

abstract：:We have studied the effect of the 3' terminal CCA sequence in precursors of tRNAs on catalysis by the RNase P RNA or the holoenzyme from the cyanobacterium Synechocystis sp. PCC 6803 in a completely homologous system. We have found that the absence of the 3' terminal CCA is not detrimental to activity, which is in sha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pascual A,Vioque A

更新日期：1999-06-08 00:00:00

abstract：:Little is known about stem cell biology or the specialized environments or niches believed to control stem cell renewal and differentiation in self-renewing tissues of the body. Functional assays for stem cells are available only for hematopoiesis and spermatogenesis, and the microenvironment, or niche, for hematopoie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Shinohara T,Orwig KE,Avarbock MR,Brinster RL

更新日期：2001-05-22 00:00:00

abstract：:In contrast to mechanisms mediating uptake of intracellular bacterial pathogens, bacterial egress and cell-to-cell transmission are poorly understood. Previously, we showed that the transmission of pathogenic mycobacteria between phagocytic cells also depends on nonlytic ejection through an F-actin based structure, ca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gerstenmaier L,Pilla R,Herrmann L,Herrmann H,Prado M,Villafano GJ,Kolonko M,Reimer R,Soldati T,King JS,Hagedorn M

更新日期：2015-02-17 00:00:00

abstract：:Juvenile hormone III (JH) plays a key role in regulating the reproduction of female mosquitoes. Microarray time-course analysis revealed dynamic changes in gene expression during posteclosion (PE) development in the fat body of female Aedes aegypti. Hierarchical clustering identified three major gene clusters: 1,843 e...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zou Z,Saha TT,Roy S,Shin SW,Backman TW,Girke T,White KP,Raikhel AS

更新日期：2013-06-11 00:00:00

abstract：:Intense proteolysis of cytoskeletal proteins occurs in brain within minutes of transient ischemia, possibly because of the activation of calcium-sensitive proteases (calpains). This proteolytic event precedes overt signs of neuronal degeneration, is most pronounced in regions of selective neuronal vulnerability, and c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee KS,Frank S,Vanderklish P,Arai A,Lynch G

更新日期：1991-08-15 00:00:00

abstract：:The controlled self-assembly of complex molecules into well defined hierarchical structures is a promising route for fabricating nanostructures. These nanoscale structures can be realized by naturally occurring proteins such as tobacco mosaic virus, capsid proteins, tubulin, actin, etc. Here, we report a simple altern...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Valéry C,Paternostre M,Robert B,Gulik-Krzywicki T,Narayanan T,Dedieu JC,Keller G,Torres ML,Cherif-Cheikh R,Calvo P,Artzner F

更新日期：2003-09-02 00:00:00

abstract：:The mechanisms that regulate insulin secretion were investigated using capacitance measurements of exocytosis in single beta cells maintained in tissue culture. Exocytosis was stimulated by voltage-clamp depolarizations to activate the voltage-dependent Ca2+ channels that mediate Ca2+ influx into the beta cell. Under ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ammälä C,Eliasson L,Bokvist K,Berggren PO,Honkanen RE,Sjöholm A,Rorsman P

更新日期：1994-05-10 00:00:00

abstract：:Like protein enzymes, RNA enzymes (ribozymes) provide specific binding sites for their substrates. We now show that equilibrium dissociation constants for complexes between the Tetrahymena ribozyme and its RNA substrates and products can be directly measured by electrophoresis in polyacrylamide gels containing divalen...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pyle AM,McSwiggen JA,Cech TR

更新日期：1990-11-01 00:00:00

abstract：:Members of the CCAAT-binding transcription factor (CTF) family of proteins stimulate the initiation of adenovirus DNA replication and act as transcriptional activators. To investigate the mechanisms underlying CTF-mediated transactivation patterns, we expressed several natural CTF variants in Saccharomyces cerevisiae ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altmann H,Wendler W,Winnacker EL

更新日期：1994-04-26 00:00:00

abstract：:C1q-like genes (C1ql1-C1ql4) encode small, secreted proteins that are expressed in differential patterns in the brain but whose receptors and functions remain unknown. BAI3 protein, in contrast, is a member of the cell-adhesion class of G protein-coupled receptors that are expressed at high levels in the brain but who...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bolliger MF,Martinelli DC,Südhof TC

更新日期：2011-02-08 00:00:00

abstract：:Scanning confocal fluorescence microscopy and multiphoton fluorescence microscopy were used to image the uptake of the protein lysozyme into individual ion exchange chromatography particles in a packed bed in real time. Self-sharpening concentration fronts penetrating into the particles were observed at low salt conce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dziennik SR,Belcher EB,Barker GA,DeBergalis MJ,Fernandez SE,Lenhoff AM

