Isolation of adenyl cyclase from Escherichia coli.

abstract：:mtDNA mutations occur in a wide variety of degenerative diseases and cancer. mtDNA seems to be more susceptible to DNA damage and consequently sustains higher rates of mutation than does nuclear DNA (nDNA). Many of the somatic mtDNA mutations in human cancers are located in the displacement loop (D-loop) and in partic...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mambo E,Gao X,Cohen Y,Guo Z,Talalay P,Sidransky D

更新日期：2003-02-18 00:00:00

abstract：:The goal of the current study was to investigate the role of exogenous and endogenous hydrogen sulfide (H(2)S) on neovascularization and wound healing in vitro and in vivo. Incubation of endothelial cells (ECs) with H(2)S enhanced their angiogenic potential, evidenced by accelerated cell growth, migration, and capilla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Papapetropoulos A,Pyriochou A,Altaany Z,Yang G,Marazioti A,Zhou Z,Jeschke MG,Branski LK,Herndon DN,Wang R,Szabó C

更新日期：2009-12-22 00:00:00

abstract：:The mechanosensory hair cells of the inner ear are required for hearing and balance and have a distinctive apical structure, the hair bundle, that converts mechanical stimuli into electrical signals. This structure comprises a single cilium, the kinocilium, lying adjacent to an ensemble of actin-based projections know...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Honda A,Kita T,Seshadri SV,Misaki K,Ahmed Z,Ladbury JE,Richardson GP,Yonemura S,Ladher RK

更新日期：2018-08-14 00:00:00

abstract：:A hitherto unknown Neoproterozoic orogenic system, the Saharides, is described in North Africa. It formed during the 900-500-Ma interval. The Saharides involved large subduction accretion complexes occupying almost the entire Arabian Shield and much of Egypt and parts of the small Precambrian inliers in the Sahara inc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Şengör AMC,Lom N,Zabcı C,Sunal G,Öner T

更新日期：2020-12-22 00:00:00

abstract：:The primary structure of the Escherichia coli hemolysin polypeptide (HlyA) is used to predict intramolecular structures involved in the secretion and cytolytic activity of the molecule. The C-terminal region of HlyA contains a repeated, 8-amino acid chain represented by the consensus sequence Leu-Xaa-Gly-Gly-Xaa-Gly-A...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Felmlee T,Welch RA

更新日期：1988-07-01 00:00:00

abstract：:Wild bees are highly valuable pollinators. Along with managed honey bees, they provide a critical ecosystem service by ensuring stable pollination to agriculture and wild plant communities. Increasing concern about the welfare of both wild and managed pollinators, however, has prompted recent calls for national evalua...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Koh I,Lonsdorf EV,Williams NM,Brittain C,Isaacs R,Gibbs J,Ricketts TH

更新日期：2016-01-05 00:00:00

abstract：:The product of the Nijmegen breakage syndrome gene (NBS1) plays crucial roles in DNA damage response through its association with many proteins, including MRE11 and RAD50. However, it remains to be determined exactly how NBS1 accumulates at or near DNA double-strand breaks. Here we report that MDC1 directly binds to N...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu L,Luo K,Lou Z,Chen J

更新日期：2008-08-12 00:00:00

abstract：:There are many occasions in which humans and other animals must inhibit the production of some behavior or inhibit the processing of some internal representation. Success in inhibitory processing under normal circumstances can be revealed by the fact that certain brain pathologies render inhibitory processing ineffect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jonides J,Smith EE,Marshuetz C,Koeppe RA,Reuter-Lorenz PA

更新日期：1998-07-07 00:00:00

abstract：:Intact squid axons were injected with aequorin and bathed in 3 mM Ca seawater (a concentration close to that of squid blood). Sodium and potassium currents were pharmacologically blocked and repetitive voltage-clamp pulses of a duration of 1.5 ms were applied (to simulate the duration of an action potential) at amplit...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mullins LJ,Requena J,Whittembury J

更新日期：1985-03-01 00:00:00

abstract：:A reaction cycle for electron-transportdriven proton pumps is proposed. It includes two distinct conformational states of the pump protein in which the primary electron acceptor has different reduction potentials. This has as an unavoidable consequence that the steady-state rate equation for the catalytic reaction dri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brzezinski P,Malmström BG

更新日期：1986-06-01 00:00:00

abstract：:Chlorarachniophytes are amoeboid algae with unusual chloroplasts. Instead of the usual two membranes that surround the chloroplasts of plants, green algae, and red algae, the chloroplasts of chlorarachniophytes have four bounding membranes. The extra membranes may reflect an unusual origin of chlorarachniophyte chloro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McFadden GI,Gilson PR,Hofmann CJ,Adcock GJ,Maier UG

