Genomic imprinting effects on adult body composition in mice.

abstract：:Zea mays plasma membrane intrinsic proteins (ZmPIPs) fall into two groups, ZmPIP1s and ZmPIP2s, that exhibit different water channel activities when expressed in Xenopus oocytes. ZmPIP1s are inactive, whereas ZmPIP2s induce a marked increase in the membrane osmotic water permeability coefficient, P(f). We previously s...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zelazny E,Borst JW,Muylaert M,Batoko H,Hemminga MA,Chaumont F

更新日期：2007-07-24 00:00:00

abstract：:The matrix 2 (M2) protein from influenza A virus is a proton channel that uses His37 as a selectivity filter. Here we report high-resolution (1.10 Å) cryogenic crystallographic structures of the transmembrane domain of M2 at low and high pH. These structures reveal that waters within the pore form hydrogen-bonded netw...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Thomaston JL,Alfonso-Prieto M,Woldeyes RA,Fraser JS,Klein ML,Fiorin G,DeGrado WF

更新日期：2015-11-17 00:00:00

abstract：:Rat superior cervical sympathetic ganglion was used to begin studying the regulation of molecular components of the synapse. Ganglionic postsynaptic densities (PSDs)exhibited a thin, disc-shaped profile electron microscopically, comparable to that described for brain. Moreover, the presumptive ganglionic PSD protein (...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wu K,Black IB

更新日期：1987-12-01 00:00:00

abstract：:Plant phylogenetic estimates are most likely to be reliable when congruent evidence is obtained independently from the mitochondrial, plastid, and nuclear genomes with all methods of analysis. Here, results are presented from separate and combined genomic analyses of new and previously published data, including six an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Barkman TJ,Chenery G,McNeal JR,Lyons-Weiler J,Ellisens WJ,Moore G,Wolfe AD,dePamphilis CW

更新日期：2000-11-21 00:00:00

abstract：:Cell-cycle progression is mediated by a co-ordinated interaction between cyclin-dependent kinases and their target proteins including the pRB and E2F/DP-1 complexes. Immunoneutralization and antisense experiments have established that the abundance of cyclin D1, a regulatory subunit of the cyclin-dependent kinases, ma...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Watanabe G,Howe A,Lee RJ,Albanese C,Shu IW,Karnezis AN,Zon L,Kyriakis J,Rundell K,Pestell RG

更新日期：1996-11-12 00:00:00

abstract：:Recombinant DNA techniques have been combined with somatic cell genetic methods to identify, isolate, and amplify fragments of human DNA localized at specific regions of human chromosome 11 selected as a model system. A library of genomic DNA segments has been constructed, in lambda Charon 4A bacteriophage, from the D...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gusella JF,Keys C,VarsanyiBreiner A,Kao FT,Jones C,Puck TT,Housman D

更新日期：1980-05-01 00:00:00

abstract：:Two striking differences between humans and our closest living relatives, chimpanzees and gorillas, are the size of our brains (larger by a factor of three or four) and our life span (longer by a factor of about two). Our thesis is that these two distinctive features of humans are products of coevolutionary selection....

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kaplan HS,Robson AJ

更新日期：2002-07-23 00:00:00

abstract：:The central role of cyclin-dependent kinases (CDKs) in cell cycle regulation makes them a promising target for studying inhibitory molecules that can modify the degree of cell proliferation. The discovery of specific inhibitors of CDKs such as polyhydroxylated flavones has opened the way to investigation and design of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： De Azevedo WF Jr,Mueller-Dieckmann HJ,Schulze-Gahmen U,Worland PJ,Sausville E,Kim SH

更新日期：1996-04-02 00:00:00

abstract：:The enormous complexity of biological networks has led to the suggestion that networks are built of modules that perform particular functions and are "reused" in evolution in a manner similar to reusable domains in protein structures or modules of electronic circuits. Analysis of known biological networks has revealed...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spirin V,Gelfand MS,Mironov AA,Mirny LA

更新日期：2006-06-06 00:00:00

abstract：:Experimental exclusion of the Andean flamingo (Phoenicoparrus andinus) from shallow water areas of a salt lake in the Bolivian Andes caused large increases in the biomass of microorganisms inhabiting the surface sediments, especially a large diatom (Surirella wetzeli), amebas, ciliates, and nematodes. This is a conser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hurlbert SH,Chang CC

