Regulation of starvation- and virus-induced autophagy by the eIF2alpha kinase signaling pathway.

abstract：:DNA polymerases from Xenopus laevis oocytes, unfertilized eggs, and kidney cells grown in culture have been characterized. The same three major DNA polymerase activities are present in all cell types examined. We attempt to relate the characteristics of amphibian enzymes to those of mammalian polymerases. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tatò F,Gandini DA,Tocchini-Valentini GP

更新日期：1974-09-01 00:00:00

abstract：:Loss of heterozygosity affecting chromosome 17p has been detected at high frequencies in a variety of human tumors, including cancers of the colon, breast, lung, and brain. One presumed target of these losses is p53, a tumor suppressor gene located on 17p. To our knowledge, loss of heterozygosity has not yet been repo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meltzer SJ,Yin J,Huang Y,McDaniel TK,Newkirk C,Iseri O,Vogelstein B,Resau JH

更新日期：1991-06-01 00:00:00

abstract：:Interaction of the alpha beta T cell receptor (TCR) with major histocompatibility (MHC) molecules occupied with any of a large collection of peptides derived from self proteins is a critical step in driving T cell "positive" selection in the thymus. Interaction with this same pool of self-peptide/MHC ligands deletes T...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu CP,Crawford F,Marrack P,Kappler J

更新日期：1998-04-14 00:00:00

abstract：:Cyclotides are plant defense peptides that have been extensively investigated for pharmaceutical and agricultural applications, but key details of their posttranslational biosynthesis have remained elusive. Asparaginyl endopeptidases are crucial in the final stage of the head-to-tail cyclization reaction, but the enzy...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rehm FBH,Jackson MA,De Geyter E,Yap K,Gilding EK,Durek T,Craik DJ

更新日期：2019-04-16 00:00:00

abstract：:VEGF and angiopoietin-1 (Ang1) are two major angiogenic factors being investigated for the treatment of myocardial infarction (MI). Targeting VEGF and Ang1 expression in the ischemic myocardium can increase their local therapeutic effects and reduce possible adverse effects. Adeno-associated viral vectors (AAVs) expre...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tao Z,Chen B,Tan X,Zhao Y,Wang L,Zhu T,Cao K,Yang Z,Kan YW,Su H

更新日期：2011-02-01 00:00:00

abstract：:The cDNA sequences encoding the adult alpha- and beta-globin polypeptides of a marsupial, the native cat Dasyurus viverrinus, have been cloned and their nucleotide sequences have been determined. Using these cDNA clones we have determined the chromosomal location of the native cat alpha- and beta-globin genes by in si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wainwright B,Hope R

更新日期：1985-12-01 00:00:00

abstract：:Molecular genetic analyses of the young pseudogenes of the immunoglobulin C epsilon genes were carried out to obtain qualitative evidence for the phylogenetic branching pattern of hominoid primates. We found that Old World monkeys had two C epsilon genes, one of which was processed. Among the hominoids examined only t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ueda S,Takenaka O,Honjo T

更新日期：1985-06-01 00:00:00

abstract：:We developed a "continual engagement" model to better integrate knowledge from policy makers, communities, and researchers with the goal of promoting more effective action to balance poverty alleviation and wildlife conservation in 4 pastoral ecosystems of East Africa. The model involved the creation of a core boundar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Reid RS,Nkedianye D,Said MY,Kaelo D,Neselle M,Makui O,Onetu L,Kiruswa S,Kamuaro NO,Kristjanson P,Ogutu J,BurnSilver SB,Goldman MJ,Boone RB,Galvin KA,Dickson NM,Clark WC

更新日期：2016-04-26 00:00:00

abstract：:The evolutionary process that occurs when a species colonizes a new environment provides an opportunity to explore the mechanisms underlying genetic adaptation, which is essential knowledge for understanding evolution and the maintenance of biodiversity. Atlantic herring has an estimated total breeding stock of about ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill J,Enbody ED,Pettersson ME,Sprehn CG,Bekkevold D,Folkvord A,Laikre L,Kleinau G,Scheerer P,Andersson L

更新日期：2019-09-10 00:00:00

abstract：:Rotavirus is considered a directly transmitted disease due to its high infectivity. Environmental pathways have, therefore, largely been ignored. Rotavirus, however, persists in water sources, and both its surface water concentrations and infection incidence vary with temperature. Here, we examine the potential for wa...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kraay ANM,Brouwer AF,Lin N,Collender PA,Remais JV,Eisenberg JNS

