Nucleotide sequence of the transforming gene of simian sarcoma virus.

abstract：:Genomic imprinting results in the differential expression of genes, depending on which allele is inherited from the mother and which from the father. The effects of such differential gene expression are reflected in phenotypic differences between the reciprocal heterozygotes (Aa vs. aA). Although many imprinted genes ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Cheverud JM,Hager R,Roseman C,Fawcett G,Wang B,Wolf JB

更新日期：2008-03-18 00:00:00

abstract：:The glucose transporter isoform GLUT4 is found only in cells that exhibit insulin-sensitive glucose transport. To investigate the function of this transporter, L6 myoblasts were stably transfected with GLUT4 cDNA. GLUT4 underwent insulin-dependent movement to the cell surface in myoblasts overexpressing the transporte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lawrence JC Jr,Piper RC,Robinson LJ,James DE

更新日期：1992-04-15 00:00:00

abstract：:Intracellular bacterial pathogens evade the bactericidal functions of mammalian cells by physical escape from their phagosome and replication into the cytoplasm or through the modulation of phagosome maturation and biogenesis of a membrane-bound replicative organelle. Here, we detail in murine primary macrophages the ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Checroun C,Wehrly TD,Fischer ER,Hayes SF,Celli J

更新日期：2006-09-26 00:00:00

abstract：:Germ-line stem cells (GSCs) are maintained by the somatic microenvironment, or GSC niche, which ensures that GSCs can both self-renew and produce functional gametes. However, it remains unclear how the proper niche size and location are regulated within the developing gonads. In the Drosophila testis, the hub cells th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kitadate Y,Kobayashi S

更新日期：2010-08-10 00:00:00

abstract：:Phagocytic cells are a critical line of defense against infection. The ability of a pathogen to survive and even replicate within phagocytic cells is a potent method of evading the defense mechanisms of the host. A number of pathogens survive within macrophages after phagocytosis and this contributes to their virulenc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lindgren SW,Stojiljkovic I,Heffron F

更新日期：1996-04-30 00:00:00

abstract：:Centrosome reorientation to the immunological synapse maintains the specificity of T-cell effector function by facilitating the directional release of cytokines and cytolytic factors toward the antigen-presenting cell. This polarization response is driven by the localized accumulation of diacylglycerol, which recruits...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Liu X,Kapoor TM,Chen JK,Huse M

更新日期：2013-07-16 00:00:00

abstract：:The Skp1-Cullin1 F-box protein-Fbw7 ubiquitin ligase regulates phosphorylation-dependent cyclin E degradation, and disruption of this pathway is associated with genetic instability and tumorigenesis. Fbw7 is a human tumor suppressor that is targeted for mutation in primary cancers. However, mechanisms other than mutat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Minella AC,Welcker M,Clurman BE

更新日期：2005-07-05 00:00:00

abstract：:Some taxa in the superfamily Arctoidea, such as the giant panda and the lesser panda, have presented puzzles to taxonomists. In the present study, approximately 397 bases of the cytochrome b gene, 364 bases of the 12S rRNA gene, and 74 bases of the tRNA(Thr) and tRNA(Pro) genes from the giant panda, lesser panda, kink...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang YP,Ryder OA

更新日期：1993-10-15 00:00:00

abstract：:Four synthetic peptides that together constitute the cell attachment domain of fibronectin [Pierschbacher, M.D., Ruoslahti, E., Sundelin, J., Lind, P. & Peterson, P. (1982) J. Biol. Chem. 257, 9593-9597] were constructed and tested for their ability to induce cell attachment and spreading. One of these peptides, consi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pierschbacher M,Hayman EG,Ruoslahti E

更新日期：1983-03-01 00:00:00

abstract：:Fibrotic diseases are not well-understood. They represent a number of different diseases that are characterized by the development of severe organ fibrosis without any obvious cause, such as the devastating diseases idiopathic pulmonary fibrosis (IPF) and scleroderma. These diseases have a poor prognosis comparable wi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wernig G,Chen SY,Cui L,Van Neste C,Tsai JM,Kambham N,Vogel H,Natkunam Y,Gilliland DG,Nolan G,Weissman IL