更新日期：1994-04-26 00:00:00

abstract：:Olfactory neuroblastoma (ONB) is a malignant tumor of the nasal mucosa whose histogenesis is unclear. A relationship to neuroblastoma (NB), a pediatric tumor of the sympathetic nervous system, is based on morphologic similarities and the expression of similar neural antigens. However, the clinical presentation of ONB ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sorensen PH,Wu JK,Berean KW,Lim JF,Donn W,Frierson HF,Reynolds CP,López-Terrada D,Triche TJ

更新日期：1996-02-06 00:00:00

abstract：:Prion diseases are characterized by an accumulation of PrP(Sc), a misfolded isoform of the normal cellular prion protein, PrP(C). We previously reported the bioactivity of acridine-based compounds against PrP(Sc) replication in scrapie-infected neuroblastoma cells and now report the improved potency of bis-acridine co...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： May BC,Fafarman AT,Hong SB,Rogers M,Deady LW,Prusiner SB,Cohen FE

更新日期：2003-03-18 00:00:00

abstract：:CHD7 encodes an ATP-dependent chromatin remodeling factor. Mutation of this gene causes multiple developmental disorders, including CHARGE (Coloboma of the eye, Heart defects, Atresia of the choanae, Retardation of growth/development, Genital abnormalities, and Ear anomalies) syndrome, in which conotruncal anomalies a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan S,Thienthanasit R,Chen D,Engelen E,Brühl J,Crossman DK,Kesterson R,Wang Q,Bouazoune K,Jiao K

更新日期：2020-11-17 00:00:00

abstract：:Chemokines and their receptors direct leukocyte migration among blood, lymph and tissues. Evidence has recently accumulated that, besides their chemotactic functions, chemokine receptors are highly versatile players that fine tune immune responses. During human T cell activation by antigen-presenting cells, the chemok...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Contento RL,Molon B,Boularan C,Pozzan T,Manes S,Marullo S,Viola A

更新日期：2008-07-22 00:00:00

abstract：:Mussels adhere to a variety of surfaces by depositing a highly specific ensemble of 3,4-dihydroxyphenyl-l-alanine (DOPA) containing proteins. The adhesive properties of Mytilus edulis foot proteins mfp-1 and mfp-3 were directly measured at the nano-scale by using a surface forces apparatus (SFA). An adhesion energy of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lin Q,Gourdon D,Sun C,Holten-Andersen N,Anderson TH,Waite JH,Israelachvili JN

更新日期：2007-03-06 00:00:00

abstract：:If excision repair-proficient human cells are allowed time for repair before onset of S phase, the premutagenic lesions formed by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy- 7,8,9,10-tetrahydrobenzo[a]pyrene (benzo[a]pyrene diol epoxide, BPDE) are lost from the transcribed strand of the hypoxanthine (guanin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chen RH,Maher VM,Brouwer J,van de Putte P,McCormick JJ

更新日期：1992-06-15 00:00:00

abstract：:Smooth muscle cells (SMCs) have been shown to migrate in response to insulin-like growth factor I (IGF-I). However, the mechanism mediating this response has not been determined. The migration rates of porcine and human vascular SMCs were assessed in a monolayer wounding assay. IGF-I and IGF-II induced increases of 14...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jones JI,Prevette T,Gockerman A,Clemmons DR

更新日期：1996-03-19 00:00:00

abstract：:We investigated the influence of interareal distance on connectivity patterns in a database obtained from the injection of retrograde tracers in 29 areas distributed over six regions (occipital, temporal, parietal, frontal, prefrontal, and limbic). One-third of the 1,615 pathways projecting to the 29 target areas were...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Markov NT,Ercsey-Ravasz M,Lamy C,Ribeiro Gomes AR,Magrou L,Misery P,Giroud P,Barone P,Dehay C,Toroczkai Z,Knoblauch K,Van Essen DC,Kennedy H

更新日期：2013-03-26 00:00:00

abstract：:A central question in stem cell biology is whether organ homeostasis is maintained in adult organs through undifferentiated stem cells or self-duplication of specialized cell populations. To address this issue in the exocrine pancreas we analyzed the Bmi1-labeled cell lineage of pancreatic acinar cells. Previously, we...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sangiorgi E,Capecchi MR

更新日期：2009-04-28 00:00:00

abstract：:A study was undertaken to elucidate the molecular mechanisms by which glucocorticoids induce cleft palate in mice. It was hypothesized that a compound such as triamcinolone acetonide inhibits mRNA synthesis; that this results later in depressed protein synthesis; and that the latter is ultimately responsible for slowe...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zimmerman EF,Andrew F,Kalter H

