Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena.

abstract：:Metagenomics is expanding our knowledge of the gene content, functional significance, and genetic variability in natural microbial communities. Still, there exists limited information concerning the regulation and dynamics of genes in the environment. We report here global analysis of expressed genes in a naturally oc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Frias-Lopez J,Shi Y,Tyson GW,Coleman ML,Schuster SC,Chisholm SW,Delong EF

更新日期：2008-03-11 00:00:00

abstract：:Human cDNA clones encoding a structure-specific recognition protein, SSRP1, that binds specifically to DNA modified with cisplatin have been isolated and characterized. The SSRP1 gene maps to human chromosome 11q12. The cDNA clones, obtained by using partial-length cDNAs described previously, predict an 81-kDa protein...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bruhn SL,Pil PM,Essigmann JM,Housman DE,Lippard SJ

更新日期：1992-03-15 00:00:00

abstract：:The management of harmful species, including invasive species, pests, parasites, and diseases, is a major global challenge. Harmful species cause severe damage to ecosystems, biodiversity, agriculture, and human health. In particular, managing harmful species often requires cooperation among multiple agents, such as l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lampert A

更新日期：2020-05-12 00:00:00

abstract：:A visual scene is perceived in terms of visual objects. Similar ideas have been proposed for the analogous case of auditory scene analysis, although their hypothesized neural underpinnings have not yet been established. Here, we address this question by recording from subjects selectively listening to one of two compe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ding N,Simon JZ

更新日期：2012-07-17 00:00:00

abstract：:An experimental study of the configurational thermodynamics for a series of near-eutectic Pt80-x Cu x P20 bulk metallic glass-forming alloys is reported where 14 < x < 27. The undercooled liquid alloys exhibit very high fragility that increases as x decreases, resulting in...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Na JH,Corona SL,Hoff A,Johnson WL

更新日期：2020-02-11 00:00:00

abstract：:Reduced serum testosterone (T), or hypogonadism, affects millions of men and is associated with many pathologies, including infertility, cardiovascular diseases, metabolic syndrome, and decreased libido and sexual function. Administering T-replacement therapy (TRT) reverses many of the symptoms associated with low T l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li L,Li Y,Sottas C,Culty M,Fan J,Hu Y,Cheung G,Chemes HE,Papadopoulos V

更新日期：2019-11-12 00:00:00

abstract：:A Ca2+-channel blocker derived from funnel-web spider toxin (FTX) has made it possible to define and study the ionic channels responsible for the Ca2+ conductance in mammalian Purkinje cell neurons and the preterminal in squid giant synapse. In cerebellar slices, FTX blocked Ca2+-dependent spikes in Purkinje cells, re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Llinás R,Sugimori M,Lin JW,Cherksey B

更新日期：1989-03-01 00:00:00

abstract：:Nucleosomes in eukaryotes act as platforms for the dynamic integration of epigenetic information. Posttranslational modifications are reversibly added or removed and core histones exchanged for paralogous variants, in concert with changing demands on transcription and genome accessibility. Histones are also common in ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stevens KM,Swadling JB,Hocher A,Bang C,Gribaldo S,Schmitz RA,Warnecke T

更新日期：2020-12-29 00:00:00

abstract：:Significant inhibition of spermatogenesis and appearance of antibodies against spermatogenic cells identified by cytotoxicity and immunofluorescence reactions were observed in mice of inbred strains 129/Sv and BALB/c and in albino guinea pigs after syngeneic, allogeneic, and xenogeneic immunization with mouse F9 embry...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vojtiskova M,Pokorna Z,Draber P

更新日期：1983-01-01 00:00:00

abstract：:Circadian dysfunction is a common attribute of many neurodegenerative diseases, most of which are associated with neuroinflammation. Circadian rhythm dysfunction has been associated with inflammation in the periphery, but the role of the core clock in neuroinflammation remains poorly understood. Here we demonstrate th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Griffin P,Dimitry JM,Sheehan PW,Lananna BV,Guo C,Robinette ML,Hayes ME,Cedeño MR,Nadarajah CJ,Ezerskiy LA,Colonna M,Zhang J,Bauer AQ,Burris TP,Musiek ES

