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Protective effect of transforming growth factor beta 1 on experimental autoimmune diseases in mice.

Abstract：

:Interleukin 1 (IL-1) and tumor necrosis factor alpha are thought to contribute to the inflammatory response associated with autoimmune diseases. Transforming growth factor beta 1 (TGF-beta 1) counteracts many effects of these cytokines and has various immunosuppressive properties. In the present study, it is shown that microgram amounts of TGF-beta 1, injected daily for 1-2 weeks, protect against collagen-induced arthritis (CIA) and relapsing experimental allergic encephalomyelitis (REAE), the animal models for rheumatoid arthritis and multiple sclerosis, respectively. When administered during induction of the disease, TGF-beta 1 prevents CIA but only delays the onset of REAE by 2-3 days. However, when administered during a remission. TGF-beta 1 prevents the occurrence of relapses in REAE. The results suggest that TGF-beta 1 has powerful anti-inflammatory effects, mimicking in some respects the beneficial effects of immunosuppressive drugs in these experimental models of autoimmune disease, but without discernable adverse effects.

journal_name

Proc Natl Acad Sci U S A

journal_title

Proceedings of the National Academy of Sciences of the United States of America

authors

Kuruvilla AP,Shah R,Hochwald GM,Liggitt HD,Palladino MA,Thorbecke GJ

doi

10.1073/pnas.88.7.2918

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

2918-21

issue

7

eissn

0027-8424

issn

1091-6490

journal_volume

88

pub_type

杂志文章

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