更新日期：2003-01-21 00:00:00

abstract：:Complementary DNA clones encoding the entire rat 1,25-dihydroxyvitamin D3 receptor were isolated, and the total 423-amino acid sequence was deduced. The amino acid sequence of the rat receptor is similar but not identical to the reported human receptor sequence. The cysteine-rich DNA-binding domain is completely conse...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Burmester JK,Wiese RJ,Maeda N,DeLuca HF

更新日期：1988-12-01 00:00:00

abstract：:Invariant natural killer T (iNKT) cells recognize lipid antigens presented by CD1d and play a central role in regulating immunity and inflammation in peripheral tissues. However, the mechanisms which govern iNKT cell homeostasis after thymic emigration are incompletely understood. Here we demonstrate that microsomal t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zeissig S,Peuker K,Iyer S,Gensollen T,Dougan SK,Olszak T,Kaser A,Blumberg RS

更新日期：2017-09-26 00:00:00

abstract：:The commitment of differentiating cells to a specialized fate is fundamental to the correct assembly of tissues within a multicellular organism. Because commitment is often irreversible, entry into and progression through this phase of development must be tightly regulated. Under nitrogen-limiting conditions, the mult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Videau P,Rivers OS,Hurd K,Ushijima B,Oshiro RT,Ende RJ,O'Hanlon SM,Cozy LM

更新日期：2016-11-08 00:00:00

abstract：:In vitro studies have demonstrated that glia can express functional receptors for a variety of neurotransmitters. To determine whether similar neurotransmitter receptors are also expressed by glia in vivo, we examined the glial scar in the transected optic nerve of the albino rabbit by quantitative receptor autoradiog...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mantyh PW,Johnson DJ,Boehmer CG,Catton MD,Vinters HV,Maggio JE,Too HP,Vigna SR

更新日期：1989-07-01 00:00:00

abstract：:Many aspects of the evolutionary process of tumorigenesis that are fundamental to cancer biology and targeted treatment have been challenging to reveal, such as the divergence times and genetic clonality of metastatic lineages. To address these challenges, we performed tumor phylogenetics using molecular evolutionary ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao ZM,Zhao B,Bai Y,Iamarino A,Gaffney SG,Schlessinger J,Lifton RP,Rimm DL,Townsend JP

更新日期：2016-02-23 00:00:00

abstract：:Nucleotide variations, including SNPs, in the coding regions of disease genes are important targets for RNAi treatment, which is a promising medical treatment for intractable diseases such as triplet repeat diseases. However, the identification of such nucleotide variations and the design of siRNAs conferring disease ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takahashi M,Watanabe S,Murata M,Furuya H,Kanazawa I,Wada K,Hohjoh H

更新日期：2010-12-14 00:00:00

abstract：:The uncatalyzed reactions of O(2) (S = 1) with organic substrates (S = 0) are thermodynamically favorable but kinetically slow because they are spin-forbidden and the one-electron reduction potential of O(2) is unfavorable. In nature, many of these important O(2) reactions are catalyzed by metalloenzymes. In the case ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pau MY,Lipscomb JD,Solomon EI

更新日期：2007-11-20 00:00:00

abstract：:Clostridium difficile, a causative agent of antibiotic-associated diarrhea and its potentially lethal form, pseudomembranous colitis, produces two large protein toxins that are responsible for the cellular damage associated with the disease. The level of toxin production appears to be critical for determining the seve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mani N,Dupuy B

更新日期：2001-05-08 00:00:00

abstract：:Glutaredoxins (GRXs), also known as thioltransferases, use glutathione as a cofactor for reduction of disulfides in prokaryotes and eukaryotes. We demonstrate that the vaccinia virus O2L open reading frame encodes a functional GRX, as predicted by Johnson et al. [Johnson, G. P., Goebel, S. J., Perkus, M. E., Davis, S....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ahn BY,Moss B

更新日期：1992-08-01 00:00:00

abstract：:The development of a spider silk-manufacturing process is of great interest. However, there are serious problems with natural manufacturing through spider farming, and standard recombinant protein production platforms have provided limited progress due to their inability to assemble spider silk proteins into fibers. T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Teulé F,Miao YG,Sohn BH,Kim YS,Hull JJ,Fraser MJ Jr,Lewis RV,Jarvis DL

更新日期：2012-01-17 00:00:00