更新日期：2019-03-12 00:00:00

abstract：:Interleukin 1 (IL-1) and tumor necrosis factor alpha are thought to contribute to the inflammatory response associated with autoimmune diseases. Transforming growth factor beta 1 (TGF-beta 1) counteracts many effects of these cytokines and has various immunosuppressive properties. In the present study, it is shown tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kuruvilla AP,Shah R,Hochwald GM,Liggitt HD,Palladino MA,Thorbecke GJ

更新日期：1991-04-01 00:00:00

abstract：:Since cdc48 mutants were isolated by the first genetic screens for cell division cycle (cdc) mutants in yeast, the requirement of the chaperone-like ATPase Cdc48/p97 during cell division has remained unclear. Here, we discover an unanticipated function for Caenorhabditis elegans CDC-48 in DNA replication linked to cel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mouysset J,Deichsel A,Moser S,Hoege C,Hyman AA,Gartner A,Hoppe T

更新日期：2008-09-02 00:00:00

abstract：:Cytochrome c oxidase (COX) is a 13-subunit protein complex that catalyzes the last step in mitochondrial electron transfer in mammals. Of the 10 subunits encoded by nuclear DNA (three are mtDNA products), some are expressed as tissue- and/or development-specific isoforms. For COX subunit VIII, previous work showed tha...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Goldberg A,Wildman DE,Schmidt TR,Huttemann M,Goodman M,Weiss ML,Grossman LI

更新日期：2003-05-13 00:00:00

abstract：:The cat tongue is covered in sharp, rear-facing spines called papillae, the precise function of which is a mystery. In this combined experimental and theoretical study, we use high-speed film, grooming force measurements, and computed tomography (CT) scanning to elucidate the mechanism by which papillae are used to gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Noel AC,Hu DL

更新日期：2018-12-04 00:00:00

abstract：:A 320-base-pair repeated sequence was observed when DNA samples from the filarial parasites Brugia malayi and Brugia pahangi were digested with the restriction endonuclease Hha I. A 640-base-pair dimer of the repeated sequence from B. malayi was inserted into the plasmid pBR322. When dot hybridization was used, the co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McReynolds LA,DeSimone SM,Williams SA

更新日期：1986-02-01 00:00:00

abstract：:The attachment of human polymorphonuclear leukocytes (PMN) to bovine endothelial monolayers is increased by pretreatment of the endothelial cells with leukotriene B4 (LTB4). The response is dose dependent with a maximum at 10(-6) M, requires no more than 1 min of preincubation for the maximal effect, and decays linear...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoover RL,Karnovsky MJ,Austen KF,Corey EJ,Lewis RA

更新日期：1984-04-01 00:00:00

abstract：:Fine finger and hand movements in humans, monkeys, and rats are under the direct control of the corticospinal tract (CST). CST lesions lead to severe, long-term deficits of precision movements. We transected completely both CSTs in adult rats and treated the animals for 2 weeks with an antibody that neutralized the ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raineteau O,Fouad K,Noth P,Thallmair M,Schwab ME

更新日期：2001-06-05 00:00:00

abstract：:We have analyzed the level of intraindividual sequence variability (heteroplasmy) of mtDNA in human brain by denaturing gradient gel electrophoresis and sequencing. Single base substitutions, as well as insertions or deletions of single bases, were numerous in the noncoding control region (D-loop), and 35-45% of the m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jazin EE,Cavelier L,Eriksson I,Oreland L,Gyllensten U

更新日期：1996-10-29 00:00:00

abstract：:Recent epidemiological studies indicate beneficial effects of moderate ethanol consumption in ischemic heart disease. Most studies, however, focus on the effect of long-term consumption of ethanol. In this study, we determined whether brief exposure to ethanol immediately before ischemia also produces cardioprotection...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen CH,Gray MO,Mochly-Rosen D

更新日期：1999-10-26 00:00:00

abstract：:Insulin-degrading enzyme (IDE) selectively degrades the monomer of amyloidogenic peptides and contributes to clearance of amyloid β (Aβ). Thus, IDE retards the progression of Alzheimer's disease. IDE possesses an enclosed catalytic chamber that engulfs and degrades its peptide substrates; however, the molecular mechan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McCord LA,Liang WG,Dowdell E,Kalas V,Hoey RJ,Koide A,Koide S,Tang WJ