更新日期：2017-05-02 00:00:00

abstract：:Gastrulation is a fundamental process in early development that results in the formation of three primary germ layers. During avian gastrulation, presumptive mesodermal cells in the dorsal epiblast ingress through a furrow called the primitive streak (PS), and subsequently move away from the PS and form adult tissues....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zamir EA,Czirók A,Cui C,Little CD,Rongish BJ

更新日期：2006-12-26 00:00:00

abstract：:Voltage-gated Na channels in several classes of neurons, including cells of the cerebellum, are subject to an open-channel block and unblock by an endogenous protein. The Na(V)beta4 (Scn4b) subunit is a candidate blocking protein because a free peptide from its cytoplasmic tail, the beta4 peptide, can block open Na ch...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bant JS,Raman IM

更新日期：2010-07-06 00:00:00

abstract：:Replication and transcription of viral RNA genomes rely on host-donated proteins. Qbeta virus infects Escherichia coli and replicates and transcribes its own genomic RNA by Qbeta replicase. Qbeta replicase requires the virus-encoded RNA-dependent RNA polymerase (beta-subunit), and the host-donated translational elonga...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Takeshita D,Tomita K

更新日期：2010-09-07 00:00:00

abstract：:The Arabidopsis thaliana SOS2 and SOS3 genes are required for intracellular Na(+) and K(+) homeostasis and plant tolerance to high Na(+) and low K(+) environments. SOS3 is an EF hand type calcium-binding protein having sequence similarities with animal neuronal calcium sensors and the yeast calcineurin B. SOS2 is a se...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halfter U,Ishitani M,Zhu JK

更新日期：2000-03-28 00:00:00

abstract：:The superior colliculus (SC) is part of a network of brain areas that directs saccadic eye movements, overtly shifting both gaze and attention from position to position, in space. Here, we seek direct evidence that the SC also contributes to the control of covert spatial attention, a process that focuses attention on ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Müller JR,Philiastides MG,Newsome WT

更新日期：2005-01-18 00:00:00

abstract：:The primary photochemistry of Fe-depleted and Zn-reconstituted reaction centers from Rhodopseudomonas sphaeroides R-26.1 was studied by transient absorption spectroscopy and compared with native, Fe(2+)-containing reaction centers. Excitation of metal-free reaction centers with 30-ps flashes produced the initial charg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kirmaier C,Holten D,Debus RJ,Feher G,Okamura MY

更新日期：1986-09-01 00:00:00

abstract：:A cell separation technique was designed based on the interaction between cell-surface-bound IgG and protein A of Staphylococcus aureus. The density of lymphoid cells coated with IgG antibodies against one of the surface markers was increased by adherence of staphylococci. Cells with adhering bacteria were separated f...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ghetie V,Nilsson K,Sjöquist J

更新日期：1974-12-01 00:00:00

abstract：:A full-length cDNA clone encoding a glutamate receptor was isolated from a human brain cDNA library, and the gene product was characterized after expression in Xenopus oocytes. Degenerate PCR primers to conserved regions of published rat brain glutamate receptor sequences amplified a 1-kilobase fragment from a human b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sun W,Ferrer-Montiel AV,Schinder AF,McPherson JP,Evans GA,Montal M

更新日期：1992-02-15 00:00:00

abstract：:Successful treatment in allergic, autoimmune, and infectious diseases often requires altering the nature of a detrimental immune response mediated by a particular CD4+ T helper (Th) cell subset. While several factors contribute to the development of CD4+ Th1 and Th2 cells, the requirements for switching an established...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nabors GS,Afonso LC,Farrell JP,Scott P

更新日期：1995-04-11 00:00:00

abstract：:Hypophosphatasia is an inherited disorder characterized by defective bone mineralization and a deficiency of serum and tissue liver/bone/kidney alkaline phosphatase (L/B/K ALP) activity. Clinical severity is variable, ranging from death in utero (due to severe rickets) to pathologic fractures first presenting in adult...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Weiss MJ,Cole DE,Ray K,Whyte MP,Lafferty MA,Mulivor RA,Harris H

更新日期：1988-10-01 00:00:00

abstract：:High social status reduces stress responses in numerous species, but the stress-buffering effect of status may dissipate or even reverse during times of hierarchical instability. In an experimental test of this hypothesis, 118 participants (57.3% female) were randomly assigned to a high- or low-status position in a st...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Knight EL,Mehta PH