更新日期：1970-10-01 00:00:00

abstract：:In MtrF, an outer-membrane multiheme cytochrome, the 10 heme groups are arranged in heme binding domains II and IV along the pseudo-C2 axis, forming the electron transfer (ET) pathways. Previous reports based on molecular dynamics simulations showed that the redox potential (Em) values for the heme pairs located in sy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe HC,Yamashita Y,Ishikita H

更新日期：2017-03-14 00:00:00

abstract：:The cholesterol-dependent cytolysins (CDCs) constitute a large family of pore-forming toxins that function exclusively on cholesterol-containing membranes. A detailed analysis of the various stages in the cytolytic mechanism of three members of the CDC family revealed that significant depletion of cholesterol from the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Giddings KS,Johnson AE,Tweten RK

更新日期：2003-09-30 00:00:00

abstract：:Sprouty proteins act as intracellular inhibitors of receptor tyrosine kinase signaling. Here we show that the mammalian Sprouty2 protein contains an iron-sulfur complex that can exist in an oxidized, reduced, or nitrosylated state. Purified Sprouty2 assembles into large monodisperse spheres containing approximately 24...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu X,Alexander PB,He Y,Kikkawa M,Vogel PD,McKnight SL

更新日期：2005-09-27 00:00:00

abstract：:Rapid and efficient protocols to generate oligodendrocytes (OL) from human induced pluripotent stem cells (iPSC) are currently lacking, but may be a key technology to understand the biology of myelin diseases and to develop treatments for such disorders. Here, we demonstrate that the induction of three transcription f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ehrlich M,Mozafari S,Glatza M,Starost L,Velychko S,Hallmann AL,Cui QL,Schambach A,Kim KP,Bachelin C,Marteyn A,Hargus G,Johnson RM,Antel J,Sterneckert J,Zaehres H,Schöler HR,Baron-Van Evercooren A,Kuhlmann T

更新日期：2017-03-14 00:00:00

abstract：:Nonribosomal peptide synthetases (NRPSs) and polyketide synthases are large, multidomain enzymes that biosynthesize a number of pharmaceutically important natural products. The recognition of biosynthetic intermediates, displayed via covalent attachment to carrier proteins, by catalytic domains is critical for NRPS an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lai JR,Fischbach MA,Liu DR,Walsh CT

更新日期：2006-04-04 00:00:00

abstract：:Ubc13 is a ubiquitin-conjugating enzyme responsible for noncanonical ubiquitination of TNF receptor-associated factor (TRAF)-family adapter proteins involved in Toll-like receptor and TNF-family cytokine receptor signaling, which are regulators of innate immunity. Gene ablation was used to study the function of Ubc13 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fukushima T,Matsuzawa S,Kress CL,Bruey JM,Krajewska M,Lefebvre S,Zapata JM,Ronai Z,Reed JC

更新日期：2007-04-10 00:00:00

abstract：:The mitotic (or spindle assembly) checkpoint system prevents premature separation of sister chromatids in mitosis. When the checkpoint is turned on, the mitotic checkpoint complex (MCC) inhibits the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C). MCC is composed of the checkpoint proteins BubR1, Bub3, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Eytan E,Sitry-Shevah D,Teichner A,Hershko A

更新日期：2013-06-25 00:00:00

abstract：:The binding of thyroid hormone to the thyroid hormone receptor (TR) mediates important physiological effects. However, the transcriptional effects of TR mediated by the thyroid response element (TRE) cannot explain many actions of thyroid hormone. We postulate that TR can initiate rapid, non-TRE-mediated effects in th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hiroi Y,Kim HH,Ying H,Furuya F,Huang Z,Simoncini T,Noma K,Ueki K,Nguyen NH,Scanlan TS,Moskowitz MA,Cheng SY,Liao JK

更新日期：2006-09-19 00:00:00

abstract：:Although in decline after successful anti-HIV therapy, B-cell lymphomas are still elevated in HIV-1-seropositive (HIV+) persons, and the mechanisms are obscure. The HIV-1 matrix protein p17 persists in germinal centers long after HIV-1 drug suppression, and some p17 variants (vp17s) activate Akt signaling and promote ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dolcetti R,Giagulli C,He W,Selleri M,Caccuri F,Eyzaguirre LM,Mazzuca P,Corbellini S,Campilongo F,Marsico S,Giombini E,Muraro E,Rozera G,De Paoli P,Carbone A,Capobianchi MR,Ippolito G,Fiorentini S,Blattner WA,Lu W,

更新日期：2015-11-17 00:00:00