更新日期：2018-03-20 00:00:00

abstract：:Cl- channels in the apical membranes of salt-secreting epithelia are activated by both cAMP and Ca2+ second-messenger systems, and dysfunctions in their hormonal regulation have been demonstrated in patients with cystic fibrosis. We have transfected the epithelial cell line T84 with an expression vector containing a m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rogers KV,Goldman PS,Frizzell RA,McKnight GS

更新日期：1990-11-01 00:00:00

abstract：:Human P-glycoprotein (Pgp) confers multidrug resistance to cancer cells by ATP-dependent extrusion of a great many structurally dissimilar hydrophobic compounds. The manner in which Pgp recognizes these different substrates is unknown. The protein shows internal homology between its N- and C-terminal halves, each comp...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dey S,Ramachandra M,Pastan I,Gottesman MM,Ambudkar SV

更新日期：1997-09-30 00:00:00

abstract：:The T helper type 2 (Th2) cytokine genes Il4, Il5, and Il13 are contained within a 140-kb region of mouse chromosome 11 and their expression is controlled by a locus control region (LCR) embedded within this locus. The LCR is composed of a number of DNase I-hypersensitive sites (HSs), which are believed to encompass t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams A,Lee GR,Spilianakis CG,Hwang SS,Eisenbarth SC,Flavell RA

更新日期：2013-04-23 00:00:00

abstract：:At the synapse, presynaptic membranes specialized for vesicular traffic are linked to postsynaptic membranes specialized for signal transduction. The mechanisms that connect pre- and postsynaptic membranes into synaptic junctions are unknown. Neuroligins and beta-neurexins are neuronal cell-surface proteins that bind ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Song JY,Ichtchenko K,Südhof TC,Brose N

更新日期：1999-02-02 00:00:00

abstract：:The Pleistocene global dispersal of modern humans required the transit of arid and semiarid regions where the distribution of potable water provided a primary constraint on dispersal pathways. Here, we provide a spatially explicit continental-scale assessment of the opportunities for Pleistocene human occupation of Au...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bird MI,O'Grady D,Ulm S

更新日期：2016-10-11 00:00:00

abstract：:The effect of different total enzyme concentrations on the flux through the bacterial phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) in vitro was determined by measuring PTS-mediated carbohydrate phosphorylation at different dilutions of cell-free extract of Escherichia coli. The dependence of the fl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rohwer JM,Postma PW,Kholodenko BN,Westerhoff HV

更新日期：1998-09-01 00:00:00

abstract：:Myoglobin-mediated oxygen delivery to intracellular mitochondria is demonstrated in cardiac myocytes isolated from the hearts of mature rats. Myocytes are held at high ambient oxygen pressure, 40-340 torr (5-45 kPa); sarcoplasmic myoglobin is fully oxygenated. In this condition oxygen availability does not limit respi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wittenberg BA,Wittenberg JB

更新日期：1987-11-01 00:00:00

abstract：:Fine finger and hand movements in humans, monkeys, and rats are under the direct control of the corticospinal tract (CST). CST lesions lead to severe, long-term deficits of precision movements. We transected completely both CSTs in adult rats and treated the animals for 2 weeks with an antibody that neutralized the ce...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Raineteau O,Fouad K,Noth P,Thallmair M,Schwab ME

更新日期：2001-06-05 00:00:00

abstract：:Adult rat arterial smooth muscle cells (SMC) in primary culture modulate from contractile to synthetic phenotype. This process includes partial loss of myofilaments and formation of an extensive rough endoplasmic reticulum and a large Golgi complex. It gives the cells the ability to initiate DNA synthesis and actively...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nilsson J,Sjölund M,Palmberg L,Thyberg J,Heldin CH

更新日期：1985-07-01 00:00:00

abstract：:Murine monoclonal antibodies that bind selectively to adducts formed on DNA by the antitumor drug cis-diamminedichloroplatinum(II), cis-DDP, or to the chemotherapeutically inactive trans isomer trans-DDP were elicited by immunization with calf thymus DNA modified with either cis- or trans-DDP at ratios of bound platin...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sundquist WI,Lippard SJ,Stollar BD