更新日期：2017-01-03 00:00:00

abstract：:Integrated assessment models of climate and the economy provide estimates of the social cost of carbon and inform climate policy. We create a variant of the Regional Integrated model of Climate and the Economy (RICE)-a regionally disaggregated version of the Dynamic Integrated model of Climate and the Economy (DICE)-i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dennig F,Budolfson MB,Fleurbaey M,Siebert A,Socolow RH

更新日期：2015-12-29 00:00:00

abstract：:A glycoprotein was isolated and purified to homogeneity from the serum of a patient with chronic non-A, non-B hepatitis. NaDodSO4/PAGE of the glycoprotein revealed a single major band at Mr approximately 77,000. Antibodies to this glycoprotein were shown to possess the following immunoreactivity: (i) they reacted by r...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Seto B,Gerety RJ

更新日期：1985-08-01 00:00:00

abstract：:Macropinocytosis is a highly conserved endocytic process by which extracellular fluid and solutes are internalized into cells. Macropinocytosis starts with the formation of membrane ruffles at the plasma membrane and ends with their closure. The transient and sequential emergence of phosphoinositides PI(3,4,5)P3 and P...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Maekawa M,Terasaka S,Mochizuki Y,Kawai K,Ikeda Y,Araki N,Skolnik EY,Taguchi T,Arai H

更新日期：2014-03-18 00:00:00

abstract：:This report establishes that increasing the activity of cyclic AMP-dependent protein kinase (protein kinase A; PKA) potentiates glucocorticoid-mediated signaling in embryonic day 5.5 (E5.5) chicken retina. Expression of a glutamine synthetase-chloramphenicol acetyltransferase (CAT) fusion gene is not induced by treatm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang H,Li YC,Young AP

更新日期：1993-05-01 00:00:00

abstract：:Titania, which exhibits superwetting under light illumination, has been widely used as an ideal material for environmental solution such as self-cleaning, water-air purification, and antifogging. There have been various studies to understand such superhydrophilic conversion. The origin of superwetting has not been cla...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Lee K,Kim Q,An S,An J,Kim J,Kim B,Jhe W

更新日期：2014-04-22 00:00:00

abstract：:129/SvEv mice with a loss-of-function mutation in the heterotrimeric G protein α-subunit gene Gnai3 have fusions of ribs and lumbar vertebrae, indicating a requirement for Gα(i) (the "inhibitory" class of α-subunits) in somite derivatives. Mice with mutations of Gnai1 or Gnai2 have neither defect, but loss of both Gna...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Plummer NW,Spicher K,Malphurs J,Akiyama H,Abramowitz J,Nürnberg B,Birnbaumer L

更新日期：2012-12-26 00:00:00

abstract：:Lung cancer is the number one cause of cancer-related deaths in the world. Patients treated with current chemotherapies for non-small-cell lung cancers (NSCLCs) have a survival rate of approximately 15% after 5 years. Novel approaches are needed to treat this disease. We show elevated NAD(P)H:quinone oxidoreductase-1 ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bey EA,Bentle MS,Reinicke KE,Dong Y,Yang CR,Girard L,Minna JD,Bornmann WG,Gao J,Boothman DA

更新日期：2007-07-10 00:00:00

abstract：:There is significant variation in the reported magnitude and even the sign of [Formula: see text] shifts in thin polymer films with nominally the same chemistry, film thickness, and supporting substrate. The implicit assumption is that methods used to estimate [Formula: see text] in bulk materials are relevant for inf...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang W,Douglas JF,Starr FW

更新日期：2018-05-29 00:00:00

abstract：:The nodZ gene, which is present in various soil bacteria such as Bradyrhizobium japonicum, Azorhizobium caulinodans, and Rhizobium loti, is involved in the addition of a fucosyl residue to the reducing N-acetylglucosamine residue of lipochitin oligosaccharide (LCO) signal molecules. Using an Escherichia coli strain th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Quinto C,Wijfjes AH,Bloemberg GV,Blok-Tip L,López-Lara IM,Lugtenberg BJ,Thomas-Oates JE,Spaink HP

更新日期：1997-04-29 00:00:00