更新日期：1983-08-01 00:00:00

abstract：:Protein tyrosine phosphatase (PTP)σ (PTPRS) was shown previously to be associated with susceptibility to inflammatory bowel disease (IBD). PTPσ(-/-) mice exhibit an IBD-like phenotype in the intestine and show increased susceptibility to acute models of murine colitis. However, the function of PTPσ in the intestine is...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Murchie R,Guo CH,Persaud A,Muise A,Rotin D

更新日期：2014-01-14 00:00:00

abstract：:Through rapid genetic adaptation and natural selection, the Plasmodium falciparum parasite--the deadliest of those that cause malaria--is able to develop resistance to antimalarial drugs, thwarting present efforts to control it. Genome-wide association studies (GWAS) provide a critical hypothesis-generating tool for u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Park DJ,Lukens AK,Neafsey DE,Schaffner SF,Chang HH,Valim C,Ribacke U,Van Tyne D,Galinsky K,Galligan M,Becker JS,Ndiaye D,Mboup S,Wiegand RC,Hartl DL,Sabeti PC,Wirth DF,Volkman SK

更新日期：2012-08-07 00:00:00

abstract：:The four-helical bundle soluble N-ethylmaleimide-sensitive fusion protein (NSF) attachment protein receptor (SNARE) complex that mediates intracellular membrane fusion events contains a highly conserved ionic layer at the center of an otherwise hydrophobic core. This layer has an undetermined function; it consists of ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Scales SJ,Yoo BY,Scheller RH

更新日期：2001-12-04 00:00:00

abstract：:Ribosome crystal structures have revealed that two small subunit proteins, S9 and S13, have C-terminal tails, which, together with several features of 16S rRNA, contact the anticodon stem-loop of P-site tRNA. To test the functional importance of these protein tails, we created genomic deletions of the C-terminal regio...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hoang L,Fredrick K,Noller HF

更新日期：2004-08-24 00:00:00

abstract：:The ability of cocaine to inhibit the dopamine transporter (DAT) appears to be crucial for its reinforcing properties. The potential use of drugs that produce long-lasting inhibition of the DAT as a mean of preventing the "high" and reducing drug-seeking behavior has become a major strategy in medication development. ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Volkow ND,Wang GJ,Fowler JS,Gatley SJ,Ding YS,Logan J,Dewey SL,Hitzemann R,Lieberman J

更新日期：1996-09-17 00:00:00

abstract：:Enzyme cytochemistry has been used, at the light and electron microscope levels, to "mark" cytoplasmic organelles of mammalian cells. Catalase cytochemistry permitted identification of microperoxisomes, apparently ubiquitous organelles that are attached by numerous slender connections to the endoplasmic reticulum. Thi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Novikoff AB

更新日期：1976-08-01 00:00:00

abstract：:The different isoforms of PDGF bind with different affinities to two different receptor types. Previously, these receptors have been demonstrated mainly on mesenchymal and glial cells. We show here that PDGF beta-type receptors are present also on rat brain neurons in vivo as well as in vitro. Immunohistochemical anal...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Smits A,Kato M,Westermark B,Nistér M,Heldin CH,Funa K

更新日期：1991-09-15 00:00:00

abstract：:Resistance to thyroid hormone (RTH) is most often due to point mutations in the beta-isoform of the thyroid hormone (TH) receptor (TR-beta). The majority of mutations involve the ligand-binding domain, where they block TH binding and receptor function on both stimulatory and inhibitory TH response elements. In contras...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Machado DS,Sabet A,Santiago LA,Sidhaye AR,Chiamolera MI,Ortiga-Carvalho TM,Wondisford FE

更新日期：2009-06-09 00:00:00

abstract：:The retrosplenial cortex (RSC) is part of a network of interconnected cortical, hippocampal, and thalamic structures harboring spatially modulated neurons. The RSC contains head direction cells and connects to the parahippocampal region and anterior thalamus. Manipulations of the RSC can affect spatial and contextual ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Czajkowski R,Jayaprakash B,Wiltgen B,Rogerson T,Guzman-Karlsson MC,Barth AL,Trachtenberg JT,Silva AJ

更新日期：2014-06-10 00:00:00

abstract：:Caenorhabditis elegans sqv mutants are defective in vulval epithelial invagination and have a severe reduction in hermaphrodite fertility. The gene sqv-7 encodes a multitransmembrane hydrophobic protein resembling nucleotide sugar transporters of the Golgi membrane. A Golgi vesicle enriched fraction of Saccharomyces c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Berninsone P,Hwang HY,Zemtseva I,Horvitz HR,Hirschberg CB