更新日期：1987-12-01 00:00:00

abstract：:As countries pursue sustainable development across sectors as diverse as health, agriculture, and infrastructure, sectoral policies interact, generating synergies that alter their effectiveness. Identifying those synergies ex ante facilitates the harmonization of policies and provides an important lever to achieve the...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pedercini M,Arquitt S,Collste D,Herren H

更新日期：2019-11-12 00:00:00

abstract：:By using a simplified model of small open liquid-like clusters with surface effects, in the gas phase, it is shown how the statistical thermodynamics of small systems can be extended to include metastable supersaturated gaseous states not too far from the gas-liquid equilibrium transition point. To accomplish this, on...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hill TL,Chamberlin RV

更新日期：1998-10-27 00:00:00

abstract：:Bordetella dermonecrotizing toxin causes assembly of actin stress fibers and focal adhesions in some cultured cells and induces mobility shifts of the small GTP-binding protein Rho on electrophoresis. We attempted to clarify the molecular basis of the toxin action on Rho. Analysis of the amino acid sequence of toxin-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Horiguchi Y,Inoue N,Masuda M,Kashimoto T,Katahira J,Sugimoto N,Matsuda M

更新日期：1997-10-14 00:00:00

abstract：:Meiosis-specific homologs of RecA protein have been identified in Saccharomyces cerevisiae and higher eukaryotes including mammals, but their enzymatic activities have not been described. We have purified the human protein HsDmc1 produced in Escherichia coli from a cloned copy of the cDNA. The recombinant enzyme had D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Z,Golub EI,Gupta R,Radding CM

更新日期：1997-10-14 00:00:00

abstract：:The yeast AAA-ATPase Cdc48 and the ubiquitin fusion degradation (UFD) proteins play important, evolutionarily conserved roles in ubiquitin dependent protein degradation. The N-terminal domain of Cdc48 interacts with substrate-recruiting cofactors, whereas the C terminus of Cdc48 binds to proteins such as Ufd3 that pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhao G,Li G,Schindelin H,Lennarz WJ

更新日期：2009-09-22 00:00:00

abstract：:Cigarette smoking causes emphysema, a fatal disease involving extensive structural and functional damage of the lung. Using a guinea pig model and human lung cells, we show that oxidant(s) present in tobacco smoke not only cause direct oxidative damage of lung proteins, contributing to the major share of lung injury, ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gupta I,Ganguly S,Rozanas CR,Stuehr DJ,Panda K

更新日期：2016-07-19 00:00:00

abstract：:The formation of heparan sulfate occurs within the lumen of the endoplasmic reticulum-Golgi complex-trans-Golgi network by the concerted action of several glycosyltransferases, an epimerase, and multiple sulfotransferases. In this report, we have examined the location and interaction of tagged forms of five of the bio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pinhal MA,Smith B,Olson S,Aikawa J,Kimata K,Esko JD

更新日期：2001-11-06 00:00:00

abstract：:The nodZ gene, which is present in various soil bacteria such as Bradyrhizobium japonicum, Azorhizobium caulinodans, and Rhizobium loti, is involved in the addition of a fucosyl residue to the reducing N-acetylglucosamine residue of lipochitin oligosaccharide (LCO) signal molecules. Using an Escherichia coli strain th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quinto C,Wijfjes AH,Bloemberg GV,Blok-Tip L,López-Lara IM,Lugtenberg BJ,Thomas-Oates JE,Spaink HP

更新日期：1997-04-29 00:00:00

abstract：:Migraine is characterized by severe headaches that can be preceded by an aura likely caused by cortical spreading depression (SD). The antiepileptic pregabalin (Lyrica) shows clinical promise for migraine therapy, although its efficacy and mechanism of action are unclear. As detected by diffusion-weighted MRI (DW-MRI)...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cain SM,Bohnet B,LeDue J,Yung AC,Garcia E,Tyson JR,Alles SR,Han H,van den Maagdenberg AM,Kozlowski P,MacVicar BA,Snutch TP

更新日期：2017-02-28 00:00:00

abstract：:Establishment of functional synaptic connections in a selective manner is essential for nervous system operation. In mammalian retinas, rod and cone photoreceptors form selective synaptic connections with different classes of bipolar cells (BCs) to propagate light signals. While there has been progress in elucidating ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cao Y,Wang Y,Dunn HA,Orlandi C,Shultz N,Kamasawa N,Fitzpatrick D,Li W,Zeitz C,Hauswirth W,Martemyanov KA

更新日期：2020-09-22 00:00:00