更新日期：2013-08-20 00:00:00

abstract：:Human telomeres terminate with a single-stranded 3' G overhang, which can be recognized as a DNA damage site by replication protein A (RPA). The protection of telomeres (POT1)/POT1-interacting protein 1 (TPP1) heterodimer binds specifically to single-stranded telomeric DNA (ssTEL) and protects G overhangs against RPA ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ray S,Bandaria JN,Qureshi MH,Yildiz A,Balci H

更新日期：2014-02-25 00:00:00

abstract：:Citrus bacterial canker (CBC) caused by Xanthomonas axonopodis pv. citri (Xac) was first documented in India and Java in the mid 19th century. Since that time, the known distribution of the disease has steadily increased. Concurrent with the dispersion of the pathogen, the diversity of described strains continues to i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li W,Song Q,Brlansky RH,Hartung JS

更新日期：2007-11-20 00:00:00

abstract：:During the past several decades, numerous reports from disparate geographical areas have documented an increased frequency of "bleaching" in reef-forming corals. The phenomenon, triggered by increased sea surface temperatures, occurs when the cnidarian hosts digest and/or expel their intracellular, photosynthetic dino...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tchernov D,Kvitt H,Haramaty L,Bibby TS,Gorbunov MY,Rosenfeld H,Falkowski PG

更新日期：2011-06-14 00:00:00

abstract：:A glucose-responsive "closed-loop" insulin delivery system mimicking the function of pancreatic cells has tremendous potential to improve quality of life and health in diabetics. Here, we report a novel glucose-responsive insulin delivery device using a painless microneedle-array patch ("smart insulin patch") containi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yu J,Zhang Y,Ye Y,DiSanto R,Sun W,Ranson D,Ligler FS,Buse JB,Gu Z

更新日期：2015-07-07 00:00:00

abstract：:Let G be a reductive algebraic group and let B be an affine variety with an algebraic action of G. Everything is defined over the field C of complex numbers. Consider the trivial G-vector bundle B x S = S over B where S is a G-module. From the endomorphism ring R of the G-vector bundle S a construction of G-vector bun...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Masuda M,Petrie T

更新日期：1991-10-15 00:00:00

abstract：:Predicting whether and how populations will adapt to rapid climate change is a critical goal for evolutionary biology. To examine the genetic basis of fitness and predict adaptive evolution in novel climates with seasonal variation, we grew a diverse panel of the annual plant Arabidopsis thaliana (multiparent advanced...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fournier-Level A,Perry EO,Wang JA,Braun PT,Migneault A,Cooper MD,Metcalf CJ,Schmitt J

更新日期：2016-05-17 00:00:00

abstract：:The int-1 and int-2 genes were first isolated as targets for transcriptional activation by proviral insertion mutations in mammary carcinomas induced by the mouse mammary tumor virus (MMTV). Since these proto-oncogenes are not expressed at detectable levels in previously tested normal tissues from adult mice, we sough...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jakobovits A,Shackleford GM,Varmus HE,Martin GR

更新日期：1986-10-01 00:00:00

abstract：:Replication-competent viruses, such as Vaccinia virus (VACV), are powerful tools for the development of oncolytic viral therapies and elicit superior immune responses when used as vaccine and immunotherapeutic vectors. However, severe complications from uncontrolled viral replication can occur, particularly in immunoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grigg P,Titong A,Jones LA,Yilma TD,Verardi PH

更新日期：2013-09-17 00:00:00

abstract：:CCR5 encodes a cell surface chemokine receptor molecule that serves as the principal coreceptor, with CD4, for HIV-type 1 (HIV-1). Varied HIV-1 susceptibility and time to progression to AIDS have been associated with polymorphisms in CCR5. Many of these polymorphisms are located in the 5' cis-regulatory region of CCR5...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bamshad MJ,Mummidi S,Gonzalez E,Ahuja SS,Dunn DM,Watkins WS,Wooding S,Stone AC,Jorde LB,Weiss RB,Ahuja SK

更新日期：2002-08-06 00:00:00

abstract：:The presence of an amino acid other than aspartic acid at position 57 of the HLA-DQ beta chain (non-Asp-57) is highly associated with susceptibility to insulin-dependent diabetes mellitus (IDDM), whereas an aspartic acid at this position (Asp-57) appears to confer resistance to the disease. We hypothesize that the 30-...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dorman JS,LaPorte RE,Stone RA,Trucco M

更新日期：1990-10-01 00:00:00