更新日期：2001-03-27 00:00:00

abstract：:The synaptic vesicle membrane protein synaptotagmin (tagmin) is essential for fast, calcium-dependent, neurotransmitter release and is likely to be the calcium sensor for exocytosis, because of its many calcium-dependent properties. Polyphosphoinositides are needed for exocytosis, but it has not been known why. We now...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schiavo G,Gu QM,Prestwich GD,Söllner TH,Rothman JE

更新日期：1996-11-12 00:00:00

abstract：:Explanted mouse blastocysts were microinjected in the blastocoel cavity with simian virus 40 (SV40) viral DNA. After surgical transfer to the uteri of pseudopregnant surrogate mothers, approximately 40% of the blastocysts developed to term and became healthy adults without apparent tumors at 1 year of age. Molecular h...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jaenisch R,Mintz B

更新日期：1974-04-01 00:00:00

abstract：:Ultraviolet photosensitivity of the single-stranded forms of poly(A) and poly(dA) is compared. In contrast to poly(A), poly(dA) is rather sensitive to ultraviolet irradiation. Relatively low doses of ultraviolet light lead to characteristic changes of the ultraviolet and circular dichroism spectra of poly(dA), suggest...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pörschke D

更新日期：1973-09-01 00:00:00

abstract：:General control nonderepressible 2 (GCN2) plays a major role in the cellular response to amino acid limitation. Although maintenance of amino acid homeostasis is critical for tumor growth, the contribution of GCN2 to cancer cell survival and proliferation is poorly understood. In this study, we generated GCN2 inhibito...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakamura A,Nambu T,Ebara S,Hasegawa Y,Toyoshima K,Tsuchiya Y,Tomita D,Fujimoto J,Kurasawa O,Takahara C,Ando A,Nishigaki R,Satomi Y,Hata A,Hara T

更新日期：2018-08-14 00:00:00

abstract：:Protozoan parasites of the genus Leishmania undergo a complex life cycle involving transmission by biting sand flies and replication within mammalian macrophage phagolysosomes. A major component of the Leishmania surface coat is the glycosylphosphatidylinositol (GPI)-anchored polysaccharide called lipophosphoglycan (L...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Späth GF,Epstein L,Leader B,Singer SM,Avila HA,Turco SJ,Beverley SM

更新日期：2000-08-01 00:00:00

abstract：:A compact, well-organized, and natural motif, stabilized by three disulfide bonds, is proposed as a basic scaffold for protein engineering. This motif contains 37 amino acids only and is formed by a short helix on one face and an antiparallel triple-stranded beta-sheet on the opposite face. It has been adopted by scor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vita C,Roumestand C,Toma F,Ménez A

更新日期：1995-07-03 00:00:00

abstract：:The recently discovered potato tuber (Solanum tuberosum) alpha-glucan, water dikinase (GWD) (formerly known as R1) catalyzes the phosphorylation of starch by a dikinase-type reaction mechanism in which the beta-phosphate of ATP is transferred to either the C-6 or the C-3 position of the glucosyl residue of starch. In ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Mikkelsen R,Mutenda KE,Mant A,Schürmann P,Blennow A

更新日期：2005-02-01 00:00:00

abstract：:Hypercholesterolemia, high serum cholesterol in the form of LDL, is a major risk factor for atherosclerosis. LDL is mostly degraded in the liver after its cellular internalization with the LDL receptor (LDLR). This clathrin-mediated endocytosis depends on the protein autosomal recessive hypercholesterolemia (ARH), whi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dvir H,Shah M,Girardi E,Guo L,Farquhar MG,Zajonc DM

更新日期：2012-05-01 00:00:00

abstract：:Elevation of cytosolic free Ca2+ concentration ([Ca2+]i) in excitable cells often acts as a negative feedback signal on firing of action potentials and the associated voltage-gated Ca2+ influx. Increased [Ca2+]i stimulates Ca2+-sensitive K+ channels (IK-Ca), and this, in turn, hyperpolarizes the cell and inhibits Ca2+...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Van Goor F,Krsmanovic LZ,Catt KJ,Stojilkovic SS

更新日期：1999-03-30 00:00:00

abstract：:G9a is an epigenetic regulator that methylates H3K9, generally causing repression of gene expression, and participates in diverse cellular functions. G9a is genetically deregulated in a variety of tumor types and can silence tumor suppressor genes and, therefore, is important for carcinogenesis. Although hypoxia is re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Casciello F,Al-Ejeh F,Kelly G,Brennan DJ,Ngiow SF,Young A,Stoll T,Windloch K,Hill MM,Smyth MJ,Gannon F,Lee JS

更新日期：2017-07-03 00:00:00